Apelin Resistance Contributes to Muscle Loss during Cancer Cachexia in Mice

Arrestin-dependent and -independent internalization of GPCRs - methods, mechanisms and implications on cell signaling

(2021) Ee Von Moo et al.   MOLECULAR PHARMACOLOGY

The Effects of Apelin and Elabela Ligands on Apelin Receptor Distinct Signaling Profiles

(2021) Yunlu Jiang et al.   Frontiers in Pharmacology

Tumor-derived IL-6 and trans-signaling among tumor, fat, and muscle mediate pancreatic cancer cachexia

(2021) Joseph E. Rupert et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Lipocalin 2 mediates appetite suppression during pancreatic cancer cachexia

(2021) Brennan Olson et al.   Nature Communications

Methods to Enhance the Metabolic Stability of Peptide-Based PET Radiopharmaceuticals

(2020) Brendan J. Evans et al.   MOLECULES

Irisin prevents dexamethasone-induced atrophy in C2C12 myotubes

(2020) Jae Seung Chang et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

CCN-Based Therapeutic Peptides Modify Pancreatic Ductal Adenocarcinoma Microenvironment and Decrease Tumor Growth in Combination with Chemotherapy

(2020) Andrea Resovi et al.   Cells

Imoxin prevents dexamethasone-induced promotion of muscle-specific E3 ubiquitin ligases and stimulates anabolic signaling in C2C12 myotubes

(2020) Hyeyoon Eo et al.   BIOMEDICINE & PHARMACOTHERAPY

The Adipokines in Cancer Cachexia

(2020) Michele Mannelli et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Apelin inhibition prevents resistance and metastasis associated with anti‐angiogenic therapy

(2019) Iris Uribesalgo et al.   EMBO Molecular Medicine

Fibro–Adipogenic Progenitors Cross-Talk in Skeletal Muscle: The Social Network

(2019) Beatrice Biferali et al.   Frontiers in Physiology

Musclin, A Myokine Induced by Aerobic Exercise, Retards Muscle Atrophy During Cancer Cachexia in Mice

(2019) Andrea D. Re Cecconi et al.   Cancers

Soluble stroma‐related biomarkers of pancreatic cancer

(2018) Andrea Resovi et al.   EMBO Molecular Medicine

Fenofibrate prevents skeletal muscle loss in mice with lung cancer

(2018) Marcus D. Goncalves et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multiplatform plasma fingerprinting in cancer cachexia: a pilot observational and translational study

(2018) Mónica Patricia Cala et al.   Journal of Cachexia Sarcopenia and Muscle

The Role of Apelin in Cardiovascular Diseases, Obesity and Cancer

(2018) Marta B. Wysocka et al.   Frontiers in Physiology

The exerkine apelin reverses age-associated sarcopenia

(2018) Claire Vinel et al.   NATURE MEDICINE

Establishment and characterization of a novel murine model of pancreatic cancer cachexia

(2017) Katherine A. Michaelis et al.   Journal of Cachexia Sarcopenia and Muscle

Tumor-Induced IL-6 Reprograms Host Metabolism to Suppress Anti-tumor Immunity

(2016) Thomas R. Flint et al.   Cell Metabolism

Agonist-induced internalization and desensitization of the apelin receptor

(2016) George R. Pope et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Activation of the SDF1/CXCR4 pathway retards muscle atrophy during cancer cachexia

(2016) G B Martinelli et al.   ONCOGENE

Systems proteomics of liver mitochondria function

(2016) E. G. Williams et al.   SCIENCE

MicroRNA 139-5p coordinates APLNR-CXCR4 crosstalk during vascular maturation

(2016) Irinna Papangeli et al.   Nature Communications

Targeting Drugs to APJ Receptor: The Prospect of Treatment of Hypertension and Other Cardiovascular Diseases

(2015) Jiangang Cao et al.   CURRENT DRUG TARGETS

Malignant Drosophila Tumors Interrupt Insulin Signaling to Induce Cachexia-like Wasting

(2015) Alejandra Figueroa-Clarevega et al.   DEVELOPMENTAL CELL

Systemic Organ Wasting Induced by Localized Expression of the Secreted Insulin/IGF Antagonist ImpL2

(2015) Young Kwon et al.   DEVELOPMENTAL CELL

Inactivation of the ubiquitin-specific protease 19 deubiquitinating enzyme protects against muscle wasting

(2015) Nathalie Bédard et al.   FASEB JOURNAL

cAMP-induced phosphorylation of 26S proteasomes on Rpn6/PSMD11 enhances their activity and the degradation of misfolded proteins

(2015) Sudarsanareddy Lokireddy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sunitinib prevents cachexia and prolongs survival of mice bearing renal cancer by restraining STAT3 and MuRF-1 activation in muscle

(2015) Francesca Pretto et al.   Oncotarget

Serum Levels of Resistin, Adiponectin, and Apelin in Gastroesophageal Cancer Patients

(2014) Dorota Diakowska et al.   DISEASE MARKERS

Reduction of Arterial Stiffness by Exercise Training Is Associated with Increasing Plasma Apelin Level in Middle-Aged and Older Adults

(2014) Shumpei Fujie et al.   PLoS One

Pyroglutamyl apelin-13 identified as the major apelin isoform in human plasma

(2013) Eugene Y. Zhen et al.   ANALYTICAL BIOCHEMISTRY

Mechanisms of muscle growth and atrophy in mammals andDrosophila

(2013) Rosanna Piccirillo et al.   DEVELOPMENTAL DYNAMICS

Effect of endurance training on skeletal muscle myokine expression in obese men: identification of apelin as a novel myokine

(2013) A Besse-Patin et al.   INTERNATIONAL JOURNAL OF OBESITY

Initial Quantitative Proteomic Map of 28 Mouse Tissues Using the SILAC Mouse

(2013) Tamar Geiger et al.   MOLECULAR & CELLULAR PROTEOMICS

Identification of microRNAs involved in dexamethasone-induced muscle atrophy

(2013) He Shen et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

BMP signaling controls muscle mass

(2013) Roberta Sartori et al.   NATURE GENETICS

Tumor Endothelial Cell-Specific Drug Delivery System Using Apelin-Conjugated Liposomes

(2013) Hiroki Kawahara et al.   PLoS One

Insulin Resistance and Cancer Risk: An Overview of the Pathogenetic Mechanisms

(2012) Biagio Arcidiacono et al.   Experimental Diabetes Research

Definition and classification of cancer cachexia: an international consensus

(2011) Kenneth Fearon et al.   LANCET ONCOLOGY

G i2 Signaling Promotes Skeletal Muscle Hypertrophy, Myoblast Differentiation, and Muscle Regeneration

(2011) G. C. Minetti et al.   Science Signaling

The role of insulin resistance in the development of muscle wasting during cancer cachexia

(2011) Mary A. Honors et al.   Journal of Cachexia Sarcopenia and Muscle

Apelin and APJ regulation in adipose tissue and skeletal muscle of type 2 diabetic mice and humans

(2010) Cédric Dray et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Apelin induces enlarged and nonleaky blood vessels for functional recovery from ischemia

(2010) H. Kidoya et al.   BLOOD

Molecular, cellular and physiological characterization of the cancer cachexia-inducing C26 colon carcinoma in mouse

(2010) Paola Aulino et al.   BMC CANCER

Reversal of Cancer Cachexia and Muscle Wasting by ActRIIB Antagonism Leads to Prolonged Survival

(2010) Xiaolan Zhou et al.   CELL

Apelin is necessary for the maintenance of insulin sensitivity

(2009) Patrick Yue et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

High AAV vector purity results in serotype- and tissue-independent enhancement of transduction efficiency

(2009) E Ayuso et al.   GENE THERAPY

Evidence for the contribution of insulin resistance to the development of cachexia in tumor-bearing mice

(2009) Michelle L. Asp et al.   INTERNATIONAL JOURNAL OF CANCER

Apelin Stimulates Glucose Utilization in Normal and Obese Insulin-Resistant Mice

(2008) Cédric Dray et al.   Cell Metabolism