Glucose-regulated Protein 94 Triage of Mutant Myocilin through Endoplasmic Reticulum-associated Degradation Subverts a More Efficient Autophagic Clearance Mechanism

Hsp90 Molecular Chaperone Inhibitors: Are We There Yet?

(2012) L. Neckers et al.   CLINICAL CANCER RESEARCH

DnaJA1 Antagonizes Constitutive Hsp70-Mediated Stabilization of Tau

(2012) Jose F. Abisambra et al.   JOURNAL OF MOLECULAR BIOLOGY

Chasing the elusive mammalian microautophagy

(2011) Laura Santambrogio et al.   Autophagy

The Stability of Myocilin Olfactomedin Domain Variants Provides New Insight into Glaucoma as a Protein Misfolding Disorder

(2011) J. Nicole Burns et al.   BIOCHEMISTRY

GRP94: An HSP90-like protein specialized for protein folding and quality control in the endoplasmic reticulum

(2011) Michal Marzec et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Reduction of ER stress via a chemical chaperone prevents disease phenotypes in a mouse model of primary open angle glaucoma

(2011) Gulab S. Zode et al.   JOURNAL OF CLINICAL INVESTIGATION

Amyloid Fibril Formation by the Glaucoma-Associated Olfactomedin Domain of Myocilin

(2011) Susan D. Orwig et al.   JOURNAL OF MOLECULAR BIOLOGY

Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress

(2011) Ira Tabas et al.   NATURE CELL BIOLOGY

Rescue of Glaucoma-Causing Mutant Myocilin Thermal Stability by Chemical Chaperones

(2010) J. Nicole Burns et al.   ACS Chemical Biology

Expression of Myocilin Mutants Sensitizes Cells to Oxidative Stress-Induced Apoptosis

(2010) Myung Kuk Joe et al.   AMERICAN JOURNAL OF PATHOLOGY

Chaperone-Mediated Autophagy Markers in Parkinson Disease Brains

(2010) Lydia Alvarez-Erviti et al.   ARCHIVES OF NEUROLOGY

Chemical and Pharmacological Chaperones: Application for Recombinant Protein Production and Protein Folding Diseases

(2010) Rahul S. Rajan et al.   CURRENT MEDICINAL CHEMISTRY

Gp93, the Drosophila GRP94 ortholog, is required for gut epithelial homeostasis and nutrient assimilation-coupled growth control

(2010) Jason C. Maynard et al.   DEVELOPMENTAL BIOLOGY

Phosphorylation Dynamics Regulate Hsp27-Mediated Rescue of Neuronal Plasticity Deficits in Tau Transgenic Mice

(2010) J. F. Abisambra et al.   JOURNAL OF NEUROSCIENCE

Chaperone-mediated autophagy dysfunction in the pathogenesis of neurodegeneration

(2010) Hiroshi Koga et al.   NEUROBIOLOGY OF DISEASE

GRP94 in ER quality control and stress responses

(2010) Davide Eletto et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Potential role of lysosomal dysfunction in the pathogenesis of primary open angle glaucoma

(2009) Paloma B. Liton et al.   Autophagy

Degradation of regulator of calcineurin 1 (RCAN1) is mediated by both chaperone-mediated autophagy and ubiquitin proteasome pathways

(2009) Heng Liu et al.   FASEB JOURNAL

Drosophila Glycoprotein 93 Is an Ortholog of Mammalian Heat Shock Protein gp96 (grp94, HSP90b1, HSPC4) and Retains Disulfide Bond-Independent Chaperone Function for TLRs and Integrins

(2009) C. Morales et al.   JOURNAL OF IMMUNOLOGY

Chemical Manipulation of Hsp70 ATPase Activity Regulates Tau Stability

(2009) U. K. Jinwal et al.   JOURNAL OF NEUROSCIENCE

Primary Open-Angle Glaucoma

(2009) Young H. Kwon et al.   NEW ENGLAND JOURNAL OF MEDICINE

Overexpression of Myocilin in the Drosophila Eye Activates the Unfolded Protein Response: Implications for Glaucoma

(2009) Mary Anna Carbone et al.   PLoS One

Glaucoma-associated myocilin: A better understanding but much more to learn

(2008) Zachary T. Resch et al.   EXPERIMENTAL EYE RESEARCH

Wild Type α-Synuclein Is Degraded by Chaperone-mediated Autophagy and Macroautophagy in Neuronal Cells

(2008) Tereza Vogiatzi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Shc coordinates signals from intercellular junctions and integrins to regulate flow-induced inflammation

(2008) Yunhao Liu et al.   JOURNAL OF CELL BIOLOGY

Adapting Proteostasis for Disease Intervention

(2008) William E. Balch et al.   SCIENCE