PES inhibits human inducible Hsp70 by covalent targeting of cysteine residues in the substrate binding domain

S-Glutathionylation of human inducible Hsp70 reveals a regulatory mechanism involving the C-terminal α-helical lid

(2020) Jie Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alkynyl Benzoxazines and Dihydroquinazolines as Cysteine Targeting Covalent Warheads and Their Application in Identification of Selective Irreversible Kinase Inhibitors

(2020) Kirsten McAulay et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Irreversible kinase inhibitors targeting to cysteine residues and their applications in cancer therapy

(2020) Debasis Das et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Necroptosis-blocking compound NBC1 targets heat shock protein 70 to inhibit MLKL polymerization and necroptosis

(2020) Andrea N. Johnston et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Kinetics of the conformational cycle of Hsp70 reveals the importance of the dynamic and heterogeneous nature of Hsp70 for its function

(2020) Si Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Alkyne Moiety as a Latent Electrophile in Irreversible Covalent Small Molecule Inhibitors of Cathepsin K

(2019) Elma Mons et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Allosteric landscapes of eukaryotic cytoplasmic Hsp70s are shaped by evolutionary tuning of key interfaces

(2018) Wenli Meng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The HSP90 chaperone machinery

(2017) Florian H. Schopf et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Chaperoning the Cancer: The Proteostatic Functions of the Heat Shock Proteins in Cancer

(2017) Sepideh Vahid et al.   Recent Patents on Anti-Cancer Drug Discovery

Targeting Hsp70: A possible therapy for cancer

(2016) Sanjay Kumar et al.   CANCER LETTERS

The human HSP70 family of chaperones: where do we stand?

(2016) Jürgen Radons   CELL STRESS & CHAPERONES

Glutathionylation of the Bacterial Hsp70 Chaperone DnaK Provides a Link between Oxidative Stress and the Heat Shock Response

(2016) Hong Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel Improved Synthesis of HSP70 Inhibitor, Pifithrin-μ. In Vitro Synergy Quantification of Pifithrin-μ Combined with Pt Drugs in Prostate and Colorectal Cancer Cells

(2016) Aoife McKeon et al.   MOLECULES

2-phenylethynesulphonamide (PFT-μ) enhances the anticancer effect of the novel hsp90 inhibitor NVP-AUY922 in melanoma, by reducing GSH levels

(2016) Andree Yeramian et al.   Pigment Cell & Melanoma Research

Thiol-derivatized minihepcidins retain biological activity

(2015) Eileen Fung et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Efficacy of the HSP70 inhibitor PET-16 in multiple myeloma

(2015) Charvann K Bailey et al.   CANCER BIOLOGY & THERAPY

The Novolactone Natural Product Disrupts the Allosteric Regulation of Hsp70

(2015) A. Quamrul Hassan et al.   CHEMISTRY & BIOLOGY

Pharmacological Modulation of Reactive Oxygen Species in Cancer Treatment

(2015) Judit Ribas et al.   CURRENT DRUG TARGETS

How Hsp70 Molecular Machines Interact with Their Substrates to Mediate Diverse Physiological Functions

(2015) Eugenia M. Clerico et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural Basis for the Inhibition of HSP70 and DnaK Chaperones by Small-Molecule Targeting of a C-Terminal Allosteric Pocket

(2014) Julia I-Ju Leu et al.   ACS Chemical Biology

2-Phenylethynesulfonamide (PES) uncovers a necrotic process regulated by oxidative stress and p53

(2014) Paolo Mattiolo et al.   BIOCHEMICAL PHARMACOLOGY

Hsp70–Bag3 Interactions Regulate Cancer-Related Signaling Networks

(2014) Teresa A. Colvin et al.   CANCER RESEARCH

Transition-Metal-Free Synthesis of Ynol Ethers and Thioynol Ethers via Displacement at sp Centers: A Revised Mechanistic Pathway

(2014) Vincent James Gray et al.   JOURNAL OF ORGANIC CHEMISTRY

Hsp70 in cancer: back to the future

(2014) M Y Sherman et al.   ONCOGENE

Heat shock proteins in neurodegenerative disorders and aging

(2014) Rehana K. Leak   Journal of Cell Communication and Signaling

Molecular Chaperone Functions in Protein Folding and Proteostasis

(2013) Yujin E. Kim et al.   Annual Review of Biochemistry

The p53/HSP70 inhibitor, 2-phenylethynesulfonamide, causes oxidative stress, unfolded protein response and apoptosis in rainbow trout cells

