The Cross Talk Between p53 and mTOR Pathways in Response to Physiological and Genotoxic Stresses

Mdm2 phosphorylation by Akt regulates the p53 response to oxidative stress to promote cell proliferation and tumorigenesis

(2021) Loretah Chibaya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FBXW7 Confers Radiation Survival by Targeting p53 for Degradation

(2020) Danrui Cui et al.   Cell Reports

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

(2020) David E. Gordon et al.   NATURE

Upregulation of miR-101 during Influenza A Virus Infection Abrogates Viral Life Cycle by Targeting mTOR Pathway

(2020) Shipra Sharma et al.   Viruses-Basel

Regulation of mTORC2 Signaling

(2020) Wenxiang Fu et al.   Genes

The multiple mechanisms that regulate p53 activity and cell fate

(2019) Antonina Hafner et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Inhibition of p53 and/or AKT as a new therapeutic approach specifically targeting ALT cancers

(2019) Yuanlong Ge et al.   Protein & Cell

SCF(FBXW7)-mediated degradation of p53 promotes cell recovery after UV-induced DNA damage

(2019) María Galindo-Moreno et al.   FASEB JOURNAL

Abrogation of FBW7α-dependent p53 degradation enhances p53’s function as a tumor suppressor

(2019) Vivek Tripathi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of mTOR Signaling Enhances Maturation of Cardiomyocytes Derived from Human Induced Pluripotent Stem Cells via p53-Induced Quiescence

(2019) Jessica C. Garbern et al.   CIRCULATION

Role of p53/miR-155-5p/sirt1 loop in renal tubular injury of diabetic kidney disease

(2018) Yue Wang et al.   Journal of Translational Medicine

A Nucleolar Stress–Specific p53–miR-101 Molecular Circuit Functions as an Intrinsic Tumor-Suppressor Network

(2018) Yuko Fujiwara et al.   EBioMedicine

mTOR kinase leads to PTEN-loss-induced cellular senescence by phosphorylating p53

(2018) Seung Hee Jung et al.   ONCOGENE

Census and evaluation of p53 target genes

(2017) M Fischer   ONCOGENE

Benzyl Isothiocyanate potentiates p53 signaling and antitumor effects against breast cancer through activation of p53-LKB1 and p73-LKB1 axes

(2017) Bei Xie et al.   Scientific Reports

MicroRNA Control of p53

(2016) Juan Liu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

p53 down-regulates SARS coronavirus replication and is targeted by the SARS-unique domain and PLprovia E3 ubiquitin ligase RCHY1

(2016) Yue Ma-Lauer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms of p53 degradation

(2015) Chuck C.-K. Chao   CLINICA CHIMICA ACTA

Methylation-induced silencing of miR-34a enhances chemoresistance by directly upregulating ATG4B-induced autophagy through AMPK/mTOR pathway in prostate cancer

(2015) HAIQIU LIAO et al.   ONCOLOGY REPORTS

Transcriptional regulation of microRNA-100, −146a, and −150 genes by p53 and NFκB p65/RelA in mouse striatal STHdhQ7/ HdhQ7cells and human cervical carcinoma HeLa cells

(2015) Jayeeta Ghose et al.   RNA Biology

Targeting the mTOR-DEPTOR Pathway by CRL E3 Ubiquitin Ligases: Therapeutic Application

(2015) Yongchao Zhao et al.   NEOPLASIA

Coordinate activation of autophagy and the proteasome pathway by FoxO transcription factor

(2014) Jinghui Zhao et al.   Autophagy

A dual role of p53 in the control of autophagy

(2014) Ezgi Tasdemir et al.   Autophagy

Loss of LKB1 in high-grade endometrial carcinoma: LKB1 is a novel transcriptional target of p53

(2014) Ngai Na Co et al.   CANCER

The cytoplasmic side of p53's oncosuppressive activities

(2014) Anna Comel et al.   FEBS LETTERS

Effect of microRNA-101 on proliferation and apoptosis of human osteosarcoma cells by targeting mTOR

(2014) Song Lin et al.   Journal of Huazhong University of Science and Technology-Medical Sciences

Comprehensive analysis of microRNA-regulated protein interaction network reveals the tumor suppressive role of microRNA-149 in human hepatocellular carcinoma via targeting AKT-mTOR pathway

(2014) Yanqiong Zhang et al.   Molecular Cancer

MicroRNA-100 promotes migration and invasion through mammalian target of rapamycin in esophageal squamous cell carcinoma

(2014) NAIJIAN ZHANG et al.   ONCOLOGY REPORTS

Hypoxia-induced MIR155 is a potent autophagy inducer by targeting multiple players in the MTOR pathway

(2013) Gang Wan et al.   Autophagy

The role of ubiquitin modification in the regulation of p53

(2013) Andreas K. Hock et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Dual PI3K/mTOR Inhibitors: Does p53 Modulate Response?

(2013) O. Ekshyyan et al.   CLINICAL CANCER RESEARCH

PI3K/mTOR Inhibitor PF-04691502 Antitumor Activity Is Enhanced with Induction of Wild-Type TP53 in Human Xenograft and Murine Knockout Models of Head and Neck Cancer

(2013) A. Herzog et al.   CLINICAL CANCER RESEARCH

EEF1A2 inactivates p53 by way of PI3K/AKT/mTOR-dependent stabilization of MDM4 in hepatocellular carcinoma

(2013) Rossella Pellegrino et al.   HEPATOLOGY

MicroRNA-199a-3p Regulates Endometrial Cancer Cell Proliferation by Targeting Mammalian Target of Rapamycin (mTOR)

(2013) Dong Wu et al.   INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER

MicroRNA-99a/100 promotes apoptosis by targeting mTOR in human esophageal squamous cell carcinoma

(2013) Jian Sun et al.   MEDICAL ONCOLOGY

Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy

(2013) Peter E. Czabotar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Rapamycin Inhibits IGF-1-Mediated Up-Regulation of MDM2 and Sensitizes Cancer Cells to Chemotherapy

(2013) Wei Du et al.   PLoS One

MicroRNA-155 Promotes Autophagy to Eliminate Intracellular Mycobacteria by Targeting Rheb

(2013) Jinli Wang et al.   PLoS Pathogens

miRNA-101: A potential target for tumor therapy

(2012) Ting Gui et al.   Cancer Epidemiology

miRNA-100 Inhibits Human Bladder Urothelial Carcinogenesis by Directly Targeting mTOR

(2012) C. Xu et al.   MOLECULAR CANCER THERAPEUTICS

MicroRNA-149 Inhibits Proliferation and Cell Cycle Progression through the Targeting of ZBTB2 in Human Gastric Cancer

(2012) Ying Wang et al.   PLoS One

p53-Facilitated miR-199a-3p Regulates Somatic Cell Reprogramming

(2012) Jiaxu Wang et al.   STEM CELLS

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

The oncogenic and tumour suppressive roles of microRNAs in cancer and apoptosis

(2011) Sadegh Babashah et al.   EUROPEAN JOURNAL OF CANCER

DEPTOR, an mTOR Inhibitor, Is a Physiological Substrate of SCFβTrCP E3 Ubiquitin Ligase and Regulates Survival and Autophagy

(2011) Yongchao Zhao et al.   MOLECULAR CELL

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

MiR-145 directly targets p70S6K1 in cancer cells to inhibit tumor growth and angiogenesis

(2011) Qing Xu et al.   NUCLEIC ACIDS RESEARCH

MicroRNA-149*, a p53-responsive microRNA, functions as an oncogenic regulator in human melanoma

(2011) L. Jin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphoproteomic Analysis Identifies Grb10 as an mTORC1 Substrate That Negatively Regulates Insulin Signaling

(2011) Y. Yu et al.   SCIENCE

The mTOR-Regulated Phosphoproteome Reveals a Mechanism of mTORC1-Mediated Inhibition of Growth Factor Signaling

(2011) P. P. Hsu et al.   SCIENCE

Role of p53 in Cell Death and Human Cancers

(2011) Toshinori Ozaki et al.   Cancers

Structural Analysis and Functional Implications of the Negative mTORC1 Regulator REDD1,

(2010) Silvia Vega-Rubin-de-Celis et al.   BIOCHEMISTRY

MiR-199a-3p Regulates mTOR and c-Met to Influence the Doxorubicin Sensitivity of Human Hepatocarcinoma Cells

(2010) Francesca Fornari et al.   CANCER RESEARCH

Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

(2010) Yasemin Sancak et al.   CELL

MicroRNA: Biogenesis, Function and Role in Cancer

(2010) Leigh-Ann MacFarlane et al.   CURRENT GENOMICS

S6K1 is a multifaceted regulator of Mdm2 that connects nutrient status and DNA damage response

(2010) Keng Po Lai et al.   EMBO JOURNAL

Increased Lipogenesis, Induced by AKT-mTORC1-RPS6 Signaling, Promotes Development of Human Hepatocellular Carcinoma

(2010) Diego F. Calvisi et al.   GASTROENTEROLOGY

Regulation of the mTOR Complex 1 Pathway by Nutrients, Growth Factors, and Stress

(2010) Shomit Sengupta et al.   MOLECULAR CELL

Blinded by the Light: The Growing Complexity of p53

(2009) Karen H. Vousden et al.   CELL

DEPTOR Is an mTOR Inhibitor Frequently Overexpressed in Multiple Myeloma Cells and Required for Their Survival

(2009) Timothy R. Peterson et al.   CELL

Modes of p53 Regulation

(2009) Jan-Philipp Kruse et al.   CELL

Common mechanisms of PIKK regulation

(2009) Courtney A. Lovejoy et al.   DNA REPAIR

Raptor Binds the SAIN (Shc and IRS-1 NPXY Binding) Domain of Insulin Receptor Substrate-1 (IRS-1) and Regulates the Phosphorylation of IRS-1 at Ser-636/639 by mTOR

(2009) Alexandros Tzatsos   JOURNAL OF BIOLOGICAL CHEMISTRY

Modulation of microRNA processing by p53

(2009) Hiroshi I. Suzuki et al.   NATURE

MdmX is a substrate for the deubiquitinating enzyme USP2a

(2009) N Allende-Vega et al.   ONCOGENE

p53 represses c-Myc through induction of the tumor suppressor miR-145

(2009) M. Sachdeva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The mitochondrial p53 pathway

(2008) Angelina V. Vaseva et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

p53 Target Genes Sestrin1 and Sestrin2 Connect Genotoxic Stress and mTOR Signaling

(2008) Andrei V. Budanov et al.   CELL

Hypoxia regulates TSC1/2 mTOR signaling and tumor suppression through REDD1-mediated 14 3 3 shuttling

(2008) M. P. DeYoung et al.   GENES & DEVELOPMENT

Phosphorylation of MDMX Mediated by Akt Leads to Stabilization and Induces 14-3-3 Binding

(2008) Vanessa Lopez-Pajares et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

(2008) Dana M. Gwinn et al.   MOLECULAR CELL

Regulation of autophagy by cytoplasmic p53

(2008) Ezgi Tasdemir et al.   NATURE CELL BIOLOGY

The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

(2008) Y. Sancak et al.   SCIENCE