Pyrithione-based ruthenium complexes as inhibitors of aldo–keto reductase 1C enzymes and anticancer agents

The development of RAPTA compounds for the treatment of tumors

(2016) Benjamin S. Murray et al.   COORDINATION CHEMISTRY REVIEWS

Cytotoxicity and preliminary mode of action studies of novel 2-aryl-4-thiopyrone-based organometallics

(2016) Melanie Schmidlehner et al.   DALTON TRANSACTIONS

Cisplatin binding to human serum albumin: a structural study

(2015) Giarita Ferraro et al.   CHEMICAL COMMUNICATIONS

Ruthenium complexes as inhibitors of the aldo–keto reductases AKR1C1–1C3

(2015) Katja Traven et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Protein ruthenation and DNA alkylation: chlorambucil-functionalized RAPTA complexes and their anticancer activity

(2015) Alexey A. Nazarov et al.   DALTON TRANSACTIONS

CHARMM-GUI Input Generator for NAMD, GROMACS, AMBER, OpenMM, and CHARMM/OpenMM Simulations Using the CHARMM36 Additive Force Field

(2015) Jumin Lee et al.   Journal of Chemical Theory and Computation

Structure-Related Mode-of-Action Differences of Anticancer Organoruthenium Complexes with β-Diketonates

(2015) Sara Seršen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Antiangiogenic ruthenium(ii) benzimidazole complexes, structure-based activation of distinct signaling pathways

(2015) Haoqiang Lai et al.   Metallomics

Ruthenium complex Λ-WH0402 induces hepatocellular carcinoma LM6 (HCCLM6) cell death by triggering the Beclin-1-dependent autophagy pathway

(2015) Jian Yuan et al.   Metallomics

Discovery of a dual-targeting organometallic ruthenium complex with high activity inducing early stage apoptosis of cancer cells

(2015) Jun Du et al.   Metallomics

In vivo evaluation of small-molecule thermoresponsive anticancer drugs potentiated by hyperthermia

(2015) Catherine M. Clavel et al.   Chemical Science

Ruthenium (II) Complexes Interact with Human Serum Albumin and Induce Apoptosis of Tumor Cells

(2014) Jing Sun et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Preparation of a Cross-Linked Porous Protein Crystal Containing Ru Carbonyl Complexes as a CO-Releasing Extracellular Scaffold

(2014) Hiroyasu Tabe et al.   INORGANIC CHEMISTRY

Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012

(2014) Jacques Ferlay et al.   INTERNATIONAL JOURNAL OF CANCER

Phase I/II study with ruthenium compound NAMI-A and gemcitabine in patients with non-small cell lung cancer after first line therapy

(2014) Suzanne Leijen et al.   INVESTIGATIONAL NEW DRUGS

New method for the speciation of ruthenium-based chemotherapeutics in human serum by conjoint liquid chromatography on affinity and anion-exchange monolithic disks

(2014) Anže Martinčič et al.   JOURNAL OF CHROMATOGRAPHY A

Antiinflammatory and neurological activity of pyrithione and related sulfur-containing pyridine N-oxides from Persian shallot (Allium stipitatum)

(2014) Petra Krejčová et al.   JOURNAL OF ETHNOPHARMACOLOGY

Exploring the Influence of the Protein Environment on Metal-Binding Pharmacophores

(2014) David P. Martin et al.   JOURNAL OF MEDICINAL CHEMISTRY

Modulation of Activity of Known Cytotoxic Ruthenium(III) Compound (KP418) with Hampered Transmembrane Transport in Electrochemotherapy In Vitro and In Vivo

(2014) Rosana Hudej et al.   JOURNAL OF MEMBRANE BIOLOGY

Arene ruthenium(ii) complex, a potent inhibitor against proliferation, migration and invasion of breast cancer cells, reduces stress fibers, focal adhesions and invadopodia

(2014) Qiong Wu et al.   Metallomics

Synthesis and Biological Evaluation of Organoruthenium Complexes with Azole Antifungal Agents. First Crystal Structure of a Tioconazole Metal Complex

(2014) Jakob Kljun et al.   ORGANOMETALLICS

NKP-1339, the first ruthenium-based anticancer drug on the edge to clinical application

(2014) Robert Trondl et al.   Chemical Science

Zinc ionophores pyrithione inhibits herpes simplex virus replication through interfering with proteasome function and NF-κB activation

(2013) Min Qiu et al.   ANTIVIRAL RESEARCH

Gene expression profiling for analysis acquired oxaliplatin resistant factors in human gastric carcinoma TSGH-S3 cells: The role of IL-6 signaling and Nrf2/AKR1C axis identification

(2013) Chih-Cheng Chen et al.   BIOCHEMICAL PHARMACOLOGY

New Uses for Old Drugs: Attempts to Convert Quinolone Antibacterials into Potential Anticancer Agents Containing Ruthenium

(2013) Jakob Kljun et al.   INORGANIC CHEMISTRY

Role of aldo–keto reductase family 1 (AKR1) enzymes in human steroid metabolism

(2013) Tea Lanišnik Rižner et al.   STEROIDS

Factors that influence the antiproliferative activity of half sandwich RuII–[9]aneS3 coordination compounds: activation kinetics and interaction with guanine derivatives

(2012) Ana Rilak et al.   DALTON TRANSACTIONS

New half sandwich Ru(ii) coordination compounds for anticancer activity

(2012) Ioannis Bratsos et al.   DALTON TRANSACTIONS

Photoactivatable Organometallic Pyridyl Ruthenium(II) Arene Complexes

(2012) Soledad Betanzos-Lara et al.   ORGANOMETALLICS

Synthesis and Biological Evaluation of the Thionated Antibacterial Agent Nalidixic Acid and Its Organoruthenium(II) Complex

(2012) Rosana Hudej et al.   ORGANOMETALLICS

Ruthenium anticancer compounds: myths and realities of the emerging metal-based drugs

(2011) Alberta Bergamo et al.   DALTON TRANSACTIONS

Antineoplastic activity of ouabain and pyrithione zinc in acute myeloid leukemia

(2011) M Tailler et al.   ONCOGENE

Physicochemical Studies and Anticancer Potency of Ruthenium η6-p-Cymene Complexes Containing Antibacterial Quinolones

(2011) Jakob Kljun et al.   ORGANOMETALLICS

Zinc pyrithione induces cellular stress signaling and apoptosis in Hep-2 cervical tumor cells: the role of mitochondria and lysosomes

(2010) Emil Rudolf et al.   BIOMETALS

First Ruthenium Organometallic Complex of Antibacterial Agent Ofloxacin. Crystal Structure and Interactions with DNA

(2010) Iztok Turel et al.   INORGANIC CHEMISTRY

Inhibitors of human 20α-hydroxysteroid dehydrogenase (AKR1C1)

(2010) Ossama El-Kabbani et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Steroid Hormone Transforming Aldo-Keto Reductases and Cancer

(2009) Trevor M. Penning et al.   Annals of the New York Academy of Sciences

Maltol-Derived Ruthenium-Cymene Complexes with Tumor Inhibiting Properties: The Impact of Ligand-Metal Bond Stability on Anticancer Activity In Vitro

(2009) Wolfgang Kandioller et al.   CHEMISTRY-A EUROPEAN JOURNAL

Metal ionophores – An emerging class of anticancer drugs

(2009) Wei-Qun Ding et al.   IUBMB LIFE

Aldo-keto reductase 1C3 expression in MCF-7 cells reveals roles in steroid hormone and prostaglandin metabolism that may explain its over-expression in breast cancer

(2009) Michael C. Byrns et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

From Pyrone to Thiopyrone Ligands−Rendering Maltol-Derived Ruthenium(II)−Arene Complexes That Are Anticancer Active in Vitro

(2009) Wolfgang Kandioller et al.   ORGANOMETALLICS

Half-sandwich RuII[9]aneS3 complexes structurally similar to antitumor-active organometallic piano-stool compounds: Preparation, structural characterization and in vitro cytotoxic activity

(2008) Ioannis Bratsos et al.   JOURNAL OF INORGANIC BIOCHEMISTRY