(2013) Fanxing Zeng et al.   AQUATIC TOXICOLOGY

The HSP70 family and cancer

(2013) M. E. Murphy   CARCINOGENESIS

Identification of an Allosteric Pocket on Human Hsp70 Reveals a Mode of Inhibition of This Therapeutically Important Protein

(2013) Anna Rodina et al.   CHEMISTRY & BIOLOGY

Developing Irreversible Inhibitors of the Protein Kinase Cysteinome

(2013) Qingsong Liu et al.   CHEMISTRY & BIOLOGY

A Modified HSP70 Inhibitor Shows Broad Activity as an Anticancer Agent

(2013) Gregor M. Balaburski et al.   MOLECULAR CANCER RESEARCH

The HSP70 and Autophagy Inhibitor Pifithrin-  Enhances the Antitumor Effects of TRAIL on Human Pancreatic Cancer

(2013) H. Monma et al.   MOLECULAR CANCER THERAPEUTICS

Allosteric opening of the polypeptide-binding site when an Hsp70 binds ATP

(2013) Ruifeng Qi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Correction: Functional Analysis of Hsp70 Inhibitors

(2013) Rainer Schlecht et al.   PLoS One

Pifithrin-μ, an Inhibitor of Heat-Shock Protein 70, Can Increase the Antitumor Effects of Hyperthermia Against Human Prostate Cancer Cells

(2013) Kazumasa Sekihara et al.   PLoS One

Inhibition of HSP70: A challenging anti-cancer strategy

(2012) Anastasia R. Goloudina et al.   CANCER LETTERS

An Interdomain Energetic Tug-of-War Creates the Allosterically Active State in Hsp70 Molecular Chaperones

(2012) Anastasia Zhuravleva et al.   CELL

Cysteine Reactivity Distinguishes Redox Sensing by the Heat-Inducible and Constitutive Forms of Heat Shock Protein 70

(2012) Yoshinari Miyata et al.   CHEMISTRY & BIOLOGY

Structure and Dynamics of the ATP-Bound Open Conformation of Hsp70 Chaperones

(2012) Roman Kityk et al.   MOLECULAR CELL

Comprehensive review on the HSC70 functions, interactions with related molecules and involvement in clinical diseases and therapeutic potential

(2012) Tuoen Liu et al.   PHARMACOLOGY & THERAPEUTICS

Chemical Screens against a Reconstituted Multiprotein Complex: Myricetin Blocks DnaJ Regulation of DnaK through an Allosteric Mechanism

(2011) Lyra Chang et al.   CHEMISTRY & BIOLOGY

HSP70 Inhibition by the Small-Molecule 2-Phenylethynesulfonamide Impairs Protein Clearance Pathways in Tumor Cells

(2011) J. I.-J. Leu et al.   MOLECULAR CANCER RESEARCH

Binding of a Small Molecule at a Protein–Protein Interface Regulates the Chaperone Activity of Hsp70–Hsp40

(2010) Susanne Wisén et al.   ACS Chemical Biology

Heat Shock Protein 70 (Hsp70) as an Emerging Drug Target

(2010) Christopher G. Evans et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Small Molecule Inhibitor of Inducible Heat Shock Protein 70

(2009) J. I-Ju Leu et al.   MOLECULAR CELL

Solution conformation of wild-type E. coli Hsp70 (DnaK) chaperone complexed with ADP and substrate

(2009) E. B. Bertelsen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of small molecules that modify the protein folding activity of heat shock protein 70

(2008) Susanne Wisén et al.   ANALYTICAL BIOCHEMISTRY

Alcohol oxidase (AOX1) fromPichia pastorisis a novel inhibitor of prion propagation and a potential ATPase

(2008) Hong Zhang et al.   MOLECULAR MICROBIOLOGY

High-throughput screen for small molecules that modulate the ATPase activity of the molecular chaperone DnaK

(2007) Lyra Chang et al.   ANALYTICAL BIOCHEMISTRY