c-Jun N-terminal kinase (JNK)-mediated phosphorylation of SARM1 regulates NAD+ cleavage activity to inhibit mitochondrial respiration

The genetics of Parkinson disease

(2018) Hao Deng et al.   AGEING RESEARCH REVIEWS

Deletion of Sarm1 gene is neuroprotective in two models of peripheral neuropathy

(2017) Elliot Turkiew et al.   JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM

The SARM1 Toll/Interleukin-1 Receptor Domain Possesses Intrinsic NAD + Cleavage Activity that Promotes Pathological Axonal Degeneration

(2017) Kow Essuman et al.   NEURON

Sarm1 Deletion, but Not Wld S , Confers Lifelong Rescue in a Mouse Model of Severe Axonopathy

(2017) Jonathan Gilley et al.   Cell Reports

MAPK signaling promotes axonal degeneration by speeding the turnover of the axonal maintenance factor NMNAT2

(2017) Lauren J Walker et al.   eLife

Prevention of vincristine-induced peripheral neuropathy by genetic deletion of SARM1 in mice

(2016) Stefanie Geisler et al.   BRAIN

Attenuated traumatic axonal injury and improved functional outcome after traumatic brain injury in mice lackingSarm1

(2016) Nils Henninger et al.   BRAIN

Axon Self-Destruction: New Links among SARM1, MAPKs, and NAD+ Metabolism

(2016) Josiah Gerdts et al.   NEURON

SARM1-specific motifs in the TIR domain enable NAD+loss and regulate injury-induced SARM1 activation

(2016) Daniel W. Summers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS

(2016) Yasushi Ito et al.   SCIENCE

Pathological Axonal Death through a MAPK Cascade that Triggers a Local Energy Deficit

(2015) Jing Yang et al.   CELL

SARM1, Not MyD88, Mediates TLR7/TLR9-Induced Apoptosis in Neurons

(2015) Piyali Mukherjee et al.   JOURNAL OF IMMUNOLOGY

SARM1 activation triggers axon degeneration locally via NAD+ destruction

(2015) J. Gerdts et al.   SCIENCE

Neurodegeneration in C. elegans models of ALS requires TIR-1/Sarm1 immune pathway activation in neurons

(2015) Julie Vérièpe et al.   Nature Communications

Absence of SARM1 Rescues Development and Survival of NMNAT2-Deficient Axons

(2015) Jonathan Gilley et al.   Cell Reports

PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity

(2014) Lesley A. Kane et al.   JOURNAL OF CELL BIOLOGY

Mitochondrial Dysfunction Induces Sarm1-Dependent Cell Death in Sensory Neurons

(2014) D. W. Summers et al.   JOURNAL OF NEUROSCIENCE

Dramatic Increase in Expression of a Transgene by Insertion of Promoters Downstream of the Cargo Gene

(2014) Masakiyo Sakaguchi et al.   MOLECULAR BIOTECHNOLOGY

Ubiquitin is phosphorylated by PINK1 to activate parkin

(2014) Fumika Koyano et al.   NATURE

Wallerian degeneration: an emerging axon death pathway linking injury and disease

(2014) Laura Conforti et al.   NATURE REVIEWS NEUROSCIENCE

Activation of the Innate Signaling Molecule MAVS by Bunyavirus Infection Upregulates the Adaptor Protein SARM1, Leading to Neuronal Death

(2013) Piyali Mukherjee et al.   IMMUNITY

Sarm1-Mediated Axon Degeneration Requires Both SAM and TIR Interactions

(2013) J. Gerdts et al.   JOURNAL OF NEUROSCIENCE

SARM1 and TRAF6 bind to and stabilize PINK1 on depolarized mitochondria

(2013) Hitoshi Murata et al.   MOLECULAR BIOLOGY OF THE CELL

T-cell death following immune activation is mediated by mitochondria-localized SARM

(2012) P Panneerselvam et al.   CELL DEATH AND DIFFERENTIATION

Discovery of Potent and Selective Covalent Inhibitors of JNK

(2012) Tinghu Zhang et al.   CHEMISTRY & BIOLOGY

Axon degeneration in Parkinson's disease

(2012) Robert E. Burke et al.   EXPERIMENTAL NEUROLOGY

Axonal degeneration in Alzheimer's disease: When signaling abnormalities meet the axonal transport system

(2012) Nicholas M. Kanaan et al.   EXPERIMENTAL NEUROLOGY

dSarm/Sarm1 Is Required for Activation of an Injury-Induced Axon Death Pathway

(2012) J. M. Osterloh et al.   SCIENCE

PINK1-mediated phosphorylation of the Parkin ubiquitin-like domain primes mitochondrial translocation of Parkin and regulates mitophagy

(2012) Kahori Shiba-Fukushima et al.   Scientific Reports

Mitochondrial dysfunction associated with increased oxidative stress and α-synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain tissue

(2012) Yoichi Imaizumi et al.   Molecular Brain

Targeting of pro-apoptotic TLR adaptor SARM to mitochondria: definition of the critical region and residues in the signal sequence

(2011) Porkodi Panneerselvam et al.   BIOCHEMICAL JOURNAL

Partial sensitization of human bladder cancer cells to a gene-therapeutic adenovirus carrying REIC/Dkk-3 by downregulation of BRPK/PINK1

(2011) Nam-Ho Huh   ONCOLOGY REPORTS

SARM inhibits both TRIF- and MyD88-mediated AP-1 activation

(2010) Jun Peng et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy

(2010) Matthew E. Gegg et al.   HUMAN MOLECULAR GENETICS

A New Cytosolic Pathway from a Parkinson Disease-associated Kinase, BRPK/PINK1

(2010) Hitoshi Murata et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy

(2010) Noriyuki Matsuda et al.   JOURNAL OF CELL BIOLOGY

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

(2010) Sven Geisler et al.   NATURE CELL BIOLOGY

Axonal degeneration in multiple sclerosis: The mitochondrial hypothesis

(2009) Kimmy G. Su et al.   Current Neurology and Neuroscience Reports

Bioenergetic analysis of isolated cerebrocortical nerve terminals on a microgram scale: spare respiratory capacity and stochastic mitochondrial failure

(2009) Sung W. Choi et al.   JOURNAL OF NEUROCHEMISTRY