The exerkine apelin reverses age-associated sarcopenia

Effects of exercise-induced apelin levels on skeletal muscle and their capillarization in type 2 diabetic rats

(2017) Jun Seok Son et al.   MUSCLE & NERVE

Downregulation of the Apelinergic Axis Accelerates Aging, whereas Its Systemic Restoration Improves the Mammalian Healthspan

(2017) Rahul Rai et al.   Cell Reports

Exercise Promotes Healthy Aging of Skeletal Muscle

(2016) Gregory D. Cartee et al.   Cell Metabolism

Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents

(2016) Dongryeol Ryu et al.   NATURE MEDICINE

Loss of fibronectin from the aged stem cell niche affects the regenerative capacity of skeletal muscle in mice

(2016) Laura Lukjanenko et al.   NATURE MEDICINE

Welcome to the ICD-10 code for sarcopenia

(2016) Stefan D. Anker et al.   Journal of Cachexia Sarcopenia and Muscle

Apelin-13 promotes cardiomyocyte hypertrophy via PI3K-Akt-ERK1/2-p70S6K and PI3K-induced autophagy

(2015) Feng Xie et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Muscle weakness during aging: a deficiency state involving declining angiogenesis

(2015) Charles Ambrose   AGEING RESEARCH REVIEWS

Frequency of sarcopenia and associated factors among hospitalized elderly patients

(2015) Bruno Prata Martinez et al.   BMC MUSCULOSKELETAL DISORDERS

The relationships between body composition characteristics and cognitive functioning in a population-based sample of older British men

(2015) Efstathios Papachristou et al.   BMC Geriatrics

Sarcopenia and the Common Mental Disorders: a Potential Regulatory Role of Skeletal Muscle on Brain Function?

(2015) Julie A. Pasco et al.   Current Osteoporosis Reports

The skeletal muscle satellite cell response to a single bout of resistance-type exercise is delayed with aging in men

(2014) Tim Snijders et al.   AGE

Effect of Structured Physical Activity on Prevention of Major Mobility Disability in Older Adults

(2014) Marco Pahor et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Apelin inhibits the proliferation and migration of rat PASMCsviathe activation of PI3K/Akt/mTOR signal and the inhibition of autophagy under hypoxia

(2014) Hongyu Zhang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Inducible depletion of satellite cells in adult, sedentary mice impairs muscle regenerative capacity without affecting sarcopenia

(2014) Christopher S Fry et al.   NATURE MEDICINE

p38 MAPK signaling underlies a cell-autonomous loss of stem cell self-renewal in skeletal muscle of aged mice

(2014) Jennifer D Bernet et al.   NATURE MEDICINE

Sarcopenia as a Determinant of Blood Pressure in Older Koreans: Findings from the Korea National Health and Nutrition Examination Surveys (KNHANES) 2008–2010

(2014) Kyungdo Han et al.   PLoS One

Reduction of Arterial Stiffness by Exercise Training Is Associated with Increasing Plasma Apelin Level in Middle-Aged and Older Adults

(2014) Shumpei Fujie et al.   PLoS One

Mitochondrial Involvement and Impact in Aging Skeletal Muscle

(2014) Russell T. Hepple   Frontiers in Aging Neuroscience

Frailty and cognitive impairment—A review of the evidence and causal mechanisms

(2013) Deirdre A. Robertson et al.   AGEING RESEARCH REVIEWS

Signalling pathways regulating muscle mass in ageing skeletal muscle. The role of the IGF1-Akt-mTOR-FoxO pathway

(2013) M. Sandri et al.   BIOGERONTOLOGY

Mechanisms of skeletal muscle aging: insights from Drosophila and mammalian models

(2013) F. Demontis et al.   Disease Models & Mechanisms

Functional dysregulation of stem cells during aging: a focus on skeletal muscle stem cells

(2013) Laura García-Prat et al.   FEBS Journal

The Intestinal Glucose–Apelin Cycle Controls Carbohydrate Absorption in Mice

(2013) Cédric Dray et al.   GASTROENTEROLOGY

Effect of endurance training on skeletal muscle myokine expression in obese men: identification of apelin as a novel myokine

(2013) A Besse-Patin et al.   INTERNATIONAL JOURNAL OF OBESITY

Fast-Twitch Glycolytic Skeletal Muscle Is Predisposed to Age-Induced Impairments in Mitochondrial Function

(2013) R. A. Jacobs et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

G i2 Signaling Is Required for Skeletal Muscle Growth, Regeneration, and Satellite Cell Proliferation and Differentiation

(2013) G. C. Minetti et al.   MOLECULAR AND CELLULAR BIOLOGY

Effects of Dietary Eicosapentaenoic Acid (EPA) Supplementation in High-Fat Fed Mice on Lipid Metabolism and Apelin/APJ System in Skeletal Muscle

(2013) Chantal Bertrand et al.   PLoS One

Responsiveness of muscle size and strength to physical training in very elderly people: A systematic review

(2013) V. H. Stewart et al.   SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS

Hormone Replacement Therapy and Physical Function in Healthy Older Men. Time to Talk Hormones?

(2012) Manthos G. Giannoulis et al.   ENDOCRINE REVIEWS

A single bout of exercise activates skeletal muscle satellite cells during subsequent overnight recovery

(2012) Tim Snijders et al.   EXPERIMENTAL PHYSIOLOGY

Emerging Roles of ROS/RNS in Muscle Function and Fatigue

(2011) Håkan Westerblad et al.   ANTIOXIDANTS & REDOX SIGNALING

Apelin-transgenic mice exhibit a resistance against diet-induced obesity by increasing vascular mass and mitochondrial biogenesis in skeletal muscle

(2011) Toshihiro Yamamoto et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Immortalized pathological human myoblasts: towards a universal tool for the study of neuromuscular disorders

(2011) Kamel Mamchaoui et al.   Skeletal Muscle

Apelin and APJ regulation in adipose tissue and skeletal muscle of type 2 diabetic mice and humans

(2010) Cédric Dray et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Myocardial Apelin Production is Reduced in Humans With Left Ventricular Systolic Dysfunction

(2010) Badrinathan Chandrasekaran et al.   JOURNAL OF CARDIAC FAILURE

Apelin stimulates glucose uptake but not lipolysis in human adipose tissue ex vivo

(2010) C. Attane et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Effects of aging and gender on muscle mass and regulation of Akt-mTOR-p70s6k related signaling in the F344BN rat model

(2010) Satyanarayana Paturi et al.   MECHANISMS OF AGEING AND DEVELOPMENT

International Union of Basic and Clinical Pharmacology. LXXIV. Apelin Receptor Nomenclature, Distribution, Pharmacology, and Function

(2010) S. L. Pitkin et al.   PHARMACOLOGICAL REVIEWS

Apelin is necessary for the maintenance of insulin sensitivity

(2009) Patrick Yue et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Apelin Stimulates Glucose Utilization in Normal and Obese Insulin-Resistant Mice

(2008) Cédric Dray et al.   Cell Metabolism

Effect of hypocaloric diet-induced weight loss in obese women on plasma apelin and adipose tissue expression of apelin and APJ.

(2008) Isabelle Castan-Laurell et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Construction and analysis of compact muscle-specific promoters for AAV vectors

(2008) B Wang et al.   GENE THERAPY

Relationship Between Frailty and Cognitive Decline in Older Mexican Americans

(2008) Rafael Samper-Ternent et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Skeletal Muscle Fatigue: Cellular Mechanisms

(2008) D. G. Allen et al.   PHYSIOLOGICAL REVIEWS