Article
Endocrinology & Metabolism
Arthur Ingersen, Malte Schmucker, Christina Alexandersen, Benjamin Graungaard, Tobias Thorngreen, Jacob Borch, Jens Juul Holst, Jorn Wulff Helge, Flemming Dela
Summary: The study aimed to investigate the interaction of semaglutide treatment and aerobic training on pancreatic β-cell secretory function in patients with type 2 diabetes. The results showed that aerobic training increased insulin secretion, and semaglutide treatment further improved β-cell secretory function. The combination of aerobic training and semaglutide treatment synergistically enhanced β-cell secretory function.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Biochemistry & Molecular Biology
Guillaume Bastin, Lemieux Luu, Battsetseg Batchuluun, Alexandra Mighiu, Stephanie Beadman, Hangjung Zhang, Changhao He, Dana Al Rijjal, Michael B. Wheeler, Scott P. Heximer
Summary: RGS4 protein plays a crucial role in regulating insulin secretion in response to glucose stimulation, with its deficiency leading to impaired insulin secretion, reduced cAMP/PKA activity, and abnormal calcium oscillations in pancreatic beta-cells. These findings highlight the significance of maintaining normal levels of RGS4 function for proper insulin secretion in healthy pancreatic tissues.
Article
Multidisciplinary Sciences
Huixia Ren, Yanjun Li, Chengsheng Han, Yi Yu, Bowen Shi, Xiaohong Peng, Shufang Wu, Xiaojing Yang, Sneppen Kim, Liangyi Chen, Chao Tang, Tianming Zhang
Summary: The Ca2+ modulated pulsatile glucagon and insulin secretions by pancreatic alpha and beta cells play a crucial role in glucose homeostasis. However, the coordination between alpha and beta cells in producing different Ca2+ oscillation patterns is still unclear. This study used a microfluidic device and transgenic mice to record Ca2+ signals from islet alpha and beta cells and observed heterogeneous Ca2+ oscillation patterns intrinsic to each islet. The results showed that after glucose stimulation, the oscillations of alpha and beta cells were globally phase-locked, with a fixed time delay in the activation of alpha cells compared to beta cells and a tunable period in the activation of beta cells. The number of islet alpha cells was also found to be correlated with oscillation frequency. A mathematical model incorporating paracrine interactions was built and quantitatively agreed with the experimental data, highlighting the importance of cell-cell interaction in generating stable but tunable islet oscillation patterns.
NATURE COMMUNICATIONS
(2022)
Article
Psychiatry
Despoina Aslanoglou, Suzanne Bertera, Marta Sanchez-Soto, R. Benjamin Free, Jeongkyung Lee, Wei Zong, Xiangning Xue, Shristi Shrestha, Marcela Brissova, Ryan W. Logan, Claes B. Wollheim, Massimo Trucco, Vijay K. Yechoor, David R. Sibley, Rita Bottino, Zachary Freyberg
Summary: DA and NE signaling in the pancreas regulate hormone release, potentially contributing to metabolic disturbances caused by APDs. DA acts as a biased agonist in the pancreas, modulating hormone release. Inhibiting DA receptors can increase hormone release, leading to metabolic disturbances.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Endocrinology & Metabolism
Nizar I. Mourad, Daela Xhema, Pierre Gianello
Summary: The study investigated the glucagon secretion characteristics of pig islet cells and found that high glucose concentration significantly inhibited glucagon secretion. In vivo experiments showed a quick decrease in plasma glucagon and a slower increase in plasma insulin after glucose injection.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
M. Deepa Maheshvare, Soumyendu Raha, Matthias Koenig, Debnath Pal
Summary: The pancreas plays a critical role in regulating glucose homeostasis through hormone secretion. A systematic modeling workflow was used to develop a kinetic model of glucose-stimulated insulin secretion (GSIS) in the pancreatic β-cell. The model includes detailed glycolysis and phenomenological equations for insulin secretion, and it is based on experimental and clinical data from various studies.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Katrina Viloria, Daniela Nasteska, Julia Ast, Annie Hasib, Federica Cuozzo, Silke Heising, Linford J. B. Briant, Martin Hewison, David J. Hodson
Summary: GC-globulin (GC), also known as vitamin D-binding protein, plays a multifunctional role in transporting vitamin 25(OH)D, fatty acids, and scavenging actin. It is highly localized to glucagon-secreting alpha-cells in the pancreatic islets. Loss of GC exacerbates alpha-cell failure during metabolic stress, leading to impaired glucagon secretion and changes in alpha-cell morphology. Restoring GC levels rescues the impairments in glucagon secretion and restores the F-actin cytoskeleton of alpha-cells. Decreased GC levels in alpha-cells of type 2 diabetes donors are associated with changes in alpha-cell mass, morphology, and glucagon expression.
Article
Endocrinology & Metabolism
Shiau Chin Chong, Norlela Sukor, Sarah Anne Robert, Kim Fong Ng, Nor Azmi Kamaruddin
Summary: This study aimed to resolve conflicting findings about GLP-1 levels in different glucose tolerance states among Malay, Chinese, and Indian ethnicities. The results showed that GLP-1 levels were higher in T2DM and pre-DM compared to NGT, suggesting a possible adaptive compensatory response. Among the three ethnic groups, Indians had the highest levels of GLP-1 and insulin resistance, supporting the notion of an adaptive compensatory secretion of GLP-1.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Cell Biology
Chien-Ting Wu, Keren Hilgendorf, Romina J. Bevacqua, Yan Hang, Janos Demeter, Seung K. Kim, Peter K. Jackson
Summary: Multiple G protein-coupled receptors (GPCRs) are localized to primary cilia in pancreatic islet cells, with FFAR4 and PTGER4 stimulating cAMP signaling and hormone secretion. The transport of GPCRs to cilia requires TULP3, which plays a key role in regulating hormone secretion by islet cells.
GENES & DEVELOPMENT
(2021)
Article
Plant Sciences
Dahae Lee, Ji-Young Kim, Hak Cheol Kwon, Jaeyoung Kwon, Dae Sik Jang, Ki Sung Kang
Summary: In this study, the potential effects of alpha-Spinasterol, a phytosterol isolated from Aster pseudoglehnii, on glucose uptake and insulin secretion in skeletal muscle cells and pancreatic beta-cells were investigated. The results showed that alpha-Spinasterol enhanced glucose uptake and insulin secretion without causing any toxic effects on the cells. It also increased the expression of proteins related to glucose metabolism. These findings suggest that alpha-Spinasterol could be a potential candidate for the treatment of type 2 diabetes.
Article
Biochemistry & Molecular Biology
Geetali Pradhan, Jong Han Lee, Chia-Shan Wu, Hongying Wang, Ligen Lin, Taraka Donti, Brett H. Graham, Arun S. Rajan, Ashok Balasubramanyam, Susan L. Samson, Shaodong Guo, Yuxiang Sun
Summary: This study investigated the role of the Ghrelin receptor (GHS-R) in glucose-stimulated insulin secretion (GSIS) and its interaction with the insulin signaling pathway in pancreatic islets. The findings suggest that GHS-R affects key components of the insulin signaling pathway, likely regulating GSIS via the Akt-Pdx1-GLUT2 pathway.
Article
Pharmacology & Pharmacy
Suhadinie Gamage, Mirabela Hali, Anjaneyulu Kowluru
Summary: CARD9 plays a crucial role in regulating insulin secretion, potentially through a Rac1-independent and p38-dependent signaling module.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Endocrinology & Metabolism
Yan Yang, Zixin Cai, Zhenhong Pan, Fen Liu, Dandan Li, Yujiao Ji, Jiaxin Zhong, Hairong Luo, Shanbiao Hu, Lei Song, Shaojie Yu, Ting Li, Jiequn Li, Xianhua Ma, Weiping Zhang, Zhiguang Zhou, Feng Liu, Jingjing Zhang
Summary: The small GTPase Rheb1 plays a critical role in regulating glucose-stimulated insulin secretion in beta-cells, suggesting a potential new target for therapeutic treatment of diabetes.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2021)
Article
Multidisciplinary Sciences
Daisuke Saito, Yuko Nakagawa, Takashi Sato, Ayako Fukunaka, Ofejiro Blessing Pereye, Nobuhiro Maruyama, Hirotaka Watada, Yoshio Fujitani
Summary: In this study, we developed a method to specifically detect and measure the secretion of pancreatic polypeptide (PP), and investigated the molecular mechanisms that regulate PP secretion. We found that the secretion of PP is triggered by an increase in intracellular calcium concentrations via voltage-dependent calcium channels, unlike the mechanism of insulin secretion.
Article
Biochemistry & Molecular Biology
Dahae Lee, Young-Mi Kim, Hyun Woo Kim, You-Kyoung Choi, Bang Ju Park, Sang Hoon Joo, Ki Sung Kang
Summary: Schisandrol A and schisandrin C enhanced insulin secretion and glucose uptake, with schisandrin C showing superior effects compared to gliclazide. Treatment with schisandrin C resulted in increased expression of associated proteins in cells, potentially benefiting in improving hyperglycemia.
