Effects of Glucose Metabolism, Lipid Metabolism, and Glutamine Metabolism on Tumor Microenvironment and Clinical Implications

CD36-mediated ferroptosis dampens intratumoral CD8+ T cell effector function and impairs their antitumor ability

(2021) Xingzhe Ma et al.   Cell Metabolism

Metabolic support of tumour-infiltrating regulatory T cells by lactic acid

(2021) McLane J. Watson et al.   NATURE

Lipid signalling enforces functional specialization of Treg cells in tumours

(2021) Seon Ah Lim et al.   NATURE

Activation of MAT2A-RIP1 signaling axis reprograms monocytes in gastric cancer

(2021) Yan Zhang et al.   Journal for ImmunoTherapy of Cancer

Cell-programmed nutrient partitioning in the tumour microenvironment

(2021) Bradley I. Reinfeld et al.   NATURE

Tumor-derived exosomes drive immunosuppressive macrophages in a pre-metastatic niche through glycolytic dominant metabolic reprogramming

(2021) Samantha M. Morrissey et al.   Cell Metabolism

Uptake of oxidized lipids by the scavenger receptor CD36 promotes lipid peroxidation and dysfunction in CD8+ T cells in tumors

(2021) Shihao Xu et al.   IMMUNITY

Tumor-Associated Macrophages in Bladder Cancer: Biological Role, Impact on Therapeutic Response and Perspectives for Immunotherapy

(2021) Marine Leblond et al.   Cancers

Single-cell analysis of pancreatic ductal adenocarcinoma identifies a novel fibroblast subtype associated with poor prognosis but better immunotherapy response

(2021) Yu Wang et al.   Cell Discovery

Enhanced lipid accumulation and metabolism are required for the differentiation and activation of tumor-associated macrophages

(2020) Pan Su et al.   CANCER RESEARCH

The Pentose Phosphate Pathway and Its Involvement in Cisplatin Resistance

(2020) Isabella Giacomini et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

CD36-mediated metabolic adaptation supports regulatory T cell survival and function in tumors

(2020) Haiping Wang et al.   NATURE IMMUNOLOGY

Tumor Microenvironment, Metabolism, and Immunotherapy

(2020) Ralph J. DeBerardinis   NEW ENGLAND JOURNAL OF MEDICINE

DIVERSITY AND BIOLOGY OF CANCER-ASSOCIATED FIBROBLASTS

(2020) Giulia Biffi et al.   PHYSIOLOGICAL REVIEWS

Reprogramming of lipid metabolism in cancer-associated fibroblasts potentiates migration of colorectal cancer cells

(2020) Jin Gong et al.   Cell Death & Disease

Myeloid-Derived Suppressor Cells in the Context of Allogeneic Hematopoietic Stem Cell Transplantation

(2020) Maud D'Aveni et al.   Frontiers in Immunology

An Oncogenic Alteration Creates a Microenvironment that Promotes Tumor Progression by Conferring a Metabolic Advantage to Regulatory T Cells

(2020) Shogo Kumagai et al.   IMMUNITY

Targeting glutamine metabolism enhances tumor-specific immunity by modulating suppressive myeloid cells

(2020) Min-Hee Oh et al.   JOURNAL OF CLINICAL INVESTIGATION

Metformin and 2-Deoxyglucose Collaboratively Suppress Human CD4+ T Cell Effector Functions and Activation-Induced Metabolic Reprogramming

(2020) Stefanie Y. Tan et al.   JOURNAL OF IMMUNOLOGY

Natural killer cells in cancer biology and therapy

(2020) Song-Yang Wu et al.   Molecular Cancer

Targeting Metabolism to Improve the Tumor Microenvironment for Cancer Immunotherapy

(2020) Jackie E. Bader et al.   MOLECULAR CELL

Molecular imaging in lymphoma beyond 18F-FDG-PET: understanding the biology and its implications for diagnostics and therapy

(2020) Xaver U Kahle et al.   Lancet Haematology

Exploring the NK cell platform for cancer immunotherapy

(2020) Jacob A. Myers et al.   Nature Reviews Clinical Oncology

Lactate-Modulated Immunosuppression of Myeloid-Derived Suppressor Cells Contributes to the Radioresistance of Pancreatic Cancer

(2020) Xuguang Yang et al.   Cancer Immunology Research

Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity

(2020) Alison E. Ringel et al.   CELL

Tumor-Associated Macrophages in Tumor Immunity

(2020) Yueyun Pan et al.   Frontiers in Immunology

Tumor treating fields (TTFields) impairs aberrant glycolysis in glioblastoma as evaluated by [18F]DASA-23, a non-invasive probe of pyruvate kinase M2 (PKM2) expression

(2020) Chirag B. Patel et al.   NEOPLASIA

Pharmacologic Targeting of Hypoxia-Inducible Factors

(2019) Gregg L. Semenza   Annual Review of Pharmacology and Toxicology

Glutamine Addiction and Therapeutic Strategies in Lung Cancer

(2019) Karolien Vanhove et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Coordinative metabolism of glutamine carbon and nitrogen in proliferating cancer cells under hypoxia

(2019) Yuanyuan Wang et al.   Nature Communications

Regulatory T cells in cancer immunosuppression — implications for anticancer therapy

(2019) Yosuke Togashi et al.   Nature Reviews Clinical Oncology

Treg Cells Promote the SREBP1-Dependent Metabolic Fitness of Tumor-Promoting Macrophages via Repression of CD8+ T Cell-Derived Interferon-γ

(2019) Chang Liu et al.   IMMUNITY

Heterogeneity of the Head and Neck Squamous Cell Carcinoma Immune Landscape and Its Impact on Immunotherapy

(2019) Madison Canning et al.   Frontiers in Cell and Developmental Biology

STAT3 Activation-Induced Fatty Acid Oxidation in CD8+ T Effector Cells Is Critical for Obesity-Promoted Breast Tumor Growth

(2019) Chunyan Zhang et al.   Cell Metabolism

Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion

(2019) Robert D. Leone et al.   SCIENCE

Restricting Glycolysis Preserves T Cell Effector Functions and Augments Checkpoint Therapy

(2019) Kathrin Renner et al.   Cell Reports

Metabolic changes in tumor cells and tumor-associated macrophages: A mutual relationship

(2018) Romana T. Netea-Maier et al.   CANCER LETTERS

Aerobic Glycolysis Controls Myeloid-Derived Suppressor Cells and Tumor Immunity via a Specific CEBPB Isoform in Triple-Negative Breast Cancer

(2018) Wei Li et al.   Cell Metabolism

mTOR Complex 1 Signaling Regulates the Generation and Function of Central and Effector Foxp3+Regulatory T Cells

(2018) Im-Hong Sun et al.   JOURNAL OF IMMUNOLOGY

Cancer-cell-secreted exosomal miR-105 promotes tumour growth through the MYC-dependent metabolic reprogramming of stromal cells

(2018) Wei Yan et al.   NATURE CELL BIOLOGY

Myeloid-derived suppressor cells coming of age

(2018) Filippo Veglia et al.   NATURE IMMUNOLOGY

Fatty acid metabolism complements glycolysis in the selective regulatory T cell expansion during tumor growth

(2018) Ilenia Pacella et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In Vivo PET Assay of Tumor Glutamine Flux and Metabolism: In-Human Trial of 18F-(2S,4R)-4-Fluoroglutamine

(2018) Mark P. S. Dunphy et al.   RADIOLOGY

Monoacylglycerol lipase regulates cannabinoid receptor 2-dependent macrophage activation and cancer progression

(2018) Wei Xiang et al.   Nature Communications

Assessment of Fluorodeoxyglucose F18–Labeled Positron Emission Tomography for Diagnosis of High-Risk Lung Nodules

(2018) Amelia W. Maiga et al.   JAMA Surgery

Contribution to Tumor Angiogenesis From Innate Immune Cells Within the Tumor Microenvironment: Implications for Immunotherapy

(2018) Adriana Albini et al.   Frontiers in Immunology

Distinct Regulation of Th17 and Th1 Cell Differentiation by Glutaminase-Dependent Metabolism

(2018) Marc O. Johnson et al.   CELL

Prognostic Value of Volumetric Parameters of Pretreatment 18F-FDG PET/CT in Esophageal Cancer

(2018) Sangwon Han et al.   CLINICAL NUCLEAR MEDICINE

FDG PET/CT for assessing tumour response to immunotherapy

(2018) Nicolas Aide et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Cancer-associated fibroblasts modify lung cancer metabolism involving ROS and TGF-β signaling

(2018) Alberto Cruz-Bermúdez et al.   FREE RADICAL BIOLOGY AND MEDICINE

CD8+ cytotoxic T lymphocytes in cancer immunotherapy: A review

(2018) Bagher Farhood et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Lactate inhibits ATP6V0d2 expression in tumor-associated macrophages to promote HIF-2α–mediated tumor progression

(2018) Na Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

Metabolic subtyping of pheochromocytoma and paraganglioma by 18F-FDG pharmacokinetics using dynamic PET/CT scanning

(2018) Anouk van Berkel et al.   JOURNAL OF NUCLEAR MEDICINE

Glutamine: Metabolism and Immune Function, Supplementation and Clinical Translation

(2018) Vinicius Cruzat et al.   Nutrients

De-novo and acquired resistance to immune checkpoint targeting

(2017) Nicholas L Syn et al.   LANCET ONCOLOGY

A Pck1-directed glycogen metabolic program regulates formation and maintenance of memory CD8+ T cells

(2017) Ruihua Ma et al.   NATURE CELL BIOLOGY

Tumour-associated macrophages as treatment targets in oncology

(2017) Alberto Mantovani et al.   Nature Reviews Clinical Oncology

LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells

(2016) Almut Brand et al.   Cell Metabolism

Amino Acids Rather than Glucose Account for the Majority of Cell Mass in Proliferating Mammalian Cells

(2016) Aaron M. Hosios et al.   DEVELOPMENTAL CELL

Immunogenic Chemotherapy Sensitizes Tumors to Checkpoint Blockade Therapy

(2016) Christina Pfirschke et al.   IMMUNITY

NAFLD causes selective CD4+ T lymphocyte loss and promotes hepatocarcinogenesis

(2016) Chi Ma et al.   NATURE

Reductive carboxylation supports redox homeostasis during anchorage-independent growth

(2016) Lei Jiang et al.   NATURE

Lactate metabolism is associated with mammalian mitochondria

(2016) Ying-Jr Chen et al.   Nature Chemical Biology

The Warburg Effect: How Does it Benefit Cancer Cells?

(2016) Maria V. Liberti et al.   TRENDS IN BIOCHEMICAL SCIENCES

Effector, Memory, and Dysfunctional CD8+T Cell Fates in the Antitumor Immune Response

(2016) John Reiser et al.   Journal of Immunology Research

Neutralization of Tumor Acidity Improves Antitumor Responses to Immunotherapy

(2015) Shari Pilon-Thomas et al.   CANCER RESEARCH

Supporting Aspartate Biosynthesis Is an Essential Function of Respiration in Proliferating Cells

(2015) Lucas B. Sullivan et al.   CELL

Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses

(2015) Ping-Chih Ho et al.   CELL

Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression

(2015) Chih-Hao Chang et al.   CELL

Glycolysis controls the induction of human regulatory T cells by modulating the expression of FOXP3 exon 2 splicing variants

(2015) Veronica De Rosa et al.   NATURE IMMUNOLOGY

Regulation of mammalian nucleotide metabolism and biosynthesis

(2015) Andrew N. Lane et al.   NUCLEIC ACIDS RESEARCH

PET imaging of tumor glycolysis downstream of hexokinase through noninvasive measurement of pyruvate kinase M2

(2015) Timothy H. Witney et al.   Science Translational Medicine

Inhibition of Fatty Acid Oxidation Modulates Immunosuppressive Functions of Myeloid-Derived Suppressor Cells and Enhances Cancer Therapies

(2015) F. Hossain et al.   Cancer Immunology Research

Lactate is always the end product of glycolysis

(2015) Matthew J. Rogatzki et al.   Frontiers in Neuroscience

Antitumor Activity of the Glutaminase Inhibitor CB-839 in Triple-Negative Breast Cancer

(2014) M. I. Gross et al.   MOLECULAR CANCER THERAPEUTICS

Functional polarization of tumour-associated macrophages by tumour-derived lactic acid

(2014) Oscar R. Colegio et al.   NATURE

The pentose phosphate pathway and cancer

(2014) Krushna C. Patra et al.   TRENDS IN BIOCHEMICAL SCIENCES

Regulation of the pentose phosphate pathway in cancer

(2014) Peng Jiang et al.   Protein & Cell

Glutamine and cancer: cell biology, physiology, and clinical opportunities

(2013) Christopher T. Hensley et al.   JOURNAL OF CLINICAL INVESTIGATION

Altered metabolism in cancer

(2012) Jason W Locasale et al.   BMC BIOLOGY

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Recommendations on the Use of 18F-FDG PET in Oncology

(2008) J. W. Fletcher et al.   JOURNAL OF NUCLEAR MEDICINE