标题
The Role of Apelin in Cardiovascular Diseases, Obesity and Cancer
作者
关键词
-
出版物
Frontiers in Physiology
Volume 9, Issue -, Pages -
出版商
Frontiers Media SA
发表日期
2018-05-23
DOI
10.3389/fphys.2018.00557
参考文献
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- Apelin promotes mesenchymal stem cells survival and vascularization under hypoxic-ischemic condition in vitro involving the upregulation of vascular endothelial growth factor
- (2017) Jingying Hou et al. EXPERIMENTAL AND MOLECULAR PATHOLOGY
- Apelin/APJ system: A bifunctional target for cardiac hypertrophy
- (2017) Liqun Lu et al. INTERNATIONAL JOURNAL OF CARDIOLOGY
- Apelin attenuates TGF-β1-induced epithelial to mesenchymal transition via activation of PKC-ε in human renal tubular epithelial cells
- (2017) Li-Yan Wang et al. PEPTIDES
- Bisphenol A and its derivatives tetrabromobisphenol A and tetrachlorobisphenol A induce apelin expression and secretion in ovarian cancer cells through a peroxisome proliferator-activated receptor gamma-dependent mechanism
- (2017) Marta Hoffmann et al. TOXICOLOGY LETTERS
- Apelin involved in progression of diabetic nephropathy by inhibiting autophagy in podocytes
- (2017) Yu Liu et al. Cell Death & Disease
- Association of apelin and apelin receptor with the risk of coronary artery disease: a meta-analysis of observational studies
- (2017) Tianbao Chen et al. Oncotarget
- Apelin: A putative novel predictive biomarker for bevacizumab response in colorectal cancer
- (2017) Linda Zuurbier et al. Oncotarget
- Anti-angiogenic agents for the treatment of solid tumors: Potential pathways, therapy and current strategies – A review
- (2017) Ahmed M. Al-Abd et al. Journal of Advanced Research
- Tumor apelin, not serum apelin, is associated with the clinical features and prognosis of gastric cancer
- (2016) Meiyan Feng et al. BMC CANCER
- Apelin-13 administration protects against ischaemia/reperfusion-mediated apoptosis through the FoxO1 pathway in high-fat diet-induced obesity
- (2016) Frederic Boal et al. BRITISH JOURNAL OF PHARMACOLOGY
- Apelin/APJ system and cancer
- (2016) Yanjie Yang et al. CLINICA CHIMICA ACTA
- PAK1-cofilin phosphorylation mediates human lung adenocarcinoma cells migration induced by apelin-13
- (2016) Deguan Lv et al. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
- The association between single nucleotide polymorphisms of the Apelin gene and diabetes mellitus in a Chinese population
- (2016) Hui Zheng et al. JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
- Apelin/APJ system as a therapeutic target in diabetes and its complications
- (2016) Haoliang Hu et al. MOLECULAR GENETICS AND METABOLISM
- A role for novel adipose tissue-secreted factors in obesity-related carcinogenesis
- (2016) B. Cabia et al. Obesity Reviews
- Apelin-13 protects against apoptosis by activating AMP-activated protein kinase pathway in ischemia stroke
- (2016) Yi Yang et al. PEPTIDES
- Effect of apelin hormone on renal ischemia/reperfusion induced oxidative damage in rats
- (2016) Burak Bircan et al. RENAL FAILURE
- The role of apelin in the assessment of response to chemotherapyand prognosis in stage 4 nonsmall cell lung cancer
- (2016) Sinem ERMİN et al. Turkish Journal Of Medical Sciences
- Association of leptin, visfatin, apelin, resistin and adiponectin with clear cell renal cell carcinoma
- (2016) Hai-Ping Zhang et al. Oncology Letters
- Hypoxia promotes bone marrow-derived mesenchymal stem cell proliferation through apelin/APJ/autophagy pathway
- (2015) L. Li et al. ACTA BIOCHIMICA ET BIOPHYSICA SINICA
- The effects of apelin treatment on a rat model of type 2 diabetes
- (2015) Raziye Akcılar et al. Advances in Medical Sciences
- Intranasal Delivery of Apelin-13 Is Neuroprotective and Promotes Angiogenesis After Ischemic Stroke in Mice
- (2015) Dongdong Chen et al. ASN Neuro
- Structural apelin analogues: mitochondrial ROS inhibition and cardiometabolic protection in myocardial ischaemia reperfusion injury
- (2015) Oleg Pisarenko et al. BRITISH JOURNAL OF PHARMACOLOGY
- Apelin as a marker for monitoring the tumor vessel normalization window during antiangiogenic therapy
- (2015) Li Zhang et al. CANCER SCIENCE
- Apelin/APJ signaling in hypoxia-related diseases
- (2015) Lu He et al. CLINICA CHIMICA ACTA
- Dysregulated microRNA-224/apelin axis associated with aggressive progression and poor prognosis in patients with prostate cancer
- (2015) Yueping Wan et al. HUMAN PATHOLOGY
- Secreted factors derived from obese visceral adipose tissue regulate the expression of breast malignant transformation genes
- (2015) A B Crujeiras et al. INTERNATIONAL JOURNAL OF OBESITY
- Serum apelin is associated with left ventricular hypertrophy in untreated hypertension patients
- (2015) Lijun Ye et al. Journal of Translational Medicine
- Hypoxia induces the proliferation of endothelial progenitor cells via upregulation of Apelin/APLNR/MAPK signaling
- (2015) JINGCHANG ZHANG et al. Molecular Medicine Reports
- Apelin/APJ signaling promotes hypoxia-induced proliferation of endothelial progenitor cells via Phosphoinositide-3 kinase/Akt signaling
- (2015) JINGCHANG ZHANG et al. Molecular Medicine Reports
- Lateral intracerebroventricular injection of Apelin-13 inhibits apoptosis after cerebral ischemia/reperfusion injury
- (2015) Bo Bai et al. Neural Regeneration Research
- Signaling pathways of a structural analogue of apelin-12 involved in myocardial protection against ischemia/reperfusion injury
- (2015) Oleg I. Pisarenko et al. PEPTIDES
- Apelin Protects Primary Rat Retinal Pericytes from Chemical Hypoxia-Induced Apoptosis
- (2015) Li Chen et al. Journal of Ophthalmology
- Apelin and energy metabolism
- (2015) Chantal Bertrand et al. Frontiers in Physiology
- Apelin promotes lymphangiogenesis and lymph node metastasis
- (2015) Judit Berta et al. Oncotarget
- A static pressure sensitive receptor APJ promote H9c2 cardiomyocyte hypertrophy via PI3K-autophagy pathway
- (2014) Feng Xie et al. ACTA BIOCHIMICA ET BIOPHYSICA SINICA
- Plasma apelin: A novel biomarker for predicting diabetes
- (2014) Wen-Ya Ma et al. CLINICA CHIMICA ACTA
- Circulating Apelin is increased in patients with type 1 or type 2 diabetes and is associated with better glycaemic control
- (2014) Marana Habchi et al. CLINICAL ENDOCRINOLOGY
- Serum Levels of Resistin, Adiponectin, and Apelin in Gastroesophageal Cancer Patients
- (2014) Dorota Diakowska et al. DISEASE MARKERS
- Effect of apelin on the cardiac hemodynamics in hypertensive rats with heart failure
- (2014) HUI PANG et al. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
- Sirt3 is essential for apelin-induced angiogenesis in post-myocardial infarction of diabetes
- (2014) Xuwei Hou et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Apelin inhibits the proliferation and migration of rat PASMCsviathe activation of PI3K/Akt/mTOR signal and the inhibition of autophagy under hypoxia
- (2014) Hongyu Zhang et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Apelin levels are higher in obese patients with endometrial cancer
- (2014) S. Ozlem Altinkaya et al. JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
- Apelin-12 and its structural analog enhance antioxidant defense in experimental myocardial ischemia and reperfusion
- (2014) O. I. Pisarenko et al. MOLECULAR AND CELLULAR BIOCHEMISTRY
- Apelin-13 stimulates angiogenesis by promoting cross-talk between AMP-activated protein kinase and Akt signaling in myocardial microvascular endothelial cells
- (2014) XIAOMAN YANG et al. Molecular Medicine Reports
- Apelin-13 protects the brain against ischemia/reperfusion injury through activating PI3K/Akt and ERK1/2 signaling pathways
- (2014) Yi Yang et al. NEUROSCIENCE LETTERS
- Associations between Serum Apelin-12 Levels and Obesity-Related Markers in Chinese Children
- (2014) Hong-Jun Ba et al. PLoS One
- ERK1/2 mediates lung adenocarcinoma cell proliferation and autophagy induced by apelin-13
- (2013) L. Yang et al. ACTA BIOCHIMICA ET BIOPHYSICA SINICA
- Apelin gene therapy increases myocardial vascular density and ameliorates diabetic cardiomyopathy via upregulation of sirtuin 3
- (2013) Heng Zeng et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Inhibition of apelin expression switches endothelial cells from proliferative to mature state in pathological retinal angiogenesis
- (2013) Atsushi Kasai et al. ANGIOGENESIS
- State of the art paper Biochemistry of adipose tissue: an endocrine organ
- (2013) Marisa Coelho et al. Archives of Medical Science
- Apelin Effects on Blood Pressure and RAS in DOCA-Salt-Induced Hypertensive Rats
- (2013) Raziye Akcılar et al. CLINICAL AND EXPERIMENTAL HYPERTENSION
- Apelin Inhibits Diet-Induced Obesity by Enhancing Lymphatic and Blood Vessel Integrity
- (2013) M. Sawane et al. DIABETES
- Apelin-13 regulates proliferation, migration and survival of retinal Müller cells under hypoxia
- (2013) Qiang Lu et al. DIABETES RESEARCH AND CLINICAL PRACTICE
- Tumour co-expression of apelin and its receptor is the basis of an autocrine loop involved in the growth of colon adenocarcinomas
- (2013) François-Xavier Picault et al. EUROPEAN JOURNAL OF CANCER
- Involvement of adipokines, AMPK, PI3K and the PPAR signaling pathways in ovarian follicle development and cancer
- (2013) Jolle Dupont et al. INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY
- Apelin Attenuates Oxidative Stress in Human Adipocytes
- (2013) Aung Than et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Apelin is a positive regulator of ACE2 in failing hearts
- (2013) Teruki Sato et al. JOURNAL OF CLINICAL INVESTIGATION
- Apelin-36, a potent peptide, protects against ischemic brain injury by activating the PI3K/Akt pathway
- (2013) Qin Gu et al. NEUROCHEMISTRY INTERNATIONAL
- Developmental and hypoxia-induced cell death share common ultrastructural and biochemical apoptotic features in the central nervous system
- (2013) V.M. Pozo Devoto et al. NEUROSCIENCE
- Effects of Weight Loss and Exercise on Apelin Serum Concentrations and Adipose Tissue Expression in Human Obesity
- (2013) Joanna Krist et al. Obesity Facts
- The apelinergic system: Sexual dimorphism and tissue-specific modulations by obesity and insulin resistance in female mice
- (2013) Laura Butruille et al. PEPTIDES
- Post-infarct treatment with [Pyr1]-apelin-13 reduces myocardial damage through reduction of oxidative injury and nitric oxide enhancement in the rat model of myocardial infarction
- (2013) Yaser Azizi et al. PEPTIDES
- Loss of Apelin Exacerbates Myocardial Infarction Adverse Remodeling and Ischemia‐reperfusion Injury: Therapeutic Potential of Synthetic Apelin Analogues
- (2013) Wang Wang et al. Journal of the American Heart Association
- Apelin-13 increases myocardial progenitor cells and improves repair postmyocardial infarction
- (2012) Lanfang Li et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Discovery of 4-oxo-6-((pyrimidin-2-ylthio)methyl)-4H-pyran-3-yl 4-nitrobenzoate (ML221) as a functional antagonist of the apelin (APJ) receptor
- (2012) Patrick R. Maloney et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Apelin-13 Protects the Brain Against Ischemic Reperfusion Injury and Cerebral Edema in a Transient Model of Focal Cerebral Ischemia
- (2012) Mehdi Khaksari et al. JOURNAL OF MOLECULAR NEUROSCIENCE
- Hepatocellular carcinoma cells cause different responses in expressions of cancer-promoting genes in different cancer-associated fibroblasts
- (2012) Zu-Yau Lin et al. KAOHSIUNG JOURNAL OF MEDICAL SCIENCES
- Apelin inhibits adipogenesis and lipolysis through distinct molecular pathways
- (2012) Aung Than et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- Hypoxia-induced up-regulation of apelin is associated with a poor prognosis in oral squamous cell carcinoma patients
- (2012) Kyun Heo et al. ORAL ONCOLOGY
- Apelin supports primary rat retinal Müller cells under chemical hypoxia and glucose deprivation
- (2012) Xin-Lei Wang et al. PEPTIDES
- Effects of apelin and leptin on renal functions following renal ischemia/reperfusion: An experimental study
- (2012) TAMER SAGIROGLU et al. Experimental and Therapeutic Medicine
- Apelin-13 protects the heart against ischemia-reperfusion injury through inhibition of ER-dependent apoptotic pathways in a time-dependent fashion
- (2011) Jianping Tao et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Apelin-13 limits infarct size and improves cardiac postischemic mechanical recovery only if given after ischemia
- (2011) Raffaella Rastaldo et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Disruption of the Apelin-APJ System Worsens Hypoxia-Induced Pulmonary Hypertension
- (2011) Suparna M. Chandra et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- In Vivo Reduction of Reperfusion Injury to the Heart with Apelin-12 Peptide in Rats
- (2011) O. I. Pisarenko et al. BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
- Hallmarks of Cancer: The Next Generation
- (2011) Douglas Hanahan et al. CELL
- Hypoxia Induces Apelin Expression in Human Adipocytes
- (2011) K. Geiger et al. HORMONE AND METABOLIC RESEARCH
- Apelin stimulates glucose uptake through the PI3K/Akt pathway and improves insulin resistance in 3T3-L1 adipocytes
- (2011) Shunming Zhu et al. MOLECULAR AND CELLULAR BIOCHEMISTRY
- Ischemia and reperfusion—from mechanism to translation
- (2011) Holger K Eltzschig et al. NATURE MEDICINE
- Apelin and insulin resistance: Another arrow for the quiver?
- (2011) Shiming XU et al. Journal of Diabetes
- Apelin suppresses apoptosis of human vascular smooth muscle cells via APJ/PI3-K/Akt signaling pathways
- (2010) Rong-Rong Cui et al. AMINO ACIDS
- Apelin Is a Crucial Factor for Hypoxia-Induced Retinal Angiogenesis
- (2010) Atsushi Kasai et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Acute Cardiovascular Effects of Apelin in Humans
- (2010) A.G. Japp et al. CIRCULATION
- Plasma Apelin and ADMA Levels in Patients with Essential Hypertension
- (2010) Alper Sonmez et al. CLINICAL AND EXPERIMENTAL HYPERTENSION
- Apelin Decreases Lipolysis via Gq, Gi, and AMPK-Dependent Mechanisms
- (2010) Patrick Yue et al. ENDOCRINOLOGY
- Correlation between plasma levels of apelin and myocardial hypertrophy in rats and humans: possible target for treatment?
- (2010) Inês Falcão-Pires et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- Activation of catalase by apelin prevents oxidative stress-linked cardiac hypertrophy
- (2010) Camille Foussal et al. FEBS LETTERS
- Associations between adipokines and obesity-related cancer
- (2010) Gilberto Paz-Filho Frontiers in Bioscience-Landmark
- Transcardiac gradients of circulating apelin: extraction by normal hearts vs. release by hearts failing due to pressure overload
- (2010) Satu Helske et al. JOURNAL OF APPLIED PHYSIOLOGY
- Myocardial Apelin Production is Reduced in Humans With Left Ventricular Systolic Dysfunction
- (2010) Badrinathan Chandrasekaran et al. JOURNAL OF CARDIAC FAILURE
- Effects of Olmesartan on Apelin/APJ and Akt/Endothelial Nitric Oxide Synthase Pathway in Dahl Rats With End-stage Heart Failure
- (2010) Hiromichi Fukushima et al. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
- Decreased Plasma Apelin Levels in Pubertal Obese Children
- (2010) Serkan Tapan et al. JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
- Apelin Expression in Human Non-small Cell Lung Cancer: Role in Angiogenesis and Prognosis
- (2010) Judit Berta et al. Journal of Thoracic Oncology
- Type 2 Diabetes and Cancer: What Is the Connection?
- (2010) Dara Cannata et al. MOUNT SINAI JOURNAL OF MEDICINE
- Apelin is a novel islet peptide
- (2010) Camilla Ringström et al. REGULATORY PEPTIDES
- Serum levels of apelin and ghrelin in patients with acute coronary syndromes and established coronary artery disease—KOZANI STUDY
- (2010) Nikolaos P.E. Kadoglou et al. Translational Research
- Pulmonary apelin levels and effects in rats with hypoxic pulmonary hypertension
- (2009) C.U. Andersen et al. RESPIRATORY MEDICINE
- Apelin Stimulates Glucose Utilization in Normal and Obese Insulin-Resistant Mice
- (2008) Cédric Dray et al. Cell Metabolism
- Effect of hypocaloric diet-induced weight loss in obese women on plasma apelin and adipose tissue expression of apelin and APJ.
- (2008) Isabelle Castan-Laurell et al. EUROPEAN JOURNAL OF ENDOCRINOLOGY
- Apelin/APJ signaling system: a potential link between adipose tissue and endothelial angiogenic processes
- (2008) O. Kunduzova et al. FASEB JOURNAL
- Apelin signaling modulates splanchnic angiogenesis and portosystemic collateral vessel formation in rats with portal hypertension
- (2008) Carolina Tiani et al. JOURNAL OF HEPATOLOGY
- Vascular Effects of Apelin In Vivo in Man
- (2008) Alan G. Japp et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
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