Review
Nutrition & Dietetics
Darren G. Candow, Scott C. Forbes, Ben Kirk, Gustavo Duque
Summary: Sarcopenia, characterized by age-related reduction in muscle mass, strength, and physical performance, is associated with various age-related health conditions. Creatine supplementation, especially when combined with resistance training, shows promising effects on muscle, bone, and fat mass, as well as strength and physical performance in healthy older adults. However, more research is needed on the efficacy of creatine supplementation in older adults with specific conditions like osteoporosis and sarcopenic obesity.
Review
Biochemistry & Molecular Biology
Ikuko Okuni, Yuta Otsubo, Satoru Ebihara
Summary: Cancer is a leading cause of death globally, but survival rates have improved significantly. Taste and smell disorders may contribute to swallowing difficulties in cancer patients, necessitating a multifaceted approach from the medical care team due to the complexity of factors involved.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Geriatrics & Gerontology
Pauline Henrot, Leo Blervaque, Isabelle Dupin, Maeva Zysman, Pauline Esteves, Fares Gouzi, Maurice Hayot, Pascal Pomies, Patrick Berger
Summary: Skeletal muscle wasting, whether related to ageing, disuse or chronic disease, is a crucial factor affecting quality of life and mortality. The cellular mechanisms responsible for increased catabolism in skeletal muscle cells are often unclear. Animal models, such as rodents, provide valuable insights into this dynamic process and its underlying mechanisms. Satellite cells, fibroblasts, immune cells, and other cell types play important roles in muscle regeneration and are altered in various muscle wasting conditions. Understanding these cellular alterations can lead to potential therapeutic strategies for muscle wasting diseases.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Article
Geriatrics & Gerontology
Trace Thome, Kayla Miguez, Alexander Willms, Sarah K. Burke, Vijayendran Chandran, Angela R. de Souza, Liam F. Fitzgerald, Carolyn Baglole, Maria-Eleni Anagnostou, Jean Bourbeau, R. Thomas Jagoe, Jose A. Morais, Yana Goddard, Tanja Taivassalo, Terence E. Ryan, Russell T. Hepple
Summary: Chronic activation of the aryl hydrocarbon receptor (AHR) induced by tobacco smoke exposure mimics muscle atrophy, mitochondrial impairment, and neuromuscular junction degeneration. Studies show that smoke exposure causes down-regulation of mitochondrial and neuromuscular junction genes, as well as activation of muscle AHR signaling.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2021)
Article
Cell Biology
Alec M. Avey, Keith Baar
Summary: In organisms, the initial formation of a functional tendon relies on chemical signals from muscles, and further study is needed on how myokines affect tendon maturation, maintenance, and regeneration with age. An experimental framework is proposed to investigate the muscle-tendon crosstalk, aiming to develop new interventions for tendon development and function improvement.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2021)
Article
Cell Biology
Yu-Hsuan Lin, Shiow-Chwen Tsai, Sheng-Ju Chuang, M. Brennan Harris, Kunanya Masodsai, Pei-Ni Chen, Chao-Chieh Hsieh, Theodore Killian, Chih-Yang Huang, Chia-Hua Kuo
Summary: The study found that long-lived rats have higher bone mass percentage, but experience insulin declines and bone mass loss as they age. Insulin depletion in old rats causes rapid bone mass loss, but insulin replacement can completely block this.
Article
Public, Environmental & Occupational Health
Fanny Petermann-Rocha, Jill P. Pell, Carlos Celis-Morales, Frederick K. Ho
Summary: This study investigated the clustering and mortality risk of frailty, sarcopenia, cachexia, and malnutrition in middle-aged and older adults. The study found a considerable overlap among these clinical conditions, with frailty being the most common. In addition to frailty, the risk of all-cause mortality increased with the increasing number of other conditions.
JOURNAL OF PUBLIC HEALTH
(2022)
Article
Nutrition & Dietetics
Maria Landgrebe, Randi Tobberup, Andreas Carus, Henrik Hojgaard Rasmussen
Summary: This study aimed to evaluate the impact of malnutrition and good nutritional status on clinical outcomes and Quality of Life (QoL) in non-small cell lung cancer (NSCLC) patients and determine the predictive validity of GLIM criteria. The results showed that malnourished NSCLC patients had worse outcomes in terms of treatment cessation, disease progression, overall survival, and poorer QoL compared to well-nourished patients.
