Zinc pyrithione is a potent inhibitor of PLPro and cathepsin L enzymes with ex vivo inhibition of SARS-CoV-2 entry and replication

Evaluation of SARS-CoV-2 entry, inflammation and new therapeutics in human lung tissue cells

(2022) Judith Grau-Expósito et al.   PLoS Pathogens

ACE2 is the critical in vivo receptor for SARS-CoV-2 in a novel COVID-19 mouse model with TNF- and IFNγ-driven immunopathology

(2022) Riem Gawish et al.   eLife

Progress and Challenges in Targeting the SARS-CoV-2 Papain-like Protease

(2022) Haozhou Tan et al.   JOURNAL OF MEDICINAL CHEMISTRY

A pilot double‐blind safety and feasibility randomized controlled trial of high‐dose intravenous zinc in hospitalized COVID‐19 patients

(2021) Oneel Patel et al.   JOURNAL OF MEDICAL VIROLOGY

Structure of papain-like protease from SARS-CoV-2 and its complexes with non-covalent inhibitors

(2021) Jerzy Osipiuk et al.   Nature Communications

Low Zinc Levels at Admission Associates with Poor Clinical Outcomes in SARS-CoV-2 Infection

(2021) Marina Vogel-González et al.   Nutrients

Effect of High-Dose Zinc and Ascorbic Acid Supplementation vs Usual Care on Symptom Length and Reduction Among Ambulatory Patients With SARS-CoV-2 Infection

(2021) Suma Thomas et al.   JAMA Network Open

Zinc supplementation as an adjunct therapy for COVID‐19: challenges and opportunities

(2021) Vidyasagar Chinni et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

An analysis of inhibition of the severe acute respiratory syndrome coronavirus 2 RNA-dependent RNA polymerase by zinc ion: an in silico approach

(2021) Sina Zoghi et al.   Future Virology

A novel framework integrating AI model and enzymological experiments promotes identification of SARS-CoV-2 3CL protease inhibitors and activity-based probe

(2021) Fan Hu et al.   BRIEFINGS IN BIOINFORMATICS

Antiviral and immunological activity of zinc and possible role in COVID-19

(2021) Dilina do Nascimento Marreiro et al.   BRITISH JOURNAL OF NUTRITION

Immunopharmacological perspective on zinc in SARS-CoV-2 infection

(2021) Sima Heydarzadeh Asl et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Fe-S cofactors in the SARS-CoV-2 RNA-dependent RNA polymerase are potential antiviral targets

(2021) Nunziata Maio et al.   SCIENCE

Drug repurposing screens identify chemical entities for the development of COVID-19 interventions

(2021) Malina A. Bakowski et al.   Nature Communications

How SARS-CoV-2 makes the cut

(2021) Markus Hoffmann et al.   Nature Microbiology

Organoruthenium Complexes with Benzo-Fused Pyrithiones Overcome Platinum Resistance in Ovarian Cancer Cells

(2021) Jerneja Kladnik et al.   Cancers

The antimicrobial and immunomodulatory effects of Ionophores for the treatment of human infection

(2021) Gen Li et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Orally administered bismuth drug together with N-acetyl cysteine as a broad-spectrum anti-coronavirus cocktail therapy

(2021) Runming Wang et al.   Chemical Science

Zinc ionophores: chemistry and biological applications

(2021) Simone Scavo et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding

(2020) Roujian Lu et al.   LANCET

QT prolongation, torsades de pointes, and sudden death with short courses of chloroquine or hydroxychloroquine as used in COVID-19: A systematic review

(2020) Lior Jankelson et al.   HEART RHYTHM

Structural basis of receptor recognition by SARS-CoV-2

(2020) Jian Shang et al.   NATURE

Cathepsin L-selective inhibitors: A potentially promising treatment for COVID-19 patients

(2020) Tianxiao Liu et al.   PHARMACOLOGY & THERAPEUTICS

Risk of QT Interval Prolongation Associated With Use of Hydroxychloroquine With or Without Concomitant Azithromycin Among Hospitalized Patients Testing Positive for Coronavirus Disease 2019 (COVID-19)

(2020) Nicholas J. Mercuro et al.   JAMA Cardiology

Structural Isomerism and Enhanced Lipophilicity of Pyrithione Ligands of Organoruthenium(II) Complexes Increase Inhibition on AChE and BuChE

(2020) Jerneja Kladnik et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity

(2020) Donghyuk Shin et al.   NATURE

Hydroxychloroquine with or without Azithromycin in Mild-to-Moderate Covid-19

(2020) Alexandre B. Cavalcanti et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Potential Impact of Zinc Supplementation on COVID-19 Pathogenesis

(2020) Inga Wessels et al.   Frontiers in Immunology

A Hypothesis for the Possible Role of Zinc in the Immunological Pathways Related to COVID-19 Infection

(2020) Ander Mayor-Ibarguren et al.   Frontiers in Immunology

Potential interventions for SARS‐CoV‐2 infections: Zinc showing promise

(2020) Joseph Brewer et al.   JOURNAL OF MEDICAL VIROLOGY

Characteristics of SARS-CoV-2 and COVID-19

(2020) Ben Hu et al.   NATURE REVIEWS MICROBIOLOGY

Zinc(II)—The Overlooked Éminence Grise of Chloroquine’s Fight against COVID-19?

(2020) Aleksandra Hecel et al.   Pharmaceuticals

Zinc and SARS‑CoV‑2: A molecular modeling study of Zn interactions with RNA‑dependent RNA‑polymerase and 3C‑like proteinase enzymes

(2020) Ali Pormohammad et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Increase of the Intracellular Zinc Concentration Leads to an Activation and Internalisation of the Epidermal Growth Factor Receptor in A549 Cells

(2020) Lisa-Marie Barth et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A possible application of hinokitiol as a natural zinc ionophore and anti-infective agent for the prevention and treatment of COVID-19 and viral infections

(2020) Ba X. Hoang et al.   MEDICAL HYPOTHESES

Randomised controlled trial for high-dose intravenous zinc as adjunctive therapy in SARS-CoV-2 (COVID-19) positive critically ill patients: trial protocol

(2020) Marlon Perera et al.   BMJ Open

Harnessing Polypharmacology with Medicinal Chemistry

(2019) Maria Laura Bolognesi   ACS Medicinal Chemistry Letters

The Role of Cysteine Cathepsins in Cancer Progression and Drug Resistance

(2019) Magdalena Rudzińska et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Towards Identification of Essential Structural Elements of Organoruthenium(II)‐Pyrithionato Complexes for Anticancer Activity

(2019) Jerneja Kladnik et al.   CHEMISTRY-A EUROPEAN JOURNAL

Differential toxicities of fine particulate matters from various sources

(2018) Minhan Park et al.   Scientific Reports

SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules

(2017) Antoine Daina et al.   Scientific Reports

The biological inorganic chemistry of zinc ions

(2016) Artur Krężel et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Pyrithione-based ruthenium complexes as inhibitors of aldo–keto reductase 1C enzymes and anticancer agents

(2016) Jakob Kljun et al.   DALTON TRANSACTIONS

Drug Delivery Approaches in Addressing Clinical Pharmacology-Related Issues: Opportunities and Challenges

(2015) Hong Wen et al.   AAPS Journal

The SARS-coronavirus papain-like protease: Structure, function and inhibition by designed antiviral compounds

(2015) Yahira M. Báez-Santos et al.   ANTIVIRAL RESEARCH

Recent development of 3C and 3CL protease inhibitors for anti-coronavirus and anti-picornavirus drug discovery

(2012) R. Ramajayam et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Zinc Pyrithione Inhibits Yeast Growth through Copper Influx and Inactivation of Iron-Sulfur Proteins

(2011) Nancy L. Reeder et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The antifungal mechanism of action of zinc pyrithione

(2011) N.L. Reeder et al.   BRITISH JOURNAL OF DERMATOLOGY

A simple and efficient protocol for the production of recombinant cathepsin V and other cysteine cathepsins in soluble form in Escherichia coli

(2011) Marko Novinec et al.   PROTEIN EXPRESSION AND PURIFICATION

Zn2+ Inhibits Coronavirus and Arterivirus RNA Polymerase Activity In Vitro and Zinc Ionophores Block the Replication of These Viruses in Cell Culture

(2010) Aartjan J. W. te Velthuis et al.   PLoS Pathogens

Synthesis and Anticancer Properties of Water-Soluble Zinc Ionophores

(2008) D. Magda et al.   CANCER RESEARCH