标题
Claudin18.2 is a novel molecular biomarker for tumor-targeted immunotherapy
作者
关键词
-
出版物
Biomarker Research
Volume 10, Issue 1, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2022-05-31
DOI
10.1186/s40364-022-00385-1
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- A phase I clinical trial to evaluate the safety, tolerability, and pharmacokinetics of TST001 in patients with locally advanced or metastatic solid tumors.
- (2022) Nashat Y. Gabrail et al. JOURNAL OF CLINICAL ONCOLOGY
- Claudins and Gastric Cancer: An Overview
- (2022) Itaru Hashimoto et al. Cancers
- Linkers: An Assurance for Controlled Delivery of Antibody-Drug Conjugate
- (2022) Rotimi Sheyi et al. Pharmaceutics
- A Patent Review on FDA‐Approved Antibody‐Drug Conjugates, Their Linkers and Drug Payloads
- (2022) C. S. Brian Chia ChemMedChem
- Cancer statistics in China and United States, 2022: profiles, trends, and determinants
- (2022) Changfa Xia et al. CHINESE MEDICAL JOURNAL
- FAST: A randomised phase II study of zolbetuximab (IMAB362) plus EOX vs EOX alone for first-line treatment of advanced CLDN18.2 positive gastric and gastro-oesophageal adenocarcinoma
- (2021) U. Sahin et al. ANNALS OF ONCOLOGY
- Claudin 18.2 – a FAST-moving target in gastric cancer?
- (2021) A. Athauda et al. ANNALS OF ONCOLOGY
- Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
- (2021) Hyuna Sung et al. CA-A CANCER JOURNAL FOR CLINICIANS
- Antibody–drug conjugates in solid tumors: a look into novel targets
- (2021) Carmen Criscitiello et al. Journal of Hematology & Oncology
- SPAK-p38 MAPK signal pathway modulates claudin-18 and barrier function of alveolar epithelium after hyperoxic exposure
- (2021) Chih-Hao Shen et al. BMC Pulmonary Medicine
- Antibody–Drug Conjugates—A Tutorial Review
- (2021) Stephanie Baah et al. MOLECULES
- Structural basis for Clostridium perfringens enterotoxin targeting of claudins at tight junctions in mammalian gut
- (2021) Alex J. Vecchio et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- 1372O CLDN 18.2-targeted CAR-T cell therapy in patients with cancers of the digestive system
- (2021) C. Qi et al. ANNALS OF ONCOLOGY
- Chimeric Antigen Receptor-T Cells: A Pharmaceutical Scope
- (2021) Alejandrina Hernández-López et al. Frontiers in Pharmacology
- Global Incidence and Mortality of Gastric Cancer, 1980-2018
- (2021) Martin C. S. Wong et al. JAMA Network Open
- Claudin-18.2 as a therapeutic target in cancers: cumulative findings from basic research and clinical trials
- (2021) Daisuke Kyuno et al. Tissue Barriers
- Gastric Cancer Epidemiology
- (2021) Aaron P. Thrift et al. Gastrointestinal Endoscopy Clinics of North America
- Screening of Biomarkers Involved in Idiopathic Pulmonary Fibrosis and Regulation of Upstream miRNAs
- (2021) Li Gao et al. AMERICAN JOURNAL OF THE MEDICAL SCIENCES
- Antibody–drug conjugates: Smart chemotherapy delivery across tumor histologies
- (2021) Paolo Tarantino et al. CA-A CANCER JOURNAL FOR CLINICIANS
- Advances in Universal CAR-T Cell Therapy
- (2021) Haolong Lin et al. Frontiers in Immunology
- Novel Biomarkers of Gastric Adenocarcinoma: Current Research and Future Perspectives
- (2021) Nadja Niclauss et al. Cancers
- Gene modification strategies for next-generation CAR T cells against solid cancers
- (2020) Yonggui Tian et al. Journal of Hematology & Oncology
- How to select IgG subclasses in developing anti-tumor therapeutic antibodies
- (2020) Jifeng Yu et al. Journal of Hematology & Oncology
- Analysis of the expression and genetic alteration of CLDN18 in gastric cancer
- (2020) Jian Li et al. Aging-US
- 1496TiP Phase I study evaluating safety and tolerability of AMG 910, a half-life extended bispecific T cell engager targeting claudin-18.2 (CLDN18.2) in gastric and gastroesophageal junction (G/GEJ) adenocarcinoma
- (2020) F. Lordick et al. ANNALS OF ONCOLOGY
- DNA Methylation and Genetic Aberrations in Gastric Cancer
- (2020) Genki Usui et al. DIGESTION
