p53/NF-kB Balance in SARS-CoV-2 Infection: From OMICs, Genomics and Pharmacogenomics Insights to Tailored Therapeutic Perspectives (COVIDomics)

Multiple Early Factors Anticipate Post-Acute COVID-19 Sequelae

(2022) Yapeng Su et al.   CELL

Multi-ancestry fine mapping implicates OAS1 splicing in risk of severe COVID-19

(2022) Jennifer E. Huffman et al.   NATURE GENETICS

Identification of potentially anti-COVID-19 active drugs using the connectivity MAP

(2022) Raphaël Bonnet et al.   PLoS One

Natural products can be used in therapeutic management of COVID-19: Probable mechanistic insights

(2022) Sabeeha Ali et al.   BIOMEDICINE & PHARMACOTHERAPY

The immunology and immunopathology of COVID-19

(2022) Miriam Merad et al.   SCIENCE

Pharmacogenetics and Precision Medicine Approaches for the Improvement of COVID-19 Therapies

(2022) Mohitosh Biswas et al.   Frontiers in Pharmacology

The roles of signaling pathways in SARS-CoV-2 infection; lessons learned from SARS-CoV and MERS-CoV

(2021) Nima Hemmat et al.   ARCHIVES OF VIROLOGY

Viral strategies for circumventing p53

(2021) Camila Martin Cardozo et al.   CURRENT OPINION IN ONCOLOGY

Exploring the treatment of COVID ‐19 with Yinqiao powder based on network pharmacology

(2021) Haixiong Lin et al.   PHYTOTHERAPY RESEARCH

The p53 Pathway and Metabolism: The Tree That Hides the Forest

(2021) Airelle Lahalle et al.   Cancers

A genomic region associated with protection against severe COVID-19 is inherited from Neandertals

(2021) Hugo Zeberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of papain-like protease from SARS-CoV-2 and its complexes with non-covalent inhibitors

(2021) Jerzy Osipiuk et al.   Nature Communications

A tissue- and gender-specific regulation of the SARS-CoV-2 receptor ACE2 by p53 in pigs

(2021) Yue Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

SARS-CoV-2 infects human adult donor eyes and hESC-derived ocular epithelium

(2021) Anne Z. Eriksen et al.   Cell Stem Cell

High expression of SARS-CoV-2 entry factors in human conjunctival goblet cells

(2021) Ruiqi Ma et al.   EXPERIMENTAL EYE RESEARCH

The roles and regulation of MDM2 and MDMX: it is not just about p53

(2021) Alyssa M. Klein et al.   GENES & DEVELOPMENT

Post-acute COVID-19 syndrome

(2021) Ani Nalbandian et al.   NATURE MEDICINE

Risk factors for COVID-19 mortality: The effect of convalescent plasma administration

(2021) Martín R. Salazar et al.   PLoS One

HERV-W envelope expression in blood leukocytes as a marker of disease severity of COVID-19

(2021) Marta Garcia-Montojo et al.   EBioMedicine

Evidence of the pathogenic HERV-W envelope expression in T lymphocytes in association with the respiratory outcome of COVID-19 patients

(2021) Emanuela Balestrieri et al.   EBioMedicine

The Transmission of SARS-CoV-2 Infection on the Ocular Surface and Prevention Strategies

(2021) Koji Kitazawa et al.   Cells

A blood RNA transcriptome signature for COVID-19

(2021) Philip Kam Weng Kwan et al.   BMC Medical Genomics

COVID-19 candidate genes and pathways potentially share the association with lung cancer

(2021) Afnan M. Alnajeebi et al.   COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING

Decrypting the role of predicted SARS-CoV-2 miRNAs in COVID-19 pathogenesis: A bioinformatics approach

(2021) Motiur Rahaman et al.   COMPUTERS IN BIOLOGY AND MEDICINE

COVID-19 in Children: Expressions of Type I/II/III Interferons, TRIM28, SETDB1, and Endogenous Retroviruses in Mild and Severe Cases

(2021) Pier-Angelo Tovo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

SARS-CoV-2: Understanding the Transcriptional Regulation of ACE2 and TMPRSS2 and the Role of Single Nucleotide Polymorphism (SNP) at Codon 72 of p53 in the Innate Immune Response against Virus Infection

(2021) Niraj Lodhi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Endoplasmic reticulum stress and NF‐kB activation in SARS‐CoV ‐2 infected cells and their response to antiviral therapy

(2021) Desirée Bartolini et al.   IUBMB LIFE

The NF-κB transcriptional footprint is essential for SARS-CoV-2 replication

(2021) Benjamin E. Nilsson-Payant et al.   JOURNAL OF VIROLOGY

Risk factors and disease profile of post-vaccination SARS-CoV-2 infection in UK users of the COVID Symptom Study app: a prospective, community-based, nested, case-control study

(2021) Michela Antonelli et al.   LANCET INFECTIOUS DISEASES

Emerging importance of ACE2 in external stratified epithelial tissues

(2021) Nihal Kaplan et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Mapping the human genetic architecture of COVID-19

(2021)   NATURE

COVID-19: Mechanistic Model of the African Paradox Supports the Central Role of the NF-κB Pathway

(2021) Ralf Kircheis et al.   Viruses-Basel

Tumor suppressor p53 regulates intestinal type 2 immunity

(2021) Chun-Yuan Chang et al.   Nature Communications

Diet, Probiotics and Their Impact on the Gut Microbiota during the COVID-19 Pandemic

(2021) Marzena Jabczyk et al.   Nutrients

Allele frequencies of single nucleotide polymorphisms of clinically important drug-metabolizing enzymes CYP2C9, CYP2C19, and CYP3A4 in a Thai population

(2021) Rattanaporn Sukprasong et al.   Scientific Reports

Acute and persistent symptoms in non-hospitalized PCR-confirmed COVID-19 patients

(2021) Sofie Bliddal et al.   Scientific Reports

Exploring Phytochemicals of Traditional Medicinal Plants Exhibiting Inhibitory Activity Against Main Protease, Spike Glycoprotein, RNA-dependent RNA Polymerase and Non-Structural Proteins of SARS-CoV-2 Through Virtual Screening

(2021) Saranya Nallusamy et al.   Frontiers in Pharmacology

He-Jie-Shen-Shi Decoction as an Adjuvant Therapy on Severe Coronavirus Disease 2019: A Retrospective Cohort and Potential Mechanistic Study

(2021) Haibo Hu et al.   Frontiers in Pharmacology

Genetics and Epigenetics of One-Carbon Metabolism Pathway in Autism Spectrum Disorder: A Sex-Specific Brain Epigenome?

(2021) Veronica Tisato et al.   Genes

Antiviral Therapeutic Approaches for SARS-CoV-2 Infection: A Systematic Review

(2021) Victoria Gil Martínez et al.   Pharmaceuticals

Adaptive homeostasis and the p53 isoform network

(2021) Sunali Mehta et al.   EMBO REPORTS

Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severity

(2021) Chiara Fallerini et al.   HUMAN GENETICS

The triumvirate of NF-κB, inflammation and cytokine storm in COVID-19

(2021) Ali Attiq et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

A clinical case definition of post-COVID-19 condition by a Delphi consensus

(2021) Joan B Soriano et al.   LANCET INFECTIOUS DISEASES

COVID antiviral pills: what scientists still want to know

(2021) Heidi Ledford   NATURE

High expression of SARS-CoV2 viral entry-related proteins in human limbal stem cells

(2021) Yuzuru Sasamoto et al.   Ocular Surface

Mechano-inflammatory sensitivity of ACE2: Implications for the regional distribution of SARS-CoV-2 injury in the lung

(2021) Erzsébet Bartolák-Suki et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

SARS–CoV–2 Spike Impairs DNA Damage Repair and Inhibits V(D)J Recombination In Vitro

(2021) Hui Jiang et al.   Viruses-Basel

COVID-19 genetic risk variants are associated with expression of multiple genes in diverse immune cell types

(2021) Benjamin J. Schmiedel et al.   Nature Communications

SARS-CoV-2 spike protein induces inflammation via TLR2-dependent activation of the NF-κB pathway

(2021) Shahanshah Khan et al.   eLife

Differential Co-Expression Network Analysis Reveals Key Hub-High Traffic Genes as Potential Therapeutic Targets for COVID-19 Pandemic

(2021) Aliakbar Hasankhani et al.   Frontiers in Immunology

The Cross Talk Between p53 and mTOR Pathways in Response to Physiological and Genotoxic Stresses

(2021) Danrui Cui et al.   Frontiers in Cell and Developmental Biology

A Different Facet of p53 Function: Regulation of Immunity and Inflammation During Tumor Development

(2021) Di Shi et al.   Frontiers in Cell and Developmental Biology

The Basally Expressed p53-Mediated Homeostatic Function

(2021) Isha Nagpal et al.   Frontiers in Cell and Developmental Biology

Short-term and Long-term Rates of Postacute Sequelae of SARS-CoV-2 Infection

(2021) Destin Groff et al.   JAMA Network Open

Protective Role of Combined Polyphenols and Micronutrients against Influenza A Virus and SARS-CoV-2 Infection In Vitro

(2021) Marta De Angelis et al.   Biomedicines

MEDTEC Students against Coronavirus: Investigating the Role of Hemostatic Genes in the Predisposition to COVID-19 Severity

(2021) Claudio Cappadona et al.   Journal of Personalized Medicine

“Bridging the Gap” Everything that Could Have Been Avoided If We Had Applied Gender Medicine, Pharmacogenetics and Personalized Medicine in the Gender-Omics and Sex-Omics Era

(2020) Donato Gemmati et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

P53 and The Immune Response: 40 Years of Exploration—A Plan for the Future

(2020) Arnold J. Levine   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

(2020) Chaolin Huang et al.   LANCET

Oxidative Stress as Key Player in Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) Infection

(2020) Livan Delgado-Roche et al.   ARCHIVES OF MEDICAL RESEARCH

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

Decreased Mortality of COVID-19 with Renin-Angiotensin-Aldosterone System Inhibitors Therapy in Patients with Hypertension: A Meta-Analysis

(2020) Xiaoming Guo et al.   HYPERTENSION

COVID-19: A New Virus, but a Familiar Receptor and Cytokine Release Syndrome

(2020) Toshio Hirano et al.   IMMUNITY

P53: A Guardian of Immunity Becomes Its Saboteur through Mutation

(2020) Arjelle Decasa Agupitan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

COVID-19 and Individual Genetic Susceptibility/Receptivity: Role of ACE1/ACE2 Genes, Immunity, Inflammation and Coagulation. Might the Double X-Chromosome in Females Be Protective against SARS-CoV-2 Compared to the Single X-Chromosome in Males?

(2020) Donato Gemmati et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A guideline for homology modeling of the proteins from newly discovered betacoronavirus, 2019 novel coronavirus (2019‐nCoV)

(2020) Shengjie Dong et al.   JOURNAL OF MEDICAL VIROLOGY

Angiotensin‐converting enzyme‐2 ( ACE2 ), SARS‐CoV ‐2 and pathophysiology of coronavirus disease 2019 ( COVID ‐19)

(2020) Arno R. Bourgonje et al.   JOURNAL OF PATHOLOGY

Renin–Angiotensin–Aldosterone System Blockers and the Risk of Covid-19

(2020) Giuseppe Mancia et al.   NEW ENGLAND JOURNAL OF MEDICINE

Renin–Angiotensin–Aldosterone System Inhibitors and Risk of Covid-19

(2020) Harmony R. Reynolds et al.   NEW ENGLAND JOURNAL OF MEDICINE

Strengthening the Immune System and Reducing Inflammation and Oxidative Stress through Diet and Nutrition: Considerations during the COVID-19 Crisis

(2020) Mohammed Iddir et al.   Nutrients

Innate Immune Signaling and Proteolytic Pathways in the Resolution or Exacerbation of SARS-CoV-2 in Covid-19: Key Therapeutic Targets?

(2020) Jean-Michel Sallenave et al.   Frontiers in Immunology

ACE2 and TMPRSS2 variants and expression as candidates to sex and country differences in COVID-19 severity in Italy

(2020) Rosanna Asselta et al.   Aging-US

Single-cell RNA Expression Profiling of ACE2, The Receptor of SARS-CoV-2

(2020) Yu Zhao et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

ACE2 gene variants may underlie interindividual variability and susceptibility to COVID-19 in the Italian population

(2020) Elisa Benetti et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Potent neutralizing antibodies against multiple epitopes on SARS-CoV-2 spike

(2020) Lihong Liu et al.   NATURE

Genomewide Association Study of Severe Covid-19 with Respiratory Failure

(2020) David Ellinghaus et al.   NEW ENGLAND JOURNAL OF MEDICINE

Liu Shen capsule shows antiviral and anti-inflammatory abilities against novel coronavirus SARS-CoV-2 via suppression of NF-κB signaling pathway

