Increased sugar uptake promotes oncogenesis via EPAC/RAP1 and O-GlcNAc pathways

No evidence for a shift in pyruvate kinase PKM1 to PKM2 expression during tumorigenesis

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PKM2 Phosphorylates Histone H3 and Promotes Gene Transcription and Tumorigenesis

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Pyruvate kinase M2-specific siRNA induces apoptosis and tumor regression

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Pyruvate Kinase M2 Regulates Gene Transcription by Acting as a Protein Kinase

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Metformin and cancer therapy

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Target of Rapamycin (TOR) in Nutrient Signaling and Growth Control

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Shikonin and its analogs inhibit cancer cell glycolysis by targeting tumor pyruvate kinase-M2

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Diabetes and Cancer: A Consensus Report

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Raf-induced MMP9 disrupts tissue architecture of human breast cells in three-dimensional culture and is necessary for tumor growth in vivo

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The hexosamine biosynthetic pathway couples growth factor-induced glutamine uptake to glucose metabolism

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Depletion of nuclear actin is a key mediator of quiescence in epithelial cells

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Nutrient sensor O-GlcNAc transferase regulates breast cancer tumorigenesis through targeting of the oncogenic transcription factor FoxM1

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The Control of the Metabolic Switch in Cancers by Oncogenes and Tumor Suppressor Genes

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Identification of small molecule inhibitors of pyruvate kinase M2

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HER2 signaling pathway activation and response of breast cancer cells to HER2-targeting agents is dependent strongly on the 3D microenvironment

(2009) Britta Weigelt et al.   BREAST CANCER RESEARCH AND TREATMENT

Cyclic AMP Produced inside Mitochondria Regulates Oxidative Phosphorylation

(2009) Rebeca Acin-Perez et al.   Cell Metabolism

Modulation of mitochondrial protein phosphorylation by soluble adenylyl cyclase ameliorates cytochrome oxidase defects

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Junctional Adhesion Molecule A Interacts with Afadin and PDZ-GEF2 to Activate Rap1A, Regulate β1 Integrin Levels, and Enhance Cell Migration

(2009) Eric A. Severson et al.   MOLECULAR BIOLOGY OF THE CELL

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

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Tumor Cell Metabolism: Cancer's Achilles' Heel

(2008) Guido Kroemer et al.   CANCER CELL

A Human Breast Cell Model of Preinvasive to Invasive Transition

(2008) A. Rizki et al.   CANCER RESEARCH

Glucose and GLP-1 Stimulate cAMP Production via Distinct Adenylyl Cyclases in INS-1E Insulinoma Cells

(2008) Lavoisier S. Ramos et al.   JOURNAL OF GENERAL PHYSIOLOGY

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

(2008) Heather R. Christofk et al.   NATURE

Glucose metabolism inhibits apoptosis in neurons and cancer cells by redox inactivation of cytochrome c

(2008) Allyson E. Vaughn et al.   NATURE CELL BIOLOGY

Mitochondria in cancer: Not just innocent bystanders

(2008) Christian Frezza et al.   SEMINARS IN CANCER BIOLOGY

O-GlcNAc modification of transcription factors, glucose sensing and glucotoxicity

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