- Claudin-18 Loss Alters Transcellular Chloride Flux but not Tight Junction Ion Selectivity in Gastric Epithelial Cells
- (2020) Tyler J. Caron et al. Cellular and Molecular Gastroenterology and Hepatology
- Ultrasensitive Gastric Cancer Circulating Tumor Cellular CLDN18.2 RNA Detection Based on a Molecular Beacon
- (2020) Linyang Fan et al. ANALYTICAL CHEMISTRY
- Engineering better chimeric antigen receptor T cells
- (2020) Hao Zhang et al. Experimental Hematology & Oncology
- Highly expressed Claudin18.2 as a potential therapeutic target in advanced gastric signet-ring cell carcinoma (SRCC)
- (2020) Bo Xu et al. Journal of Gastrointestinal Oncology
- A multicentre, phase IIa study of zolbetuximab as a single agent in patients with recurrent or refractory advanced adenocarcinoma of the stomach or lower oesophagus: the MONO study
- (2019) O Türeci et al. ANNALS OF ONCOLOGY
- Expression of the potential therapeutic target claudin-18.2 is frequently decreased in gastric cancer: results from a large Caucasian cohort study
- (2019) Matthias Dottermusch et al. VIRCHOWS ARCHIV
- Targeting CLDN18.2 by CD3 Bispecific and ADC Modalities for the Treatments of Gastric and Pancreatic Cancer
- (2019) Guoyun Zhu et al. Scientific Reports
- 198TiPSPOTLIGHT: Comparison of zolbetuximab or placebo + mFOLFOX6 as first-line treatment in patients with claudin18.2+/HER2– locally advanced unresectable or metastatic gastric or gastroesophageal junction adenocarcinoma (GEJ): A randomized phase III study
- (2019) K Yamaguchi et al. ANNALS OF ONCOLOGY
- Multimerization through Pegylation Improves Pharmacokinetic Properties of scFv Fragments of GD2-Specific Antibodies
- (2019) Irina V. Kholodenko et al. MOLECULES
- Clinical Implications of Claudin18.2 Expression in Patients With Gastric Cancer
- (2019) JIN HO BAEK et al. ANTICANCER RESEARCH
- GMP CAR-T cell production
- (2018) Adrian P. Gee BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY
- A phase I dose-escalation study of IMAB362 (Zolbetuximab) in patients with advanced gastric and gastro-oesophageal junction cancer
- (2018) Ugur Sahin et al. EUROPEAN JOURNAL OF CANCER
- OUP accepted manuscript
- (2018) JNCI-Journal of the National Cancer Institute
- OUP accepted manuscript
- (2018) JNCI-Journal of the National Cancer Institute
- Programming CAR-T cells to kill cancer
- (2018) Louai Labanieh et al. Nature Biomedical Engineering
- Emerging Therapies in the Management of Advanced-Stage Gastric Cancer
- (2018) Vivek Kumar et al. Frontiers in Pharmacology
- Loss of Tight Junction Protein Claudin 18 Promotes Progressive Neoplasia Development in Mouse Stomach
- (2018) Susan J. Hagen et al. GASTROENTEROLOGY
- Characterization of zolbetuximab in pancreatic cancer models
- (2018) Ӧzlem Türeci et al. OncoImmunology
- The Claudins: From Tight Junctions to Biological Systems
- (2018) Sachiko Tsukita et al. TRENDS IN BIOCHEMICAL SCIENCES
- Anti-claudin 18.2 antibody as new targeted therapy for advanced gastric cancer
- (2017) Prabhsimranjot Singh et al. Journal of Hematology & Oncology
- Visualizing the dynamic coupling of claudin strands to the actin cytoskeleton through ZO-1
- (2017) Christina M. Van Itallie et al. MOLECULAR BIOLOGY OF THE CELL
- miR-767-3p inhibits growth and migration of lung adenocarcinoma cells by regulating CLDN18
- (2017) Yi Long Wan et al. ONCOLOGY RESEARCH
- Novel Targeted Therapies for Esophagogastric Cancer
- (2017) Steven B. Maron et al. Surgical Oncology Clinics of North America
- Final results of the FAST study, an international, multicenter, randomized, phase II trial of epirubicin, oxaliplatin, and capecitabine (EOX) with or without the anti-CLDN18.2 antibody IMAB362 as first-line therapy in patients with advanced CLDN18.2+ gastric and gastroesophageal junction (GEJ) adenocarcinoma
- (2016) M. Schuler et al. ANNALS OF ONCOLOGY
- The role of claudins in cancer metastasis
- (2016) S Tabariès et al. ONCOGENE
