Mitochondrial Calcium: Effects of Its Imbalance in Disease

Mitochondria-associated membranes (MAMs): a potential therapeutic target for treating Alzheimer’s disease

(2021) Weiwei Yu et al.   CLINICAL SCIENCE

Mitochondrial Structure and Bioenergetics in Normal and Disease Conditions

(2021) Margherita Protasoni et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mitochondria-plasma membrane interactions and communication

(2021) Pavel Montes de Oca Balderas   JOURNAL OF BIOLOGICAL CHEMISTRY

Reappraisal of metabolic dysfunction in neurodegeneration: Focus on mitochondrial function and calcium signaling

(2021) Pooja Jadiya et al.   Acta Neuropathologica Communications

Mitochondrial Ca2+ Signaling in Health, Disease and Therapy

(2021) Lorenzo Modesti et al.   Cells

Pharmacokinetics, Safety, and Tolerability of Orally Administered Ursodeoxycholic Acid in Patients With Parkinson's Disease—A Pilot Study

(2020) Abhishek G. Sathe et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Strenuous Acute Exercise Induces Slow and Fast Twitch-Dependent NADPH Oxidase Expression in Rat Skeletal Muscle

(2020) Juliana Osório Alves et al.   Antioxidants

PINK1 and Parkin mitochondrial quality control: a source of regional vulnerability in Parkinson’s disease

(2020) Preston Ge et al.   Molecular Neurodegeneration

Structure and mechanism of the mitochondrial Ca2+ uniporter holocomplex

(2020) Minrui Fan et al.   NATURE

Clinical Characterization of Parkinson's Disease Patients With Cognitive Impairment

(2020) Ana Simon-Gozalbo et al.   Frontiers in Neurology

Interaction of Oxidative Stress and Misfolded Proteins in the Mechanism of Neurodegeneration

(2020) Andrey Y. Abramov et al.   Life-Basel

The contribution of uncoupling protein 2 to mitochondrial Ca2+ homeostasis - a short revisit

(2020) Zhanat Koshenov et al.   MITOCHONDRION

Structure and Function of the Human Ryanodine Receptors and Their Association with Myopathies—Present State, Challenges, and Perspectives

(2020) Vladena Bauerová-Hlinková et al.   MOLECULES

Hydrogen peroxide diffusion and scavenging shapes mitochondrial network instability and failure by sensitizing ROS-induced ROS release

(2020) Brent Millare et al.   Scientific Reports

Coming together to define membrane contact sites

(2019) Luca Scorrano et al.   Nature Communications

LRRK2 deficiency induced mitochondrial Ca2+ efflux inhibition can be rescued by Na+/Ca2+/Li+ exchanger upregulation

(2019) Marthe H. R. Ludtmann et al.   Cell Death & Disease

Dimers of mitochondrial ATP synthase induce membrane curvature and self-assemble into rows

(2019) Thorsten B. Blum et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial calcium: Transport and modulation of cellular processes in homeostasis and cancer (Review)

(2019) Susana Romero-Garcia et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Peripheral mitochondrial function correlates with clinical severity in idiopathic Parkinson's disease

(2019) Chiara Milanese et al.   MOVEMENT DISORDERS

LETM1: Essential for Mitochondrial Biology and Cation Homeostasis?

(2019) Shane Austin et al.   TRENDS IN BIOCHEMICAL SCIENCES

N‐Acetyl Cysteine Is Associated With Dopaminergic Improvement in Parkinson's Disease

(2019) Daniel A. Monti et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Biochemical basis and metabolic interplay of redox regulation

(2019) Lixiao Zhang et al.   Redox Biology

MICU1 controls cristae junction and spatially anchors mitochondrial Ca2+ uniporter complex

(2019) Benjamin Gottschalk et al.   Nature Communications

IP3 receptor isoforms differently regulate ER-mitochondrial contacts and local calcium transfer

(2019) Adam Bartok et al.   Nature Communications

Tau inhibits mitochondrial calcium efflux and makes neurons vulnerable to calcium-induced cell death

(2019) Elena Britti et al.   CELL CALCIUM

ROS and diseases: role in metabolism and energy supply

(2019) Shenshu Yang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Mitochondrial Uncoupling Proteins: Subtle Regulators of Cellular Redox Signaling

(2018) Petr Ježek et al.   ANTIOXIDANTS & REDOX SIGNALING

Effects of bisphenol A and its analogs bisphenol F and S on life parameters, antioxidant system, and response of defensome in the marine rotifer Brachionus koreanus

(2018) Jun Chul Park et al.   AQUATIC TOXICOLOGY

Mitochondrial abnormalities in Parkinson's disease and Alzheimer's disease: can mitochondria be targeted therapeutically?

(2018) Ruby Macdonald et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

VDAC1 functions in Ca 2+ homeostasis and cell life and death in health and disease

(2018) Varda Shoshan-Barmatz et al.   CELL CALCIUM

Calcium Signaling and Reactive Oxygen Species in Mitochondria

(2018) Edoardo Bertero et al.   CIRCULATION RESEARCH

Advances and current challenges in calcium signaling

(2018) Jörg Kudla et al.   NEW PHYTOLOGIST

Calcium Dynamics as a Machine for Decoding Signals

(2018) Carlotta Giorgi et al.   TRENDS IN CELL BIOLOGY

Role of Mitochondria-Associated ER Membranes in Calcium Regulation in Cancer-Specific Settings

(2018) Giampaolo Morciano et al.   NEOPLASIA

Structure and mechanism of mitochondrial electron transport chain

(2018) Runyu Guo et al.   Biomedical Journal

Mitochondrial dysfunction in pathophysiology of heart failure

(2018) Bo Zhou et al.   JOURNAL OF CLINICAL INVESTIGATION

The machineries, regulation and cellular functions of mitochondrial calcium

(2018) Carlotta Giorgi et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Antioxidant and Oxidative Stress: A Mutual Interplay in Age-Related Diseases

(2018) Bee Ling Tan et al.   Frontiers in Pharmacology

ROS-induced ROS release in plant and animal cells

(2017) Sara I. Zandalinas et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondrial Calcium Dysregulation Contributes to Dendrite Degeneration Mediated by PD/LBD-Associated LRRK2 Mutants

(2017) Manish Verma et al.   JOURNAL OF NEUROSCIENCE

Intracellular Ca 2+ Sensing: Its Role in Calcium Homeostasis and Signaling

(2017) Rafaela Bagur et al.   MOLECULAR CELL

The mitochondrial Na+/Ca2+ exchanger is essential for Ca2+ homeostasis and viability

(2017) Timothy S. Luongo et al.   NATURE

Transient Opening of the Mitochondrial Permeability Transition Pore Induces Microdomain Calcium Transients in Astrocyte Processes

(2017) Amit Agarwal et al.   NEURON

The role of mitochondria in amyotrophic lateral sclerosis

(2017) Emma F. Smith et al.   NEUROSCIENCE LETTERS

Pro- and Antioxidant Functions of the Peroxisome-Mitochondria Connection and Its Impact on Aging and Disease

(2017) Amparo Pascual-Ahuir et al.   Oxidative Medicine and Cellular Longevity

Mediating ER-mitochondrial cross-talk

(2017) Alyssa A. Lombardi et al.   SCIENCE

Peroxisomal Dysfunction in Age-Related Diseases

(2017) Cynthia M. Cipolla et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

PINK1-mediated phosphorylation of LETM1 regulates mitochondrial calcium transport and protects neurons against mitochondrial stress

(2017) En Huang et al.   Nature Communications

LETM1-Mediated K+ and Na+ Homeostasis Regulates Mitochondrial Ca2+ Efflux

(2017) Shane Austin et al.   Frontiers in Physiology

Hydrogen peroxide as a central redox signaling molecule in physiological oxidative stress: Oxidative eustress

(2017) Helmut Sies   Redox Biology

Calcium and Mitochondrial Reactive Oxygen Species Generation: How to Read the Facts

(2017) Vera Adam-Vizi et al.   JOURNAL OF ALZHEIMERS DISEASE

The Alzheimer's Disease Mitochondrial Cascade Hypothesis

(2017) Russell H. Swerdlow et al.   JOURNAL OF ALZHEIMERS DISEASE

Mitochondrial DNA Depletion in Respiratory Chain-Deficient Parkinson Disease Neurons

(2016) Anne Grünewald et al.   ANNALS OF NEUROLOGY

The coming of age of the mitochondria–ER contact: a matter of thickness

(2016) M Giacomello et al.   CELL DEATH AND DIFFERENTIATION

Molecular Basis of Familial and Sporadic Alzheimer's Disease

(2016) Jolanta Dorszewska et al.   Current Alzheimer Research

Transport of Calcium Ions into Mitochondria

(2016) Zhaolong Xu et al.   CURRENT GENOMICS

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Excitotoxicity in ALS: Overstimulation, or overreaction?

(2016) Anna E. King et al.   EXPERIMENTAL NEUROLOGY

Oxidative metabolism and Ca2+handling in isolated brain mitochondria and striatal neurons from R6/2 mice, a model of Huntington’s disease

(2016) James Hamilton et al.   HUMAN MOLECULAR GENETICS

Ca2+/H+exchange by acidic organelles regulates cell migration in vivo

(2016) Manuela Melchionda et al.   JOURNAL OF CELL BIOLOGY

Mitoapocynin Treatment Protects Against Neuroinflammation and Dopaminergic Neurodegeneration in a Preclinical Animal Model of Parkinson’s Disease

(2016) Anamitra Ghosh et al.   Journal of Neuroimmune Pharmacology

The m -AAA Protease Associated with Neurodegeneration Limits MCU Activity in Mitochondria

(2016) Tim König et al.   MOLECULAR CELL

Role of ROS and RNS Sources in Physiological and Pathological Conditions

(2016) Sergio Di Meo et al.   Oxidative Medicine and Cellular Longevity

MICU1 Serves as a Molecular Gatekeeper to Prevent In Vivo Mitochondrial Calcium Overload

(2016) Julia C. Liu et al.   Cell Reports

Presenilin 2 Modulates Endoplasmic Reticulum-Mitochondria Coupling by Tuning the Antagonistic Effect of Mitofusin 2

(2016) Riccardo Filadi et al.   Cell Reports

A  -Secretase Independent Role for Presenilin in Calcium Homeostasis Impacts Mitochondrial Function and Morphology in Caenorhabditis elegans

(2015) S. Sarasija et al.   GENETICS

Peroxisome-mitochondria interplay and disease

(2015) Michael Schrader et al.   JOURNAL OF INHERITED METABOLIC DISEASE

The mitochondrial Ca2+ uniporter complex

(2015) J. Kevin Foskett et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Ca2+handling in isolated brain mitochondria and cultured neurons derived from the YAC128 mouse model of Huntington's disease

(2015) Jessica J. Pellman et al.   JOURNAL OF NEUROCHEMISTRY

N-Methyl, N-propynyl-2-phenylethylamine (MPPE), a Selegiline Analog, Attenuates MPTP-induced Dopaminergic Toxicity with Guaranteed Behavioral Safety: Involvement of Inhibitions of Mitochondrial Oxidative Burdens and p53 Gene-elicited Pro-apoptotic Change

(2015) Eun-Joo Shin et al.   MOLECULAR NEUROBIOLOGY

The molecular era of the mitochondrial calcium uniporter

(2015) Kimberli J. Kamer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Conserved SMP domains of the ERMES complex bind phospholipids and mediate tether assembly

(2015) Andrew P. AhYoung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PI4P/phosphatidylserine countertransport at ORP5- and ORP8-mediated ER-plasma membrane contacts

(2015) J. Chung et al.   SCIENCE

N-Acetylcysteine improves mitochondrial function and ameliorates behavioral deficits in the R6/1 mouse model of Huntington's disease

(2015) D J Wright et al.   Translational Psychiatry

Calcium and ROS: A mutual interplay

(2015) Agnes Görlach et al.   Redox Biology

Oxidatively generated base damage to cellular DNA by hydroxyl radical and one-electron oxidants: Similarities and differences

(2014) Jean Cadet et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

 -Synuclein Is Localized to Mitochondria-Associated ER Membranes

(2014) C. Guardia-Laguarta et al.   JOURNAL OF NEUROSCIENCE

MICU1 and MICU2 Finely Tune the Mitochondrial Ca2+ Uniporter by Exerting Opposite Effects on MCU Activity

(2014) Maria Patron et al.   MOLECULAR CELL

Ursodeoxycholic Acid Ameliorates Apoptotic Cascade in the Rotenone Model of Parkinson’s Disease: Modulation of Mitochondrial Perturbations

(2014) Noha F. Abdelkader et al.   MOLECULAR NEUROBIOLOGY

Dysfunctional mitochondrial Ca2+ handling in mutant SOD1 mouse models of fALS: integration of findings from motor neuron somata and motor terminals

(2014) Ellen F. Barrett et al.   Frontiers in Cellular Neuroscience

ER–mitochondria associations are regulated by the VAPB–PTPIP51 interaction and are disrupted by ALS/FTD-associated TDP-43

(2014) Radu Stoica et al.   Nature Communications

Oxidative stress and mitochondrial dysfunction in Alzheimer's disease

(2013) Xinglong Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The mitochondrial calcium uniporter is a multimer that can include a dominant-negative pore-forming subunit

(2013) Anna Raffaello et al.   EMBO JOURNAL

NCX3 regulates mitochondrial Ca 2+ handling through the AKAP121-anchored signaling complex and prevents hypoxia-induced neuronal death

(2013) Antonella Scorziello et al.   JOURNAL OF CELL SCIENCE

Targeting mitochondrial reactive oxygen species as novel therapy for inflammatory diseases and cancers

(2013) Xinyuan Li et al.   Journal of Hematology & Oncology

The coupling of plasma membrane calcium entry to calcium uptake by endoplasmic reticulum and mitochondria

(2013) Javier García-Sancho   JOURNAL OF PHYSIOLOGY-LONDON

The mitochondrial calcium uniporter complex: molecular components, structure and physiopathological implications

(2013) Saverio Marchi et al.   JOURNAL OF PHYSIOLOGY-LONDON

In-depth proteomic analysis of mammalian mitochondria-associated membranes (MAM)

(2013) Chloe N. Poston et al.   Journal of Proteomics

Mitochondrial respiratory chain Complexes I and IV are impaired by β-amyloid via direct interaction and through Complex I-dependent ROS production, respectively

(2013) A. Bobba et al.   MITOCHONDRION

Loss-of-function mutations in MICU1 cause a brain and muscle disorder linked to primary alterations in mitochondrial calcium signaling

(2013) Clare V Logan et al.   NATURE GENETICS

State of play in amyotrophic lateral sclerosis genetics

(2013) Alan E Renton et al.   NATURE NEUROSCIENCE

MICU2, a Paralog of MICU1, Resides within the Mitochondrial Uniporter Complex to Regulate Calcium Handling

(2013) Molly Plovanich et al.   PLoS One

Canonical transient receptor potential 3 channels regulate mitochondrial calcium uptake

(2013) S. Feng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

EMRE Is an Essential Component of the Mitochondrial Calcium Uniporter Complex

(2013) Y. Sancak et al.   SCIENCE

Calcium signalling remodelling and disease

(2012) Michael J. Berridge   BIOCHEMICAL SOCIETY TRANSACTIONS

VDAC structure, selectivity, and dynamics

(2012) Marco Colombini   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Alterations in axonal transport motor proteins in sporadic and experimental Parkinson’s disease

(2012) Yaping Chu et al.   BRAIN

Systems biology of antioxidants

(2012) Ramaroson Andriantsitohaina et al.   CLINICAL SCIENCE

Upregulated function of mitochondria-associated ER membranes in Alzheimer disease

(2012) Estela Area-Gomez et al.   EMBO JOURNAL

The Pathophysiology of LETM1

(2012) Karin Nowikovsky et al.   JOURNAL OF GENERAL PHYSIOLOGY

Mitochondria as sensors and regulators of calcium signalling

(2012) Rosario Rizzuto et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The interplay of neuronal mitochondrial dynamics and bioenergetics: Implications for Parkinson's disease

(2012) Victor S. Van Laar et al.   NEUROBIOLOGY OF DISEASE

Mitochondria, calcium-dependent neuronal death and neurodegenerative disease

(2012) Michael R. Duchen   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

VDAC1: from structure to cancer therapy

(2012) Varda Shoshan-Barmatz et al.   Frontiers in Oncology

Metabolic and functional differences between brain and spinal cord mitochondria underlie different predisposition to pathology

(2011) Alexander V. Panov et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

The role of cholesterol in the association of endoplasmic reticulum membranes with mitochondria

(2011) Michiko Fujimoto et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

VDAC isoforms in mammals

(2011) Angela Messina et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Huntington's disease, calcium, and mitochondria

(2011) Marta Giacomello et al.   BIOFACTORS

VDAC1 selectively transfers apoptotic Ca2+ signals to mitochondria

(2011) D De Stefani et al.   CELL DEATH AND DIFFERENTIATION

VAPB interacts with the mitochondrial protein PTPIP51 to regulate calcium homeostasis

(2011) Kurt J. De Vos et al.   HUMAN MOLECULAR GENETICS

Signal transduction by reactive oxygen species

(2011) Toren Finkel   JOURNAL OF CELL BIOLOGY

Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter

(2011) Joshua M. Baughman et al.   NATURE

Calcium dysregulation, mitochondrial pathology and protein aggregation in a culture model of amyotrophic lateral sclerosis: Mechanistic relationship and differential sensitivity to intervention

(2011) Miranda L. Tradewell et al.   NEUROBIOLOGY OF DISEASE

PKC-dependent coupling of calcium permeation through transient receptor potential canonical 3 (TRPC3) to calcineurin signaling in HL-1 myocytes

(2011) M. Poteser et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Presenilin 2 modulates endoplasmic reticulum (ER)-mitochondria interactions and Ca2+ cross-talk

(2011) E. Zampese et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oxidative stress caused by mitochondrial calcium overload

(2010) Tsung-I Peng et al.   Annals of the New York Academy of Sciences

Mitochondria: The calcium connection

(2010) Laura Contreras et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

SnapShot: Reactive Oxygen Intermediates (ROI)

(2010) Carl Nathan et al.   CELL

The dysregulation of intracellular calcium in Alzheimer disease

(2010) Charlene Supnet et al.   CELL CALCIUM

Mitochondrial dysfunction and intracellular calcium dysregulation in ALS

(2010) Hibiki Kawamata et al.   MECHANISMS OF AGEING AND DEVELOPMENT

MICU1 encodes a mitochondrial EF hand protein required for Ca2+ uptake

(2010) Fabiana Perocchi et al.   NATURE

Gain-of-Function Enhancement of IP3 Receptor Modal Gating by Familial Alzheimer's Disease-Linked Presenilin Mutants in Human Cells and Mouse Neurons

(2010) K.-H. Cheung et al.   Science Signaling

Cytosolic Ca2+ Buffers

(2010) B. Schwaller   Cold Spring Harbor Perspectives in Biology

Ryanodine Receptors: Structure, Expression, Molecular Details, and Function in Calcium Release

(2010) J. T. Lanner et al.   Cold Spring Harbor Perspectives in Biology

Regulation of mitochondrial dehydrogenases by calcium ions

(2009) Richard M. Denton   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Ca2+ transfer from the ER to mitochondria: When, how and why

(2009) Rosario Rizzuto et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mitochondrial permeability transition pore in Alzheimer's disease: Cyclophilin D and amyloid beta

(2009) Heng Du et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Crosstalk signaling between mitochondrial Ca2+ and ROS

(2009) Robert et al.   Frontiers in Bioscience-Landmark

PINK1-Associated Parkinson's Disease Is Caused by Neuronal Vulnerability to Calcium-Induced Cell Death

(2009) Sonia Gandhi et al.   MOLECULAR CELL

Genome-Wide RNAi Screen Identifies Letm1 as a Mitochondrial Ca2+/H+ Antiporter

(2009) D. Jiang et al.   SCIENCE

TRPM1 Forms Ion Channels Associated with Melanin Content in Melanocytes

(2009) E. Oancea et al.   Science Signaling

TRPM2 Functions as a Lysosomal Ca2+-Release Channel in   Cells

(2009) I. Lange et al.   Science Signaling

Reactive oxygen species: Destroyers or messengers?

(2008) Grzegorz Bartosz   BIOCHEMICAL PHARMACOLOGY

Is supercomplex organization of the respiratory chain required for optimal electron transfer activity?

(2008) M.L. Genova et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Optical Reporters for the Conformation of  -Synuclein Reveal a Specific Interaction with Mitochondria

(2008) K. Nakamura et al.   JOURNAL OF NEUROSCIENCE

Analysis of cardiac mitochondrial Na+-Ca2+exchanger kinetics with a biophysical model of mitochondrial Ca2+handing suggests a 3: 1 stoichiometry

(2008) Ranjan K. Dash et al.   JOURNAL OF PHYSIOLOGY-LONDON

Analysis of TRPC3-Interacting Proteins by Tandem Mass Spectrometry

(2008) Timothy Lockwich et al.   JOURNAL OF PROTEOME RESEARCH

The type IV mucolipidosis-associated protein TRPML1 is an endolysosomal iron release channel

(2008) Xian-Ping Dong et al.   NATURE

The amyloid  -peptide is imported into mitochondria via the TOM import machinery and localized to mitochondrial cristae

(2008) C. A. Hansson Petersen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA