The physiological and pathophysiological roles of the autophagy lysosomal system in the conventional aqueous humor outflow pathway: More than cellular clean up

Autophagy, tissue repair, and fibrosis: a delicate balance

(2021) Francis Migneault et al.   MATRIX BIOLOGY

Autophagy stimulation reduces ocular hypertension in a murine glaucoma model via autophagic degradation of mutant myocilin

(2021) Ramesh B. Kasetti et al.   JCI Insight

The Role of Autophagy in Eye Diseases

(2021) José A. Fernández-Albarral et al.   Life-Basel

Primary cilia and the reciprocal activation of AKT and SMAD2/3 regulate stretch-induced autophagy in trabecular meshwork cells

(2021) Myoung Sup Shim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quantitative trait locus mapping identifies the Gpnmb gene as a modifier of mouse macrophage lysosome function

(2021) Peggy Robinet et al.   Scientific Reports

Dexamethasone Downregulates Autophagy through Accelerated Turn-Over of the Ulk-1 Complex in a Trabecular Meshwork Cells Strain: Insights on Steroid-Induced Glaucoma Pathogenesis

(2021) Diego Sbardella et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Links between autophagy and tissue mechanics

(2021) Aurore Claude-Taupin et al.   JOURNAL OF CELL SCIENCE

Glaucoma in mucopolysaccharidoses

(2021) Weijing Kong et al.   Orphanet Journal of Rare Diseases

Cathepsin K Regulates Intraocular Pressure by Modulating Extracellular Matrix Remodeling and Actin-Bundling in the Trabecular Meshwork Outflow Pathway

(2021) Avinash Soundararajan et al.   Cells

Organelle-specific autophagy in inflammatory diseases: a potential therapeutic target underlying the quality control of multiple organelles

(2020) Ren-Qi Yao et al.   Autophagy

Primary cilium-dependent autophagy drafts PIK3C2A to generate PtdIns3P in response to shear stress

(2020) Asma Boukhalfa et al.   Autophagy

mTOR at the nexus of nutrition, growth, ageing and disease

(2020) Grace Y. Liu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Autophagy in metabolic syndrome: breaking the wheel by targeting the renin–angiotensin system

(2020) Kalhara R. Menikdiwela et al.   Cell Death & Disease

Anterior Chamber Angles in Different Types of Mucopolysaccharidoses

(2020) Jia-Rong Zhang et al.   AMERICAN JOURNAL OF OPHTHALMOLOGY

Roles of Autophagy in Oxidative Stress

(2020) Hyeong Rok Yun et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A current view of molecular dissection in autophagy machinery

(2020) Md. Abdul Alim Al-Bari   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Shear Stress in Schlemm’s Canal as a Sensor of Intraocular Pressure

(2020) Fiona McDonnell et al.   Scientific Reports

Optogenetic stimulation of phosphoinositides reveals a critical role of primary cilia in eye pressure regulation

(2020) Philipp P. Prosseda et al.   Science Advances

Vascular autophagy in health and disease

(2020) William E. Hughes et al.   BASIC RESEARCH IN CARDIOLOGY

Progress in retinal and eye research normal and glaucomatous outflow regulation

(2020) Ted S. Acott et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Protective Effects of Rapamycin on Trabecular Meshwork Cells in Glucocorticoid-Induced Glaucoma Mice

(2020) Xiaolu Zhu et al.   Frontiers in Pharmacology

Fluid flow-induced shear stress controls the metabolism of proximal tubule kidney epithelial cells through primary cilium-dependent lipophagy and mitochondrial biogenesis

(2020) Caterina Miceli et al.   Autophagy

Autophagy in Human Diseases

(2020) Noboru Mizushima et al.   NEW ENGLAND JOURNAL OF MEDICINE

Piezo1 channels mediate trabecular meshwork mechanotransduction and promote aqueous fluid outflow

(2020) Oleg Yarishkin et al.   JOURNAL OF PHYSIOLOGY-LONDON

Cathepsin B Localizes in the Caveolae and Participates in the Proteolytic Cascade in Trabecular Meshwork Cells. Potential New Drug Target for the Treatment of Glaucoma

(2020) April Nettesheim et al.   Journal of Clinical Medicine

Autophagy in the Regulation of Tissue Differentiation and Homeostasis

(2020) Cristiana Perrotta et al.   Frontiers in Cell and Developmental Biology

Aqueous outflow regulation – 21st century concepts

(2020) Murray Johnstone et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Cysteine Cathepsins and their Extracellular Roles: Shaping the Microenvironment

(2019) Eva Vidak et al.   Cells

A model of the oscillatory mechanical forces in the conventional outflow pathway

(2019) Joseph M. Sherwood et al.   Journal of the Royal Society Interface

Watch What You (Self-) Eat: Autophagic Mechanisms that Modulate Metabolism

(2019) Vikramjit Lahiri et al.   Cell Metabolism

Emerging Role of the Nucleolar Stress Response in Autophagy

(2019) Astrid S. Pfister   Frontiers in Cellular Neuroscience

Lipid-dependent Akt-ivity: where, when, and how

(2019) Katharina M. Siess et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The autophagic protein LC3 translocates to the nucleus and localizes in the nucleolus associated to NUFIP1 in response to cyclic mechanical stress

(2019) Myoung Sup Shim et al.   Autophagy

SQSTM1/p62 and PPARGC1A/PGC-1alpha at the interface of autophagy and vascular senescence

(2019) Gloria Salazar et al.   Autophagy

The Nucleolus as a Proteostasis Regulator

(2019) Fatima Amer-Sarsour et al.   TRENDS IN CELL BIOLOGY

Ophthalmological Findings in Mucopolysaccharidoses

(2019) Shizuka Tomatsu et al.   Journal of Clinical Medicine

Mechanisms of Autophagy in Metabolic Stress Response

(2019) Angelina S. Gross et al.   JOURNAL OF MOLECULAR BIOLOGY

Autophagosome Biogenesis Machinery

(2019) Simon A. Walker et al.   JOURNAL OF MOLECULAR BIOLOGY

Transcriptome analysis reveals autophagy as regulator of TGFβ/Smad-induced fibrogenesis in trabecular meshwork cells

(2019) April Nettesheim et al.   Scientific Reports

Local synthesis of hepcidin in the anterior segment of the eye: A novel observation with physiological and pathological implications

(2019) Ajay Ashok et al.   EXPERIMENTAL EYE RESEARCH

Autophagy and Age-Related Eye Diseases

(2019) Xue Yang et al.   Biomed Research International

The ATG conjugation systems in autophagy

(2019) Noboru Mizushima   CURRENT OPINION IN CELL BIOLOGY

The Role of Autophagy in the Heart

(2018) Sebastiano Sciarretta et al.   Annual Review of Physiology

Three Distinct Types of Microautophagy Based on Membrane Dynamics and Molecular Machineries

(2018) Masahide Oku et al.   BIOESSAYS

A brief history of autophagy from cell biology to physiology and disease

(2018) Noboru Mizushima   NATURE CELL BIOLOGY

The coming of age of chaperone-mediated autophagy

(2018) Susmita Kaushik et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanism and medical implications of mammalian autophagy

(2018) Ivan Dikic et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

NUFIP1 is a ribosome receptor for starvation-induced ribophagy

(2018) Gregory A. Wyant et al.   SCIENCE

Adjustment of the lysosomal-mitochondrial axis for control of cellular senescence

(2018) Joon Tae Park et al.   AGEING RESEARCH REVIEWS

Autophagy-dependent cell death

(2018) Donna Denton et al.   CELL DEATH AND DIFFERENTIATION

Glycoprotein Non-Metastatic Protein B: An Emerging Biomarker for Lysosomal Dysfunction in Macrophages

(2018) Martijn van der Lienden et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

TREK-1 channels regulate pressure sensitivity and calcium signaling in trabecular meshwork cells

(2018) Oleg Yarishkin et al.   JOURNAL OF GENERAL PHYSIOLOGY

Autophagy and the cell biology of age-related disease

(2018) Andrew M. Leidal et al.   NATURE CELL BIOLOGY

Autophagy and mechanotransduction in outflow pathway cells

(2017) Joshua Hirt et al.   EXPERIMENTAL EYE RESEARCH

Aqueous outflow - A continuum from trabecular meshwork to episcleral veins

(2017) Teresia Carreon et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Disorders of lysosomal acidification—The emerging role of v-ATPase in aging and neurodegenerative disease

(2016) Daniel J. Colacurcio et al.   AGEING RESEARCH REVIEWS

Endothelial Mechanosignaling: Does One Sensor Fit All?

(2016) Chris Givens et al.   ANTIOXIDANTS & REDOX SIGNALING

Optineurin: The autophagy connection

(2016) Hongyu Ying et al.   EXPERIMENTAL EYE RESEARCH

The autophagic lysosomal system in outflow pathway physiology and pathophysiology

(2016) Paloma B. Liton   EXPERIMENTAL EYE RESEARCH

Primary-cilium-dependent autophagy controls epithelial cell volume in response to fluid flow

(2016) Idil Orhon et al.   NATURE CELL BIOLOGY

Gpnmb Is a Potential Marker for the Visceral Pathology in Niemann-Pick Type C Disease

(2016) André R. A. Marques et al.   PLoS One

Autophagy in the eye: Development, degeneration, and aging

(2016) Patricia Boya et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Endocytic Control of Cellular Signaling at the Primary Cilium

(2016) Lotte B. Pedersen et al.   TRENDS IN BIOCHEMICAL SCIENCES

Ubiquitin-Dependent And Independent Signals In Selective Autophagy

(2016) Aliaksandr Khaminets et al.   TRENDS IN CELL BIOLOGY

Elevation of glycoprotein nonmetastatic melanoma protein B in type 1 Gaucher disease patients and mouse models

(2016) Gertjan Kramer et al.   FEBS Open Bio

DNA Damage Response and Autophagy: A Meaningful Partnership

(2016) Aristides G. Eliopoulos et al.   Frontiers in Genetics

TRPV4 regulates calcium homeostasis, cytoskeletal remodeling, conventional outflow and intraocular pressure in the mammalian eye

(2016) Daniel A. Ryskamp et al.   Scientific Reports

Lysosomal Physiology

(2015) Haoxing Xu et al.   Annual Review of Physiology

ER stress: Autophagy induction, inhibition and selection

(2015) Harun-Or Rashid et al.   Autophagy

Autophagic dysregulation in glaucomatous trabecular meshwork cells

(2015) Kristine Porter et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

ROS and Autophagy: Interactions and Molecular Regulatory Mechanisms

(2015) Lulu Li et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Animal models of glucocorticoid-induced glaucoma

(2015) Darryl R. Overby et al.   EXPERIMENTAL EYE RESEARCH

Extracellular matrix in the trabecular meshwork: Intraocular pressure regulation and dysregulation in glaucoma

(2015) Janice A. Vranka et al.   EXPERIMENTAL EYE RESEARCH

The role for autophagy in cancer

(2015) Eileen White   JOURNAL OF CLINICAL INVESTIGATION

Autophagy at the crossroads of catabolism and anabolism

(2015) Jasvinder Kaur et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Intracellular and extracellular forces drive primary cilia movement

(2015) Christopher Battle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biomechanics of Schlemm's canal endothelium and intraocular pressure reduction

(2015) W. Daniel Stamer et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Cathepsin B Mediates the pH-Dependent Proinvasive Activity of Tumor-Shed Microvesicles

(2015) Ilaria Giusti et al.   NEOPLASIA

Autophagy Regulates Vascular Endothelial Cell eNOS and ET-1 Expression Induced by Laminar Shear Stress in an Ex Vivo Perfused System

(2014) Fengxia Guo et al.   ANNALS OF BIOMEDICAL ENGINEERING

Autophagy revisited: A conversation with Christian de Duve

(2014) Daniel J. Klionsky   Autophagy

MTOR-independent induction of autophagy in trabecular meshwork cells subjected to biaxial stretch

(2014) Kristine M. Porter et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Impairment of autophagy in endothelial cells prevents shear-stress-induced increases in nitric oxide bioavailability

(2014) Leena P. Bharath et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Oxidative stress and autophagy: the clash between damage and metabolic needs

(2014) G Filomeni et al.   CELL DEATH AND DIFFERENTIATION

Autophagy and human disease: emerging themes

(2014) Jaime L Schneider et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Anterior segment OCT imaging in mucopolysaccharidoses type I, II and VI

(2014) T Y Ahmed et al.   EYE

Pericellular proteolysis in cancer

(2014) Lisa Sevenich et al.   GENES & DEVELOPMENT

Shear Stress-Triggered Nitric Oxide Release From Schlemm's Canal Cells

(2014) N. E. Ashpole et al.   INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

Regulation of TGF-β1-driven Differentiation of Human Lung Fibroblasts

(2014) Mariana Kasabova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ocular-specific ER stress reduction rescues glaucoma in murine glucocorticoid-induced glaucoma

(2014) Gulab S. Zode et al.   JOURNAL OF CLINICAL INVESTIGATION

Ascorbic Acid Modulation of Iron Homeostasis and Lysosomal Function in Trabecular Meshwork Cells

(2014) Ping Xu et al.   JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS

Intraocular Pressure Homeostasis: Maintaining Balance in a High-Pressure Environment

(2014) Ted S. Acott et al.   JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS

Autophagy—a key player in cellular and body metabolism

(2014) Kook Hwan Kim et al.   Nature Reviews Endocrinology

Cellular Processing of Myocilin

(2014) Ye Qiu et al.   PLoS One

Oxidative Damage and Autophagy in the Human Trabecular Meshwork as Related with Ageing

(2014) Alessandra Pulliero et al.   PLoS One

Primary cilia signaling mediates intraocular pressure sensation

(2014) N. Luo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cathepsin B: Multiple roles in cancer

(2014) Neha Aggarwal et al.   Proteomics Clinical Applications

Lysosomal basification and decreased autophagic flux in oxidatively stressed trabecular meshwork cells

(2013) Kristine Porter et al.   Autophagy

The ULK1 complex

(2013) Pui-Mun Wong et al.   Autophagy

Regulation of autophagy by mTOR-dependent and mTOR-independent pathways: autophagy dysfunction in neurodegenerative diseases and therapeutic application of autophagy enhancers

(2013) Sovan Sarkar   BIOCHEMICAL SOCIETY TRANSACTIONS

Chaperone-mediated autophagy: roles in disease and aging

(2013) Ana Maria Cuervo et al.   CELL RESEARCH

Substratum stiffness and latrunculin B modulate the gene expression of the mechanotransducers YAP and TAZ in human trabecular meshwork cells

(2013) Sara M. Thomasy et al.   EXPERIMENTAL EYE RESEARCH

The Mechanism and Physiological Function of Macroautophagy

(2013) Daniel J. Klionsky et al.   Journal of Innate Immunity

mTOR is a key modulator of ageing and age-related disease

(2013) Simon C. Johnson et al.   NATURE

Functional interaction between autophagy and ciliogenesis

(2013) Olatz Pampliega et al.   NATURE

The role of autophagy in neurodegenerative disease

(2013) Ralph A Nixon   NATURE MEDICINE

TGF-β Signaling Is Associated with Endocytosis at the Pocket Region of the Primary Cilium

(2013) Christian Alexandro Clement et al.   Cell Reports

Glucose-regulated Protein 94 Triage of Mutant Myocilin through Endoplasmic Reticulum-associated Degradation Subverts a More Efficient Autophagic Clearance Mechanism

(2012) Amirthaa Suntharalingam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Up-Regulated Expression of Extracellular Matrix Remodeling Genes in Phagocytically Challenged Trabecular Meshwork Cells

(2012) Kristine M. Porter et al.   PLoS One

Mechanical stress meets autophagy: potential implications for physiology and pathology

(2012) Jason S. King   TRENDS IN MOLECULAR MEDICINE

Trabecular Meshwork in Normal and Pathological Eyes

(2012) Nicola Pescosolido et al.   ULTRASTRUCTURAL PATHOLOGY

Autophagy in Pulmonary Diseases

(2011) Stefan W. Ryter et al.   Annual Review of Physiology

The induction of autophagy by mechanical stress

(2011) Jason S. King et al.   Autophagy

Microautophagy: lesser-known self-eating

(2011) Wen-wen Li et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Autophagy-based unconventional secretory pathway for extracellular delivery of IL-1β

(2011) Nicolas Dupont et al.   EMBO JOURNAL

Pathophysiological Role of Autophagy: Lesson from Autophagy-Deficient Mouse Models

(2011) Yoshinobu ICHIMURA et al.   EXPERIMENTAL ANIMALS

Functions of Autophagy in Hepatic and Pancreatic Physiology and Disease

(2011) Mark J. Czaja   GASTROENTEROLOGY

The mechanics of the primary cilium: An intricate structure with complex function

(2011) David A. Hoey et al.   JOURNAL OF BIOMECHANICS

Reduction of ER stress via a chemical chaperone prevents disease phenotypes in a mouse model of primary open angle glaucoma

(2011) Gulab S. Zode et al.   JOURNAL OF CLINICAL INVESTIGATION

Canonical and non-canonical autophagy: variations on a common theme of self-eating?

(2011) Patrice Codogno et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Extracellular Matrix Degradation and Remodeling in Development and Disease

(2011) P. Lu et al.   Cold Spring Harbor Perspectives in Biology

Chaperone-Assisted Selective Autophagy Is Essential for Muscle Maintenance

(2010) Verena Arndt et al.   CURRENT BIOLOGY

Autophagy for tissue homeostasis and neuroprotection

(2010) Guillermo Mariño et al.   CURRENT OPINION IN CELL BIOLOGY

The Nucleolus under Stress

(2010) Séverine Boulon et al.   MOLECULAR CELL

The genetics of ageing

(2010) Cynthia J. Kenyon   NATURE

Autophagy in mammalian development and differentiation

(2010) Noboru Mizushima et al.   NATURE CELL BIOLOGY

BAMBI Is Expressed in Endothelial Cells and Is Regulated by Lysosomal/Autolysosomal Degradation

(2010) Sandhya Xavier et al.   PLoS One

Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease

(2010) M. M. Lipinski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

THE PRESSURE LOWERING EFFECT OF ASCORBIC ACID IN OCULAR HYPERTENSION

(2009) ERIK LINNÉR   ACTA OPHTHALMOLOGICA

Release of endo-lysosomal cathepsins B, D, and L from IEC6 cells in a cell culture model mimicking intestinal manipulation

(2009) Kristina Mayer et al.   BIOLOGICAL CHEMISTRY

Lipid Rafts and Caveolin-1 Are Required for Invadopodia Formation and Extracellular Matrix Degradation by Human Breast Cancer Cells

(2009) H. Yamaguchi et al.   CANCER RESEARCH

Ascorbic acid concentration is reduced in the secondary aqueous humour of glaucomatous patients

(2009) Mauro T Leite et al.   CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

The trabecular meshwork outflow pathways: Structural and functional aspects

(2009) Ernst R. Tamm   EXPERIMENTAL EYE RESEARCH

Nucleocytoplasmic Shuttling of p62/SQSTM1 and Its Role in Recruitment of Nuclear Polyubiquitinated Proteins to Promyelocytic Leukemia Bodies

(2009) Serhiy Pankiv et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ULK1·ATG13·FIP200 Complex Mediates mTOR Signaling and Is Essential for Autophagy

(2009) Ian G. Ganley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stress Response of the Trabecular Meshwork

(2009) Paloma B. Liton et al.   JOURNAL OF GLAUCOMA

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

(2009) David E. Harrison et al.   NATURE

Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys

(2009) R. J. Colman et al.   SCIENCE

Lysosomal Cathepsin B Participates in the Podosome-Mediated Extracellular Matrix Degradation and Invasion via Secreted Lysosomes in v-Src Fibroblasts

(2008) C. Tu et al.   CANCER RESEARCH

Autophagy in the Pathogenesis of Disease

(2008) Beth Levine et al.   CELL

Ocular manifestation of storage diseases

(2008) Jyotirmay Biswas et al.   CURRENT OPINION IN OPHTHALMOLOGY

Mechanobiology of trabecular meshwork cells

(2008) Darrell WuDunn   EXPERIMENTAL EYE RESEARCH

Structural changes of the trabecular meshwork in different kinds of glaucoma

(2008) Ozan-Yüksel Tektas et al.   EXPERIMENTAL EYE RESEARCH

Oxidative Stress in Primary Open-angle Glaucoma

(2008) Vicente Zanon-Moreno et al.   JOURNAL OF GLAUCOMA

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE

Cysteine cathepsins: Cellular roadmap to different functions

(2007) Klaudia Brix et al.   BIOCHIMIE

Mechanical stimulation of primary cilia

(2007) Andrew Resnick   Frontiers in Bioscience-Landmark