(2020) Qinhai Ma et al.   PHARMACOLOGICAL RESEARCH

Phillyrin (KD-1) exerts anti-viral and anti-inflammatory activities against novel coronavirus (SARS-CoV-2) and human coronavirus 229E (HCoV-229E) by suppressing the nuclear factor kappa B (NF-κB) signaling pathway

(2020) Qinhai Ma et al.   PHYTOMEDICINE

Antibody cocktail to SARS-CoV-2 spike protein prevents rapid mutational escape seen with individual antibodies

(2020) Alina Baum et al.   SCIENCE

Type I and III interferons disrupt lung epithelial repair during recovery from viral infection

(2020) Jack Major et al.   SCIENCE

Rationale for Considering Oral Idasanutlin as a Therapeutic Option for COVID-19 Patients

(2020) Giorgio Zauli et al.   Frontiers in Pharmacology

Traditional Herbal Remedies with a Multifunctional Therapeutic Approach as an Implication in COVID-19 Associated Co-Infections

(2020) Aprajita Tiwari Pandey et al.   Coatings

Oncogenic pathways activated by pro-inflammatory cytokines promote mutant p53 stability: clue for novel anticancer therapies

(2020) Gabriella D’Orazi et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Unpuzzling COVID-19: tissue-related signaling pathways associated with SARS-CoV-2 infection and transmission

(2020) Daniella S. Battagello et al.   CLINICAL SCIENCE

SARS-CoV-2 infections and COVID-19 mortalities strongly correlate with ACE1 I/D genotype

(2020) Naoki Yamamoto et al.   GENE

The importance of vitamin d metabolism as a potential prophylactic, immunoregulatory and neuroprotective treatment for COVID-19

(2020) Yi Xu et al.   Journal of Translational Medicine

The major genetic risk factor for severe COVID-19 is inherited from Neanderthals

(2020) Hugo Zeberg et al.   NATURE

S2 subunit of SARS-nCoV-2 interacts with tumor suppressor protein p53 and BRCA: an in silico study

(2020) Nishant Singh et al.   Translational Oncology

Can data from paediatric cohorts solve the COVID-19 puzzle?

(2020) Lien Anh Ha Do et al.   PLoS Pathogens

Genetic Hypothesis and Pharmacogenetics Side of Renin-Angiotensin-System in COVID-19

(2020) Donato Gemmati et al.   Genes

Spatial and temporal roles of SARS‐CoV PL pro —A snapshot

(2020) Shaomin Yan et al.   FASEB JOURNAL

Association of Sex, Age, and Comorbidities with Mortality in COVID-19 Patients: A Systematic Review and Meta-Analysis

(2020) Mohitosh Biswas et al.   INTERVIROLOGY

Anti–coronavirus disease 2019 (COVID‐19) targets and mechanisms of puerarin

(2020) Xingyue Qin et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Genetic associations between genes in the renin-angiotensin-aldosterone system and renal disease: a systematic review and meta-analysis

(2019) Laura Jane Smyth et al.   BMJ Open

The combination of ACE I/D and ACE2 G8790A polymorphisms revels susceptibility to hypertension: A genetic association study in Brazilian patients

(2019) Denise S. Pinheiro et al.   PLoS One

Maternal Haplotypes in DHFR Promoter and MTHFR Gene in Tuning Childhood Acute Lymphoblastic Leukemia Onset-Latency: Genetic/Epigenetic Mother/Child Dyad Study (GEMCDS)

(2019) Veronica Tisato et al.   Genes

Inhibition of Noncanonical Mouse Double Minute 2 Homolog Abrogates Ocular Inflammation through NF-κB Suppression

(2018) Yan Fan et al.   AMERICAN JOURNAL OF PATHOLOGY

Role of p53/NF-κB functional balance in respiratory syncytial virus-induced inflammation response

(2018) Daniela Machado et al.   JOURNAL OF GENERAL VIROLOGY

Gene-gene interactions among coding genes of iron-homeostasis proteins and APOE-alleles in cognitive impairment diseases

(2018) Veronica Tisato et al.   PLoS One

Small-molecule MDM2 antagonists attenuate the senescence-associated secretory phenotype

(2018) Christopher D. Wiley et al.   Scientific Reports

MDM2/X inhibitors under clinical evaluation: perspectives for the management of hematological malignancies and pediatric cancer

(2017) Veronica Tisato et al.   Journal of Hematology & Oncology

Sex-Based Differences in Susceptibility to Severe Acute Respiratory Syndrome Coronavirus Infection

(2017) Rudragouda Channappanavar et al.   JOURNAL OF IMMUNOLOGY

TheACE2G8790A Polymorphism: Involvement in Type 2 Diabetes Mellitus Combined with Cerebral Stroke

(2016) Yan-Hui Wu et al.   JOURNAL OF CLINICAL LABORATORY ANALYSIS

p53 down-regulates SARS coronavirus replication and is targeted by the SARS-unique domain and PLprovia E3 ubiquitin ligase RCHY1

(2016) Yue Ma-Lauer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Age-associated changes in basal NF-κB function in human CD4+ T lymphocytes via dysregulation of PI3 kinase

(2016) Arsun Bektas et al.   Aging-US

The Active Metabolite of Warfarin (3'-Hydroxywarfarin) and Correlation with INR, Warfarin and Drug Weekly Dosage in Patients under Oral Anticoagulant Therapy: A Pharmacogenetics Study

(2016) Donato Gemmati et al.   PLoS One

Differential regulation of angiotensin converting enzyme 2 and nuclear factor-κB by angiotensin II receptor subtypes in type 2 diabetic kidney

(2015) Anuradha Pandey et al.   BIOCHIMIE

Human intestine luminal ACE2 and amino acid transporter expression increased by ACE-inhibitors

(2014) Raphael N. Vuille-dit-Bille et al.   AMINO ACIDS

A genetic variant inSLC6A20is associated with Type 2 diabetes in white-European and Chinese populations

(2014) Y. Ling et al.   DIABETIC MEDICINE

The association between angiotensin-converting enzyme 2 polymorphisms and essential hypertension risk: A meta-analysis involving 14,122 patients

(2014) Mei Yang et al.   JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM

Influence of ABO genotype and phenotype on angiotensin-converting enzyme plasma activity

(2014) Patricia Gassó et al.   JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM

Quantitative Variation in Plasma Angiotensin-I Converting Enzyme Activity Shows Allelic Heterogeneity in theABOBlood Group Locus

(2013) Chikashi Terao et al.   ANNALS OF HUMAN GENETICS

A combinatorial approach of Proteomics and Systems Biology in unravelling the mechanisms of acute kidney injury (AKI): involvement of NMDA receptor GRIN1 in murine AKI

(2013) Holger Husi et al.   BMC Systems Biology

Sex and inflammation in respiratory diseases: a clinical viewpoint

(2013) Georges J Casimir et al.   Biology of Sex Differences

Meta analysis of angiotensin-converting enzyme I/D polymorphism as a risk factor for preeclampsia in Chinese women

(2012) W.G. Zhong et al.   GENETICS AND MOLECULAR RESEARCH

Lack of Association of ACE2 G8790A Gene Mutation with Essential Hypertension in the Chinese Population: A Meta-Analysis Involving 5260 Subjects

(2012) Yan-yan Li   Frontiers in Physiology

Tissue-specific apoptotic effects of the p53 codon 72 polymorphism in a mouse model

(2011) Gregory A. Azzam et al.   CELL CYCLE

The Codon 72 Polymorphism of p53 Regulates Interaction with NF- B and Transactivation of Genes Involved in Immunity and Inflammation

(2011) A. K. Frank et al.   MOLECULAR AND CELLULAR BIOLOGY

A genome-wide association study identifies new loci for ACE activity: potential implications for response to ACE inhibitor

(2010) C-M Chung et al.   PHARMACOGENOMICS JOURNAL

Signaling mechanisms of angiotensin II in regulating vascular senescence

(2009) Li-Juan Min et al.   AGEING RESEARCH REVIEWS

DHFR 19-bp insertion/deletion polymorphism and MTHFR C677T in adult acute lymphoblastic leukaemia: Is the risk reduction due to intracellular folate unbalancing?

(2009) Donato Gemmati et al.   AMERICAN JOURNAL OF HEMATOLOGY

The IKK Complex, a Central Regulator of NF- B Activation

(2009) A. Israel   Cold Spring Harbor Perspectives in Biology

53BP1 facilitates long-range DNA end-joining during V(D)J recombination

(2008) Simone Difilippantonio et al.   NATURE