标题
Synaptic failure and α-synuclein
作者
关键词
-
出版物
MOVEMENT DISORDERS
Volume 31, Issue 2, Pages 169-177
出版商
Wiley
发表日期
2016-01-21
DOI
10.1002/mds.26479
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Direct visualization of alpha-synuclein oligomers reveals previously undetected pathology in Parkinson’s disease brain
- (2015) Rosalind F. Roberts et al. BRAIN
- Dopamine transporter activity is modulated by α-synuclein.
- (2015) Brittany Butler et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- -synuclein and synapsin III cooperatively regulate synaptic function in dopamine neurons
- (2015) M. Zaltieri et al. JOURNAL OF CELL SCIENCE
- Evidence for α-synuclein prions causing multiple system atrophy in humans with parkinsonism
- (2015) Stanley B. Prusiner et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Impaired intracellular trafficking defines early Parkinson's disease
- (2015) Benjamin H.M. Hunn et al. TRENDS IN NEUROSCIENCES
- Parkinson-causing α-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation
- (2015) Ulf Dettmer et al. Nature Communications
- Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats
- (2014) Staffan Holmqvist et al. ACTA NEUROPATHOLOGICA
- α-Synuclein Multimers Cluster Synaptic Vesicles and Attenuate Recycling
- (2014) Lina Wang et al. CURRENT BIOLOGY
- Is Parkinson's Disease a Vesicular Dopamine Storage Disorder? Evidence from a Study in Isolated Synaptic Vesicles of Human and Nonhuman Primate Striatum
- (2014) C. Pifl et al. JOURNAL OF NEUROSCIENCE
- Synucleins Regulate the Kinetics of Synaptic Vesicle Endocytosis
- (2014) K. J. Vargas et al. JOURNAL OF NEUROSCIENCE
- A novel α-synuclein mutation A53E associated with atypical multiple system atrophy and Parkinson's disease-type pathology
- (2014) Petra Pasanen et al. NEUROBIOLOGY OF AGING
- α-Synuclein assembles into higher-order multimers upon membrane binding to promote SNARE complex formation
- (2014) Jacqueline Burré et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Pathological alpha-synuclein propagates through neural networks
- (2014) Masami Masuda-Suzukake et al. Acta Neuropathologica Communications
- α-Synucleinopathy associated with G51D SNCA mutation: a link between Parkinson’s disease and multiple system atrophy?
- (2013) Aoife P. Kiely et al. ACTA NEUROPATHOLOGICA
- Lewy body extracts from Parkinson disease brains trigger α-synuclein pathology and neurodegeneration in mice and monkeys
- (2013) Ariadna Recasens et al. ANNALS OF NEUROLOGY
- α-Synuclein Can Inhibit SNARE-Mediated Vesicle Fusion through Direct Interactions with Lipid Bilayers
- (2013) David C. DeWitt et al. BIOCHEMISTRY
- Caudo-rostral brain spreading of α-synuclein through vagal connections
- (2013) Ayse Ulusoy et al. EMBO Molecular Medicine
- Endogenous alpha-synuclein influences the number of dopaminergic neurons in mouse substantia nigra
- (2013) Pablo Garcia-Reitboeck et al. EXPERIMENTAL NEUROLOGY
- Alpha-synuclein p.H50Q, a novel pathogenic mutation for Parkinson's disease
- (2013) Silke Appel-Cresswell et al. MOVEMENT DISORDERS
- Progression of intestinal permeability changes and alpha-synuclein expression in a mouse model of Parkinson's disease
- (2013) Leo P. Kelly et al. MOVEMENT DISORDERS
- Deficits in dopaminergic transmission precede neuron loss and dysfunction in a new Parkinson model
- (2013) S. Janezic et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Large -synuclein oligomers inhibit neuronal SNARE-mediated vesicle docking
- (2013) B.-K. Choi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Native α-synuclein induces clustering of synaptic-vesicle mimics via binding to phospholipids and synaptobrevin-2/VAMP2
- (2013) Jiajie Diao et al. eLife
- Nigrostriatal overabundance of α-synuclein leads to decreased vesicle density and deficits in dopamine release that correlate with reduced motor activity
- (2012) Meret Nora Gaugler et al. ACTA NEUROPATHOLOGICA
- Neuron-to-neuron transmission of α-synuclein fibrils through axonal transport
- (2012) Eric C. Freundt et al. ANNALS OF NEUROLOGY
- Alterations in axonal transport motor proteins in sporadic and experimental Parkinson’s disease
- (2012) Yaping Chu et al. BRAIN
- Monomeric Synucleins Generate Membrane Curvature
- (2012) Christopher H. Westphal et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice
- (2012) Kelvin C. Luk et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Potential role of α-synuclein in neurodegeneration: studies in a rat animal model
- (2012) George Stoica et al. JOURNAL OF NEUROCHEMISTRY
- -Synuclein Inhibits Intersynaptic Vesicle Mobility and Maintains Recycling-Pool Homeostasis
- (2012) D. Scott et al. JOURNAL OF NEUROSCIENCE
- Systematic Mutagenesis of -Synuclein Reveals Distinct Sequence Requirements for Physiological and Pathological Activities
- (2012) J. Burre et al. JOURNAL OF NEUROSCIENCE
- The many faces of α-synuclein: from structure and toxicity to therapeutic target
- (2012) Hilal A. Lashuel et al. NATURE REVIEWS NEUROSCIENCE
- Lewy pathology is not the first sign of degeneration in vulnerable neurons in Parkinson disease
- (2012) J. M. Milber et al. NEUROLOGY
- Identification of CSPα Clients Reveals a Role in Dynamin 1 Regulation
- (2012) Yong-Quan Zhang et al. NEURON
- Alpha-Synuclein Cell-to-Cell Transfer and Seeding in Grafted Dopaminergic Neurons In Vivo
- (2012) Elodie Angot et al. PLoS One
- Impaired neurotransmission caused by overexpression of -synuclein in nigral dopamine neurons
- (2012) M. Lundblad et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Environmental toxins trigger PD-like progression via increased alpha-synuclein release from enteric neurons in mice
- (2012) Francisco Pan-Montojo et al. Scientific Reports
- Decreased reuptake of dopamine in the dorsal striatum in the absence of alpha-synuclein
- (2011) Heramb Chadchankar et al. BRAIN RESEARCH
- α-Synuclein Stimulates a Dopamine Transporter-dependent Chloride Current and Modulates the Activity of the Transporter
- (2011) Jarod Swant et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells
- (2011) Christian Hansen et al. JOURNAL OF CLINICAL INVESTIGATION
- Functional Alterations to the Nigrostriatal System in Mice Lacking All Three Members of the Synuclein Family
- (2011) S. Anwar et al. JOURNAL OF NEUROSCIENCE
- α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation
- (2011) Tim Bartels et al. NATURE
- Exogenous α-Synuclein Fibrils Induce Lewy Body Pathology Leading to Synaptic Dysfunction and Neuron Death
- (2011) Laura A. Volpicelli-Daley et al. NEURON
- Redistribution of DAT/α-Synuclein Complexes Visualized by “In Situ” Proximity Ligation Assay in Transgenic Mice Modelling Early Parkinson's Disease
- (2011) Arianna Bellucci et al. PLoS One
- In vivo demonstration that -synuclein oligomers are toxic
- (2011) B. Winner et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Proteinase K-resistant α-synuclein is deposited in presynapses in human Lewy body disease and A53T α-synuclein transgenic mice
- (2010) Kunikazu Tanji et al. ACTA NEUROPATHOLOGICA
- SNARE protein redistribution and synaptic failure in a transgenic mouse model of Parkinson’s disease
