Fe-S cofactors in the SARS-CoV-2 RNA-dependent RNA polymerase are potential antiviral targets

Cryo-EM structures of human RNA polymerase III in its unbound and transcribing states

(2021) Mathias Girbig et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Fe-S cofactors in the SARS-CoV-2 RNA-dependent RNA polymerase are potential antiviral targets

(2021) Nunziata Maio et al.   SCIENCE

Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro

(2020) Manli Wang et al.   CELL RESEARCH

A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster

(2020) Jasper Fuk-Woo Chan et al.   LANCET

Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study

(2020) Nanshan Chen et al.   LANCET

A new coronavirus associated with human respiratory disease in China

(2020) Fan Wu et al.   NATURE

Outlining the Complex Pathway of Mammalian Fe-S Cluster Biogenesis

(2020) Nunziata Maio et al.   TRENDS IN BIOCHEMICAL SCIENCES

Nitric oxide orchestrates metabolic rewiring in M1 macrophages by targeting aconitase 2 and pyruvate dehydrogenase

(2020) Erika M. Palmieri et al.   Nature Communications

Cohesin Causes Replicative DNA Damage by Trapping DNA Topological Stress

(2020) Nicola Elizabeth Minchell et al.   MOLECULAR CELL

Structure of replicating SARS-CoV-2 polymerase

(2020) Hauke S. Hillen et al.   NATURE

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

(2020) David E. Gordon et al.   NATURE

Structure of the RNA-dependent RNA polymerase from COVID-19 virus

(2020) Yan Gao et al.   SCIENCE

Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir

(2020) Wanchao Yin et al.   SCIENCE

Structural Basis for Helicase-Polymerase Coupling in the SARS-CoV-2 Replication-Transcription Complex

(2020) James Chen et al.   CELL

SARS-CoV-2 Disrupts Splicing, Translation, and Protein Trafficking to Suppress Host Defenses

(2020) Abhik K. Banerjee et al.   CELL

Heme biosynthesis depends on previously unrecognized acquisition of iron-sulfur cofactors in human amino-levulinic acid dehydratase

(2020) Gang Liu et al.   Nature Communications

The SARS-CoV-2 RNA–protein interactome in infected human cells

(2020) Nora Schmidt et al.   Nature Microbiology

Absence of iron-responsive element-binding protein 2 causes a novel neurodegenerative syndrome

(2019) Gregory Costain et al.   BRAIN

Structural evidence for an essential Fe–S cluster in the catalytic core domain of DNA polymerase ϵ

(2019) Josy ter Beek et al.   NUCLEIC ACIDS RESEARCH

Redox Chemistry in the Genome: Emergence of the [4Fe4S] Cofactor in Repair and Replication

(2019) Jacqueline K. Barton et al.   Annual Review of Biochemistry

Structure of the SARS-CoV nsp12 polymerase bound to nsp7 and nsp8 co-factors

(2019) Robert N. Kirchdoerfer et al.   Nature Communications

The Paradoxical Leishmanicidal Effects of Superoxide Dismutase (SOD)-Mimetic Tempol in Leishmania braziliensis Infection in vitro

(2019) Laíse B. Oliveira et al.   Frontiers in Cellular and Infection Microbiology

Cytosolic HSC20 integrates de novo iron–sulfur cluster biogenesis with the CIAO1-mediated transfer to recipients

(2018) Ki Soon Kim et al.   HUMAN MOLECULAR GENETICS

Translational repression of HIF2α expression in mice with Chuvash polycythemia reverses polycythemia

(2018) Manik C. Ghosh et al.   JOURNAL OF CLINICAL INVESTIGATION

Zinc Salts Block Hepatitis E Virus Replication by Inhibiting the Activity of Viral RNA-Dependent RNA Polymerase

(2017) Nidhi Kaushik et al.   JOURNAL OF VIROLOGY

Nonredox thiolation in tRNA occurring via sulfur activation by a [4Fe-4S] cluster

(2017) Simon Arragain et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The [4Fe4S] cluster of human DNA primase functions as a redox switch using DNA charge transport

(2017) Elizabeth O’Brien et al.   SCIENCE

Disease-Causing SDHAF1 Mutations Impair Transfer of Fe-S Clusters to SDHB

(2016) Nunziata Maio et al.   Cell Metabolism

Cleavage and polyadenylation specificity factor 30: An RNA-binding zinc-finger protein with an unexpected 2Fe–2S cluster

(2016) Geoffrey D. Shimberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mössbauer spectroscopy of Fe/S proteins

(2015) Maria-Eirini Pandelia et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Iron –sulfur cluster biogenesis in mammalian cells: New insights into the molecular mechanisms of cluster delivery

(2015) Nunziata Maio et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Cochaperone Binding to LYR Motifs Confers Specificity of Iron Sulfur Cluster Delivery

(2014) Nunziata Maio et al.   Cell Metabolism

Crystal Structure of the Human Primase

(2014) Andrey G. Baranovskiy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

One severe acute respiratory syndrome coronavirus protein complex integrates processive RNA polymerase and exonuclease activities

(2014) Lorenzo Subissi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biochemical characterization of a recombinant SARS coronavirus nsp12 RNA-dependent RNA polymerase capable of copying viral RNA templates

(2012) Dae-Gyun Ahn et al.   ARCHIVES OF VIROLOGY

The rotavirus nonstructural protein NSP5 coordinates a [2Fe-2S] iron-sulfur cluster that modulates interaction to RNA

(2012) Davy Martin et al.   FASEB JOURNAL

A Conserved Motif in the C-terminal Tail of DNA Polymerase α Tethers Primase to the Eukaryotic Replisome

(2012) Mairi L. Kilkenny et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MMS19 Assembles Iron-Sulfur Proteins Required for DNA Metabolism and Genomic Integrity

(2012) O. Stehling et al.   SCIENCE

Crystal structure of the C-terminal domain of human DNA primase large subunit

(2011) Vinod B. Agarkar et al.   CELL CYCLE

Eukaryotic DNA polymerases require an iron-sulfur cluster for the formation of active complexes

(2011) Daili J A Netz et al.   Nature Chemical Biology

Shared Active Site Architecture between the Large Subunit of Eukaryotic Primase and DNA Photolyase

(2010) Ludovic Sauguet et al.   PLoS One

Insights into eukaryotic DNA priming from the structure and functional interactions of the 4Fe-4S cluster domain of human DNA primase

(2010) S. Vaithiyalingam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Zn2+ Inhibits Coronavirus and Arterivirus RNA Polymerase Activity In Vitro and Zinc Ionophores Block the Replication of These Viruses in Cell Culture

(2010) Aartjan J. W. te Velthuis et al.   PLoS Pathogens

Crystal Structure of Miner1: The Redox-active 2Fe-2S Protein Causative in Wolfram Syndrome 2

(2009) Andrea R. Conlan et al.   JOURNAL OF MOLECULAR BIOLOGY

Tempol-mediated activation of latent iron regulatory protein activity prevents symptoms of neurodegenerative disease in IRP2 knockout mice

(2008) M. C. Ghosh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA