Review
Geriatrics & Gerontology
Yu-Qing Ni, You-Shuo Liu
Summary: Spermidine, a natural polyamine, has shown promising effects in modulating aging, suppressing age-related diseases, and prolonging lifespan. However, the specific mechanisms of how spermidine exerts its anti-aging effects are yet to be fully understood, but it holds great potential in the diagnosis and treatment of aging and age-related diseases.
Review
Geriatrics & Gerontology
Mingkai Lin, Hongwen Yu, Qiuyan Xie, Zhiyun Xu, Pei Shang
Summary: Microglia, as key immune cells in the CNS, respond to damage, regulate inflammation, and engulf specific segments. Microglia autophagy participates in subcellular regulation and maintains neuronal homeostasis and neuroinflammation.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Review
Nutrition & Dietetics
Yi Wu, Ye Xie, Yixiong Yuan, Ruilin Xiong, Yuxin Hu, Kang Ning, Jason Ha, Wei Wang, Xiaotong Han, Mingguang He
Summary: The Mediterranean diet is associated with reduced risks of age-related eye diseases, such as diabetic retinopathy and age-related macular degeneration. However, its effects on cataract, glaucoma, and dry eye syndrome are less conclusive. Further high-quality studies are needed to evaluate the potential benefits of the Mediterranean diet on these eye diseases.
Review
Public, Environmental & Occupational Health
Cong Li, Bo Zhu, Jie Zhang, Peng Guan, Guisen Zhang, Honghua Yu, Xiaohong Yang, Lei Liu
Summary: The prevalence of visual impairment and age-related eye diseases has increased significantly in mainland China due to the aging population. Comprehensive evidence on ophthalmic epidemiological research is limited, highlighting the need for improved awareness and public health policies for eye disease prevention.
FRONTIERS IN PUBLIC HEALTH
(2022)
Review
Food Science & Technology
Phaniendra Alugoju, V. K. D. Krishna Swamy, Naga Venkata Anusha Anthikapalli, Tewin Tencomnao
Summary: The translation section discusses the impact of age-related diseases on societal and healthcare expenditure, as well as the importance of anti-aging strategies. It then lists the various protective effects of astaxanthin, covering multiple organs and diseases, including neurodegenerative diseases, bone-related diseases, cancers, cardiovascular disorders, diabetes-associated complications, eye disorders, gastric disorders, kidney disorders, liver diseases, pulmonary disorders, muscle disorders, and skin diseases.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Review
Cell Biology
Caterina Miceli, Manuela Leri, Massimo Stefani, Monica Bucciantini
Summary: Autophagy plays a key role in maintaining cellular and organismal homeostasis, providing the necessary energy during critical development stages and nutrient shortage. It is considered a pro-survival mechanism, but its dysregulation is associated with non-apoptotic cell death. Declining autophagy efficiency with age contributes to various pathological conditions, including cancer, cardiomyopathy, diabetes, liver disease, autoimmune diseases, infections, and neurodegeneration. Understanding the relationship between autophagy and age-related pathologies is crucial for proposing disease prevention strategies and potential clinical applications for long-term health promotion.
AGEING RESEARCH REVIEWS
(2023)
Review
Cell Biology
Anita V. Kumar, Joslyn Mills
Summary: Autophagy, a mechanism of protein homeostasis, has implications for aging and age-related diseases. Recently, it has been discovered that autophagy-related proteins have additional roles in non-canonical degradation and secretion, revealing alternative pathways for autophagic cargo. Some of these pathways are linked to neurodegenerative diseases, and understanding this connection is important for potential therapeutic targets in aging and age-related diseases. This review discusses recent investigations into the involvement of non-canonical autophagy players and pathways in age-related diseases that are just beginning to be understood. Unraveling these pathways and their relationship to classical autophagy could provide a fascinating new layer of protein homeostasis regulation during normal aging and longevity.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Ahmed Makarem, Ahmed Abass, Fangjun Bao, Ahmed Elsheikh
Summary: This study aimed to estimate the material stiffness of the orbital soft tissue (OST) in human orbits using an inverse numerical analysis approach. Clinical data from 185 Chinese participants were collected, and numerical models of the eye globes were built. The results showed weak correlation between OST stiffness and age, as well as significant differences in OST stiffness between different age groups. The study also found that the optimized mechanical properties of the OST were almost four times stiffer than fatty tissue.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Cell Biology
Kai Kaarniranta, Janusz Blasiak, Paloma Liton, Michael Boulton, Daniel J. Klionsky, Debasish Sinha
Summary: Age-related macular degeneration (AMD) is a leading cause of visual impairment in the aging population. The progression of AMD is characterized by atrophic alterations in the retinal pigment epithelium and the formation of lipofuscin and deposits. Chronic oxidative stress, protein aggregation, and inflammation may contribute to the development of AMD.
Review
Cell Biology
Xiaokang Li, Lin Liu, Tian Li, Manling Liu, Yishi Wang, Heng Ma, Nan Mu, Haiyan Wang
Summary: SIRT6, a NAD(+)-dependent deacetylase, plays diverse roles in aging, metabolism and disease, similar to SIR2. Increasing sirtuin levels through genetic manipulation extends lifespan, but SIRT6 deficiency can lead to chronic inflammation, autophagy disorder, and cardiovascular diseases. Agonists targeting SIRT6 show promise for therapeutic interventions in aging-related CVDs.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Anam Naseer, Snober Shabnam Mir, Krisztina Takacs-Vellai, Aamir Nazir
Summary: Age-associated neurodegenerative diseases are characterized by impaired protein clearance, leading to accumulation of unwanted proteins and subsequent neurodegeneration. Failure to regulate the autophagic machinery and the role of sirtuins are key factors contributing to this process. The model system C. elegans has been instrumental in studying the relationship between sirtuins, autophagy, and aging-related neurodegeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Ophthalmology
Odunayo O. Mugisho, Colin R. Green
Summary: The inflammasome pathway is crucial in chronic age-related eye diseases, with NLRP3 inflammasome being the most studied in the eye. Finding a shared solution may help effectively address inflammation in multiple diseases.
EXPERIMENTAL EYE RESEARCH
(2022)
Review
Medicine, Research & Experimental
Hangui Ren, Rongchen Dai, Wan Najbah Nik Nabil, Zhichao Xi, Feng Wang, Hongxi Xu
Summary: This review article focuses on the regulatory roles of autophagy in vascular remodelling and its impact on related diseases, while summarizing recent advancements in therapeutic agents targeting autophagy.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Chemistry, Medicinal
Suhyeon Park, Bo-Kyoung Kim, Sang-Kyu Park
Summary: Fisetin, a flavonoid found in fruits and vegetables, has antioxidant, anti-inflammatory, and anti-tumor effects. It can reduce cellular oxidative stress, delay aging, and improve age-related diseases.
Review
Cell Biology
Ping Li, Yuanzheng Ma, Chengwei Yu, Shoutong Wu, Kai Wang, Hongyang Yi, Weizheng Liang
Summary: Autophagy is a crucial degradative process for cell quality control and defense, while aging is characterized by the accumulation of damaged molecules and reduced turnover of cellular components. As age advances, autophagic activity decreases, but enhanced autophagy may help prevent the progression of age-related diseases and extend lifespan.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Oncology
Huangyan Zhou, Min Yuan, Qiongfang Yu, Xiaoyan Zhou, Weiping Min, Dian Gao
Article
Oncology
Qiongfang Yu, Wei Shen, Huangyan Zhou, Weiguo Dong, Dian Gao
MOLECULAR MEDICINE REPORTS
(2016)
Article
Parasitology
Dian Gao, Qiongfang Yu, Guangqiang Wang, Guitang Wang, Fan Xiong
PARASITES & VECTORS
(2016)
Article
Marine & Freshwater Biology
Dian Gao, Zhen'e Xu, Xiaoyan Zhang, Hongmei Wang, Yannan Wang, Weiping Min
AQUATIC TOXICOLOGY
(2013)
Article
Biochemistry & Molecular Biology
Dian Gao, Zhen'e Xu, Xiaodong Kuang, Panpan Qiao, Shen Liu, Li Zhang, Penghui He, Wirnkar S. Jadwiga, Yannan Wang, Weiping Min
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2014)
Article
Fisheries
Dian Gao, Zhen'e Xu, Xiaoyan Zhang, Chunchao Zhu, Yannan Wang, Weiping Min
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2013)
Article
Biotechnology & Applied Microbiology
Yan Hu, Qiongfang Yu, Yao Zhong, Wei Shen, Xiaoyan Zhou, Xu Liu, Mingpu Xu, Nanjin Zhou, Weiping Min, Dian Gao
BIOMED RESEARCH INTERNATIONAL
(2018)
Review
Medicine, Research & Experimental
Xiaorui Zhao, Yue Wang, Qiongfang Yu, Pei Yu, Qiaoyu Zheng, Xue Yang, Dian Gao
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2020)
Article
Pharmacology & Pharmacy
Xu Liu, Qiaoyu Zheng, Qiongfang Yu, Yan Hu, Yanmin Cheng, Zhaozhao Shao, Li Chen, Wenjie Ding, Dian Gao
Summary: The study demonstrates that Apatinib inhibits the proliferation of GC cells by promoting apoptosis and autophagy, altering cell cycle distribution, and inhibiting invasion and migration capacities of GC cells.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Lingqin Zhu, Qiongfang Yu, Yuanheng Li, Meng Zhang, Zhiwei Peng, Song Wang, Ziyi Quan, Dian Gao
Summary: Gastric cancer (GC) is the third leading cause of cancer-related death worldwide. There is an urgent need to identify biomarkers for early detection, prognosis evaluation, and targeted treatment of GC. Studies have shown that SKAP1 promotes cell proliferation and invasion and is associated with poor prognosis in various cancers, but its role and mechanism in GC are unclear.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)