- (2010) Pablo Garcia-Reitböck et al. BRAIN
- α-Synuclein sequesters arachidonic acid to modulate SNARE-mediated exocytosis
- (2010) Frédéric Darios et al. EMBO REPORTS
- A Pathologic Cascade Leading to Synaptic Dysfunction in -Synuclein-Induced Neurodegeneration
- (2010) D. A. Scott et al. JOURNAL OF NEUROSCIENCE
- Methylation Regulates Alpha-Synuclein Expression and Is Decreased in Parkinson's Disease Patients' Brains
- (2010) A. Jowaed et al. JOURNAL OF NEUROSCIENCE
- α-Synuclein Delays Endoplasmic Reticulum (ER)-to-Golgi Transport in Mammalian Cells by Antagonizing ER/Golgi SNAREs
- (2010) Nandhakumar Thayanidhi et al. MOLECULAR BIOLOGY OF THE CELL
- CSPα promotes SNARE-complex assembly by chaperoning SNAP-25 during synaptic activity
- (2010) Manu Sharma et al. NATURE CELL BIOLOGY
- Neurotransmitter changes in dementia with Lewy bodies and Parkinson disease dementia in vivo
- (2010) J. C. Klein et al. NEUROLOGY
- Increased Expression of α-Synuclein Reduces Neurotransmitter Release by Inhibiting Synaptic Vesicle Reclustering after Endocytosis
- (2010) Venu M. Nemani et al. NEURON
- Progression of Parkinson's Disease Pathology Is Reproduced by Intragastric Administration of Rotenone in Mice
- (2010) Francisco Pan-Montojo et al. PLoS One
- -Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro
- (2010) J. Burre et al. SCIENCE
- Unified staging system for Lewy body disorders: correlation with nigrostriatal degeneration, cognitive impairment and motor dysfunction
- (2009) Thomas G. Beach et al. ACTA NEUROPATHOLOGICA
- SNCAvariants are associated with increased risk for multiple system atrophy
- (2009) Sonja W. Scholz et al. ANNALS OF NEUROLOGY
- In vivo imaging of synaptic function in the central nervous system
- (2009) Susanne Nikolaus et al. BEHAVIOURAL BRAIN RESEARCH
- Pre-fibrillar α-synuclein variants with impaired β-structure increase neurotoxicity in Parkinson's disease models
- (2009) Damla Pinar Karpinar et al. EMBO JOURNAL
- Dynamic Changes in Presynaptic and Axonal Transport Proteins Combined with Striatal Neuroinflammation Precede Dopaminergic Neuronal Loss in a Rat Model of AAV -Synucleinopathy
- (2009) C. Y. Chung et al. JOURNAL OF NEUROSCIENCE
- Inclusion formation and neuronal cell death through neuron-to-neuron transmission of -synuclein
- (2009) P. Desplats et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The progression of pathology in longitudinally followed patients with Parkinson’s disease
- (2008) Glenda Halliday et al. ACTA NEUROPATHOLOGICA
- Selective detection, quantification, and subcellular location of α-synuclein aggregates with a protein aggregate filtration assay
- (2008) Michael L. Kramer et al. BIOTECHNIQUES
- Alpha-synuclein aggregation and cell death triggered by energy deprivation and dopamine overload are counteracted by D2D3receptor activation
- (2008) Arianna Bellucci et al. JOURNAL OF NEUROCHEMISTRY
- Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation
- (2008) Jia-Yi Li et al. NATURE MEDICINE
- Lewy body–like pathology in long-term embryonic nigral transplants in Parkinson's disease
- (2008) Jeffrey H Kordower et al. NATURE MEDICINE
- Red Blood Cells Are the Major Source of Alpha-Synuclein in Blood
- (2008) Robin Barbour et al. Neurodegenerative Diseases
- Axonal -synuclein aggregates herald centripetal degeneration of cardiac sympathetic nerve in Parkinson's disease
- (2007) S. Orimo et al. BRAIN
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreDiscover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversation