Mucosal‐associated invariant T cells: A cryptic coordinator in HIV‐infected immune reconstitution

Human anogenital monocyte-derived dendritic cells and langerin+cDC2 are major HIV target cells

(2021) Jake W. Rhodes et al.   Nature Communications

Translocated microbiome composition determines immunological outcome in treated HIV infection

(2021) Krystelle Nganou-Makamdop et al.   CELL

Mucosal-associated invariant T cells in natural immunity and vaccination against infectious diseases in humans

(2021) Nomawethu Masina et al.   CURRENT OPINION IN IMMUNOLOGY

MAIT cells regulate NK cell-mediated tumor immunity

(2021) Emma V. Petley et al.   Nature Communications

Activated Mucosal-associated Invariant T Cells Have a Pathogenic Role in a Murine Model of Inflammatory Bowel Disease

(2021) Yusuke Yasutomi et al.   Cellular and Molecular Gastroenterology and Hepatology

MAIT Cells in Health and Disease

(2020) Nicholas M. Provine et al.   Annual Review of Immunology

Incomplete immune reconstitution in HIV/AIDS patients on antiretroviral therapy: Challenges of immunological non‐responders

(2020) Xiaodong Yang et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Dynamic MAIT cell response with progressively enhanced innateness during acute HIV-1 infection

(2020) Kerri G. Lal et al.   Nature Communications

Sustained IFN-I stimulation impairs MAIT cell responses to bacteria by inducing IL-10 during chronic HIV-1 infection

(2020) X. Tang et al.   Science Advances

Human liver CD8+ MAIT cells exert TCR/MR1-independent innate-like cytotoxicity in response to IL-15

(2020) Min-Seok Rha et al.   JOURNAL OF HEPATOLOGY

Prevalence of malnutrition and associated factors among adult patients on antiretroviral therapy follow-up care in Jimma Medical Center, Southwest Ethiopia

(2020) Dawit Wolde Daka et al.   PLoS One

MAIT Cell Activation and Functions

(2020) Timothy S. C. Hinks et al.   Frontiers in Immunology

MAIT Cell Development and Functions: the Microbial Connection

(2020) François Legoux et al.   IMMUNITY

Antiretroviral Drugs for Treatment and Prevention of HIV Infection in Adults

(2020) Michael S. Saag et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Recommendations for measuring HIV reservoir size in cure-directed clinical trials

(2020) Mohamed Abdel-Mohsen et al.   NATURE MEDICINE

Understanding the Role of Mucosal-Associated Invariant T-Cells in Non-human Primate Models of HIV Infection

(2020) Isaac M. Barber-Axthelm et al.   Frontiers in Immunology

Human Immunodeficiency Virus–Infected Immunological Nonresponders Have Colon-Restricted Gut Mucosal Immune Dysfunction

(2020) Malin Holm Meyer-Myklestad et al.   JOURNAL OF INFECTIOUS DISEASES

Widespread B cell perturbations in HIV-1 infection afflict naive and marginal zone B cells

(2019) Thomas Liechti et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The biology and functional importance of MAIT cells

(2019) Dale I. Godfrey et al.   NATURE IMMUNOLOGY

Microbial metabolites control the thymic development of mucosal-associated invariant T cells

(2019) François Legoux et al.   SCIENCE

MAIT Cells Are Major Contributors to the Cytokine Response in Group A Streptococcal Toxic Shock Syndrome

(2019) Johanna Emgård et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MAIT cells are imprinted by the microbiota in early life and promote tissue repair

(2019) Michael G. Constantinides et al.   SCIENCE

CD161+ CD4+ T Cells Harbor Clonally Expanded Replication-Competent HIV-1 in Antiretroviral Therapy-Suppressed Individuals

(2019) Xiaomin Li et al.   mBio

A Critical Role for Mucosal-Associated Invariant T Cells as Regulators and Therapeutic Targets in Systemic Lupus Erythematosus

(2019) Goh Murayama et al.   Frontiers in Immunology

A divergent transcriptional landscape underpins the development and functional branching of MAIT cells

(2019) H.-F. Koay et al.   Science Immunology

T‐cell exhaustion in HIV infection

(2019) Craig Fenwick et al.   IMMUNOLOGICAL REVIEWS

Definition of Immunological Nonresponse to Antiretroviral Therapy

(2019) Rita Rb-Silva et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Human blood MAIT cell subsets defined using MR1 tetramers

(2018) Nicholas A Gherardin et al.   IMMUNOLOGY AND CELL BIOLOGY

Role of the gut microbiota in nutrition and health

(2018) Ana M Valdes et al.   BMJ-British Medical Journal

Food Insecurity, Nutritional Status, and Factors Associated with Malnutrition among People Living with HIV/AIDS Attending Antiretroviral Therapy at Public Health Facilities in West Shewa Zone, Central Ethiopia

(2018) Delelegn Yilma Gebremichael et al.   Biomed Research International

Role of the gut microbiota in nutrition and health

(2018) Ana M Valdes et al.   BMJ-British Medical Journal

Association Between Gut Microbiota and CD4 Recovery in HIV-1 Infected Patients

(2018) Wei Lu et al.   Frontiers in Microbiology

HIV

(2018) Jade Ghosn et al.   LANCET

MAIT cells protect against pulmonary Legionella longbeachae infection

(2018) Huimeng Wang et al.   Nature Communications

Mucosal-Associated Invariant T Cells Improve Nonalcoholic Fatty Liver Disease Through Regulating Macrophage Polarization

(2018) Yanmei Li et al.   Frontiers in Immunology

Microbiota-Induced TNF-like Ligand 1A Drives Group 3 Innate Lymphoid Cell-Mediated Barrier Protection and Intestinal T Cell Activation during Colitis

(2018) Jim G. Castellanos et al.   IMMUNITY

The CD4−CD8− MAIT cell subpopulation is a functionally distinct subset developmentally related to the main CD8+ MAIT cell pool

(2018) Joana Dias et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MAIT cells contribute to protection against lethal influenza infection in vivo

(2018) Bonnie van Wilgenburg et al.   Nature Communications

Perturbation of mucosal-associated invariant T cells and iNKT cells in HIV infection

(2018) Jennifer A. Juno et al.   Current Opinion in HIV and AIDS

Activation of Human Mucosal-Associated Invariant T Cells Induces CD40L-Dependent Maturation of Monocyte-Derived and Primary Dendritic Cells

(2017) Mariolina Salio et al.   JOURNAL OF IMMUNOLOGY

Human mucosal-associated invariant T (MAIT) cells possess capacity for B cell help

(2017) Michael S. Bennett et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Multiple layers of heterogeneity and subset diversity in human MAIT cell responses to distinct microorganisms and to innate cytokines

(2017) Joana Dias et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Shared and Distinct Phenotypes and Functions of Human CD161++ Vα7.2+ T Cell Subsets

(2017) Ayako Kurioka et al.   Frontiers in Immunology

Impaired gut junctional complexes feature late-treated individuals with suboptimal CD4+ T-cell recovery upon virologically suppressive combination antiretroviral therapy

(2016) Camilla Tincati et al.   AIDS

The gut microbiome in human immunodeficiency virus infection

(2016) Gili Zilberman-Schapira et al.   BMC Medicine

Altered Virome and Bacterial Microbiome in Human Immunodeficiency Virus-Associated Acquired Immunodeficiency Syndrome

(2016) Cynthia L. Monaco et al.   Cell Host & Microbe

Innate Lymphoid Cells Are Depleted Irreversibly during Acute HIV-1 Infection in the Absence of Viral Suppression

(2016) Henrik N. Kløverpris et al.   IMMUNITY

Functional role of mucosal-associated invariant T cells in HIV infection

(2016) Alireza Saeidi et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Mucosa-Associated Invariant T Cells Are Systemically Depleted in Simian Immunodeficiency Virus-Infected Rhesus Macaques

(2016) Carol Vinton et al.   JOURNAL OF VIROLOGY

The microbiome and innate immunity

(2016) Christoph A. Thaiss et al.   NATURE

A three-stage intrathymic development pathway for the mucosal-associated invariant T cell lineage

(2016) Hui-Fern Koay et al.   NATURE IMMUNOLOGY

HIV-Infected Children Have Lower Frequencies of CD8+ Mucosal-Associated Invariant T (MAIT) Cells that Correlate with Innate, Th17 and Th22 Cell Subsets

(2016) Alka Khaitan et al.   PLoS One

Human mucosal-associated invariant T cells contribute to antiviral influenza immunity via IL-18–dependent activation

(2016) Liyen Loh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MAIT cells are activated during human viral infections

(2016) Bonnie van Wilgenburg et al.   Nature Communications

The effect of HAART-induced HIV suppression on circulating markers of inflammation and immune activation

(2015) Nikolas Itaru Wada et al.   AIDS

Blood-Derived CD4 T Cells Naturally Resist Pyroptosis during Abortive HIV-1 Infection

(2015) Isa Muñoz-Arias et al.   Cell Host & Microbe

Increased Tryptophan Catabolism Is Associated With Increased Frequency of CD161+Tc17/MAIT Cells and Lower CD4+ T-Cell Count in HIV-1 Infected Patients on cART After 2 Years of Follow-Up

(2015) Julie C. Gaardbo et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Increased ex vivo cell death of central memory CD4 T cells in treated HIV infected individuals with unsatisfactory immune recovery

(2015) Marta Massanella et al.   Journal of Translational Medicine

Initiation of Antiretroviral Therapy (ART) at Different Stages of HIV-1 Disease Is Not Associated with the Proportion of Exhausted CD8+ T Cells

(2015) Sanne Skov Jensen et al.   PLoS One

Arming of MAIT Cell Cytolytic Antimicrobial Activity Is Induced by IL-7 and Defective in HIV-1 Infection

(2015) Edwin Leeansyah et al.   PLoS Pathogens

CD4/CD8 ratio normalisation and non-AIDS-related events in individuals with HIV who achieve viral load suppression with antiretroviral therapy: an observational cohort study

(2015) Cristina Mussini et al.   Lancet HIV

Gut Microbiota Promote Hematopoiesis to Control Bacterial Infection

(2014) Arya Khosravi et al.   Cell Host & Microbe

MAIT cells are depleted early but retain functional cytokine expression in HIV infection

(2014) Caroline S Fernandez et al.   IMMUNOLOGY AND CELL BIOLOGY

Early microbial translocation blockade reduces SIV-mediated inflammation and viral replication

(2014) Jan Kristoff et al.   JOURNAL OF CLINICAL INVESTIGATION

An altered intestinal mucosal microbiome in HIV-1 infection is associated with mucosal and systemic immune activation and endotoxemia

(2014) S M Dillon et al.   Mucosal Immunology

MAIT cells are licensed through granzyme exchange to kill bacterially sensitized targets

(2014) A Kurioka et al.   Mucosal Immunology

T-cell activation by transitory neo-antigens derived from distinct microbial pathways

(2014) Alexandra J. Corbett et al.   NATURE

Acquisition of innate-like microbial reactivity in mucosal tissues during human fetal MAIT-cell development

(2014) Edwin Leeansyah et al.   Nature Communications

Initiation of ART during Early Acute HIV Infection Preserves Mucosal Th17 Function and Reverses HIV-Related Immune Activation

(2014) Alexandra Schuetz et al.   PLoS Pathogens

Hypercytotoxicity and Rapid Loss of NKp44+ Innate Lymphoid Cells during Acute SIV Infection

(2014) Haiying Li et al.   PLoS Pathogens

A Compositional Look at the Human Gastrointestinal Microbiome and Immune Activation Parameters in HIV Infected Subjects

(2014) Ece A. Mutlu et al.   PLoS Pathogens

Will loss of your mucosa-associated invariant T cells weaken your HAART?

(2013) Johan K. Sandberg et al.   AIDS

SIV-Induced Instability of the Chimpanzee Gut Microbiome

(2013) Andrew H. Moeller et al.   Cell Host & Microbe

CD161++CD8+T cells, including the MAIT cell subset, are specifically activated by IL-12+IL-18 in a TCR-independent manner

(2013) James E. Ussher et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Antigen-loaded MR1 tetramers define T cell receptor heterogeneity in mucosal-associated invariant T cells

(2013) Rangsima Reantragoon et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mucosal immunity in human and simian immunodeficiency lentivirus infections

(2013) J M Brenchley   Mucosal Immunology

HIV-1 causes CD4 cell death through DNA-dependent protein kinase during viral integration

(2013) Arik Cooper et al.   NATURE

Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection

(2013) Gilad Doitsh et al.   NATURE

MAIT cells are critical for optimal mucosal immune responses during in vivo pulmonary bacterial infection

(2013) A. Meierovics et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IFI16 DNA Sensor Is Required for Death of Lymphoid CD4 T Cells Abortively Infected with HIV

(2013) K. M. Monroe et al.   SCIENCE

MAIT Cells Detect and Efficiently Lyse Bacterially-Infected Epithelial Cells

(2013) Lionel Le Bourhis et al.   PLoS Pathogens

Risk of clinical progression among patients with immunological nonresponse despite virological suppression after combination antiretroviral treatment

(2012) Giuseppe Lapadula et al.   AIDS

Microbial Translocation Across the GI Tract

(2012) Jason M. Brenchley et al.   Annual Review of Immunology

Activation, exhaustion, and persistent decline of the antimicrobial MR1-restricted MAIT-cell population in chronic HIV-1 infection

(2012) E. Leeansyah et al.   BLOOD

Early and nonreversible decrease of CD161++/MAIT cells in HIV infection

(2012) C. Cosgrove et al.   BLOOD

Loss of mucosal CD103+ DCs and IL-17+ and IL-22+ lymphocytes is associated with mucosal damage in SIV infection

(2012) N R Klatt et al.   Mucosal Immunology

IL-17-producing innate lymphoid cells are restricted to mucosal tissues and are depleted in SIV-infected macaques

(2012) H Xu et al.   Mucosal Immunology

MR1 presents microbial vitamin B metabolites to MAIT cells

(2012) Lars Kjer-Nielsen et al.   NATURE

Microbial translocation in HIV infection: causes, consequences and treatment opportunities

(2012) Netanya G. Sandler et al.   NATURE REVIEWS MICROBIOLOGY

CD4 Cell Count and the Risk of AIDS or Death in HIV-Infected Adults on Combination Antiretroviral Therapy with a Suppressed Viral Load: A Longitudinal Cohort Study from COHERE

(2012)   PLOS MEDICINE

HIV and Inflammation: Mechanisms and Consequences

(2012) Peter W. Hunt   Current HIV/AIDS Reports

Mucosal-associated invariant T cells promote inflammation and exacerbate disease in murine models of arthritis

(2011) Asako Chiba et al.   ARTHRITIS AND RHEUMATISM

Immune reconstitution under antiretroviral therapy: the new challenge in HIV-1 infection

(2011) P. Corbeau et al.   BLOOD

The Absence of CD4+ T Cell Count Recovery Despite Receipt of Virologically Suppressive Highly Active Antiretroviral Therapy: Clinical Risk, Immunological Gaps, and Therapeutic Options

(2011) L. Gazzola et al.   CLINICAL INFECTIOUS DISEASES

Reduced Thymic Output Is a Major Mechanism of Immune Reconstitution Failure in HIV-Infected Patients After Long-term Antiretroviral Therapy

(2011) Taisheng Li et al.   CLINICAL INFECTIOUS DISEASES

Immunologic Failure Despite Suppressive Antiretroviral Therapy Is Related to Activation and Turnover of Memory CD4 Cells

(2011) Michael M. Lederman et al.   JOURNAL OF INFECTIOUS DISEASES

Plasma Levels of Soluble CD14 Independently Predict Mortality in HIV Infection

(2011) Netanya G. Sandler et al.   JOURNAL OF INFECTIOUS DISEASES

Relationship between Functional Profile of HIV-1 Specific CD8 T Cells and Epitope Variability with the Selection of Escape Mutants in Acute HIV-1 Infection

(2011) Guido Ferrari et al.   PLoS Pathogens

Early Events in Sexual Transmission of HIV and SIV and Opportunities for Interventions

(2010) Ashley T. Haase   Annual Review of Medicine

Human MAIT cells are xenobiotic-resistant, tissue-targeted, CD161hi IL-17-secreting T cells

(2010) M. Dusseaux et al.   BLOOD

Nadir CD4 T Cell Count as Predictor and High CD4 T Cell Intrinsic Apoptosis as Final Mechanism of Poor CD4 T Cell Recovery in Virologically Suppressed HIV‐Infected Patients: Clinical Implications

(2010) Eugènia Negredo et al.   CLINICAL INFECTIOUS DISEASES

Loss of IL-17-Producing CD8 T Cells during Late Chronic Stage of Pathogenic Simian Immunodeficiency Virus Infection

(2010) P. Nigam et al.   JOURNAL OF IMMUNOLOGY

Antimicrobial activity of mucosal-associated invariant T cells

(2010) Lionel Le Bourhis et al.   NATURE IMMUNOLOGY

Recognition of peptidoglycan from the microbiota by Nod1 enhances systemic innate immunity

(2010) Thomas B Clarke et al.   NATURE MEDICINE

Analysis of CD161 expression on human CD8+ T cells defines a distinct functional subset with tissue-homing properties

(2010) E. Billerbeck et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human Mucosal Associated Invariant T Cells Detect Bacterially Infected Cells

(2010) Marielle C. Gold et al.   PLOS BIOLOGY

Incomplete Peripheral CD4+Cell Count Restoration in HIV‐Infected Patients Receiving Long‐Term Antiretroviral Treatment

(2009) Colleen F. Kelley et al.   CLINICAL INFECTIOUS DISEASES

IL-22: A critical mediator in mucosal host defense

(2009) S. J. Aujla et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Stepwise Development of MAIT Cells in Mouse and Human

(2009) Emmanuel Martin et al.   PLOS BIOLOGY

Microbial translocation is associated with sustained failure in CD4+ T-cell reconstitution in HIV-infected patients on long-term highly active antiretroviral therapy

(2008) Giulia Marchetti et al.   AIDS

CD4+ count and risk of non-AIDS diseases following initial treatment for HIV infection

(2008) Jason V Baker et al.   AIDS

Differential Th17 CD4 T-cell depletion in pathogenic and nonpathogenic lentiviral infections

(2008) J. M. Brenchley et al.   BLOOD

Altered Clonogenic Capability and Stromal Cell Function Characterize Bone Marrow of HIV‐Infected Subjects with Low CD4+T Cell Counts Despite Viral Suppression during HAART

(2008) Antonella Isgrò et al.   CLINICAL INFECTIOUS DISEASES

Patients Characteristics and Clinical Implications of Suboptimal CD4 T-Cell Gains After 1 Year of Successful Antiretroviral Therapy

(2008) Felix Gutierrez et al.   CURRENT HIV RESEARCH

Clinical Outcome of HIV-Infected Antiretroviral-Naive Patients With Discordant Immunologic and Virologic Responses to Highly Active Antiretroviral Therapy

(2008) Ruimin Tan et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Altered balance between Th17 and Th1 cells at mucosal sites predicts AIDS progression in simian immunodeficiency virus-infected macaques

(2008) V Cecchinato et al.   Mucosal Immunology

A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity

(2008) Marina Cella et al.   NATURE

Inflammatory and Coagulation Biomarkers and Mortality in Patients with HIV Infection

(2008) Lewis H Kuller et al.   PLOS MEDICINE

Detectable serum flagellin and lipopolysaccharide and upregulated anti-flagellin and lipopolysaccharide immunoglobulins in human short bowel syndrome

(2007) Thomas R. Ziegler et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY