Potent mechanism-based sirtuin-2-selective inhibition by an in situ-generated occupant of the substrate-binding site, “selectivity pocket” and NAD+-binding site

SIRT2 inhibition modulate glutamate and serotonin systems in the prefrontal cortex and induces antidepressant-like action

(2017) Mercedes Erburu et al.   NEUROPHARMACOLOGY

SIRT7 Is an RNA-Activated Protein Lysine Deacylase

(2016) Zhen Tong et al.   ACS Chemical Biology

Structure-Based Development of an Affinity Probe for Sirtuin 2

(2016) Matthias Schiedel et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A SIRT2-Selective Inhibitor Promotes c-Myc Oncoprotein Degradation and Exhibits Broad Anticancer Activity

(2016) Hui Jing et al.   CANCER CELL

False HDAC Inhibition by Aurone Compound

(2016) Yukihiro Itoh et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

SIRT2 Reverses 4-Oxononanoyl Lysine Modification on Histones

(2016) Jing Jin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

SIRT2 is an unfavorable prognostic biomarker in patients with acute myeloid leukemia

(2016) Ailing Deng et al.   Scientific Reports

Kinetic and Structural Basis for Acyl-Group Selectivity and NAD+ Dependence in Sirtuin-Catalyzed Deacylation

(2015) Jessica L. Feldman et al.   BIOCHEMISTRY

AK-1, a specific SIRT2 inhibitor, induces cell cycle arrest by downregulating Snail in HCT116 human colon carcinoma cells

(2015) Min Gyeong Cheon et al.   CANCER LETTERS

Chronic stress and antidepressant induced changes in Hdac5 and Sirt2 affect synaptic plasticity

(2015) M. Erburu et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Rotenone affects p53 transcriptional activity and apoptosis via targeting SIRT1 and H3K9 acetylation in SH-SY5Y cells

(2015) Ya Feng et al.   JOURNAL OF NEUROCHEMISTRY

Selective Sirt2 inhibition by ligand-induced rearrangement of the active site

(2015) Tobias Rumpf et al.   Nature Communications

SIRT2 is involved in the modulation of depressive behaviors

(2015) Rui Liu et al.   Scientific Reports

Efficient Demyristoylase Activity of SIRT2 Revealed by Kinetic and Structural Studies

(2015) Yan-Bin Teng et al.   Scientific Reports

SIRT1 and SIRT2: emerging targets in neurodegeneration

(2013) Gizem Donmez et al.   EMBO Molecular Medicine

SIRT2: Tumour suppressor or tumour promoter in operable breast cancer?

(2013) Liane M. McGlynn et al.   EUROPEAN JOURNAL OF CANCER

Activation of the Protein Deacetylase SIRT6 by Long-chain Fatty Acids and Widespread Deacylation by Mammalian Sirtuins

(2013) Jessica L. Feldman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Three-Gene Immunohistochemical Panel Adds to Clinical Staging Algorithms to Predict Prognosis for Patients With Esophageal Adenocarcinoma

(2013) Chin-Ann J. Ong et al.   JOURNAL OF CLINICAL ONCOLOGY

Screen of Pseudopeptidic Inhibitors of Human Sirtuins 1–3: Two Lead Compounds with Antiproliferative Effects in Cancer Cells

(2013) Paolo Mellini et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and biological characterisation of sirtuin inhibitors based on the tenovins

(2012) Anna R. McCarthy et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Activation of p53 by SIRT1 Inhibition Enhances Elimination of CML Leukemia Stem Cells in Combination with Imatinib

(2012) Ling Li et al.   CANCER CELL

The histone deacetylase SIRT2 stabilizes Myc oncoproteins

(2012) P Y Liu et al.   CELL DEATH AND DIFFERENTIATION

Cortactin is associated with tumour progression and poor prognosis in prostate cancer and SIRT2 other than HADC6 may work as facilitator in situ

(2012) Huilian Hou et al.   JOURNAL OF CLINICAL PATHOLOGY

Design, Synthesis, and Biological Activity of a Novel Series of Human Sirtuin-2-Selective Inhibitors

(2012) Takayoshi Suzuki et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of Salermide-Related Sirtuin Inhibitors: Binding Mode Studies and Antiproliferative Effects in Cancer Cells Including Cancer Stem Cells

(2012) Dante Rotili et al.   JOURNAL OF MEDICINAL CHEMISTRY

Inhibition of SIRT1 Impairs the Accumulation and Transcriptional Activity of HIF-1α Protein under Hypoxic Conditions

(2012) Alexander Laemmle et al.   PLoS One

SIRT2 Maintains Genome Integrity and Suppresses Tumorigenesis through Regulating APC/C Activity

(2011) Hyun-Seok Kim et al.   CANCER CELL

Deacetylation of FOXO3 by SIRT1 or SIRT2 leads to Skp2-mediated FOXO3 ubiquitination and degradation

(2011) F Wang et al.   ONCOGENE

Sirt5 Is a NAD-Dependent Protein Lysine Demalonylase and Desuccinylase

(2011) J. Du et al.   SCIENCE

Inhibition of SIRT1 by a small molecule induces apoptosis in breast cancer cells

(2010) Arunasree M. Kalle et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis

(2010) Ruth Luthi-Carter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of a small molecule SIRT2 inhibitor with selective tumor cytotoxicity

(2009) Yingjia Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Identification of a cell-active non-peptide sirtuin inhibitor containing N-thioacetyl lysine

(2009) Takayoshi Suzuki et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Sigma-1 receptors regulate hippocampal dendritic spine formation via a free radical-sensitive mechanism involving Rac1·GTP pathway

(2009) Shang-Yi Tsai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuro2A Differentiation by G i/o Pathway

(2009) A. Ma'ayan et al.   Science Signaling