SPAK-p38 MAPK signal pathway modulates claudin-18 and barrier function of alveolar epithelium after hyperoxic exposure

WNK-SPAK/OSR1-NCC kinase signaling pathway as a novel target for the treatment of salt-sensitive hypertension

(2020) Archie Brown et al.   ACTA PHARMACOLOGICA SINICA

Physiological Processes Modulated by the Chloride-Sensitive WNK-SPAK/OSR1 Kinase Signaling Pathway and the Cation-Coupled Chloride Cotransporters

(2020) Adrián Rafael Murillo-de-Ozores et al.   Frontiers in Physiology

The effect of hyperoxia on mortality in critically ill patients: a systematic review and meta analysis

(2019) Yue-Nan Ni et al.   BMC Pulmonary Medicine

Oxygen radical disease in the newborn, revisited: Oxidative stress and disease in the newborn period

(2019) Marta Perez et al.   FREE RADICAL BIOLOGY AND MEDICINE

Acute Respiratory Barrier Disruption by Ozone Exposure in Mice

(2019) Milena Sokolowska et al.   Frontiers in Immunology

Inactivation of SPAK kinase reduces body weight gain in mice fed a high-fat diet by improving energy expenditure and insulin sensitivity

(2018) Ivan Torre-Villalvazo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Inhibition of NKCC1 Modulates Alveolar Fluid Clearance and Inflammation in Ischemia-Reperfusion Lung Injury via TRAF6-Mediated Pathways

(2018) Chih-Hao Shen et al.   Frontiers in Immunology

Role of TLR4-p38 MAPK-Hsp27 signal pathway in LPS-induced pulmonary epithelial hyperpermeability

(2018) Weiju Wang et al.   BMC Pulmonary Medicine

Effects of SPAK on vascular reactivity and nitric oxide production in endotoxemic mice

(2017) Chih-Chin Shih et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Pharmacological targeting of SPAK kinase in disorders of impaired epithelial transport

(2017) Jinwei Zhang et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Inhibition of Na-K-Cl cotransporter isoform 1 reduces lung injury induced by ischemia–reperfusion

(2017) Chou-Chin Lan et al.   JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY

Hyperoxia induces paracellular leak and alters claudin expression by neonatal alveolar epithelial cells

(2017) Shilpa Vyas-Read et al.   PEDIATRIC PULMONOLOGY

SPAK plays a pathogenic role in IgA nephropathy through the activation of NF-κB/MAPKs signaling pathway

(2016) Tsai-Jung Lin et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondrial ROS regulation of proliferating cells

(2016) Lauren Diebold et al.   FREE RADICAL BIOLOGY AND MEDICINE

Deletion of the WNK3-SPAK kinase complex in mice improves radiographic and clinical outcomes in malignant cerebral edema after ischemic stroke

(2016) Hanshu Zhao et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Tight junctions in pulmonary epithelia during lung inflammation

(2016) Oliver H. Wittekindt   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Molecular mechanisms underlying hyperoxia acute lung injury

(2016) Francisca Dias-Freitas et al.   RESPIRATORY MEDICINE

With-No-Lysine Kinase 4 Mediates Alveolar Fluid Regulation in Hyperoxia-Induced Lung Injury*

(2015) Hsueh-Ju Lin et al.   CRITICAL CARE MEDICINE

Association Between Arterial Hyperoxia and Outcome in Subsets of Critical Illness

(2015) Hendrik J. F. Helmerhorst et al.   CRITICAL CARE MEDICINE

Effects of hyperoxic exposure on signal transduction pathways in the lung

(2015) Andrea Porzionato et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Claudins: Gatekeepers of lung epithelial function

(2015) Barbara Schlingmann et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Knockout of Ste20-Like Proline/Alanine-Rich Kinase (SPAK) Attenuates Intestinal Inflammation in Mice

(2013) Yuchen Zhang et al.   AMERICAN JOURNAL OF PATHOLOGY

New roles for old pathways? A circuitous relationship between reactive oxygen species and cyclo-oxygenase in hypertension

(2013) Raquel Hernanz et al.   CLINICAL SCIENCE

Effects of hyperoxia on the permeability of 16HBE14o- cell monolayers - the protective role of antioxidant vitamins E and C

(2013) Hanady S. Al-Shmgani et al.   FEBS Journal

Hyperoxic Acute Lung Injury

(2013) R. H. Kallet et al.   Respiratory Care

Claudins and alveolar epithelial barrier function in the lung

(2012) James A. Frank   Annals of the New York Academy of Sciences

Roles for claudins in alveolar epithelial barrier function

(2012) Christian E. Overgaard et al.   Annals of the New York Academy of Sciences

Altered expression of tight junction molecules in alveolar septa in lung injury and fibrosis

(2011) Hiromitsu Ohta et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Tight Junctions and Tissue Barriers

(2011) Ingolf E. Blasig et al.   ANTIOXIDANTS & REDOX SIGNALING

Claudins: Control of Barrier Function and Regulation in Response to Oxidant Stress

(2011) Christian E. Overgaard et al.   ANTIOXIDANTS & REDOX SIGNALING

Occludin Protein Family: Oxidative Stress and Reducing Conditions

(2011) Ingolf E. Blasig et al.   ANTIOXIDANTS & REDOX SIGNALING

Overexpression of Ste20-Related Proline/Alanine-Rich Kinase Exacerbates Experimental Colitis in Mice

(2011) Y. Yan et al.   JOURNAL OF IMMUNOLOGY

Hyperoxia sensing: From molecular mechanisms to significance in disease

(2010) Ashwini Gore et al.   Journal of Immunotoxicology

SPAK-Knockout Mice Manifest Gitelman Syndrome and Impaired Vasoconstriction

(2010) S.-S. Yang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY