Identification of a c-MYB-directed therapeutic for acute myeloid leukemia

Convergent organization of aberrant MYB complex controls oncogenic gene expression in acute myeloid leukemia

(2021) Sumiko Takao et al.   eLife

C/EBPβ is a MYB- and p300-cooperating pro-leukemogenic factor and promising drug target in acute myeloid leukemia

(2021) Maria V. Yusenko et al.   ONCOGENE

PES inhibits human inducible Hsp70 by covalent targeting of cysteine residues in the substrate binding domain

(2020) Jie Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Studies on oral bioavailability and first‐pass metabolism of withaferin A in rats using LC–MS/MS and Q‐TRAP

(2019) Tianming Dai et al.   BIOMEDICAL CHROMATOGRAPHY

Withaferin A: From ayurvedic folk medicine to preclinical anti-cancer drug

(2019) Behrouz Hassannia et al.   BIOCHEMICAL PHARMACOLOGY

A TFIID-SAGA Perturbation that Targets MYB and Suppresses Acute Myeloid Leukemia

(2018) Yali Xu et al.   CANCER CELL

The natural anti-tumor compound Celastrol targets a Myb-C/EBPβ-p300 transcriptional module implicated in myeloid gene expression

(2018) Anna Coulibaly et al.   PLoS One

Peptidomimetic blockade of MYB in acute myeloid leukemia

(2018) Kavitha Ramaswamy et al.   Nature Communications

Enhancer Activation by Pharmacologic Displacement of LSD1 from GFI1 Induces Differentiation in Acute Myeloid Leukemia

(2018) Alba Maiques-Diaz et al.   Cell Reports

Targeting acute myeloid leukemia by drug-induced c-MYB degradation

(2017) V Walf-Vorderwülbecke et al.   LEUKEMIA

Synergistic antileukemic therapies inNOTCH1-induced T-ALL

(2017) Marta Sanchez-Martin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Small-Molecule Disruption of the Myb/p300 Cooperation Targets Acute Myeloid Leukemia Cells

(2016) Sagar Uttarkar et al.   MOLECULAR CANCER THERAPEUTICS

Withaferin A is a leptin sensitizer with strong antidiabetic properties in mice

(2016) Jaemin Lee et al.   NATURE MEDICINE

The molecular mechanics of mixed lineage leukemia

(2016) R K Slany   ONCOGENE

A CRISPR Dropout Screen Identifies Genetic Vulnerabilities and Therapeutic Targets in Acute Myeloid Leukemia

(2016) Konstantinos Tzelepis et al.   Cell Reports

Interaction of c-Myb with p300 is required for the induction of acute myeloid leukemia (AML) by human AML oncogenes

(2014) D. R. Pattabiraman et al.   BLOOD

Recent progress toward epigenetic therapies: the example of mixed lineage leukemia

(2013) T. Neff et al.   BLOOD

SPIEDw: a searchable platform-independent expression database web tool

(2013) Gareth Williams   BMC GENOMICS

Retinoic Acid and Arsenic Trioxide for Acute Promyelocytic Leukemia

(2013) Francesco Lo-Coco et al.   NEW ENGLAND JOURNAL OF MEDICINE

Molecular insight in the multifunctional activities of Withaferin A

(2012) Wim Vanden Berghe et al.   BIOCHEMICAL PHARMACOLOGY

Role and potential for therapeutic targeting of MYB in leukemia

(2012) D R Pattabiraman et al.   LEUKEMIA

Using the Heat-Shock Response To Discover Anticancer Compounds that Target Protein Homeostasis

(2011) Sandro Santagata et al.   ACS Chemical Biology

The Pathogenesis of Mixed-Lineage Leukemia

(2011) Andrew G. Muntean et al.   Annual Review of Pathology-Mechanisms of Disease

An integrated approach to dissecting oncogene addiction implicates a Myb-coordinated self-renewal program as essential for leukemia maintenance

(2011) J. Zuber et al.   GENES & DEVELOPMENT

Biology, Risk Stratification, and Therapy of Pediatric Acute Leukemias: An Update

(2011) Ching-Hon Pui et al.   JOURNAL OF CLINICAL ONCOLOGY

Inhibition of Myb-dependent gene expression by the sesquiterpene lactone mexicanin-I

(2011) T Bujnicki et al.   LEUKEMIA

HSP70 Inhibition by the Small-Molecule 2-Phenylethynesulfonamide Impairs Protein Clearance Pathways in Tumor Cells

(2011) J. I.-J. Leu et al.   MOLECULAR CANCER RESEARCH

Molecular chaperones in protein folding and proteostasis

(2011) F. Ulrich Hartl et al.   NATURE

Integrated genome-wide chromatin occupancy and expression analyses identify key myeloid pro-differentiation transcription factors repressed by Myb

(2011) Liang Zhao et al.   NUCLEIC ACIDS RESEARCH

Grist for the MLL: how do MLL oncogenic fusion proteins generate leukemia stem cells?

(2010) Tim C. P. Somervaille et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

c-Myb binds MLL through menin in human leukemia cells and is an important driver of MLL-associated leukemogenesis

(2010) Shenghao Jin et al.   JOURNAL OF CLINICAL INVESTIGATION

Hierarchical Maintenance of MLL Myeloid Leukemia Stem Cells Employs a Transcriptional Program Shared with Embryonic Rather Than Adult Stem Cells

(2009) Tim C.P. Somervaille et al.   Cell Stem Cell

The molecular biology of mixed lineage leukemia

(2009) R. K. Slany   HAEMATOLOGICA

A Small Molecule Inhibitor of Inducible Heat Shock Protein 70

(2009) J. I-Ju Leu et al.   MOLECULAR CELL

The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line

(2009) Harukazu Suzuki et al.   NATURE GENETICS

Conditional c-myb knockout in adult hematopoietic stem cells leads to loss of self-renewal due to impaired proliferation and accelerated differentiation

(2009) Y. K. Lieu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA