Alpha-synucleinopathy reduces NMNAT3 protein levels and neurite formation that can be rescued by targeting the NAD+ pathway
出版年份 2022 全文链接
标题
Alpha-synucleinopathy reduces NMNAT3 protein levels and neurite formation that can be rescued by targeting the NAD+ pathway
作者
关键词
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出版物
HUMAN MOLECULAR GENETICS
Volume -, Issue -, Pages -
出版商
Oxford University Press (OUP)
发表日期
2022-04-09
DOI
10.1093/hmg/ddac077
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- High Expression of Nicotinamide N-Methyltransferase in Patients with Sporadic Alzheimer’s Disease
- (2021) Altin Kocinaj et al. MOLECULAR NEUROBIOLOGY
- Resting-state fMRI reveals increased functional connectivity in the cerebellum but decreased functional connectivity of the caudate nucleus in Parkinson’s disease
- (2020) Oliver Kaut et al. NEUROLOGICAL RESEARCH
- Axons Matter: The Promise of Treating Neurodegenerative Disorders by Targeting SARM1-Mediated Axonal Degeneration
- (2020) Raul Krauss et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Protein trapping leads to altered synaptic proteostasis in synucleinopathies
- (2020) Patrícia I. Santos et al. FEBS Journal
- Autonomic failure in Parkinson’s disease is associated with striatal dopamine deficiencies
- (2020) Dagmar N. van Deursen et al. JOURNAL OF NEUROLOGY
- The SARM1 axon degeneration pathway: control of the NAD+ metabolome regulates axon survival in health and disease
- (2020) Matthew D Figley et al. CURRENT OPINION IN NEUROBIOLOGY
- Oxidized nicotinamide adenine dinucleotide-dependent mitochondrial deacetylase sirtuin-3 as a potential therapeutic target of Parkinson’s disease
- (2020) Zhi Dong Zhou et al. AGEING RESEARCH REVIEWS
- The nicotinamide phosphoribosyltransferase antagonist FK866 inhibits growth of prostate tumour spheroids and increases doxorubicin retention without changes in drug transporter and cancer stem cell protein expression
- (2020) Heinrich Sauer et al. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
- Cholinergic Differentiation of Human Neuroblastoma SH-SY5Y Cell Line and Its Potential Use as an In vitro Model for Alzheimer’s Disease Studies
- (2019) Liana M. de Medeiros et al. MOLECULAR NEUROBIOLOGY
- Implications of NAD metabolism in pathophysiology and therapeutics for neurodegenerative diseases
- (2019) Keisuke Hikosaka et al. NUTRITIONAL NEUROSCIENCE
- NAD+ in Brain Aging and Neurodegenerative Disorders
- (2019) Sofie Lautrup et al. Cell Metabolism
- α-synuclein accumulation in SH-SY5Y cell impairs autophagy in microglia by exosomes overloading miR-19a-3p
- (2019) Tianen Zhou et al. Epigenomics
- Mitochondrial impairment activates the Wallerian pathway through depletion of NMNAT2 leading to SARM1-dependent axon degeneration
- (2019) Andrea Loreto et al. NEUROBIOLOGY OF DISEASE
- HMGB1 promotes the starvation-induced autophagic degradation of α-synuclein in SH-SY5Y cells Atg 5-dependently
- (2018) Yi Guan et al. LIFE SCIENCES
- Mechanisms of α-Synuclein Induced Synaptopathy in Parkinson's Disease
- (2018) Jessika C. Bridi et al. Frontiers in Neuroscience
- Cannabinoid-Based Therapies and Brain Development: Potential Harmful Effect of Early Modulation of the Endocannabinoid System
- (2018) Patrícia Schonhofen et al. CNS DRUGS
- Pharmacological bypass of NAD+ salvage pathway protects neurons from chemotherapy-induced degeneration
- (2018) Hui-wen Liu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- c-Jun N-terminal kinase (JNK)-mediated phosphorylation of SARM1 regulates NAD+ cleavage activity to inhibit mitochondrial respiration
- (2018) Hitoshi Murata et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- NAD Metabolism in Cancer Therapeutics
- (2018) Keisuke Yaku et al. Frontiers in Oncology
- Cerebellar atrophy in neurodegeneration—a meta-analysis
- (2017) Helena M Gellersen et al. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
- The SH-SY5Y cell line in Parkinson’s disease research: a systematic review
- (2017) Helena Xicoy et al. Molecular Neurodegeneration
- SIRT3 and mitochondrial metabolism in neurodegenerative diseases
- (2017) Illari Salvatori et al. NEUROCHEMISTRY INTERNATIONAL
- The SARM1 Toll/Interleukin-1 Receptor Domain Possesses Intrinsic NAD + Cleavage Activity that Promotes Pathological Axonal Degeneration
- (2017) Kow Essuman et al. NEURON
- RA Differentiation Enhances Dopaminergic Features, Changes Redox Parameters, and Increases Dopamine Transporter Dependency in 6-Hydroxydopamine-Induced Neurotoxicity in SH-SY5Y Cells
- (2017) Fernanda M. Lopes et al. NEUROTOXICITY RESEARCH
- The Synucleinopathies: Twenty Years On
- (2017) Michel Goedert et al. Journal of Parkinsons Disease
- Axonal damage and loss of connectivity in nigrostriatal and mesolimbic dopamine pathways in early Parkinson's disease
- (2017) Silvia Paola Caminiti et al. NeuroImage-Clinical
- Depletion of AADC activity in caudate nucleus and putamen of Parkinson’s disease patients; implications for ongoing AAV2-AADC gene therapy trial
- (2017) Agnieszka Ciesielska et al. PLoS One
- Mitochondrial SIRT3 Mediates Adaptive Responses of Neurons to Exercise and Metabolic and Excitatory Challenges
- (2016) Aiwu Cheng et al. Cell Metabolism
- CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism
- (2016) Juliana Camacho-Pereira et al. Cell Metabolism
- Cerebellar role in Parkinson's disease
- (2016) Jasmine L. Mirdamadi JOURNAL OF NEUROPHYSIOLOGY
- Synaptic failure and α-synuclein
- (2016) Laura Calo et al. MOVEMENT DISORDERS
- Review: Parkinson's disease: from synaptic loss to connectome dysfunction
- (2016) Arianna Bellucci et al. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
- Systematic and general method for quantifying localization in microscopy images
- (2016) Huanjie Sheng et al. Biology Open
- Nicotinamide N-methyltransferase increases complex I activity in SH-SY5Y cells via sirtuin 3
- (2015) Karolina Y. Liu et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Calcium mobilizing second messengers derived from NAD
- (2015) Andreas H. Guse BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
- NAD+ Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus
- (2015) Carles Cantó et al. Cell Metabolism
- Parkinson's disease
- (2015) Lorraine V Kalia et al. LANCET
- SARM1 activation triggers axon degeneration locally via NAD+ destruction
- (2015) J. Gerdts et al. SCIENCE
- Tissue-based map of the human proteome
- (2015) M. Uhlen et al. SCIENCE
- Absence of SARM1 Rescues Development and Survival of NMNAT2-Deficient Axons
- (2015) Jonathan Gilley et al. Cell Reports
- A rise in NAD precursor nicotinamide mononucleotide (NMN) after injury promotes axon degeneration
- (2014) M Di Stefano et al. CELL DEATH AND DIFFERENTIATION
- Wallerian degeneration: an emerging axon death pathway linking injury and disease
- (2014) Laura Conforti et al. NATURE REVIEWS NEUROSCIENCE
- Axonopathy in an α-Synuclein Transgenic Model of Lewy Body Disease Is Associated with Extensive Accumulation of C-Terminal–Truncated α-Synuclein
- (2013) Dora Games et al. AMERICAN JOURNAL OF PATHOLOGY
- α-Synuclein Overexpression Represses 14-3-3θ Transcription
- (2013) Huiping Ding et al. JOURNAL OF MOLECULAR NEUROSCIENCE
- NMNATs, evolutionarily conserved neuronal maintenance factors
- (2013) Yousuf O. Ali et al. TRENDS IN NEUROSCIENCES
- Axonal protection by Nmnat3 overexpression with involvement of autophagy in optic nerve degeneration
- (2013) Y Kitaoka et al. Cell Death & Disease
- Nicotinamide N-methyltransferase expression in SH-SY5Y neuroblastoma and N27 mesencephalic neurones induces changes in cell morphology via ephrin-B2 and Akt signalling
- (2013) M G Thomas et al. Cell Death & Disease
- Nicotinamide mononucleotide adenylyltransferase maintains active zone structure by stabilizing Bruchpilot
- (2012) Shaoyun Zang et al. EMBO REPORTS
- Chaperoning the synapse—NMNAT protects Bruchpilot from crashing
- (2012) Elsa Lauwers et al. EMBO REPORTS
- The NAMPT inhibitor FK866 reverts the damage in spinal cord injury
- (2012) Emanuela Esposito et al. Journal of Neuroinflammation
- The expression of nicotinamideN-methyltransferase increases ATP synthesis and protects SH-SY5Y neuroblastoma cells against the toxicity of Complex I inhibitors
- (2011) Richard B. Parsons et al. BIOCHEMICAL JOURNAL
- Pathways and Subcellular Compartmentation of NAD Biosynthesis in Human Cells
- (2011) Andrey Nikiforov et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- α-Synuclein: Membrane Interactions and Toxicity in Parkinson's Disease
- (2010) Pavan K. Auluck et al. Annual Review of Cell and Developmental Biology
- Comparison between proliferative and neuron-like SH-SY5Y cells as an in vitro model for Parkinson disease studies
- (2010) Fernanda Martins Lopes et al. BRAIN RESEARCH
- SIRT3 Is a Mitochondria-Localized Tumor Suppressor Required for Maintenance of Mitochondrial Integrity and Metabolism during Stress
- (2010) Hyun-Seok Kim et al. CANCER CELL
- Isoform-specific Targeting and Interaction Domains in Human Nicotinamide Mononucleotide Adenylyltransferases
- (2010) Corinna Lau et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Expression, Localization, and Biochemical Characterization of Nicotinamide Mononucleotide Adenylyltransferase 2
- (2010) Paul R. Mayer et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The Active Zone T-Bar—A Plasticity Module?
- (2010) Carolin Wichmann et al. JOURNAL OF NEUROGENETICS
- α-Synuclein and dopamine at the crossroads of Parkinson's disease
- (2010) Lara Lourenço Venda et al. TRENDS IN NEUROSCIENCES
- Identification of Neuronal Nuclei (NeuN) as Fox-3, a New Member of the Fox-1 Gene Family of Splicing Factors
- (2009) Kee K. Kim et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Nicotinamide Mononucleotide Adenylyltransferase Expression in Mitochondrial Matrix Delays Wallerian Degeneration
- (2009) N. Yahata et al. JOURNAL OF NEUROSCIENCE
- Transgenic Mice Expressing the Nmnat1 Protein Manifest Robust Delay in Axonal Degeneration In Vivo
- (2009) Y. Sasaki et al. JOURNAL OF NEUROSCIENCE
- Nmnat2 delays axon degeneration in superior cervical ganglia dependent on its NAD synthesis activity
- (2009) Tingting Yan et al. NEUROCHEMISTRY INTERNATIONAL
- Nmnat Delays Axonal Degeneration Caused by Mitochondrial and Oxidative Stress
- (2008) C. Press et al. JOURNAL OF NEUROSCIENCE
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