Modulating the differentiation status of ex vivo-cultured anti-tumor T cells using cytokine cocktails

In vitro generated anti-tumor T lymphocytes exhibit distinct subsets mimicking in vivo antigen-experienced cells

(2011) Shicheng Yang et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Durable Complete Responses in Heavily Pretreated Patients with Metastatic Melanoma Using T-Cell Transfer Immunotherapy

(2011) S. A. Rosenberg et al.   CLINICAL CANCER RESEARCH

Tumor Regression in Patients With Metastatic Synovial Cell Sarcoma and Melanoma Using Genetically Engineered Lymphocytes Reactive With NY-ESO-1

(2011) Paul F. Robbins et al.   JOURNAL OF CLINICAL ONCOLOGY

Improving Adoptive T Cell Therapy by Targeting and Controlling IL-12 Expression to the Tumor Environment

(2011) Ling Zhang et al.   MOLECULAR THERAPY

A human memory T cell subset with stem cell–like properties

(2011) Luca Gattinoni et al.   NATURE MEDICINE

Chimeric Antigen Receptor–Modified T Cells in Chronic Lymphoid Leukemia

(2011) David L. Porter et al.   NEW ENGLAND JOURNAL OF MEDICINE

IL-7 and IL-21 are superior to IL-2 and IL-15 in promoting human T cell-mediated rejection of systemic lymphoma in immunodeficient mice

(2010) J. C. Markley et al.   BLOOD

Eradication of B-lineage cells and regression of lymphoma in a patient treated with autologous T cells genetically engineered to recognize CD19

(2010) J. N. Kochenderfer et al.   BLOOD

IL-21-treated naive CD45RA+ CD8+ T cells represent a reliable source for producing leukemia-reactive cytotoxic T lymphocytes with high proliferative potential and early differentiation phenotype

(2010) Jana Albrecht et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Tumor-Specific CD8+ T Cells Expressing Interleukin-12 Eradicate Established Cancers in Lymphodepleted Hosts

(2010) S. P. Kerkar et al.   CANCER RESEARCH

Reprogramming of T Cells from Human Peripheral Blood

(2010) Yuin-Han Loh et al.   Cell Stem Cell

Reprogramming of Human Peripheral Blood Cells to Induced Pluripotent Stem Cells

(2010) Judith Staerk et al.   Cell Stem Cell

Defect of CD8+ Memory T Cells Developed in Absence of IL-12 Priming for Secondary Expansion

(2010) Zhenmin Ye et al.   Cellular & Molecular Immunology

A Simplified Method for the Clinical-scale Generation of Central Memory-like CD8+ T Cells After Transduction With Lentiviral Vectors Encoding Antitumor Antigen T-cell Receptors

(2010) Shicheng Yang et al.   JOURNAL OF IMMUNOTHERAPY

 c deficiency precludes CD8+ T cell memory despite formation of potent T cell effectors

(2010) H. Decaluwe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gene therapy with human and mouse T-cell receptors mediates cancer regression and targets normal tissues expressing cognate antigen

(2009) L. A. Johnson et al.   BLOOD

IL-7 + IL-15 are superior to IL-2 for the ex vivo expansion of 4T1 mammary carcinoma-specific T cells with greater efficacy against tumors in vivo

(2009) Esther Cha et al.   BREAST CANCER RESEARCH AND TREATMENT

Lentiviral Vector Design for Optimal T Cell Receptor Gene Expression in the Transduction of Peripheral Blood Lymphocytes and Tumor-Infiltrating Lymphocytes

(2009) Stephanie Jones et al.   HUMAN GENE THERAPY

A Distinct Subset of Self-Renewing Human Memory CD8+ T Cells Survives Cytotoxic Chemotherapy

(2009) Cameron J. Turtle et al.   IMMUNITY

Genetic Modification of T Cells With IL-21 Enhances Antigen Presentation and Generation of Central Memory Tumor-specific Cytotoxic T-lymphocytes

(2009) Anjum S. Kaka et al.   JOURNAL OF IMMUNOTHERAPY

Differentiation stage determines potential of hematopoietic cells for reprogramming into induced pluripotent stem cells

(2009) Sarah Eminli et al.   NATURE GENETICS

Wnt signaling arrests effector T cell differentiation and generates CD8+ memory stem cells

(2009) Luca Gattinoni et al.   NATURE MEDICINE

Pharmacologic Induction of CD8+ T Cell Memory: Better Living Through Chemistry

(2009) L. Gattinoni et al.   Science Translational Medicine

IL-2 and IL-21 confer opposing differentiation programs to CD8+ T cells for adoptive immunotherapy

(2008) C. S. Hinrichs et al.   BLOOD

Development of optimal bicistronic lentiviral vectors facilitates high-level TCR gene expression and robust tumor cell recognition

(2008) S Yang et al.   GENE THERAPY

Adoptive transfer of effector CD8+ T cells derived from central memory cells establishes persistent T cell memory in primates

(2008) Carolina Berger et al.   JOURNAL OF CLINICAL INVESTIGATION

Adoptive Cell Therapy for Patients With Metastatic Melanoma: Evaluation of Intensive Myeloablative Chemoradiation Preparative Regimens

(2008) Mark E. Dudley et al.   JOURNAL OF CLINICAL ONCOLOGY

Clinical-scale Lentiviral Vector Transduction of PBL for TCR Gene Therapy and Potential for Expression in Less-differentiated Cells

(2008) Shicheng Yang et al.   JOURNAL OF IMMUNOTHERAPY