Lactate inhibits ATP6V0d2 expression in tumor-associated macrophages to promote HIF-2α–mediated tumor progression

Regulation of V-ATPase activity

(2017) Michael Forgac   Frontiers in Bioscience-Landmark

Regulation of V-ATPase assembly and function of V-ATPases in tumor cell invasiveness

(2016) Christina McGuire et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

A Small-Molecule Antagonist of HIF2α Is Efficacious in Preclinical Models of Renal Cell Carcinoma

(2016) Eli M. Wallace et al.   CANCER RESEARCH

The role of the local environment and epigenetics in shaping macrophage identity and their effect on tissue homeostasis

(2016) Ido Amit et al.   NATURE IMMUNOLOGY

Metabolic Symbiosis Enables Adaptive Resistance to Anti-angiogenic Therapy that Is Dependent on mTOR Signaling

(2016) Elizabeth Allen et al.   Cell Reports

Macrophages and Therapeutic Resistance in Cancer

(2015) Brian Ruffell et al.   CANCER CELL

A Lactate-Induced Response to Hypoxia

(2015) Dong Chul Lee et al.   CELL

Recent Insights into the Structure, Regulation, and Function of the V-ATPases

(2015) Kristina Cotter et al.   TRENDS IN BIOCHEMICAL SCIENCES

Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

(2014) Peter J. Murray et al.   IMMUNITY

Origin and Functions of Tissue Macrophages

(2014) Slava Epelman et al.   IMMUNITY

Functional polarization of tumour-associated macrophages by tumour-derived lactic acid

(2014) Oscar R. Colegio et al.   NATURE

Autophagy mediates HIF2α degradation and suppresses renal tumorigenesis

(2014) X-D Liu et al.   ONCOGENE

Cyclin-dependent kinases regulate lysosomal degradation of hypoxia-inducible factor 1  to promote cell-cycle progression

(2014) M. E. Hubbi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lactate Engages Receptor Tyrosine Kinases Axl, Tie2, and Vascular Endothelial Growth Factor Receptor 2 to Activate Phosphoinositide 3-Kinase/Akt and Promote Angiogenesis

(2013) Guo-Xiang Ruan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chaperone-mediated Autophagy Targets Hypoxia-inducible Factor-1α (HIF-1α) for Lysosomal Degradation

(2013) Maimon E. Hubbi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Microenvironmental regulation of tumor progression and metastasis

(2013) Daniela F Quail et al.   NATURE MEDICINE

The updated biology of hypoxia-inducible factor

(2012) Samantha N Greer et al.   EMBO JOURNAL

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

(2012) Carmine Settembre et al.   EMBO JOURNAL

Macrophage plasticity and polarization: in vivo veritas

(2012) Antonio Sica et al.   JOURNAL OF CLINICAL INVESTIGATION

HIF-2α Expression Is Suppressed in SCLC Cells, Which Survive in Moderate and Severe Hypoxia When HIF-1α Is Repressed

(2011) Matilda Munksgaard Persson et al.   AMERICAN JOURNAL OF PATHOLOGY

HRG Inhibits Tumor Growth and Metastasis by Inducing Macrophage Polarization and Vessel Normalization through Downregulation of PlGF

(2011) Charlotte Rolny et al.   CANCER CELL

TFEB Links Autophagy to Lysosomal Biogenesis

(2011) C. Settembre et al.   SCIENCE

Macrophage Diversity Enhances Tumor Progression and Metastasis

(2010) Bin-Zhi Qian et al.   CELL

Alternative Activation of Macrophages: Mechanism and Functions

(2010) Siamon Gordon et al.   IMMUNITY

Hypoxia-inducible factor 2α regulates macrophage function in mouse models of acute and tumor inflammation

(2010) Hongxia Z. Imtiyaz et al.   JOURNAL OF CLINICAL INVESTIGATION

Stromal Macrophage Expressing CD204 is Associated with Tumor Aggressiveness in Lung Adenocarcinoma

(2010) Yoichi Ohtaki et al.   Journal of Thoracic Oncology

HIF at a glance

(2009) M. C. Brahimi-Horn et al.   JOURNAL OF CELL SCIENCE

Live Imaging of Neuronal Degradation by Microglia Reveals a Role for v0-ATPase a1 in Phagosomal Fusion In Vivo

(2008) Francesca Peri et al.   CELL

Autophagy in the Pathogenesis of Disease

(2008) Beth Levine et al.   CELL

Deletion of vascular endothelial growth factor in myeloid cells accelerates tumorigenesis

(2008) Christian Stockmann et al.   NATURE