Different cAMP sources are critically involved in G protein–coupled receptor CRHR1 signaling

Endothelial CD99 signals through soluble adenylyl cyclase and PKA to regulate leukocyte transendothelial migration

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A C-terminal HSP90 inhibitor restores glucocorticoid sensitivity and relieves a mouse allograft model of Cushing disease

(2015) Mathias Riebold et al.   NATURE MEDICINE

Fourth-Generation Epac-Based FRET Sensors for cAMP Feature Exceptional Brightness, Photostability and Dynamic Range: Characterization of Dedicated Sensors for FLIM, for Ratiometry and with High Affinity

(2015) Jeffrey Klarenbeek et al.   PLoS One

Biochemical and Pharmacological Characterizations of ESI-09 Based EPAC Inhibitors: Defining the ESI-09 “Therapeutic Window”

(2015) Yingmin Zhu et al.   Scientific Reports

Inhibition of soluble adenylyl cyclase increases the radiosensitivity of prostate cancer cells

(2014) Avinash Appukuttan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Hydrogen peroxide stimulation of CFTR reveals an Epac-mediated, soluble AC-dependent cAMP amplification pathway common to GPCR signalling

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GPCR signaling along the endocytic pathway

(2014) Roshanak Irannejad et al.   CURRENT OPINION IN CELL BIOLOGY

Endosomal generation of cAMP in GPCR signaling

(2014) Jean-Pierre Vilardaga et al.   Nature Chemical Biology

Spatial encoding of cyclic AMP signaling specificity by GPCR endocytosis

(2014) Nikoleta G Tsvetanova et al.   Nature Chemical Biology

Crystal structures of human soluble adenylyl cyclase reveal mechanisms of catalysis and of its activation through bicarbonate

(2014) S. Kleinboelting et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A long Stokes shift red fluorescent Ca2+ indicator protein for two-photon and ratiometric imaging

(2014) Jiahui Wu et al.   Nature Communications

Glucagon-like peptide-1 receptor-mediated endosomal cAMP generation promotes glucose-stimulated insulin secretion in pancreatic β-cells

(2013) Ramya S. Kuna et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Noncanonical Control of Vasopressin Receptor Type 2 Signaling by Retromer and Arrestin

(2013) Timothy N. Feinstein et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Compartmentalization of Distinct cAMP Signaling Pathways in Mammalian Sperm

(2013) Eva Wertheimer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The inner and outer compartments of mitochondria are sites of distinct cAMP/PKA signaling dynamics

(2013) Konstantinos Lefkimmiatis et al.   JOURNAL OF CELL BIOLOGY

Increased sugar uptake promotes oncogenesis via EPAC/RAP1 and O-GlcNAc pathways

(2013) Yasuhito Onodera et al.   JOURNAL OF CLINICAL INVESTIGATION

Pituitary Adenylate Cyclase 1 Receptor Internalization and Endosomal Signaling Mediate the Pituitary Adenylate Cyclase Activating Polypeptide-Induced Increase in Guinea Pig Cardiac Neuron Excitability

(2013) L. A. Merriam et al.   JOURNAL OF NEUROSCIENCE

B-Raf and CRHR1 Internalization Mediate Biphasic ERK1/2 Activation by CRH in Hippocampal HT22 Cells

(2013) Juan J. Bonfiglio et al.   MOLECULAR ENDOCRINOLOGY

Receptor signals come in waves

(2013) Martin J. Lohse et al.   NATURE

Conformational biosensors reveal GPCR signalling from endosomes

(2013) Roshanak Irannejad et al.   NATURE

Epac-Inhibitors: Facts and Artefacts

(2013) Holger Rehmann   Scientific Reports

Mapping Structural Determinants within Third Intracellular Loop That Direct Signaling Specificity of Type 1 Corticotropin-releasing Hormone Receptor

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Type 10 Soluble Adenylyl Cyclase Is Overexpressed in Prostate Carcinoma and Controls Proliferation of Prostate Cancer Cells

(2012) Jan-Paul Flacke et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Soluble Adenylyl Cyclase Activity Is Necessary for Retinal Ganglion Cell Survival and Axon Growth

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Metabolic Communication between Astrocytes and Neurons via Bicarbonate-Responsive Soluble Adenylyl Cyclase

(2012) Hyun B. Choi et al.   NEURON

Multidrug Resistance Protein 4 (MRP4/ABCC4) Regulates cAMP Cellular Levels and Controls Human Leukemia Cell Proliferation and Differentiation

(2011) Sabrina Copsel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

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Retromer terminates the generation of cAMP by internalized PTH receptors

(2011) Timothy N Feinstein et al.   Nature Chemical Biology

The Corticotropin-Releasing Hormone Network and the Hypothalamic-Pituitary-Adrenal Axis: Molecular and Cellular Mechanisms Involved

(2011) Juan José Bonfiglio et al.   NEUROENDOCRINOLOGY

Endocytosis Promotes Rapid Dopaminergic Signaling

(2011) Sarah J. Kotowski et al.   NEURON

β-Adrenergic activation of electrogenic K+ and Cl− secretion in guinea pig distal colonic epithelium proceeds via separate cAMP signaling pathways

(2010) Susan T. Halm et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Visualization of PKA activity in plasma membrane microdomains

(2010) Charlene Depry et al.   Molecular BioSystems

Teaching old receptors new tricks: biasing seven-transmembrane receptors

(2010) Sudarshan Rajagopal et al.   NATURE REVIEWS DRUG DISCOVERY

Stress Hormone Regulation: Biological Role and Translation into Therapy

(2009) Florian Holsboer et al.   Annual Review of Psychology

Sustained cyclic AMP production by parathyroid hormone receptor endocytosis

(2009) Sébastien Ferrandon et al.   Nature Chemical Biology

Corticotropin releasing factor-induced ERK phosphorylation in AtT20 cells occurs via a cAMP-dependent mechanism requiring EPAC2

(2009) Kristof Van Kolen et al.   NEUROPHARMACOLOGY

Molecular Mechanisms of Corticotropin-Releasing Factor Receptor-Induced Calcium Signaling

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