ROS-mediated amplification of AKT/mTOR signalling pathway leads to myeloproliferative syndrome in Foxo3−/− mice

Novel mutations in the inhibitory adaptor protein LNK drive JAK-STAT signaling in patients with myeloproliferative neoplasms

(2010) S. T. Oh et al.   BLOOD

Lnk constrains myeloproliferative diseases in mice

(2010) Alexey Bersenev et al.   JOURNAL OF CLINICAL INVESTIGATION

TGF-β–FOXO signalling maintains leukaemia-initiating cells in chronic myeloid leukaemia

(2010) Kazuhito Naka et al.   NATURE

Regulation of Lifespan, Metabolism, and Stress Responses by the Drosophila SH2B Protein, Lnk

(2010) Cathy Slack et al.   PLoS Genetics

Transcription factor Foxo3 controls the magnitude of T cell immune responses by modulating the function of dendritic cells

(2009) Anne S Dejean et al.   NATURE IMMUNOLOGY

The Drosophila SH2B Family Adaptor Lnk Acts in Parallel to Chico in the Insulin Signaling Pathway

(2009) Christian Werz et al.   PLoS Genetics

Oxidative Stress in the Regulation of Normal and Neoplastic Hematopoiesis

(2008) Saghi Ghaffari   ANTIOXIDANTS & REDOX SIGNALING

FoxO3a regulates hematopoietic homeostasis through a negative feedback pathway in conditions of stress or aging

(2008) K. Miyamoto et al.   BLOOD

Myeloproliferative disorders

(2008) R. L. Levine et al.   BLOOD

Foxo3 Is Essential for the Regulation of Ataxia Telangiectasia Mutated and Oxidative Stress-mediated Homeostasis of Hematopoietic Stem Cells

(2008) Safak Yalcin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TSC–mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species

(2008) Chong Chen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Functional interaction between FOXO3a and ATM regulates DNA damage response

(2008) Wen-Bin Tsai et al.   NATURE CELL BIOLOGY