- Structural basis for disruption of claudin assembly in tight junctions by an enterotoxin
- (2016) Takehiro Shinoda et al. Scientific Reports
- Antibody-drug conjugates as novel anti-cancer chemotherapeutics
- (2015) C. Peters et al. BIOSCIENCE REPORTS
- RHOA mutation in diffuse-type gastric cancer: a comparative clinicopathology analysis of 87 cases
- (2015) Tetsuo Ushiku et al. Gastric Cancer
- Model for the Architecture of Claudin-Based Paracellular Ion Channels through Tight Junctions
- (2015) Hiroshi Suzuki et al. JOURNAL OF MOLECULAR BIOLOGY
- Structural insight into tight junction disassembly by Clostridium perfringens enterotoxin
- (2015) Y. Saitoh et al. SCIENCE
- Assembly and function of claudins: Structure–function relationships based on homology models and crystal structures
- (2015) G. Krause et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- Antibody–drug conjugates—A new wave of cancer drugs
- (2014) Hervé Bouchard et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Peptide microarrays enable rapid mimotope optimization for pharmacokinetic analysis of the novel therapeutic antibody IMAB362
- (2014) Karsten Schnatbaum et al. Biotechnology Journal
- Aberrantly activated claudin 6 and 18.2 as potential therapy targets in non-small-cell lung cancer
- (2014) Patrick Micke et al. INTERNATIONAL JOURNAL OF CANCER
- Crystal Structure of a Claudin Provides Insight into the Architecture of Tight Junctions
- (2014) H. Suzuki et al. SCIENCE
- The role of molecular remodeling in differential regulation of tight junction permeability
- (2014) Jerrold R. Turner et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- Claudin-2 pore function requires an intramolecular disulfide bond between two conserved extracellular cysteines
- (2013) Jiahua Li et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- Claudin 18.2 is a target for IMAB362 antibody in pancreatic neoplasms
- (2013) Stefan Wöll et al. INTERNATIONAL JOURNAL OF CANCER
- Site-specific antibody drug conjugates for cancer therapy
- (2013) Siler Panowski et al. mAbs
- Regulation of paracellular permeability: factors and mechanisms
- (2013) Yan-Jun Hu et al. MOLECULAR BIOLOGY REPORTS
- Expression of claudin-7 and loss of claudin-18 correlate with poor prognosis in gastric cancer
- (2013) Kyong-Hwa Jun et al. International Journal of Surgery
- Deficiency of Claudin-18 Causes Paracellular H+ Leakage, Up-regulation of Interleukin-1β, and Atrophic Gastritis in Mice
- (2011) Daisuke Hayashi et al. GASTROENTEROLOGY
- Claudin-18 gene structure, regulation, and expression is evolutionary conserved in mammals
- (2011) Özlem Türeci et al. GENE
- Transcriptional regulation of claudin-18 via specific protein kinase C signaling pathways and modification of DNA methylation in human pancreatic cancer cells
- (2011) Tatsuya Ito et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Claudin-18 Is an Early-Stage Marker of Pancreatic Carcinogenesis
- (2011) Mariko Tanaka et al. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
- Role of claudin species–specific dynamics in reconstitution and remodeling of the zonula occludens
- (2011) Yuji Yamazaki et al. MOLECULAR BIOLOGY OF THE CELL
- Immunohistochemical Staining of Reg IV and Claudin-18 is Useful in the Diagnosis of Gastrointestinal Signet Ring Cell Carcinoma
- (2009) Kazuhiro Sentani et al. AMERICAN JOURNAL OF SURGICAL PATHOLOGY
- New Markers of Pancreatic Cancer Identified Through Differential Gene Expression Analyses: Claudin 18 and Annexin A8
- (2009) Zarir E. Karanjawala et al. AMERICAN JOURNAL OF SURGICAL PATHOLOGY
- Structure-Function Studies of Claudin Extracellular Domains by Cysteine-scanning Mutagenesis
- (2009) Susanne Angelow et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Claudin-18 Splice Variant 2 Is a Pan-Cancer Target Suitable for Therapeutic Antibody Development
- (2008) U. Sahin et al. CLINICAL CANCER RESEARCH
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