Targeting acute myeloid leukemia by drug-induced c-MYB degradation

Future prospects of therapeutic clinical trials in acute myeloid leukemia

(2017) Maliha Khan et al.   Future Oncology

The molecular mechanics of mixed lineage leukemia

(2016) R K Slany   ONCOGENE

Targeting acute myeloid leukemia with a small molecule inhibitor of the Myb/p300 interaction

(2015) Sagar Uttarkar et al.   BLOOD

Interaction of c-Myb with p300 is required for the induction of acute myeloid leukemia (AML) by human AML oncogenes

(2014) D. R. Pattabiraman et al.   BLOOD

Assessment of Anthelmintic Efficacy of Mebendazole in School Children in Six Countries Where Soil-Transmitted Helminths Are Endemic

(2014) Bruno Levecke et al.   PLoS Neglected Tropical Diseases

Drug repositioning from bench to bedside: Tumour remission by the antihelmintic drug mebendazole in refractory metastatic colon cancer

(2013) Peter Nygren et al.   ACTA ONCOLOGICA

Recent progress toward epigenetic therapies: the example of mixed lineage leukemia

(2013) T. Neff et al.   BLOOD

SPIEDw: a searchable platform-independent expression database web tool

(2013) Gareth Williams   BMC GENOMICS

Repositioning of the anthelmintic drug mebendazole for the treatment for colon cancer

(2013) Peter Nygren et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

The AAA+ ATPase RUVBL2 is a critical mediator of MLL-AF9 oncogenesis

(2013) H Osaki et al.   LEUKEMIA

The MLL recombinome of acute leukemias in 2013

(2013) C Meyer et al.   LEUKEMIA

Glioma pathogenesis-related protein 1 induces prostate cancer cell death through Hsc70-mediated suppression of AURKA and TPX2

(2013) Likun Li et al.   Molecular Oncology

Frat2 mediates the oncogenic activation of Rac by MLL fusions

(2012) V. Walf-Vorderwulbecke et al.   BLOOD

Role and potential for therapeutic targeting of MYB in leukemia

(2012) D R Pattabiraman et al.   LEUKEMIA

Expression of p89c-Mybex9b, an alternatively spliced form of c-Myb, is required for proliferation and survival of p210BCR/ABL-expressing cells

(2012) G Manzotti et al.   Blood Cancer Journal

The Pathogenesis of Mixed-Lineage Leukemia

(2011) Andrew G. Muntean et al.   Annual Review of Pathology-Mechanisms of Disease

An integrated approach to dissecting oncogene addiction implicates a Myb-coordinated self-renewal program as essential for leukemia maintenance

(2011) J. Zuber et al.   GENES & DEVELOPMENT

c-Myb and its target Bmi1 are required for p190BCR/ABL leukemogenesis in mouse and human cells

(2011) T Waldron et al.   LEUKEMIA

Integrated genome-wide chromatin occupancy and expression analyses identify key myeloid pro-differentiation transcription factors repressed by Myb

(2011) Liang Zhao et al.   NUCLEIC ACIDS RESEARCH

Grist for the MLL: how do MLL oncogenic fusion proteins generate leukemia stem cells?

(2010) Tim C. P. Somervaille et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

c-Myb binds MLL through menin in human leukemia cells and is an important driver of MLL-associated leukemogenesis

(2010) Shenghao Jin et al.   JOURNAL OF CLINICAL INVESTIGATION

Hierarchical Maintenance of MLL Myeloid Leukemia Stem Cells Employs a Transcriptional Program Shared with Embryonic Rather Than Adult Stem Cells

(2009) Tim C.P. Somervaille et al.   Cell Stem Cell

The molecular biology of mixed lineage leukemia

(2009) R. K. Slany   HAEMATOLOGICA

The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line

(2009) Harukazu Suzuki et al.   NATURE GENETICS

Conditional c-myb knockout in adult hematopoietic stem cells leads to loss of self-renewal due to impaired proliferation and accelerated differentiation

(2009) Y. K. Lieu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcriptional repression of c-Myb and GATA-2 is involved in the biologic effects of C/EBP  in p210BCR/ABL-expressing cells

(2008) A. R. Soliera et al.   BLOOD

Acute myeloid leukemia induced by MLL-ENL is cured by oncogene ablation despite acquisition of complex genetic abnormalities

(2008) S. J. Horton et al.   BLOOD

Requirement of c-Myb for p210BCR/ABL-dependent transformation of hematopoietic progenitors and leukemogenesis

(2008) M. R. Lidonnici et al.   BLOOD