Article
Biochemistry & Molecular Biology
Hai Vu Nguyen, Cassandra J. Vandenberg, Mikara R. Robati, Ashley P. Ng, Suzanne Cory
Summary: The importance of c-MYC in regulating lymphopoiesis and promoting lymphomagenesis is well-established. Far less appreciated is the vital supporting role of MYC's relative MNT. Using genetic deletion experiments in mice, the researchers demonstrate that loss of MNT leads to enhanced apoptosis and reduces the development of T lymphomas in both normal and irradiated mice. These findings suggest that targeting MNT could be a promising strategy for treating T and B lymphoid malignancies.
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Biology
Nina Tanaskovic, Mattia Dalsass, Marco Filipuzzi, Giorgia Ceccotti, Alessandro Verrecchia, Paola Nicoli, Mirko Doni, Daniela Olivero, Diego Pasini, Haruhiko Koseki, Arianna Sabo, Andrea Bisso, Bruno Amati
Summary: Loss of Mga and PRC1.6 has no significant impact on Myc-induced lymphomagenesis in transgenic mice, but loss of Pcgf6 accelerates tumor formation. This suggests an unexpected tumor suppressor activity of Pcgf6 independent of Mga and PRC1.6.
LIFE SCIENCE ALLIANCE
(2022)
Article
Multidisciplinary Sciences
Wei Li, Junjie Kou, Zhenxi Zhang, Haoyue Li, Li Li, Wenjing Du
Summary: Research reveals that MYC gene plays an important role in driving T cell lymphomagenesis, and malic enzyme 2 (ME2), an enzyme associated with glutamine metabolism, is essential in this process. By establishing a CD4-Cre; Myc flox/+ transgenic mouse model, it is found that knockout of Me2 significantly suppresses T cell lymphomagenesis. Mechanistically, MYC up-regulates ME2 to maintain redox homeostasis, while ME2 stimulates mTORC1 activity through adjusting glutamine metabolism, promoting MYC translation. Overall, these findings highlight the crucial role of ME2 in MYC-driven T cell lymphomagenesis and suggest the MYC-ME2 circuit as a potential target for TCL therapy.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Biology
Elisa Redl, Raheleh Sheibani-Tezerji, Crhistian de Jesus Cardona, Patricia Hamminger, Gerald Timelthaler, Melanie Rosalia Hassler, Masa Zrimsek, Sabine Lagger, Thomas Dillinger, Lorena Hofbauer, Kristina Draganic, Andreas Tiefenbacher, Michael Kothmayer, Charles H. Dietz, Bernard H. Ramsahoye, Lukas Kenner, Christoph Bock, Christian Seiser, Wilfried Ellmeier, Gabriele Schweikert, Gerda Egger
Summary: Malignant transformation relies on genetic and epigenetic events leading to dysregulated gene expression and chromatin changes. A lymphoma model reveals that transformation shifts thymic cell populations to an undifferentiated immunophenotype, accompanied by induction of the MYC-NOTCH1 axis and deregulation of key epigenetic enzymes. The faithful maintenance of tumor-specific methylation through DNMT1 is critical for sustained proliferation and tumorigenesis, even in the presence of oncogenic signaling from NPM-ALK.
LIFE SCIENCE ALLIANCE
(2021)
Article
Oncology
Bandish B. Kapadia, Anirban Roychowdhury, Forum Kayastha, Nahid Nanaji, Ronald B. Gartenhaus
Summary: In this study, the researchers found that PARK2 ubiquitinates eIF4B and regulates overall protein translational activity, which is negatively regulated by mTORC1 signaling. Phosphorylation of PARK2 reduces its ubiquitination activity, thereby hindering its tumor suppressor effect on eIF4B's stability.
MOLECULAR CANCER RESEARCH
(2022)
Editorial Material
Biochemistry & Molecular Biology
Chi Dang
Summary: The study shows that inhibiting RNA helicase DDX3X can alleviate MYC-induced proteotoxic stress, preventing tumor initiation. In male MYC-driven lymphomas, the homologous helicase DDX3Y, encoded on the Y chromosome, is subsequently induced to promote disease progression.
