标题
The Role of PI3K/Akt and ERK in Neurodegenerative Disorders
作者
关键词
NDs, neurodegenerative disorders, MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, 6-OHDA, 6-hydroxydopamine, PD, Parkinson’s disease, HD, Huntington disease, BDNF, brain-derived neurotrophic factor, MAPK, mitogen-activated protein-extracellular kinase, Nrf2, nuclear factor erythroid 2 p45-related factor 2
出版物
NEUROTOXICITY RESEARCH
Volume 35, Issue 3, Pages 775-795
出版商
Springer Nature
发表日期
2019-02-01
DOI
10.1007/s12640-019-0003-y
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- α-Lipoic acid attenuates oxidative stress and neurotoxicity via the ERK/Akt-dependent pathway in the mutant hSOD1 related Drosophila model and the NSC34 cell line of amyotrophic lateral sclerosis
- (2018) Tianhang Wang et al. BRAIN RESEARCH BULLETIN
- Astrocyte truncated-TrkB mediates BDNF antiapoptotic effect leading to neuroprotection
- (2018) Julieta Saba et al. JOURNAL OF NEUROCHEMISTRY
- Vitexin protects dopaminergic neurons in MPTP-induced Parkinson’s disease through PI3K/Akt signaling pathway
- (2018) Ming Hu et al. Drug Design Development and Therapy
- Natural Cannabinoids Improve Dopamine Neurotransmission and Tau and Amyloid Pathology in a Mouse Model of Tauopathy
- (2018) Maria J. Casarejos et al. JOURNAL OF ALZHEIMERS DISEASE
- Sulfuretin Attenuates MPP+-Induced Neurotoxicity through Akt/GSK3β and ERK Signaling Pathways
- (2017) Ramesh Pariyar et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- ERK1b, a 46-kDa ERK isoform that is differentially regulated by MEK.
- (2017) Yuval Yung et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Neurotoxic reactive astrocytes are induced by activated microglia
- (2017) Shane A. Liddelow et al. NATURE
- Neurotrophic Effect of Asiatic acid, a Triterpene of Centella asiatica Against Chronic 1-Methyl 4-Phenyl 1, 2, 3, 6-Tetrahydropyridine Hydrochloride/Probenecid Mouse Model of Parkinson’s disease: The Role of MAPK, PI3K-Akt-GSK3β and mTOR Signalling Pathways
- (2017) Jagatheesan Nataraj et al. NEUROCHEMICAL RESEARCH
- Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities
- (2017) Fiona M. Menzies et al. NEURON
- Neuroprotective properties of icariin in MPTP-induced mouse model of Parkinson's disease: Involvement of PI3K/Akt and MEK/ERK signaling pathways
- (2017) Wen-Fang Chen et al. PHYTOMEDICINE
- Amentoflavone protects dopaminergic neurons in MPTP-induced Parkinson's disease model mice through PI3K/Akt and ERK signaling pathways
- (2017) Qin Cao et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Mucuna pruriens Protects against MPTP Intoxicated Neuroinflammation in Parkinson’s Disease through NF-κB/pAKT Signaling Pathways
- (2017) Sachchida N. Rai et al. Frontiers in Aging Neuroscience
- Brain ischaemia induces shedding of a BDNF-scavenger ectodomain from TrkB receptors by excitotoxicity activation of metalloproteinases and γ-secretases
- (2016) Gonzalo S Tejeda et al. JOURNAL OF PATHOLOGY
- Protective effects of activated signaling pathways by insulin on C6 glial cell model of MPP+-induced Parkinson’s disease
- (2016) Mahesh Ramalingam et al. JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION
- Progressive inflammation-mediated neurodegeneration after traumatic brain or spinal cord injury
- (2015) Alan I Faden et al. BRITISH JOURNAL OF PHARMACOLOGY
