Withaferin A is a leptin sensitizer with strong antidiabetic properties in mice

Treatment of Obesity with Celastrol

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Celastrol Protects against Obesity and Metabolic Dysfunction through Activation of a HSF1-PGC1α Transcriptional Axis

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(2015) Sara Ramírez et al.   FEBS LETTERS

Xbp1s in Pomc Neurons Connects ER Stress with Energy Balance and Glucose Homeostasis

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PPARγ ablation sensitizes proopiomelanocortin neurons to leptin during high-fat feeding

(2014) Lihong Long et al.   JOURNAL OF CLINICAL INVESTIGATION

Mitochondrial Dynamics Controlled by Mitofusins Regulate Agrp Neuronal Activity and Diet-Induced Obesity

(2013) Marcelo O. Dietrich et al.   CELL

Mitofusin 2 in POMC Neurons Connects ER Stress with Leptin Resistance and Energy Imbalance

(2013) Marc Schneeberger et al.   CELL

Leptin at the Intersection of Neuroendocrinology and Metabolism: Current Evidence and Therapeutic Perspectives

(2013) Maria Dalamaga et al.   Cell Metabolism

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(2012) Martin G. Myers et al.   Cell Metabolism

Anti-obesity drugs: past, present and future

(2012) R. J. Rodgers et al.   Disease Models & Mechanisms

Elevated Hypothalamic TCPTP in Obesity Contributes to Cellular Leptin Resistance

(2011) Kim Loh et al.   Cell Metabolism

Peroxisome proliferation–associated control of reactive oxygen species sets melanocortin tone and feeding in diet-induced obesity

(2011) Sabrina Diano et al.   NATURE MEDICINE

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Body-Mass Index and Mortality among 1.46 Million White Adults

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Synaptic input organization of the melanocortin system predicts diet-induced hypothalamic reactive gliosis and obesity

(2010) T. L. Horvath et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Withaferin A targets heat shock protein 90 in pancreatic cancer cells

(2009) Yanke Yu et al.   BIOCHEMICAL PHARMACOLOGY

Endoplasmic Reticulum Stress Plays a Central Role in Development of Leptin Resistance

(2009) Lale Ozcan et al.   Cell Metabolism

Steroidal Lactones from Withania somnifera, an Ancient Plant for Novel Medicine

(2009) Mohammad Mirjalili et al.   MOLECULES

Central Administration of an Endoplasmic Reticulum Stress Inducer Inhibits the Anorexigenic Effects of Leptin and Insulin

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Will All Americans Become Overweight or Obese? Estimating the Progression and Cost of the US Obesity Epidemic

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