CLINICAL NUTRITION
(2023)
Article
Oncology
Donal Michael McSweeney, Sophie Raby, Ganesh Radhakrishna, Jamie Weaver, Andrew Green, Paul Alan Bromiley, Marcel van Herk, Alan McWilliam
Summary: In this study, we found that skeletal muscle area assessed at T12 is a feasible and valuable prognostic marker for overall survival and radiation-induced lymphopenia in patients with unresectable oesophageal cancer. The prognostic value of low muscle mass is influenced by BMI, and low muscle mass is more detrimental in patients with low BMI.
RADIOTHERAPY AND ONCOLOGY
(2023)
Review
Cell Biology
Jeremy B. Ducharme, Zachary J. McKenna, Michael R. Deyhle
Summary: Conditions characterized by muscle wasting, such as cachexia and sarcopenia, have a significant impact on individuals and public health. Inflammation, specifically lipopolysaccharide-induced inflammation through Toll-like receptor-4 activation, plays a role in the pathogenesis of these conditions. Understanding the mechanisms of Toll-like receptor-4 activation and the effects of exercise on this axis may lead to nonpharmacological therapeutic interventions.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Cell Biology
Shawna L. McMillin, Everett C. Minchew, Dawn A. Lowe, Espen E. Spangenburg
Summary: The importance of understanding sex differences in biological and physiological mechanisms is now more recognized. It is crucial to consider sex as a biological variable when developing interventions for muscle wasting conditions. However, the effects of sex or sex hormones on muscle wasting are still not well understood. While recent investigations are making progress in assessing the impact of sex-specific hormones, more scientific tools are needed in this field.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Oncology
Mark Farrugia, Kayleigh Erickson, Elizabeth Wendel, Mary E. Platek, Wenyan Ji, Kristopher Attwood, Sung Jun Ma, Fangyi Gu, Anurag K. Singh, Andrew D. Ray
Summary: This study revealed that functional decline in head and neck cancer patients is associated with reduced QoL and transition to frailty status. The Short Physical Performance Battery (SPPB) may be a useful tool in identifying patients who could benefit from rehabilitation in future studies.
Article
Oncology
Qianyi Wan, Zhetao Wang, Rui Zhao, Tingting Tu, Xiaoding Shen, Yuhou Shen, Tao Li, Yi Chen, Yinghan Song
Summary: CT-determined low SMM is associated with overall survival (OS) in gastric cancer patients, with a more significant prediction in patients with cachexia. Patients with synchronous low SMM and cachexia need more attention.
Article
Nutrition & Dietetics
Justin C. Brown, Bette J. Caan, Elizabeth M. Cespedes Feliciano, Jingjie Xiao, Erin Weltzien, Carla M. Prado, Candyce H. Kroenke, Adrienne Castillo, Marilyn L. Kwan, Jeffrey A. Meyerhardt
Summary: The study suggests that body weight stability may mask clinically meaningful skeletal muscle depletion, while skeletal muscle depletion may independently predict a higher risk of death apart from changes in body weight. Men are more likely to maintain weight stability compared to women, and among weight-stable men, the incidence of sarcopenia and myosteatosis is lower.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2021)
Article
Cell Biology
Maraiza Alves Teixeira, Marilisa De Feudis, Simone Reano, Tommaso Raiteri, Andrea Scircoli, Ivan Zaggia, Sara Ruga, Laura Salvadori, Flavia Prodam, Paolo Marzullo, Claudio Molinari, Davide Cora, Nicoletta Filigheddu
Summary: The study found that cholecalciferol (VD3) has a protective effect on muscle cells, preserving cell size and modulating autophagic flux possibly through promoting cell differentiation and fusion. VD3 may directly impact skeletal muscle homeostasis, depending on VDR activation.
