Claudin-18.2 as a therapeutic target in cancers: cumulative findings from basic research and clinical trials
出版年份 2021 全文链接
标题
Claudin-18.2 as a therapeutic target in cancers: cumulative findings from basic research and clinical trials
作者
关键词
-
出版物
Tissue Barriers
Volume -, Issue -, Pages -
出版商
Informa UK Limited
发表日期
2021-09-06
DOI
10.1080/21688370.2021.1967080
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Colitis‐associated colorectal adenocarcinomas frequently express claudin 18 isoform 2: Implications for claudin 18.2 monoclonal antibody therapy
- (2021) Mai Iwaya et al. HISTOPATHOLOGY
- Clinicopathologic Relevance of Claudin 18.2 Expression in Gastric Cancer: A Meta-Analysis
- (2021) Bogdan Silviu Ungureanu et al. Frontiers in Oncology
- Target specific tight junction modulators
- (2021) Joël Brunner et al. ADVANCED DRUG DELIVERY REVIEWS
- ERBB2 copy number (CN) as a quantitative biomarker for real-world (RW) outcomes to anti-HER2 therapy in advanced gastroesophageal adenocarcinoma (adv GEA).
- (2021) Samuel J Klempner et al. JOURNAL OF CLINICAL ONCOLOGY
- Prognostic significance of rate of tumor marker (TM) decline during high-dose chemotherapy (HDCT) for relapsed germ cell tumors (rGCT).
- (2020) Nabil Adra et al. JOURNAL OF CLINICAL ONCOLOGY
- Prognostic impact of Claudin 18.2 in gastric and esophageal adenocarcinomas
- (2020) A. Arnold et al. Clinical & Translational Oncology
- Distinct Local and Systemic Molecular Signatures in the Esophageal and Gastric Cancers: Possible Therapy Targets and Biomarkers for Gastric Cancer
- (2020) Iwona Bednarz-Misa et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- CAR-T Cell Therapy—An Overview of Targets in Gastric Cancer
- (2020) Dominika Bębnowska et al. Journal of Clinical Medicine
- Correlation between Claudin-18 expression and clinicopathological features and prognosis in patients with gastric cancer
- (2020) Yufeng Lu et al. Journal of Gastrointestinal Oncology
- Role of tight junctions in the epithelial-to-mesenchymal transition of cancer cells
- (2020) Daisuke Kyuno et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
- Tight Junction Proteins and Signaling Pathways in Cancer and Inflammation: A Functional Crosstalk
- (2019) Ajaz A. Bhat et al. Frontiers in Physiology
- Enrichment of CLDN18 -ARHGAP fusion gene in gastric cancers in young adults
- (2019) Izuma Nakayama et al. CANCER SCIENCE
- ZO-2 Suppresses Cell Migration Mediated by a Reduction in Matrix Metalloproteinase 2 in Claudin-18-Expressing Lung Adenocarcinoma A549 Cells
- (2019) Risa Akizuki et al. BIOLOGICAL & PHARMACEUTICAL BULLETIN
- Phase I trial of Claudin 18.2-specific chimeric antigen receptor T cells for advanced gastric and pancreatic adenocarcinoma.
- (2019) Xianbao Zhan et al. JOURNAL OF CLINICAL ONCOLOGY
- Upregulated claudin-1 expression promotes colitis-associated cancer by promoting β-catenin phosphorylation and activation in Notch/p-AKT-dependent manner
- (2019) Saiprasad Gowrikumar et al. ONCOGENE
- A multicentre, phase IIa study of zolbetuximab as a single agent in patients with recurrent or refractory advanced adenocarcinoma of the stomach or lower oesophagus: the MONO study
- (2019) O Türeci et al. ANNALS OF ONCOLOGY
- Claudin-18 expression in oesophagogastric adenocarcinomas: a tissue microarray study of 523 molecularly profiled cases
- (2019) Irene Coati et al. BRITISH JOURNAL OF CANCER
- Expression of the potential therapeutic target claudin-18.2 is frequently decreased in gastric cancer: results from a large Caucasian cohort study
- (2019) Matthias Dottermusch et al. VIRCHOWS ARCHIV
- 198TiPSPOTLIGHT: Comparison of zolbetuximab or placebo + mFOLFOX6 as first-line treatment in patients with claudin18.2+/HER2– locally advanced unresectable or metastatic gastric or gastroesophageal junction adenocarcinoma (GEJ): A randomized phase III study
- (2019) K Yamaguchi et al. ANNALS OF ONCOLOGY
- Development of Human Monoclonal Antibody for Claudin-3 Overexpressing Carcinoma Targeting
- (2019) Hobin Yang et al. Biomolecules
- A phase I dose-escalation study of IMAB362 (Zolbetuximab) in patients with advanced gastric and gastro-oesophageal junction cancer
- (2018) Ugur Sahin et al. EUROPEAN JOURNAL OF CANCER
- Claudin-3 Inhibits Lung Squamous Cell Carcinoma Cell Epithelial-mesenchymal Transition and Invasion via Suppression of the Wnt/β-catenin Signaling Pathway
- (2018) Juanjuan Che et al. International Journal of Medical Sciences
- Claudin-18–mediated YAP activity regulates lung stem and progenitor cell homeostasis and tumorigenesis
- (2018) Beiyun Zhou et al. JOURNAL OF CLINICAL INVESTIGATION
- OUP accepted manuscript
- (2018) JNCI-Journal of the National Cancer Institute
- Frequent CLDN18-ARHGAP fusion in highly metastatic diffuse-type gastric cancer with relatively early onset
- (2018) Atsushi Tanaka et al. Oncotarget
- OUP accepted manuscript
- (2018) JNCI-Journal of the National Cancer Institute
- Loss of Tight Junction Protein Claudin 18 Promotes Progressive Neoplasia Development in Mouse Stomach
- (2018) Susan J. Hagen et al. GASTROENTEROLOGY
- Tight junction proteins in gastrointestinal and liver disease
- (2018) Mirjam B Zeisel et al. GUT
- MUC5B, CA9 and CLDN18 are potential theranostic markers of gallbladder carcinoma
- (2018) Jaime A. Espinoza et al. HISTOPATHOLOGY
- RhoGAP domain-containing fusions and PPAPDC1A fusions are recurrent and prognostic in diffuse gastric cancer
- (2018) Hanna Yang et al. Nature Communications
- Characterization of zolbetuximab in pancreatic cancer models
- (2018) Ӧzlem Türeci et al. OncoImmunology
- Therapeutic Targeting Cancer-Initiating Cell Markers by Exosome miRNA: Efficacy and Functional Consequences Exemplified for claudin7 and EpCAM
- (2018) Daisuke Kyuno et al. Translational Oncology
- Claudin-18 deficiency is associated with airway epithelial barrier dysfunction and asthma
- (2017) Kelly Sweerus et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Anti-claudin 18.2 antibody as new targeted therapy for advanced gastric cancer
- (2017) Prabhsimranjot Singh et al. Journal of Hematology & Oncology
- Claudin-18 inhibits cell proliferation and motility mediated by inhibition of phosphorylation of PDK1 and Akt in human lung adenocarcinoma A549 cells
- (2016) Shun Shimobaba et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Immunocytochemistry for Claudin-18 and Maspin in biliary brushing cytology increases the accuracy of diagnosing pancreatobiliary malignancies
- (2016) T. Tokumitsu et al. CYTOPATHOLOGY
- Tight junctions: from simple barriers to multifunctional molecular gates
- (2016) Ceniz Zihni et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Recurrent Fusion Genes in Gastric Cancer: CLDN18-ARHGAP26 Induces Loss of Epithelial Integrity
- (2015) Fei Yao et al. Cell Reports
- CLDN3 inhibits cancer aggressiveness via Wnt-EMT signaling and is a potential prognostic biomarker for hepatocellular carcinoma
- (2015) Lei Jiang et al. Oncotarget
- Claudin-18 Deficiency Results in Alveolar Barrier Dysfunction and Impaired Alveologenesis in Mice
- (2014) Michael J. LaFemina et al. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
- Mitochondrial Transfer of Induced Pluripotent Stem Cell–Derived Mesenchymal Stem Cells to Airway Epithelial Cells Attenuates Cigarette Smoke–Induced Damage
- (2014) Xiang Li et al. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
- Aberrantly activated claudin 6 and 18.2 as potential therapy targets in non-small-cell lung cancer
- (2014) Patrick Micke et al. INTERNATIONAL JOURNAL OF CANCER
- An immunohistochemical marker panel including claudin-18, maspin, and p53 improves diagnostic accuracy of bile duct neoplasms in surgical and presurgical biopsy specimens
- (2014) Yoshiko Keira et al. VIRCHOWS ARCHIV
- Protein kinase Cα inhibitor protects against downregulation of claudin-1 during epithelial–mesenchymal transition of pancreatic cancer
- (2013) Daisuke Kyuno et al. CARCINOGENESIS
- Claudin 18.2 is a target for IMAB362 antibody in pancreatic neoplasms
- (2013) Stefan Wöll et al. INTERNATIONAL JOURNAL OF CANCER
- Claudins and the Modulation of Tight Junction Permeability
- (2013) Dorothee Günzel et al. PHYSIOLOGICAL REVIEWS
- Down-Regulation of Claudin-18 Is Associated with the Proliferative and Invasive Potential of Gastric Cancer at the Invasive Front
- (2013) Tadayuki Oshima et al. PLoS One
- Expression of claudin-7 and loss of claudin-18 correlate with poor prognosis in gastric cancer
- (2013) Kyong-Hwa Jun et al. International Journal of Surgery
- Expression of claudins 7 and 18 in pancreatic ductal adenocarcinoma: association with features of differentiation
- (2012) Y Soini et al. JOURNAL OF CLINICAL PATHOLOGY
- Claudin-1 induces epithelial–mesenchymal transition through activation of the c-Abl-ERK signaling pathway in human liver cells
- (2012) Y Suh et al. ONCOGENE
- Altered expression of tight junction molecules in alveolar septa in lung injury and fibrosis
- (2011) Hiromitsu Ohta et al. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
- Deficiency of Claudin-18 Causes Paracellular H+ Leakage, Up-regulation of Interleukin-1β, and Atrophic Gastritis in Mice
- (2011) Daisuke Hayashi et al. GASTROENTEROLOGY
- Transcriptional regulation of claudin-18 via specific protein kinase C signaling pathways and modification of DNA methylation in human pancreatic cancer cells
- (2011) Tatsuya Ito et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Claudin-2 expression increases tumorigenicity of colon cancer cells: role of epidermal growth factor receptor activation
- (2011) P Dhawan et al. ONCOGENE
- Claudin-18 in biliary neoplasms. Its significance in the classification of intrahepatic cholangiocarcinoma
- (2011) Aya Shinozaki et al. VIRCHOWS ARCHIV
- Claudin Family of Proteins and Cancer: An Overview
- (2010) Amar B. Singh et al. Journal of Oncology
- New Markers of Pancreatic Cancer Identified Through Differential Gene Expression Analyses: Claudin 18 and Annexin A8
- (2009) Zarir E. Karanjawala et al. AMERICAN JOURNAL OF SURGICAL PATHOLOGY
- Claudin-18 Splice Variant 2 Is a Pan-Cancer Target Suitable for Therapeutic Antibody Development
- (2008) U. Sahin et al. CLINICAL CANCER RESEARCH
- Transcriptional activation of the human claudin-18 gene promoter through two AP-1 motifs in PMA-stimulated MKN45 gastric cancer cells
- (2007) Koichi Yano et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
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