A Patent Review on FDA‐Approved Antibody‐Drug Conjugates, Their Linkers and Drug Payloads
出版年份 2022 全文链接
标题
A Patent Review on FDA‐Approved Antibody‐Drug Conjugates, Their Linkers and Drug Payloads
作者
关键词
-
出版物
ChemMedChem
Volume -, Issue -, Pages -
出版商
Wiley
发表日期
2022-04-06
DOI
10.1002/cmdc.202200032
参考文献
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- Enfortumab Vedotin in Previously Treated Advanced Urothelial Carcinoma
- (2021) Thomas Powles et al. NEW ENGLAND JOURNAL OF MEDICINE
- FDA Approval Summary: Fam-trastuzumab deruxtecan-nxki for the treatment of unresectable or metastatic HER2-positive breast cancer
- (2021) Preeti Narayan et al. CLINICAL CANCER RESEARCH
- Discovery and development of trastuzumab deruxtecan and safety management for patients with HER2-positive gastric cancer
- (2021) Kohei Shitara et al. Gastric Cancer
- ADC sacituzumab govitecan shows efficacy and safety
- (2021) Peter Sidaway Nature Reviews Urology
- Sacituzumab Govitecan in Metastatic Triple-Negative Breast Cancer
- (2021) Aditya Bardia et al. NEW ENGLAND JOURNAL OF MEDICINE
- Longer term outcomes with single‐agent belantamab mafodotin in patients with relapsed or refractory multiple myeloma: 13‐month follow‐up from the pivotal DREAMM‐2 study
- (2021) Sagar Lonial et al. CANCER
- Belantamab Mafodotin for the Treatment of Multiple Myeloma: An Overview of the Clinical Efficacy and Safety
- (2021) Massimo Offidani et al. Drug Design Development and Therapy
- Camptothecin's journey from discovery to WHO Essential Medicine: Fifty years of promise
- (2021) Noura Khaiwa et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Understanding the basics of patenting
- (2020) Sadhana Chitale et al. NATURE BIOTECHNOLOGY
- Advances in Antibody–Drug Conjugate Design: Current Clinical Landscape and Future Innovations
- (2020) Laurence Gauzy-Lazo et al. SLAS Discovery
- FDA Approval Summary: Enfortumab Vedotin for Locally Advanced or Metastatic Urothelial Carcinoma
- (2020) Elaine Chang et al. CLINICAL CANCER RESEARCH
- Making smart drugs smarter: The importance of linker chemistry in targeted drug delivery
- (2020) Xiaoxiao Yang et al. MEDICINAL RESEARCH REVIEWS
- Antibody–Drug Conjugates: The Last Decade
- (2020) Nicolas Joubert et al. Pharmaceuticals
- Final Results of a Phase 1 Study of Loncastuximab Tesirine in Relapsed/Refractory B-Cell Non-Hodgkin Lymphoma
- (2020) Mehdi Hamadani et al. BLOOD
- Antibody-Drug Conjugate-Based Therapeutics: State of the Science
- (2019) Michael J Birrer et al. JNCI-Journal of the National Cancer Institute
- The Latest Research and Development into the Antibody–Drug Conjugate, [fam-] Trastuzumab Deruxtecan (DS-8201a), for HER2 Cancer Therapy
- (2019) Takashi Nakada et al. CHEMICAL & PHARMACEUTICAL BULLETIN
- Polatuzumab Vedotin: First Global Approval
- (2019) Emma D. Deeks DRUGS
- Polatuzumab Vedotin in Relapsed or Refractory Diffuse Large B-Cell Lymphoma
- (2019) Laurie H. Sehn et al. JOURNAL OF CLINICAL ONCOLOGY
- Antibody-Drug Conjugates: A Comprehensive Review
- (2019) Puregmaa Khongorzul et al. MOLECULAR CANCER RESEARCH
- Tisotumab Vedotin in Previously Treated Recurrent or Metastatic Cervical Cancer
- (2019) David S. Hong et al. CLINICAL CANCER RESEARCH
- Trastuzumab Deruxtecan in Previously Treated HER2-Positive Breast Cancer
- (2019) Shanu Modi et al. NEW ENGLAND JOURNAL OF MEDICINE
- Pre-clinical pharmacology and mechanism of action of SG3199, the pyrrolobenzodiazepine (PBD) dimer warhead component of antibody-drug conjugate (ADC) payload tesirine
- (2018) John A. Hartley et al. Scientific Reports
- Inotuzumab ozogamicin in relapsed B-cell acute lymphoblastic leukemia
- (2017) Swapna Thota et al. EUROPEAN JOURNAL OF HAEMATOLOGY
- Strategies and challenges for the next generation of antibody–drug conjugates
- (2017) Alain Beck et al. NATURE REVIEWS DRUG DISCOVERY
- Novel antibody drug conjugates containing exatecan derivative-based cytotoxic payloads
- (2016) Takashi Nakada et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Enfortumab Vedotin Antibody-Drug Conjugate Targeting Nectin-4 Is a Highly Potent Therapeutic Agent in Multiple Preclinical Cancer Models
- (2016) P. M. Challita-Eid et al. CANCER RESEARCH
- Inotuzumab Ozogamicin versus Standard Therapy for Acute Lymphoblastic Leukemia
- (2016) Hagop M. Kantarjian et al. NEW ENGLAND JOURNAL OF MEDICINE
- Design and Synthesis of Tesirine, a Clinical Antibody–Drug Conjugate Pyrrolobenzodiazepine Dimer Payload
- (2016) Arnaud C. Tiberghien et al. ACS Medicinal Chemistry Letters
- Structural Basis of Microtubule Destabilization by Potent Auristatin Anti-Mitotics
- (2016) Andrew B. Waight et al. PLoS One
- Sacituzumab Govitecan (IMMU-132), an Anti-Trop-2/SN-38 Antibody–Drug Conjugate: Characterization and Efficacy in Pancreatic, Gastric, and Other Cancers
- (2015) Thomas M. Cardillo et al. BIOCONJUGATE CHEMISTRY
- Antibody-drug conjugates: Intellectual property considerations
- (2015) Ulrich Storz mAbs
- Improving the Therapeutic Index in Cancer Therapy by Using Antibody–Drug Conjugates Designed with a Moderately Cytotoxic Drug
- (2014) Serengulam V. Govindan et al. MOLECULAR PHARMACEUTICS
- A new tubulin-binding site and pharmacophore for microtubule-destabilizing anticancer drugs
- (2014) A. E. Prota et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Brentuximab vedotin
- (2012) Niels W. C.J. van de Donk et al. mAbs
- Trastuzumab Emtansine for HER2-Positive Advanced Breast Cancer
- (2012) Sunil Verma et al. NEW ENGLAND JOURNAL OF MEDICINE
- Antibody-Drug Conjugates of Calicheamicin Derivative: Gemtuzumab Ozogamicin and Inotuzumab Ozogamicin
- (2011) A. D. Ricart CLINICAL CANCER RESEARCH
- Brentuximab Vedotin (SGN-35)
- (2011) J. Katz et al. CLINICAL CANCER RESEARCH
- Novel Peptide Linkers for Highly Potent Antibody−Auristatin Conjugate
- (2008) Svetlana O. Doronina et al. BIOCONJUGATE CHEMISTRY
- Targeting HER2-Positive Breast Cancer with Trastuzumab-DM1, an Antibody-Cytotoxic Drug Conjugate
- (2008) G. D. Lewis Phillips et al. CANCER RESEARCH
- Antibody Conjugates of 7-Ethyl-10-hydroxycamptothecin (SN-38) for Targeted Cancer Chemotherapy
- (2008) Sung-Ju Moon et al. JOURNAL OF MEDICINAL CHEMISTRY
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