Tumor-derived IL-6 and trans-signaling among tumor, fat, and muscle mediate pancreatic cancer cachexia
出版年份 2021 全文链接
标题
Tumor-derived IL-6 and trans-signaling among tumor, fat, and muscle mediate pancreatic cancer cachexia
作者
关键词
-
出版物
JOURNAL OF EXPERIMENTAL MEDICINE
Volume 218, Issue 6, Pages -
出版商
Rockefeller University Press
发表日期
2021-04-17
DOI
10.1084/jem.20190450
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Fat Wasting Is Damaging: Role of Adipose Tissue in Cancer-Associated Cachexia
- (2020) Xiaoting Sun et al. Frontiers in Cell and Developmental Biology
- Management of Cancer Cachexia: ASCO Guideline
- (2020) Eric J. Roeland et al. JOURNAL OF CLINICAL ONCOLOGY
- Diverging metabolic programmes and behaviours during states of starvation, protein malnutrition, and cachexia
- (2020) Brennan Olson et al. Journal of Cachexia Sarcopenia and Muscle
- SSMD: a semi-supervised approach for a robust cell type identification and deconvolution of mouse transcriptomics data
- (2020) Xiaoyu Lu et al. BRIEFINGS IN BIOINFORMATICS
- Inflammation and Skeletal Muscle Wasting During Cachexia
- (2020) Justine M. Webster et al. Frontiers in Physiology
- Identification of Potential Serum Protein Biomarkers and Pathways for Pancreatic Cancer Cachexia Using an Aptamer-Based Discovery Platform
- (2020) Ashok Narasimhan et al. Cancers
- Cancer statistics, 2019
- (2019) Rebecca L. Siegel et al. CA-A CANCER JOURNAL FOR CLINICIANS
- Prediction of Unresectability and Prognosis in Patients Undergoing Surgery on Suspicion of Pancreatic Cancer Using Carbohydrate Antigen 19-9, Interleukin 6, and YKL-40
- (2019) Camilla Palmquist et al. PANCREAS
- Interleukin-6 promotes pancreatic cancer cell migration by rapidly activating the small GTPase CDC42
- (2018) Gina L. Razidlo et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Sarcopenia and myosteatosis are accompanied by distinct biological profiles in patients with pancreatic and periampullary adenocarcinomas
- (2018) Cynthia Stretch et al. PLoS One
- Circulating monocyte chemoattractant protein-1 (MCP-1) is associated with cachexia in treatment-naïve pancreatic cancer patients
- (2018) Erin E. Talbert et al. Journal of Cachexia Sarcopenia and Muscle
- Three cachexia phenotypes and the impact of fat-only loss on survival in FOLFIRINOX therapy for pancreatic cancer
- (2018) Joshua K. Kays et al. Journal of Cachexia Sarcopenia and Muscle
- Association Between Changes in Body Composition and Neoadjuvant Treatment for Pancreatic Cancer
- (2018) Marta Sandini et al. JAMA Surgery
- Plasma inflammatory cytokines and survival of pancreatic cancer patients
- (2018) A. Babic et al. Clinical and Translational Gastroenterology
- Cancer-associated cachexia
- (2018) Vickie E. Baracos et al. Nature Reviews Disease Primers
- Altered exocrine function can drive adipose wasting in early pancreatic cancer
- (2018) Laura V. Danai et al. NATURE
- Inter-tissue communication in cancer cachexia
- (2018) Josep M. Argilés et al. Nature Reviews Endocrinology
- Circulating interleukin-6 is associated with disease progression, but not cachexia in pancreatic cancer
- (2018) Mitchell L. Ramsey et al. PANCREATOLOGY
- Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer
- (2017) Daniel Öhlund et al. JOURNAL OF EXPERIMENTAL MEDICINE
- IL6 Receptor Blockade Enhances Chemotherapy Efficacy in Pancreatic Ductal Adenocarcinoma
- (2017) Kristen B. Long et al. MOLECULAR CANCER THERAPEUTICS
- A soluble form of the interleukin-6 family signal transducer gp130 is dimerized via a C-terminal disulfide bridge resulting from alternative mRNA splicing
- (2016) Janina Wolf et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Differential Effects of IL6 and Activin A in the Development of Cancer-Associated Cachexia
- (2016) Justin L. Chen et al. CANCER RESEARCH
- Tumor-Induced IL-6 Reprograms Host Metabolism to Suppress Anti-tumor Immunity
- (2016) Thomas R. Flint et al. Cell Metabolism
- The impact of sarcopenia and myosteatosis on outcomes of unresectable pancreatic cancer or distal cholangiocarcinoma
- (2016) Katie E. Rollins et al. CLINICAL NUTRITION
- Inhibition of ER stress and unfolding protein response pathways causes skeletal muscle wasting during cancer cachexia
- (2016) Kyle R. Bohnert et al. FASEB JOURNAL
- IL-6 and PD-L1 antibody blockade combination therapy reduces tumour progression in murine models of pancreatic cancer
- (2016) Thomas A Mace et al. GUT
- An AMP-activated protein kinase–stabilizing peptide ameliorates adipose tissue wasting in cancer cachexia in mice
- (2016) Maria Rohm et al. NATURE MEDICINE
- Excessive fatty acid oxidation induces muscle atrophy in cancer cachexia
- (2016) Tomoya Fukawa et al. NATURE MEDICINE
- Lipolytic and thermogenic depletion of adipose tissue in cancer cachexia
- (2016) Maria Tsoli et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- Protein breakdown in cancer cachexia
- (2016) Marco Sandri SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- Prevalence and clinical impact of cachexia in chronic illness in Europe, USA, and Japan: facts and numbers update 2016
- (2016) Stephan von Haehling et al. Journal of Cachexia Sarcopenia and Muscle
- The soluble interleukin-6 receptor and related proteins
- (2015) Stefan Rose-John BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM
- Development and validation of panoptic Meso scale discovery assay to quantify total systemic interleukin-6
- (2015) Shalini Chaturvedi et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
- Blocking IL-6 trans-Signaling Prevents High-Fat Diet-Induced Adipose Tissue Macrophage Recruitment but Does Not Improve Insulin Resistance
- (2015) Michael J. Kraakman et al. Cell Metabolism
- Interleukin-6: Biology, signaling and strategies of blockade
- (2015) Fred Schaper et al. CYTOKINE & GROWTH FACTOR REVIEWS
- Shedding of Endogenous Interleukin-6 Receptor (IL-6R) Is Governed by A Disintegrin and Metalloproteinase (ADAM) Proteases while a Full-length IL-6R Isoform Localizes to Circulating Microvesicles
- (2015) Neele Schumacher et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Potential Biomarkers of Fat Loss as a Feature of Cancer Cachexia
- (2015) Maryam Ebadi et al. MEDIATORS OF INFLAMMATION
- An Epidemiological Survey of Cachexia in Advanced Cancer Patients and Analysis on Its Diagnostic and Treatment Status
- (2015) Lei Sun et al. NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
- NF-κBp65 and Expression of Its Pro-Inflammatory Target Genes Are Upregulated in the Subcutaneous Adipose Tissue of Cachectic Cancer Patients
- (2015) Rodolfo Camargo et al. Nutrients
- Evaluating potential biomarkers of cachexia and survival in skeletal muscle of upper gastrointestinal cancer patients
- (2015) Nathan A. Stephens et al. Journal of Cachexia Sarcopenia and Muscle
- A Switch from White to Brown Fat Increases Energy Expenditure in Cancer-Associated Cachexia
- (2014) Michele Petruzzelli et al. Cell Metabolism
- Prognostic impact of fat tissue loss and cachexia assessed by computed tomography scan in elderly patients with diffuse large B-cell lymphoma treated with immunochemotherapy
- (2014) Vincent Camus et al. EUROPEAN JOURNAL OF HAEMATOLOGY
- Interleukin-6: a villain in the drama of pancreatic cancer development and progression
- (2014) Reinhild Holmer et al. Hepatobiliary & Pancreatic Diseases International
- Preclinical validation of interleukin 6 as a therapeutic target in multiple myeloma
- (2014) Timothy R. Rosean et al. IMMUNOLOGIC RESEARCH
- Role of diacylglycerol activation of PKCθ in lipid-induced muscle insulin resistance in humans
- (2014) Julia Szendroedi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- IL-6 and related cytokines as the critical lynchpins between inflammation and cancer
- (2014) Koji Taniguchi et al. SEMINARS IN IMMUNOLOGY
- Inflammation Based Regulation of Cancer Cachexia
- (2014) Jill K. Onesti et al. Biomed Research International
- Role of interleukin-6 in cachexia
- (2014) Aditi A. Narsale et al. Current Opinion in Supportive and Palliative Care
- Interleukin-6 Is Required for Pancreatic Cancer Progression by Promoting MAPK Signaling Activation and Oxidative Stress Resistance
- (2013) Y. Zhang et al. CANCER RESEARCH
- Cancer Cachexia in the Age of Obesity: Skeletal Muscle Depletion Is a Powerful Prognostic Factor, Independent of Body Mass Index
- (2013) Lisa Martin et al. JOURNAL OF CLINICAL ONCOLOGY
- Relationships Between Right Ventricular Function, Body Composition, and Prognosis in Advanced Heart Failure
- (2013) Vojtech Melenovsky et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Imaging of neutral lipids by oil red O for analyzing the metabolic status in health and disease
- (2013) Annika Mehlem et al. Nature Protocols
- Early Activation of Rat Skeletal Muscle IL-6/STAT1/STAT3 Dependent Gene Expression in Resistance Exercise Linked to Hypertrophy
- (2013) Gwénaëlle Begue et al. PLoS One
- Diagnostic and Prognostic Impact of Circulating YKL-40, IL-6, and CA 19.9 in Patients with Pancreatic Cancer
- (2013) Nicolai A. Schultz et al. PLoS One
- Interleukin-6 but not tumour necrosis factor-alpha predicts survival in patients with advanced cancer
- (2013) Sang-Yeon Suh et al. SUPPORTIVE CARE IN CANCER
- JAK/STAT3 pathway inhibition blocks skeletal muscle wasting downstream of IL-6 and in experimental cancer cachexia
- (2012) Andrea Bonetto et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- STAR: ultrafast universal RNA-seq aligner
- (2012) Alexander Dobin et al. BIOINFORMATICS
- Accelerated muscle and adipose tissue loss may predict survival in pancreatic cancer patients: the relationship with diabetes and anaemia
- (2012) Katie M. Di Sebastiano et al. BRITISH JOURNAL OF NUTRITION
- Relationships Among Body Mass Index, Longitudinal Body Composition Alterations, and Survival in Patients With Locally Advanced Pancreatic Cancer Receiving Chemoradiation: A Pilot Study
- (2012) Shalini Dalal et al. JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
- Differential expression analysis of multifactor RNA-Seq experiments with respect to biological variation
- (2012) Davis J. McCarthy et al. NUCLEIC ACIDS RESEARCH
- Inflammation, organomegaly, and muscle wasting despite hyperphagia in a mouse model of burn cachexia
- (2012) Felipe E. Pedroso et al. Journal of Cachexia Sarcopenia and Muscle
- Skeletal muscle mass recovery from atrophy in IL-6 knockout mice
- (2011) T. A. Washington et al. Acta Physiologica
- Stat3/Socs3 Activation by IL-6 Transsignaling Promotes Progression of Pancreatic Intraepithelial Neoplasia and Development of Pancreatic Cancer
- (2011) Marina Lesina et al. CANCER CELL
- Cytokines
- (2011) Gerrit van Hall CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE
- STAT3 Activation in Skeletal Muscle Links Muscle Wasting and the Acute Phase Response in Cancer Cachexia
- (2011) Andrea Bonetto et al. PLoS One
- Adipose Triglyceride Lipase Contributes to Cancer-Associated Cachexia
- (2011) S. K. Das et al. SCIENCE
- Hypothalamic mechanisms in cachexia
- (2010) Aaron J. Grossberg et al. PHYSIOLOGY & BEHAVIOR
- edgeR: a Bioconductor package for differential expression analysis of digital gene expression data
- (2009) M. D. Robinson et al. BIOINFORMATICS
- Association of Interleukin-6 Signalling with the Muscle Stem Cell Response Following Muscle-Lengthening Contractions in Humans
- (2009) Bryon R. McKay et al. PLoS One
- Muscle wasting and interleukin-6-induced atrogin-I expression in the cachectic Apc Min/+ mouse
- (2008) Kristen A. Baltgalvis et al. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
- Interleukin-6 and cachexia in ApcMin/+ mice
- (2007) Kristen A. Baltgalvis et al. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started