Article
Chemistry, Multidisciplinary
S. Kalhor-Monfared, M. R. Jafari, J. T. Patterson, P. I. Kitov, J. J. Dwyer, J. M. Nuss, R. Derda
Article
Immunology
Suman Asalla, Krishnaveni Mohareer, Sharmistha Banerjee
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2017)
Article
Endocrinology & Metabolism
Shravan Babu Glrada, Ramya S. Kuna, Shilpak Bele, Zhimeng Zhu, N. R. Chakravarthi, Richard D. DiMarchi, Prasenjit Mitra
MOLECULAR METABOLISM
(2017)
Article
Multidisciplinary Sciences
Suman Asalla, Shravan Babu Girada, Ramya S. Kuna, Debabrata Chowdhury, Bhaskar Kandagatla, Srinivas Oruganti, Utpal Bhadra, Manika Pal Bhadra, Shasi Vardhan Kalivendi, Swetha Pavani Rao, Anupama Row, A. Ibrahim, Partha Pratim Ghosh, Prasenjit Mitra
SCIENTIFIC REPORTS
(2016)
Article
Multidisciplinary Sciences
Ying Lin, Jacob M. Wozniak, Neil J. Grimsey, Sravan Girada, Anand Patwardhan, Olivia Molinar-Inglis, Thomas H. Smith, John D. Lapek, David J. Gonzalez, Joann Trejo
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Meeting Abstract
Biochemistry & Molecular Biology
Ying Lin, Jacob Wozniak, Neil Grimsey, Sravan Girada, Anand Patwardan, Olivia Molinar-Inglis, Thomas Smith, John Lapek, David Gonzalez, JoAnn Trejo
Review
Cell Biology
Prasenjit Mitra
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2020)
Article
Biology
Shilpak Bele, Shravan Babu Girada, Aramita Ray, Abhishek Gupta, Srinivas Oruganti, Phanithi Prakash Babu, Rahul S. R. Rayalla, Shashi Vardhan Kalivendi, Ahamed Ibrahim, Vishwajeet Puri, Venkateswar Adalla, Madhumohan R. Katika, Richard DiMarchi, Prasenjit Mitra
Article
Endocrinology & Metabolism
Raghd Abu Helal, Lucia Russo, Hilda E. Ghadieh, Harrison T. Muturi, Suman Asalla, Abraham D. Lee, Cara Gatto-Weis, Sonia M. Najjar
Summary: The study revealed that reconstituting CEACAM1 in the liver of Cc1(-/-) mice can reverse diet-induced liver dysfunction and NASH, including hepatic fibrosis. Treatment with nicotinic acid failed to eliminate hepatic fibrosis in HF-fed Cc1(-/-) mice.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2021)
Article
Biochemistry & Molecular Biology
Ashraf Nahle, Yemisi Deborah Joseph, Sandra Pereira, Yusaku Mori, Frankie Poon, Hilda E. Ghadieh, Aleksandar Ivovic, Tejas Desai, Simona S. Ghanem, Suman Asalla, Harrison T. Muturi, Emelien M. Jentz, Jamie W. Joseph, Sonia M. Najjar, Adria Giacca
Summary: The study showed that NMN can improve glucose tolerance caused by a high-fat diet, but it may impair glucose tolerance under normal levels of free fatty acids. Therefore, caution should be exercised when considering the therapeutic use of NMN due to its dual effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Vinay Kumar, Rachel Rosenzweig, Suman Asalla, Sarita Nehra, Sumanth D. Prabhu, Shyam S. Bansal
Summary: CD4+ T cells become pathological during heart failure, and the expression of tumor necrosis factor alpha (TNF-α) and tumor necrosis factor receptor 1 (TNFR1) increases in these activated cells. The study shows that TNFR1 plays a crucial role in suppressing prosurvival and proliferative signals in CD4+ T cells during heart failure, without altering their pathological activity.
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2022)
Article
Chemistry, Medicinal
James T. Patterson, Jason Isaacson, Lisa Kerwin, Ghazi Atassi, Rohit Duggal, Damien Bresson, Tong Zhu, Heyue Zhou, Yanwen Fu, Gunnar F. Kaufmann
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2017)
Article
Chemistry, Medicinal
James T. Patterson, Edwige Gros, Heyue Zhou, Ghazi Atassi, Lisa Kerwin, Lisa Carmody, Tong Zhu, Bryan Jones, Yanwen Fu, Gunnar F. Kaufmann
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2017)