- BDNF, via truncated TrkB receptor, modulates GlyT1 and GlyT2 in astrocytes
- (2015) Rita I. Aroeira et al. GLIA
- Brain-derived neurotrophic factor mediates neuroprotection against Aβ-induced toxicity through a mechanism independent on adenosine 2A receptor activation
- (2015) André Jerónimo-Santos et al. GROWTH FACTORS
- Autophagy in Neurodegenerative Diseases: From Mechanism to Therapeutic Approach
- (2015) Jihoon Nah et al. MOLECULES AND CELLS
- The estrogen receptor β-PI3K/Akt pathway mediates the cytoprotective effects of tocotrienol in a cellular Parkinson's disease model
- (2014) Kazuhiro Nakaso et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- The role of PI3K/AKT/mTOR pathway in the modulation of autophagy and the clearance of protein aggregates in neurodegeneration
- (2014) David Heras-Sandoval et al. CELLULAR SIGNALLING
- Mitochondria, Energetics, Epigenetics, and Cellular Responses to Stress
- (2014) Daniel T. Shaughnessy et al. ENVIRONMENTAL HEALTH PERSPECTIVES
- Human-induced pluripotent stem cells: potential for neurodegenerative diseases
- (2014) C. A. Ross et al. HUMAN MOLECULAR GENETICS
- Dietary regulation of PI3K/AKT/GSK-3β pathway in Alzheimer’s disease
- (2014) Yasuko Kitagishi et al. Alzheimers Research & Therapy
- BDNF-Dependent Recycling Facilitates TrkB Translocation to Postsynaptic Density during LTP via a Rab11-Dependent Pathway
- (2013) S.-H. Huang et al. JOURNAL OF NEUROSCIENCE
- Cellular Mechanisms Controlling Caspase Activation and Function
- (2013) A. B. Parrish et al. Cold Spring Harbor Perspectives in Biology
- Probing Mechanisms That Underlie Human Neurodegenerative Diseases inDrosophila
- (2012) M. Jaiswal et al. Annual Review of Genetics
- Imbalance of neurotrophin receptor isoforms TrkB-FL/TrkB-T1 induces neuronal death in excitotoxicity
- (2012) Ó G Vidaurre et al. Cell Death & Disease
- Expression analysis of dopaminergic neurons in Parkinson’s disease and aging links transcriptional dysregulation of energy metabolism to cell death
- (2011) Matthias Elstner et al. ACTA NEUROPATHOLOGICA
- A novel target for Huntington's disease: ERK at the crossroads of signaling
- (2011) László Bodai et al. BIOESSAYS
- Preventing H2O2-induced apoptosis in cerebellar granule neurons by regulating the VEGFR-2/Akt signaling pathway using a novel dimeric antiacetylcholinesterase bis(12)-hupyridone
- (2011) Wei Cui et al. BRAIN RESEARCH
- Selective Toxicity by HDAC3 in Neurons: Regulation by Akt and GSK3
- (2011) F. H. Bardai et al. JOURNAL OF NEUROSCIENCE
- PI3-K/Akt and ERK pathways activated by VEGF play opposite roles in MPP+-induced neuronal apoptosis
- (2011) Wei Cui et al. NEUROCHEMISTRY INTERNATIONAL
- Nonapoptotic Function of BAD and BAX in Long-Term Depression of Synaptic Transmission
- (2011) Song Jiao et al. NEURON
- Upregulation of Heme Oxygenase-1 by Acteoside Through ERK and PI3 K/Akt Pathway Confer Neuroprotection Against Beta-Amyloid-Induced Neurotoxicity
- (2011) Hong-Quan Wang et al. NEUROTOXICITY RESEARCH
- Cellular Stress Responses, The Hormesis Paradigm, and Vitagenes: Novel Targets for Therapeutic Intervention in Neurodegenerative Disorders
- (2010) Vittorio Calabrese et al. ANTIOXIDANTS & REDOX SIGNALING
- Pathological roles of MAPK signaling pathways in human diseases
- (2010) Eun Kyung Kim et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Mechanisms Underlying Inflammation in Neurodegeneration
- (2010) Christopher K. Glass et al. CELL
- Genetic etiology of Parkinson disease associated with mutations in the SNCA, PARK2, PINK1, PARK7, and LRRK2 genes: a mutation update
- (2010) Karen Nuytemans et al. HUMAN MUTATION
- Increased platelet GSK3B activity in patients with mild cognitive impairment and Alzheimer’s disease
- (2010) Orestes V. Forlenza et al. JOURNAL OF PSYCHIATRIC RESEARCH
- Correlation of Nrf2, HO-1, and MRP3 in Gallbladder Cancer and Their Relationships to Clinicopathologic Features and Survival
- (2010) Jiansheng Wang et al. JOURNAL OF SURGICAL RESEARCH
- ERK2 but Not ERK1 Induces Epithelial-to-Mesenchymal Transformation via DEF Motif-Dependent Signaling Events
- (2010) Sejeong Shin et al. MOLECULAR CELL
- Asymmetric tyrosine kinase arrangements in activation or autophosphorylation of receptor tyrosine kinases
- (2010) Jae Hyun Bae et al. MOLECULES AND CELLS
- The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1
- (2010) Masaaki Komatsu et al. NATURE CELL BIOLOGY
- Tau Mislocalization to Dendritic Spines Mediates Synaptic Dysfunction Independently of Neurodegeneration
- (2010) Brian R. Hoover et al. NEURON
- Involvement of Akt in neurite outgrowth
- (2009) Danielle E. Read et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Kinase Inhibitors as Potential Therapeutics for Acute and Chronic Neurodegenerative Conditions
- (2009) G. Cuny CURRENT PHARMACEUTICAL DESIGN
- ERK and cell death: ERK1/2 in neuronal death
- (2009) Srinivasa Subramaniam et al. FEBS Journal
- RTP801 Is Induced in Parkinson's Disease and Mediates Neuron Death by Inhibiting Akt Phosphorylation/Activation
- (2009) C. Malagelada et al. JOURNAL OF NEUROSCIENCE
- GSK3 Inhibitors and Disease
- (2009) Felix Hernandez et al. MINI-REVIEWS IN MEDICINAL CHEMISTRY
- Mitochondrial kinases in Parkinson’s disease: Converging insights from neurotoxin and genetic models
- (2009) Ruben K. Dagda et al. MITOCHONDRION
- Cell fate decisions are specified by the dynamic ERK interactome
- (2009) Alex von Kriegsheim et al. NATURE CELL BIOLOGY
- Involvment of Cytosolic and Mitochondrial GSK-3β in Mitochondrial Dysfunction and Neuronal Cell Death of MPTP/MPP+-Treated Neurons
- (2009) Agnès Petit-Paitel et al. PLoS One
- Mutant huntingtin activates Nrf2-responsive genes and impairs dopamine synthesis in a PC12 model of Huntington's disease
- (2008) Willeke MC van Roon-Mom et al. BMC MOLECULAR BIOLOGY
- PI3 kinase/Akt activation mediates estrogen and IGF-1 nigral DA neuronal neuroprotection against a unilateral rat model of Parkinson's disease
- (2008) Arnulfo Quesada et al. Developmental Neurobiology
- Nrf2 Activation in Astrocytes Protects against Neurodegeneration in Mouse Models of Familial Amyotrophic Lateral Sclerosis
- (2008) M. R. Vargas et al. JOURNAL OF NEUROSCIENCE
- Nuclear factor erythroid 2-related factor 2 protects against beta amyloid
- (2008) Katja Kanninen et al. MOLECULAR AND CELLULAR NEUROSCIENCE
- Identification and Characterization of a General Nuclear Translocation Signal in Signaling Proteins
- (2008) Dana Chuderland et al. MOLECULAR CELL
- Activation of p38MAPK Contributes to Expanded Polyglutamine-Induced Cytotoxicity
- (2008) Maria Tsirigotis et al. PLoS One
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