Neurotoxins subvert the allosteric activation mechanism of SARM1 to induce neuronal loss

Multiple domain interfaces mediate SARM1 autoinhibition

(2021) Chen Shen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SARM1 is a metabolic sensor activated by an increased NMN/NAD+ ratio to trigger axon degeneration

(2021) Matthew D. Figley et al.   NEURON

Permeant fluorescent probes visualize the activation of SARM1 and uncover an anti-neurodegenerative drug candidate

(2021) Wan Hua Li et al.   eLife

cADPR is a gene dosage-sensitive biomarker of SARM1 activity in healthy, compromised, and degenerating axons

(2020) Yo Sasaki et al.   EXPERIMENTAL NEUROLOGY

The SARM1 axon degeneration pathway: control of the NAD+ metabolome regulates axon survival in health and disease

(2020) Matthew D Figley et al.   CURRENT OPINION IN NEUROBIOLOGY

The NAD+-mediated self-inhibition mechanism of pro-neurodegenerative Sarm1

(2020) Yuefeng Jiang et al.   NATURE

Neuromodulation With Burst and Tonic Stimulation Decreases Opioid Consumption: A Post Hoc Analysis of the Success Using Neuromodulation With BURST (SUNBURST) Randomized Controlled Trial

(2020) Ryan S. D'Souza et al.   NEUROMODULATION

Axon degeneration

(2019) Aaron DiAntonio   PAIN

TIR domains of plant immune receptors are NAD+-cleaving enzymes that promote cell death

(2019) Li Wan et al.   SCIENCE

NAD+ cleavage activity by animal and plant TIR domains in cell death pathways

(2019) Shane Horsefield et al.   SCIENCE

The Role of Ablation in Cancer Pain Relief

(2019) Dimitrios K. Filippiadis et al.   Current Oncology Reports

TIR Domain Proteins Are an Ancient Family of NAD + -Consuming Enzymes

(2018) Kow Essuman et al.   CURRENT BIOLOGY

The SARM1 Toll/Interleukin-1 Receptor Domain Possesses Intrinsic NAD + Cleavage Activity that Promotes Pathological Axonal Degeneration

(2017) Kow Essuman et al.   NEURON

3-Acetylpyridine neurotoxicity in mice

(2017) L. Wecker et al.   NEUROTOXICOLOGY

SARM1-specific motifs in the TIR domain enable NAD+loss and regulate injury-induced SARM1 activation

(2016) Daniel W. Summers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NMNAT1 inhibits axon degeneration via blockade of SARM1-mediated NAD+ depletion

(2016) Yo Sasaki et al.   eLife

SARM1, Not MyD88, Mediates TLR7/TLR9-Induced Apoptosis in Neurons

(2015) Piyali Mukherjee et al.   JOURNAL OF IMMUNOLOGY

SARM1 activation triggers axon degeneration locally via NAD+ destruction

(2015) J. Gerdts et al.   SCIENCE

A rise in NAD precursor nicotinamide mononucleotide (NMN) after injury promotes axon degeneration

(2014) M Di Stefano et al.   CELL DEATH AND DIFFERENTIATION

Mitochondrial Dysfunction Induces Sarm1-Dependent Cell Death in Sensory Neurons

(2014) D. W. Summers et al.   JOURNAL OF NEUROSCIENCE

Activation of the Innate Signaling Molecule MAVS by Bunyavirus Infection Upregulates the Adaptor Protein SARM1, Leading to Neuronal Death

(2013) Piyali Mukherjee et al.   IMMUNITY

Sarm1-Mediated Axon Degeneration Requires Both SAM and TIR Interactions

(2013) J. Gerdts et al.   JOURNAL OF NEUROSCIENCE

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Endogenous Nmnat2 Is an Essential Survival Factor for Maintenance of Healthy Axons

(2010) Jonathan Gilley et al.   PLOS BIOLOGY

Nicotinamide Mononucleotide Adenylyl Transferase-Mediated Axonal Protection Requires Enzymatic Activity But Not Increased Levels of Neuronal Nicotinamide Adenine Dinucleotide

(2009) Y. Sasaki et al.   JOURNAL OF NEUROSCIENCE

The Immune Adaptor Molecule SARM Modulates Tumor Necrosis Factor Alpha Production and Microglia Activation in the Brainstem and Restricts West Nile Virus Pathogenesis

(2009) K. J. Szretter et al.   JOURNAL OF VIROLOGY