标题
Chimeric Antigen Receptor-T Cells: A Pharmaceutical Scope
作者
关键词
-
出版物
Frontiers in Pharmacology
Volume 12, Issue -, Pages -
出版商
Frontiers Media SA
发表日期
2021-08-20
DOI
10.3389/fphar.2021.720692
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Reversible ON- and OFF-switch chimeric antigen receptors controlled by lenalidomide
- (2021) Max Jan et al. Science Translational Medicine
- Allogeneic CAR Cell Therapy—More Than a Pipe Dream
- (2021) Kenneth J. Caldwell et al. Frontiers in Immunology
- Chimeric Antigen Receptor beyond CAR-T Cells
- (2021) Vicky Mengfei Qin et al. Cancers
- Cancer Immunotherapy Update: FDA-Approved Checkpoint Inhibitors and Companion Diagnostics
- (2021) Julianne D. Twomey et al. AAPS Journal
- Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma
- (2021) Nikhil C. Munshi et al. NEW ENGLAND JOURNAL OF MEDICINE
- Selecting the Optimal CAR-T for the Treatment of B-Cell Malignancies
- (2021) Taha Al-Juhaishi et al. Current Hematologic Malignancy Reports
- T Cell Exhaustion and CAR-T Immunotherapy in Hematological Malignancies
- (2021) Lu Tang et al. Biomed Research International
- Biomarkers for Chimeric Antigen Receptor T Cell Therapy in Acute Lymphoblastic Leukemia: Prospects for Personalized Management and Prognostic Prediction
- (2021) Ruimin Hong et al. Frontiers in Immunology
- Current status and perspective of CAR-T and CAR-NK cell therapy trials in Germany
- (2021) Nawid Albinger et al. GENE THERAPY
- CAR-T cells and BiTEs in solid tumors: challenges and perspectives
- (2021) Julien Edeline et al. Journal of Hematology & Oncology
- SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
- (2021) Joseph H. Choe et al. Science Translational Medicine
- A bibliometric review of oncolytic virus research as a novel approach for cancer therapy
- (2021) Amir Sasan Mozaffari Nejad et al. Virology Journal
- Natural Killer Cells Generated From Human Induced Pluripotent Stem Cells Mature to CD56brightCD16+NKp80+/-In-Vitro and Express KIR2DL2/DL3 and KIR3DL1
- (2021) Johanna Euchner et al. Frontiers in Immunology
- Reactions Related to CAR-T Cell Therapy
- (2021) Lele Miao et al. Frontiers in Immunology
- Lisocabtagene Maraleucel for the treatment of B-cell lymphoma
- (2021) Chaitanya Iragavarapu et al. EXPERT OPINION ON BIOLOGICAL THERAPY
- Identification and Validation of Predictive Biomarkers to CD19- and BCMA-Specific CAR T-Cell Responses in CAR T-Cell Precursors
- (2020) Meng Wang et al. BLOOD
- Autologous CAR T-cell therapies supply chain: challenges and opportunities?
- (2020) Maria M. Papathanasiou et al. CANCER GENE THERAPY
- CAR T cells: continuation in a revolution of immunotherapy
- (2020) Anurag K Singh et al. LANCET ONCOLOGY
- ‘Off-the-shelf’ allogeneic CAR T cells: development and challenges
- (2020) S. Depil et al. NATURE REVIEWS DRUG DISCOVERY
- Recent advances of oncolytic virus in cancer therapy
- (2020) Moumita Mondal et al. Human Vaccines & Immunotherapeutics
- Developmental Relationships of Four Exhausted CD8+ T Cell Subsets Reveals Underlying Transcriptional and Epigenetic Landscape Control Mechanisms
- (2020) Jean-Christophe Beltra et al. IMMUNITY
- CD4/CD8 T-Cell Selection Affects Chimeric Antigen Receptor (CAR) T-Cell Potency and Toxicity: Updated Results From a Phase I Anti-CD22 CAR T-Cell Trial
- (2020) Nirali N. Shah et al. JOURNAL OF CLINICAL ONCOLOGY
- Point-Of-Care CAR T-Cell Production (ARI-0001) Using a Closed Semi-automatic Bioreactor: Experience From an Academic Phase I Clinical Trial
- (2020) Maria Castella et al. Frontiers in Immunology
- Head-to-head comparison of in-house produced CD19 CAR-T cell in ALL and NHL patients
- (2020) Orit Itzhaki et al. Journal for ImmunoTherapy of Cancer
- Hinge and Transmembrane Domains of Chimeric Antigen Receptor Regulate Receptor Expression and Signaling Threshold
- (2020) Kento Fujiwara et al. Cells
- Current Challenges in Providing Good Leukapheresis Products for Manufacturing of CAR-T Cells for Patients with Relapsed/Refractory NHL or ALL
- (2020) Felix Korell et al. Cells
- γδ T Cells: The Ideal Tool for Cancer Immunotherapy
- (2020) Mahboubeh Yazdanifar et al. Cells
- Progress and Perspectives in the Development of Lentiviral Vector Producer Cells
- (2020) Mariana V. Ferreira et al. Biotechnology Journal
- New targets and technologies for CAR-T cells
- (2020) Fabian Freitag et al. CURRENT OPINION IN ONCOLOGY
- Recent advances in CAR-T cell engineering
- (2020) Ruihao Huang et al. Journal of Hematology & Oncology
- CAR-T Cells Hit the Tumor Microenvironment: Strategies to Overcome Tumor Escape
- (2020) Alba Rodriguez-Garcia et al. Frontiers in Immunology
- Oncolytic virus therapy benefits from control theory
- (2020) Anet J. N. Anelone et al. Royal Society Open Science
- Mechanisms underlying CD19-positive ALL relapse after anti-CD19 CAR T cell therapy and associated strategies
- (2020) Yuru Nie et al. Biomarker Research
- Human immunology and immunotherapy: main achievements and challenges
- (2020) Jezabel Varadé et al. Cellular & Molecular Immunology
- Emerging vistas in CAR T-cell therapy: challenges and opportunities in solid tumors
- (2020) Varada Date et al. EXPERT OPINION ON BIOLOGICAL THERAPY
- Bispecific anti-CD20, anti-CD19 CAR T cells for relapsed B cell malignancies: a phase 1 dose escalation and expansion trial
- (2020) Nirav N. Shah et al. NATURE MEDICINE
- Chimeric Antigen Receptor T Cell Exhaustion during Treatment for Hematological Malignancies
- (2020) Chunyi Shen et al. Biomed Research International
- Neurotoxicity and Cytokine Release Syndrome After Chimeric Antigen Receptor T Cell Therapy: Insights Into Mechanisms and Novel Therapies
- (2020) Elizabeth L. Siegler et al. Frontiers in Immunology
- Identification of Targets to Redirect CAR T Cells in Glioblastoma and Colorectal Cancer: An Arduous Venture
- (2020) Eleonora Ponterio et al. Frontiers in Immunology
- CAR-NK cells: A promising cellular immunotherapy for cancer
- (2020) Guozhu Xie et al. EBioMedicine
- Engineering Next-Generation CAR-T Cells for Better Toxicity Management
- (2020) Alain E. Andrea et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Counteracting CAR T cell dysfunction
- (2020) Mansour Poorebrahim et al. ONCOGENE
