Structural basis of SARM1 activation, substrate recognition, and inhibition by small molecules
出版年份 2022 全文链接
标题
Structural basis of SARM1 activation, substrate recognition, and inhibition by small molecules
作者
关键词
-
出版物
MOLECULAR CELL
Volume 82, Issue 9, Pages 1643-1659.e10
出版商
Elsevier BV
发表日期
2022-03-25
DOI
10.1016/j.molcel.2022.03.007
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- SARM1 is a multi-functional NAD(P)ase with prominent base exchange activity, all regulated bymultiple physiologically relevant NAD metabolites
- (2022) Carlo Angeletti et al. iScience
- Multiple domain interfaces mediate SARM1 autoinhibition
- (2021) Chen Shen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Small Molecule SARM1 Inhibitors Recapitulate the SARM1−/− Phenotype and Allow Recovery of a Metastable Pool of Axons Fated to Degenerate
- (2021) Robert O. Hughes et al. Cell Reports
- SARM1 is a metabolic sensor activated by an increased NMN/NAD+ ratio to trigger axon degeneration
- (2021) Matthew D. Figley et al. NEURON
- MyD88 TIR domain higher-order assembly interactions revealed by microcrystal electron diffraction and serial femtosecond crystallography
- (2021) Max T. B. Clabbers et al. Nature Communications
- Permeant fluorescent probes visualize the activation of SARM1 and uncover an anti-neurodegenerative drug candidate
- (2021) Wan Hua Li et al. eLife
- A phase transition enhances the catalytic activity of SARM1, an NAD+ glycohydrolase involved in neurodegeneration
- (2021) Heather S Loring et al. eLife
- Antiviral activity of bacterial TIR domains via immune signalling molecules
- (2021) Gal Ofir et al. NATURE
- A phytobacterial TIR domain effector manipulates NAD + to promote virulence
- (2021) Samuel Eastman et al. NEW PHYTOLOGIST
- Neurotoxins subvert the allosteric activation mechanism of SARM1 to induce neuronal loss
- (2021) Tong Wu et al. Cell Reports
- cADPR is a gene dosage-sensitive biomarker of SARM1 activity in healthy, compromised, and degenerating axons
- (2020) Yo Sasaki et al. EXPERIMENTAL NEUROLOGY
- Axons Matter: The Promise of Treating Neurodegenerative Disorders by Targeting SARM1-Mediated Axonal Degeneration
- (2020) Raul Krauss et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Sarm1 loss reduces axonal damage and improves cognitive outcome after repetitive mild closed head injury
- (2020) Mark E. Maynard et al. EXPERIMENTAL NEUROLOGY
- Programmed axon degeneration: from mouse to mechanism to medicine
- (2020) Michael P. Coleman et al. NATURE REVIEWS NEUROSCIENCE
- SARM1 acts downstream of neuroinflammatory and necroptotic signaling to induce axon degeneration
- (2020) Kwang Woo Ko et al. JOURNAL OF CELL BIOLOGY
- Structural and Mechanistic Regulation of the Pro-degenerative NAD Hydrolase SARM1
- (2020) Matthew Bratkowski et al. Cell Reports
- The NAD+-mediated self-inhibition mechanism of pro-neurodegenerative Sarm1
- (2020) Yuefeng Jiang et al. NATURE
- Non-uniform refinement: adaptive regularization improves single-particle cryo-EM reconstruction
- (2020) Ali Punjani et al. NATURE METHODS
- Direct pathogen-induced assembly of an NLR immune receptor complex to form a holoenzyme
- (2020) Shoucai Ma et al. SCIENCE
- Structure of the activated ROQ1 resistosome directly recognizing the pathogen effector XopQ
- (2020) Raoul Martin et al. SCIENCE
- Gene therapy targeting SARM1 blocks pathological axon degeneration in mice
- (2019) Stefanie Geisler et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Structural Evidence for an Octameric Ring Arrangement of SARM1
- (2019) Michael Sporny et al. JOURNAL OF MOLECULAR BIOLOGY
- Namdinator – automatic molecular dynamics flexible fitting of structural models into cryo-EM and crystallography experimental maps
- (2019) Rune Thomas Kidmose et al. IUCrJ
- TIR domains of plant immune receptors are NAD+-cleaving enzymes that promote cell death
- (2019) Li Wan et al. SCIENCE
- NAD+ cleavage activity by animal and plant TIR domains in cell death pathways
- (2019) Shane Horsefield et al. SCIENCE
- Sarm1 deletion reduces axon damage, demyelination, and white matter atrophy after experimental traumatic brain injury
- (2019) Christina M. Marion et al. EXPERIMENTAL NEUROLOGY
- Positive-unlabeled convolutional neural networks for particle picking in cryo-electron micrographs
- (2019) Tristan Bepler et al. NATURE METHODS
- TIR Domain Proteins Are an Ancient Family of NAD + -Consuming Enzymes
- (2018) Kow Essuman et al. CURRENT BIOLOGY
- Primary Traumatic Axonopathy in Mice Subjected to Impact Acceleration: A Reappraisal of Pathology and Mechanisms with High-Resolution Anatomical Methods
- (2018) Nikolaos K. Ziogas et al. JOURNAL OF NEUROSCIENCE
- ISOLDE: a physically realistic environment for model building into low-resolution electron-density maps
- (2018) Tristan Ian Croll Acta Crystallographica Section D-Structural Biology
- New tools for the analysis and validation of cryo-EM maps and atomic models
- (2018) Pavel V. Afonine et al. Acta Crystallographica Section D-Structural Biology
- Arpeggio: A Web Server for Calculating and Visualising Interatomic Interactions in Protein Structures
- (2017) Harry C Jubb et al. JOURNAL OF MOLECULAR BIOLOGY
- Deletion of Sarm1 gene is neuroprotective in two models of peripheral neuropathy
- (2017) Elliot Turkiew et al. JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM
- cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination
- (2017) Ali Punjani et al. NATURE METHODS
- Structural basis of TIR-domain-assembly formation in MAL- and MyD88-dependent TLR4 signaling
- (2017) Thomas Ve et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- The SARM1 Toll/Interleukin-1 Receptor Domain Possesses Intrinsic NAD + Cleavage Activity that Promotes Pathological Axonal Degeneration
- (2017) Kow Essuman et al. NEURON
- UCSF ChimeraX: Meeting modern challenges in visualization and analysis
- (2017) Thomas D. Goddard et al. PROTEIN SCIENCE
- MolProbity: More and better reference data for improved all-atom structure validation
- (2017) Christopher J. Williams et al. PROTEIN SCIENCE
- Potent mechanism-based sirtuin-2-selective inhibition by an in situ-generated occupant of the substrate-binding site, “selectivity pocket” and NAD+-binding site
- (2017) Paolo Mellini et al. Chemical Science
- Structural basis of TIR-domain-assembly formation in MAL- and MyD88-dependent TLR4 signaling
- (2017) Thomas Ve et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Prevention of vincristine-induced peripheral neuropathy by genetic deletion of SARM1 in mice
- (2016) Stefanie Geisler et al. BRAIN
- Attenuated traumatic axonal injury and improved functional outcome after traumatic brain injury in mice lackingSarm1
- (2016) Nils Henninger et al. BRAIN
- Gctf: Real-time CTF determination and correction
- (2016) Kai Zhang JOURNAL OF STRUCTURAL BIOLOGY
- NMNAT1 inhibits axon degeneration via blockade of SARM1-mediated NAD+ depletion
- (2016) Yo Sasaki et al. eLife
- SARM1 activation triggers axon degeneration locally via NAD+ destruction
- (2015) J. Gerdts et al. SCIENCE
- Wallerian Degeneration Is Executed by an NMN-SARM1-Dependent Late Ca 2+ Influx but Only Modestly Influenced by Mitochondria
- (2015) Andrea Loreto et al. Cell Reports
- A rise in NAD precursor nicotinamide mononucleotide (NMN) after injury promotes axon degeneration
- (2014) M Di Stefano et al. CELL DEATH AND DIFFERENTIATION
- The role of ligand efficiency metrics in drug discovery
- (2014) Andrew L. Hopkins et al. NATURE REVIEWS DRUG DISCOVERY
- How good are my data and what is the resolution?
- (2013) Philip R. Evans et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Sarm1-Mediated Axon Degeneration Requires Both SAM and TIR Interactions
- (2013) J. Gerdts et al. JOURNAL OF NEUROSCIENCE
- High-resolution noise substitution to measure overfitting and validate resolution in 3D structure determination by single particle electron cryomicroscopy
- (2013) Shaoxia Chen et al. ULTRAMICROSCOPY
- Towards automated crystallographic structure refinement withphenix.refine
- (2012) Pavel V. Afonine et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- RELION: Implementation of a Bayesian approach to cryo-EM structure determination
- (2012) Sjors H.W. Scheres JOURNAL OF STRUCTURAL BIOLOGY
- Prevention of overfitting in cryo-EM structure determination
- (2012) Sjors H W Scheres et al. NATURE METHODS
- dSarm/Sarm1 Is Required for Activation of an Injury-Induced Axon Death Pathway
- (2012) J. M. Osterloh et al. SCIENCE
- XDS
- (2010) Wolfgang Kabsch ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Quantitative analysis of cryo-EM density map segmentation by watershed and scale-space filtering, and fitting of structures by alignment to regions
- (2010) Grigore D. Pintilie et al. JOURNAL OF STRUCTURAL BIOLOGY
- MolProbity: all-atom structure validation for macromolecular crystallography
- (2009) Vincent B. Chen et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Nicotinamide Mononucleotide Adenylyl Transferase-Mediated Axonal Protection Requires Enzymatic Activity But Not Increased Levels of Neuronal Nicotinamide Adenine Dinucleotide
- (2009) Y. Sasaki et al. JOURNAL OF NEUROSCIENCE
- The Immune Adaptor Molecule SARM Modulates Tumor Necrosis Factor Alpha Production and Microglia Activation in the Brainstem and Restricts West Nile Virus Pathogenesis
- (2009) K. J. Szretter et al. JOURNAL OF VIROLOGY
- The base exchange reaction of NAD+ glycohydrolase: Identification of novel heterocyclic alternative substrates
- (2008) Frank Preugschat et al. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now