Article
Oncology
Michael P. Chu, Larissa McCaw, Cynthia Stretch, Charles Butts, John Hanson, Michelle Kuzma, Vijaya L. Damaraju, Vickie E. Baracos, Michael B. Sawyer
CANCER CHEMOTHERAPY AND PHARMACOLOGY
(2015)
Article
Biochemistry & Molecular Biology
G. B. Martinelli, D. Olivari, A. D. Re Cecconi, L. Talamini, L. Ottoboni, S. H. Lecker, C. Stretch, V. E. Baracos, O. F. Bathe, A. Resovi, R. Giavazzi, L. Cervo, R. Piccirillo
Article
Geriatrics & Gerontology
Neil Johns, Cynthia Stretch, Benjamin H. L. Tan, Tora S. Solheim, Sveinung Sorhaug, Nathan A. Stephens, Ioannis Gioulbasanis, Richard J. E. Skipworth, D. A. Christopher Deans, Antonio Vigano, James A. Ross, Oliver F. Bathe, Michel L. Tremblay, Stein Kaasa, Florian Strasser, Bruno Gagnon, Vickie E. Baracos, Sambasivarao Damaraju, Kenneth C. H. Fearon
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2017)
Article
Geriatrics & Gerontology
Ashok Narasimhan, Sunita Ghosh, Cynthia Stretch, Russell Greiner, Oliver F. Bathe, Vickie Baracos, Sambasivarao Damaraju
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2017)
Article
Multidisciplinary Sciences
Cynthia Stretch, Jean-Michel Aubin, Beata Mickiewicz, Derek Leugner, Tariq Almanasra, Elizabeth Tobola, Santiago Salazar, Francis R. Sutherland, Chad G. Ball, Elijah Dixon, Hans J. Vogel, Sambasivario Damaraju, Vickie E. Baracos, Oliver F. Bathe
Article
Nutrition & Dietetics
Cynthia Stretch, Thomas Eastman, Rupasri Mandal, Roman Eisner, David S. Wishart, Marina Mourtzakis, Carla M. M. Prado, Sambasivarao Damaraju, Ronald O. Ball, Russell Greiner, Vickie E. Baracos
JOURNAL OF NUTRITION
(2012)
Article
Endocrinology & Metabolism
Roman Eisner, Cynthia Stretch, Thomas Eastman, Jianguo Xia, David Hau, Sambasivarao Damaraju, Russell Greiner, David S. Wishart, Vickie E. Baracos
Article
Biophysics
Ienaka Takeda, Cynthia Stretch, Pamela Barnaby, Kriti Bhatnager, Kathryn Rankin, Hao Fu, Aalim Weljie, Naresh Jha, Carolyn Slupsky
NMR IN BIOMEDICINE
(2009)
Article
Multidisciplinary Sciences
Cynthia Stretch, Sheehan Khan, Nasimeh Asgarian, Roman Eisner, Saman Vaisipour, Sambasivarao Damaraju, Kathryn Graham, Oliver F. Bathe, Helen Steed, Russell Greiner, Vickie E. Baracos
Article
Geriatrics & Gerontology
Ana Anoveros-Barrera, Amritpal S. Bhullar, Cynthia Stretch, Nina Esfandiari, Abha R. Dunichand-Hoedl, Karen J. B. Martins, David Bigam, Rachel G. Khadaroo, Todd McMullen, Oliver F. Bathe, Sambasivarao Damaraju, Richard J. Skipworth, Charles T. Putman, Vickie E. Baracos, Vera C. Mazurak
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2019)
Article
Cell Biology
Ana Anoveros-Barrera, Amritpal S. Bhuliar, Cynthia Stretch, Abha R. Dunichand-Hoedl, Karen J. B. Martins, Aja Rieger, David Bigam, Todd McMullen, Oliver F. Bathe, Charles T. Putman, Catherine J. Field, Vickie E. Baracos, Vera C. Mazurak
Article
Immunology
Rosalyn W. Sayaman, Mohamad Saad, Vesteinn Thorsson, Donglei Hu, Wouter Hendrickx, Jessica Roelands, Eduard Porta-Pardo, Younes Mokrab, Farshad Farshidfar, Tomas Kirchhoff, Randy F. Sweis, Oliver F. Bathe, Carolina Heimann, Michael J. Campbell, Cynthia Stretch, Scott Huntsman, Rebecca E. Graff, Najeeb Syed, Laszlo Radvanyi, Simon Shelley, Denise Wolf, Francesco M. Marincola, Michele Ceccarelli, Jerome Galon, Elad Ziv, Davide Bedognetti
Summary: Understanding the host's genetic background's contribution to cancer immunity has significant impact on the composition and functional orientation of the tumor immune microenvironment, with certain genes potentially acting as immune modulators. Investigating the effects of germline variants on immune traits provides a resource toward further understanding tumor-immune interactions.
Article
Endocrinology & Metabolism
Erin S. Coyne, Nathalie Bedard, Linda Wykes, Cynthia Stretch, Samer Jammoul, Sihan Li, Kezhuo Zhang, Robert S. Sladek, Oliver F. Bathe, Robert Thomas Jagoe, Barry I. Posner, Simon S. Wing