- Cancer statistics, 2019
- (2019) Rebecca L. Siegel et al. CA-A CANCER JOURNAL FOR CLINICIANS
- Lymphocytes in Cellular Therapy: Functional Regulation of CAR T Cells
- (2019) Dwivedi Alka et al. Frontiers in Immunology
- Next Generation CAR T Cells for the Immunotherapy of High-Grade Glioma
- (2019) Christopher T. Petersen et al. Frontiers in Oncology
- Current approaches in the grading and management of cytokine release syndrome after chimeric antigen receptor T-cell therapy
- (2019) Lara L. Riegler et al. Therapeutics and Clinical Risk Management
- CAR T-cells: costs, comparisons, and commentary
- (2019) Annette E. Hay et al. JOURNAL OF MEDICAL ECONOMICS
- IL-15-mediated reduction of mTORC1 activity preserves the stem cell memory phenotype of CAR-T cells and confers superior antitumor activity
- (2019) Darya Alizadeh et al. Cancer Immunology Research
- An immunoproteomic approach to characterize the CAR interactome and signalosome
- (2019) Maria C. Ramello et al. Science Signaling
- Manufacturing chimeric antigen receptor T cells: issues and challenges
- (2019) Claire Roddie et al. CYTOTHERAPY
- Cellular therapy for acute myeloid Leukemia – Current status and future prospects
- (2019) Panupong Hansrivijit et al. BLOOD REVIEWS
- 2First-in-human CAR T for solid tumors targets the MUC1 transmembrane cleavage product
- (2019) C. Bamdad et al. CYTOTHERAPY
- Chimeric Antigen Receptor-T Cells for Targeting Solid Tumors: Current Challenges and Existing Strategies
- (2019) Lorraine Springuel et al. BIODRUGS
- The FDA’s Regulatory Framework for Chimeric Antigen Receptor‐T Cell Therapies
- (2019) Peter Marks CTS-Clinical and Translational Science
- Target selection for CAR-T therapy
- (2019) Jianshu Wei et al. Journal of Hematology & Oncology
- Phase I study of lentiviral-transduced chimeric antigen receptor modified T cells recognizing mesothelin in advanced solid cancers
- (2019) Andrew R. Haas et al. MOLECULAR THERAPY
- Solid Tumors Challenges and New Insights of CAR T Cell Engineering
- (2019) Safa Tahmasebi et al. Stem Cell Reviews and Reports
- Induced Pluripotent Stem Cell (iPSC)–Derived Lymphocytes for Adoptive Cell Immunotherapy: Recent Advances and Challenges
- (2019) Alexandros Nianias et al. Current Hematologic Malignancy Reports
- CAR-T Engineering: Optimizing Signal Transduction and Effector Mechanisms
- (2019) Emiliano Roselli et al. BIODRUGS
- γ-secretase inhibition increases efficacy of BCMA-specific chimeric antigen receptor T cells in multiple myeloma
- (2019) Margot J. Pont et al. BLOOD
- Next generation chimeric antigen receptor T cells: safety strategies to overcome toxicity
- (2019) Shengnan Yu et al. Molecular Cancer
- Pursuit of tumor-infiltrating lymphocyte immunotherapy speeds up
- (2019) Ken Garber NATURE BIOTECHNOLOGY
- Regulatory Framework for Advanced Therapy Medicinal Products in Europe and United States
- (2019) Carolina Iglesias-López et al. Frontiers in Pharmacology
- Novel Strategies for Cancer Treatment: Highlights from the 55th IACR Annual Conference
- (2019) Sara Charmsaz et al. Cancers
- Combination Immunotherapy with CAR T Cells and Checkpoint Blockade for the Treatment of Solid Tumors
- (2019) Rachel Grosser et al. CANCER CELL
- Management of adults and children undergoing CAR t-cell therapy: best practice recommendations of the European Society for Blood and Marrow Transplantation (EBMT) and the Joint Accreditation Committee of ISCT and EBMT (JACIE)
- (2019) Ibrahim Yakoub-Agha et al. HAEMATOLOGICA
- Multi-antigen-targeted chimeric antigen receptor T cells for cancer therapy
- (2019) Xiao Han et al. Journal of Hematology & Oncology
- Retention of CD19 intron 2 contributes to CART-19 resistance in leukemias with subclonal frameshift mutations in CD19
- (2019) Mukta Asnani et al. LEUKEMIA
- Efficiency and safety of autologous chimeric antigen receptor T-cells therapy used for patients with lymphoma
- (2019) Genmao Cao et al. MEDICINE
- GMP-Compliant Manufacturing of NKG2D CAR Memory T Cells Using CliniMACS Prodigy
- (2019) Lucía Fernández et al. Frontiers in Immunology
- Mechanisms of Relapse After CD19 CAR T-Cell Therapy for Acute Lymphoblastic Leukemia and Its Prevention and Treatment Strategies
- (2019) Xinjie Xu et al. Frontiers in Immunology
- Understanding the Mechanisms of Resistance to CAR T-Cell Therapy in Malignancies
- (2019) Jiali Cheng et al. Frontiers in Oncology
- Optimizing Manufacturing Protocols of Chimeric Antigen Receptor T Cells for Improved Anticancer Immunotherapy
- (2019) Sophia Stock et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- CD19-targeting CAR T cell immunotherapy outcomes correlate with genomic modification by vector integration
- (2019) Christopher L. Nobles et al. JOURNAL OF CLINICAL INVESTIGATION
- c-Jun overexpression in CAR T cells induces exhaustion resistance
- (2019) Rachel C. Lynn et al. NATURE
- Engineering strategies to overcome the current roadblocks in CAR T cell therapy
- (2019) Sarwish Rafiq et al. Nature Reviews Clinical Oncology
- Chimeric antigen receptor T cells in solid tumors: a war against the tumor microenvironment
- (2019) Zijun Zhao et al. Science China-Life Sciences
- GMP CAR-T cell production
- (2018) Adrian P. Gee BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY
- CAR T Cells in Trials: Recent Achievements and Challenges that Remain in the Production of Modified T Cells for Clinical Applications
- (2018) Ulrike Köhl et al. HUMAN GENE THERAPY
- The expansion of targetable biomarkers for CAR T cell therapy
- (2018) Michelle H. Townsend et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Chimeric antigen receptor T cell (CAR-T) immunotherapy for solid tumors: lessons learned and strategies for moving forward
- (2018) Jian Li et al. Journal of Hematology & Oncology
- Long-Term Follow-up of CD19 CAR Therapy in Acute Lymphoblastic Leukemia
- (2018) Jae H. Park et al. NEW ENGLAND JOURNAL OF MEDICINE
- Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia
- (2018) Shannon L. Maude et al. NEW ENGLAND JOURNAL OF MEDICINE
- Engineered Tumor-Targeted T Cells Mediate Enhanced Anti-Tumor Efficacy Both Directly and through Activation of the Endogenous Immune System
- (2018) Mauro P. Avanzi et al. Cell Reports
- Differences in Expansion Potential of Naive Chimeric Antigen Receptor T Cells from Healthy Donors and Untreated Chronic Lymphocytic Leukemia Patients
- (2018) Jean-Marc Hoffmann et al. Frontiers in Immunology
- A single centre phase II trial to assess the immunological activity of TroVax® plus pemetrexed/cisplatin in patients with malignant pleural mesothelioma – the SKOPOS trial
- (2018) Jason F Lester et al. OncoImmunology
- Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
- (2018) Freddie Bray et al. CA-A CANCER JOURNAL FOR CLINICIANS
- Cell Therapy Products: Focus on Issues with Manufacturing and Quality Control of Chimeric Antigen Receptor T-cell therapies
- (2018) Jim E. Eyles et al. JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY
- CD19 alterations emerging after CD19-directed immunotherapy cause retention of the misfolded protein in the endoplasmic reticulum
- (2018) Asen Bagashev et al. MOLECULAR AND CELLULAR BIOLOGY
- Genetic mechanisms of target antigen loss in CAR19 therapy of acute lymphoblastic leukemia
- (2018) Elena J. Orlando et al. NATURE MEDICINE
- Immune Cell Hacking: Challenges and Clinical Approaches to Create Smarter Generations of Chimeric Antigen Receptor T Cells
- (2018) Reza Elahi et al. Frontiers in Immunology
- Emerging Cellular Therapies for Cancer
- (2018) Sonia Guedan et al. Annual Review of Immunology
- ASBMT Consensus Grading for Cytokine Release Syndrome and Neurological Toxicity Associated with Immune Effector Cells
- (2018) Daniel W Lee et al. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
- Standardizing CAR-T therapy: Getting it scaled up
- (2018) Xiaofeng Dai et al. BIOTECHNOLOGY ADVANCES
- Cytokines in clinical cancer immunotherapy
- (2018) Pedro Berraondo et al. BRITISH JOURNAL OF CANCER
- FDA Approval Summary: Axicabtagene Ciloleucel for Relapsed or Refractory Large B-cell Lymphoma
- (2018) Najat Bouchkouj et al. CLINICAL CANCER RESEARCH
- Neurotoxicity Associated with CD19-Targeted CAR-T Cell Therapies
- (2018) Juliane Gust et al. CNS DRUGS
- Functional Improvement of Chimeric Antigen Receptor Through Intrinsic Interleukin-15Ra Signaling
- (2018) Sushmita Nair et al. CURRENT GENE THERAPY
- Predictive and therapeutic biomarkers in chimeric antigen receptor T-cell therapy: A clinical perspective
- (2018) Hamid Reza Mirzaei et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Tisagenlecleucel in Adult Relapsed or Refractory Diffuse Large B-Cell Lymphoma
- (2018) Stephen J. Schuster et al. NEW ENGLAND JOURNAL OF MEDICINE
- Adoptive cellular therapies: the current landscape
- (2018) Maartje W. Rohaan et al. VIRCHOWS ARCHIV
- Automated Manufacturing of Potent CD20-Directed Chimeric Antigen Receptor T Cells for Clinical Use
- (2017) Dominik Lock et al. HUMAN GENE THERAPY
- New development in CAR-T cell therapy
- (2017) Zhenguang Wang et al. Journal of Hematology & Oncology
- CD19 Isoforms Enabling Resistance to CART-19 Immunotherapy Are Expressed in B-ALL Patients at Initial Diagnosis
- (2017) Jeannette Fischer et al. JOURNAL OF IMMUNOTHERAPY
- Elutriated lymphocytes for manufacturing chimeric antigen receptor T cells
- (2017) David F. Stroncek et al. Journal of Translational Medicine
- CAR T cell therapy for multiple myeloma: where are we now and where are we headed?
- (2017) Arnab Ghosh et al. LEUKEMIA & LYMPHOMA
- CD22-targeted CAR T cells induce remission in B-ALL that is naive or resistant to CD19-targeted CAR immunotherapy
- (2017) Terry J Fry et al. NATURE MEDICINE
- Chimeric antigen receptor T-cell therapy — assessment and management of toxicities
- (2017) Sattva S. Neelapu et al. Nature Reviews Clinical Oncology
- FDA approves first CAR T therapy
- (2017) Asher Mullard NATURE REVIEWS DRUG DISCOVERY
- Axicabtagene Ciloleucel CAR T-Cell Therapy in Refractory Large B-Cell Lymphoma
- (2017) Sattva S. Neelapu et al. NEW ENGLAND JOURNAL OF MEDICINE
- Generation of “Off-the-Shelf” Natural Killer Cells from Peripheral Blood Cell-Derived Induced Pluripotent Stem Cells
- (2017) Jieming Zeng et al. Stem Cell Reports
- Chimeric Antigen Receptors T Cell Therapy in Solid Tumor: Challenges and Clinical Applications
- (2017) Hamid R. Mirzaei et al. Frontiers in Immunology
- Global Manufacturing of CAR T Cell Therapy
- (2017) Bruce L. Levine et al. Molecular Therapy-Methods & Clinical Development
- Variations of B cell subpopulations in peripheral blood of healthy Mexican population according to age: Relevance for diagnosis of primary immunodeficiencies
- (2016) L. Berrón-Ruíz et al. ALLERGOLOGIA ET IMMUNOPATHOLOGIA
- An analytical biomarker for treatment of patients with recurrent B-ALL after remission induced by infusion of anti-CD19 chimeric antigen receptor T (CAR-T) cells
- (2016) Yajing Zhang et al. Science China-Life Sciences
- T Cells Expressing CD19/CD20 Bispecific Chimeric Antigen Receptors Prevent Antigen Escape by Malignant B Cells
- (2016) E. Zah et al. Cancer Immunology Research
- Clinical manufacturing of CAR T cells: foundation of a promising therapy
- (2016) Xiuyan Wang et al. Molecular Therapy-Oncolytics
- Biomarkers in Cancer Immunotherapy
- (2015) Ton N. Schumacher et al. CANCER CELL
- Towards a commercial process for the manufacture of genetically modified T cells for therapy
- (2015) A D Kaiser et al. CANCER GENE THERAPY
- The pharmacology of second-generation chimeric antigen receptors
- (2015) Sjoukje J. C. van der Stegen et al. NATURE REVIEWS DRUG DISCOVERY
- Chimeric antigen receptor T cells persist and induce sustained remissions in relapsed refractory chronic lymphocytic leukemia
- (2015) David L. Porter et al. Science Translational Medicine
- New approaches for cancer immunotherapy
- (2015) Ayfer Karlitepe et al. TUMOR BIOLOGY
- Convergence of Acquired Mutations and Alternative Splicing of CD19 Enables Resistance to CART-19 Immunotherapy
- (2015) E. Sotillo et al. Cancer Discovery
- Chimeric Antigen Receptor T Cells for Sustained Remissions in Leukemia
- (2014) Shannon L. Maude et al. NEW ENGLAND JOURNAL OF MEDICINE
- The inducible caspase-9 suicide gene system as a “safety switch†to limit on-target, off-tumor toxicities of chimeric antigen receptor T cells
- (2014) Tessa Gargett et al. Frontiers in Pharmacology
- Chimeric Antigen Receptor–Modified T Cells for Acute Lymphoid Leukemia
- (2013) Stephan A. Grupp et al. NEW ENGLAND JOURNAL OF MEDICINE
- PD-1- and CTLA-4-Based Inhibitory Chimeric Antigen Receptors (iCARs) Divert Off-Target Immunotherapy Responses
- (2013) V. D. Fedorov et al. Science Translational Medicine
- CD19-Targeted T Cells Rapidly Induce Molecular Remissions in Adults with Chemotherapy-Refractory Acute Lymphoblastic Leukemia
- (2013) R. J. Brentjens et al. Science Translational Medicine
- T Lymphocyte Potential Marks the Emergence of Definitive Hematopoietic Progenitors in Human Pluripotent Stem Cell Differentiation Cultures
- (2012) Marion Kennedy et al. Cell Reports
- The split nature of tumor-infiltrating leukocytes
- (2012) Telma Lança et al. OncoImmunology
- Safety and persistence of adoptively transferred autologous CD19-targeted T cells in patients with relapsed or chemotherapy refractory B-cell leukemias
- (2011) R. J. Brentjens et al. BLOOD
- Costimulation by chimeric antigen receptors revisited the T cell antitumor response benefits from combined CD28-OX40 signalling
- (2011) Andreas A. Hombach et al. INTERNATIONAL JOURNAL OF CANCER
- T cell exhaustion
- (2011) E John Wherry NATURE IMMUNOLOGY
- T Cells with Chimeric Antigen Receptors Have Potent Antitumor Effects and Can Establish Memory in Patients with Advanced Leukemia
- (2011) M. Kalos et al. Science Translational Medicine
- Assessment of the Evolution of Cancer Treatment Therapies
- (2011) Manuel Arruebo et al. Cancers
- The promise and potential pitfalls of chimeric antigen receptors
- (2009) Michel Sadelain et al. CURRENT OPINION IN IMMUNOLOGY
- Manufacturing Validation of Biologically Functional T Cells Targeted to CD19 Antigen for Autologous Adoptive Cell Therapy
- (2009) Daniel Hollyman et al. JOURNAL OF IMMUNOTHERAPY
- Chimeric Receptors Containing CD137 Signal Transduction Domains Mediate Enhanced Survival of T Cells and Increased Antileukemic Efficacy In Vivo
- (2009) Michael C. Milone et al. MOLECULAR THERAPY
- CD19: a promising B cell target for rheumatoid arthritis
- (2009) Thomas F. Tedder Nature Reviews Rheumatology
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now