Article
Biochemistry & Molecular Biology
Brian J. Leibowitz, Guangyi Zhao, Wenxin Xia, Yuhan Wang, Hang Ruan, Lin Zhang, Jian Yu
Summary: In this study, the researchers discovered that mTOR inhibition can effectively suppress the formation of intestinal polyps, reverse established polyps, and prolong the lifespan of APC(Min/+) mice. Everolimus reduces the levels of p-4EBP1, p-S6, and Myc in the polyps and induces apoptosis of cells with activated beta-catenin. This cell death is accompanied by ER stress, activation of the extrinsic apoptotic pathway, innate immune cell recruitment, and subsequent T-cell infiltration.
Article
Immunology
Yavuz F. Yazicioglu, Eros Marin, Ciaran Sandhu, Silvia Galiani, Iwan G. A. Raza, Mohammad Ali, Barbara Kronsteiner, Ewoud B. Compeer, Moustafa Attar, Susanna J. Dunachie, Michael L. Dustin, Alexander J. Clarke
Summary: Clarke and colleagues discovered that germinal center B cells have dynamic mitochondria regulated by the transcription factor TFAM. TFAM helps the B cells enter the germinal center reaction by modulating cellular motility. Understanding this mechanism is important as germinal center B cells undergo rapid proliferation in a hypoxic microenvironment.
Article
Immunology
Wenjie Zhang, Guangyan Zhangyuan, Fei Wang, Kangpeng Jin, Haiyuan Shen, Liansheng Zhang, Xiang Yuan, Jincheng Wang, Haitian Zhang, Weiwei Yu, Ruyi Huang, Xiaoliang Xu, Yin Yin, Guisheng Zhong, Anning Lin, Beicheng Sun
Summary: Chronic inflammation in hepatocellular carcinoma (HCC) is influenced by the zinc finger transcription factor Miz1, which restricts hepatocyte-driven inflammation through sequestration of the oncoprotein metadherin (MTDH) and prevention of NF-kappa B activation. Miz1 acts as a tumor suppressor by preventing a subset of hepatocytes from promoting inflammation in HCC, leading to disease recurrence and poor prognosis in patients.
Review
Biochemistry & Molecular Biology
Marika Scafuro, Lucia Capasso, Vincenzo Carafa, Lucia Altucci, Angela Nebbioso
Summary: MYC is a proto-oncogene that regulates numerous genes involved in cellular functions. Dysregulation of MYC leads to activation of gene expression and increased protein stability, contributing to malignant growth. Recent studies have shown that MYC acts as a key regulator of cancer genome and epigenome, modulating gene expression and altering chromatin structure. Novel therapeutic strategies targeting MYC and its epigenetic cofactors are being explored.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Margaret A. Potts, Shinsuke Mizutani, Alexandra L. Garnham, Connie S. N. Li Wai Suen, Andrew J. Kueh, Lin Tai, Martin Pal, Andreas Strasser, Marco J. Herold
Summary: Many lymphoid malignancies result from abnormal c-MYC expression along with other genetic abnormalities. While many of these genetic abnormalities have been discovered, there may still be others that have not been investigated. In this study, TFAP4 was identified as a suppressor of c-MYC driven lymphoma development. Deletion of TFAP4 accelerated lymphoma development and blocked differentiation during early B cell development.
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Biochemistry & Molecular Biology
Yu Pan, Wanzhen Li, Zhu Deng, Yihao Sun, Xianjue Ma, Ruijuan Liang, Xiaowei Guo, Ying Sun, Wenzhe Li, Renjie Jiao, Lei Xue
Summary: Despite natural selection, same-sex sexual attraction is common across animals. This study reveals that the proto-oncogene Myc inhibits male-male courtship in fruit flies by acting in dopaminergic neurons. This finding highlights the crucial roles of genetic factors in inter-male sexual behavior.
Review
Oncology
Barbara Vannata, Maria Cristina Pirosa, Francesco Bertoni, Davide Rossi, Emanuele Zucca
Summary: This review summarizes the evidence for a causal relationship between bacterial infections and the development of malignant lymphomas, particularly extranodal marginal zone lymphoma. Multiple microorganisms have been associated with specific lymphoma sites, but the evidence is not always definitive. Lymphoma growth is believed to be a result of continuous antigenic stimulation induced by chronic infection. Eradicating associated chronic infections may lead to sustained lymphoma regression. Additionally, preventing or treating predisposing infections may reduce lymphoma incidence.
CURRENT OPINION IN ONCOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Bolin Chen, Chengcheng Dong, Fang Wang, Jiacai Wu
Summary: The novel inhibitor of histone acetyltransferase repressor (NIR) has been found to be associated with poor prognosis in breast cancer patients. Knockdown of NIR suppressed proliferation of breast cancer cells by enhancing FOXO3 transcription. The interaction between NIR and EZH2 may play a crucial role in switching the H3K27me3 and H3K27ac marks at the FOXO3 promoter in breast cancer cells, suggesting a potential therapeutic target.
ONCOTARGETS AND THERAPY
(2021)
Article
Oncology
Shouhei Miyagi, Takahiro Watanabe, Yuya Hara, Masataka Arata, Md. Kamal Uddin, Keisuke Mantoku, Ken Sago, Yusuke Yanagi, Takeshi Suzuki, H. M. Abdullah Al Masud, Jun-ichi Kawada, Shigeo Nakamura, Yasuyuki Miyake, Yoshitaka Sato, Takayuki Murata, Hiroshi Kimura
Summary: The STING inhibitor C-176 suppresses EBV-induced transformation in peripheral blood mononuclear cells, prolongs survival, and reduces tumor formation. Even without direct contact between B cells and T cells, the STING inhibitor can lower the transformation activity of EBV through intercellular communication.
Meeting Abstract
Oncology
Cassandra Vandenberg, Suzanne Cory, Rebecca Bilardi, Natasha Anstee, Phillipe Bouillet, Andreas Strasser
CLINICAL CANCER RESEARCH
(2015)
Editorial Material
Immunology
Suzanne Cory
JOURNAL OF IMMUNOLOGY
(2015)
Article
Biochemistry & Molecular Biology
Natasha S. Anstee, Cassandra J. Vandenberg, Kirsteen J. Campbell, Peter D. Hughes, Lorraine A. O'Reilly, Suzanne Cory
CELL DEATH AND DIFFERENTIATION
(2017)
Article
Cell Biology
Rebecca A. Bilardi, Natasha S. Anstee, Stefan P. Glaser, Mikara Robati, Cassandra J. Vandenberg, Suzanne Cory
CELL DEATH & DISEASE
(2016)
Article
Multidisciplinary Sciences
Seth A. Cory, Jonathan G. Van Vranken, Edward J. Brignole, Shachin Patra, Dennis R. Winge, Catherine L. Drennan, Jared Rutter, David P. Barondeau
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2017)
Article
Biochemistry & Molecular Biology
Mark Mensink, Natasha S. Anstee, Mikara Robati, Robyn L. Schenk, Marco J. Herold, Suzanne Cory, Cassandra J. Vandenberg
CELL DEATH AND DIFFERENTIATION
(2018)
Article
Biochemistry & Molecular Biology
Selma Tuzlak, Manuel D. Haschka, Anna-Maria Mokina, Thomas Ruelicke, Suzanne Cory, Verena Labi, Andreas Villunger
Article
Biochemistry & Molecular Biology
Natasha S. Anstee, Rebecca A. Bilardi, Ashley P. Ng, Zhen Xu, Mikara Robati, Cassandra J. Vandenberg, Suzanne Cory
CELL DEATH AND DIFFERENTIATION
(2019)
Editorial Material
Multidisciplinary Sciences
Suzanne Cory
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2018)
Article
Hematology
Hai Vu Nguyen, Cassandra J. Vandenberg, Ashley P. Ng, Mikara R. Robati, Natasha S. Anstee, Joel Rimes, Edwin D. Hawkins, Suzanne Cory
Article
Biochemistry & Molecular Biology
Kirsteen J. Campbell, Cassandra J. Vandenberg, Natasha S. Anstee, Peter J. Hurlin, Suzanne Cory
CELL DEATH AND DIFFERENTIATION
(2017)
Article
Biochemistry & Molecular Biology
Emma M. Carrington, Yifan Zhan, Jamie L. Brady, Jian-Guo Zhang, Robyn M. Sutherland, Natasha S. Anstee, Robyn L. Schenk, Ingela B. Vikstrom, Rebecca B. Delconte, David Segal, Nicholas D. Huntington, Philippe Bouillet, David M. Tarlinton, David C. S. Huang, Andreas Strasser, Suzanne Cory, Marco J. Herold, Andrew M. Lew
CELL DEATH AND DIFFERENTIATION
(2017)
Review
Oncology
Suzanne Cory, Andrew W. Roberts, Peter M. Colman, Jerry M. Adams
Article
Biochemistry & Molecular Biology
Jerry M. Adams, Suzanne Cory
CELL DEATH AND DIFFERENTIATION
(2018)