Inhibition of cGAS-STING by JQ1 alleviates oxidative stress-induced retina inflammation and degeneration
出版年份 2022 全文链接
标题
Inhibition of cGAS-STING by JQ1 alleviates oxidative stress-induced retina inflammation and degeneration
作者
关键词
-
出版物
CELL DEATH AND DIFFERENTIATION
Volume -, Issue -, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2022-03-29
DOI
10.1038/s41418-022-00967-4
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Treatments for dry age-related macular degeneration: therapeutic avenues, clinical trials and future directions
- (2021) Thales Antonio Cabral de Guimaraes et al. BRITISH JOURNAL OF OPHTHALMOLOGY
- STING enhances cell death through regulation of reactive oxygen species and DNA damage
- (2021) Thomas J. Hayman et al. Nature Communications
- Heterochromatin inhibits cGAS and STING during oxidative stress-induced retinal pigment epithelium and retina degeneration
- (2021) Ming Zou et al. FREE RADICAL BIOLOGY AND MEDICINE
- Mitochondria-to-nucleus retrograde signaling drives formation of cytoplasmic chromatin and inflammation in senescence
- (2020) Maria Grazia Vizioli et al. GENES & DEVELOPMENT
- mtDNA Activates cGAS Signaling and Suppresses the YAP-Mediated Endothelial Cell Proliferation Program to Promote Inflammatory Injury
- (2020) Long Shuang Huang et al. IMMUNITY
- ATM inhibition enhances cancer immunotherapy by promoting mtDNA leakage and cGAS/STING activation
- (2020) Mengjie Hu et al. JOURNAL OF CLINICAL INVESTIGATION
- DNA sensing by the cGAS–STING pathway in health and disease
- (2019) Mona Motwani et al. NATURE REVIEWS GENETICS
- Mitochondrial Damage Causes Inflammation via cGAS-STING Signaling in Acute Kidney Injury
- (2019) Hiroshi Maekawa et al. Cell Reports
- Oxidative stress-induced KLF4 activates inflammatory response through IL17RA and its downstream targets in retinal pigment epithelial cells
- (2019) Qian Sun et al. FREE RADICAL BIOLOGY AND MEDICINE
- Modulation of three key innate immune pathways for the most common retinal degenerative diseases
- (2018) Isha Akhtar‐Schäfer et al. EMBO Molecular Medicine
- Targeting STING with covalent small-molecule inhibitors
- (2018) Simone M. Haag et al. NATURE
- Design of amidobenzimidazole STING receptor agonists with systemic activity
- (2018) Joshi M. Ramanjulu et al. NATURE
- Bromodomain Protein BRD4 Is a Transcriptional Repressor of Autophagy and Lysosomal Function
- (2017) Jun-ichi Sakamaki et al. MOLECULAR CELL
- cGAS drives noncanonical-inflammasome activation in age-related macular degeneration
- (2017) Nagaraj Kerur et al. NATURE MEDICINE
- The impact of oxidative stress and inflammation on RPE degeneration in non-neovascular AMD
- (2017) Sayantan Datta et al. PROGRESS IN RETINAL AND EYE RESEARCH
- THE PATHOPHYSIOLOGY OF GEOGRAPHIC ATROPHY SECONDARY TO AGE-RELATED MACULAR DEGENERATION AND THE COMPLEMENT PATHWAY AS A THERAPEUTIC TARGET
- (2017) David S. Boyer et al. RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
- Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing
- (2016) Qi Chen et al. NATURE IMMUNOLOGY
- BRD4 is a histone acetyltransferase that evicts nucleosomes from chromatin
- (2016) Ballachanda N Devaiah et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- deepTools2: a next generation web server for deep-sequencing data analysis
- (2016) Fidel Ramírez et al. NUCLEIC ACIDS RESEARCH
- BRD4 Connects Enhancer Remodeling to Senescence Immune Surveillance
- (2016) N. Tasdemir et al. Cancer Discovery
- BRD4 is a histone acetyltransferase that evicts nucleosomes from chromatin
- (2016) Ballachanda N Devaiah et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- RPE necroptosis in response to oxidative stress and in AMD
- (2015) Jakub Hanus et al. AGEING RESEARCH REVIEWS
- Sambamba: fast processing of NGS alignment formats
- (2015) Artem Tarasov et al. BIOINFORMATICS
- Nuclear PTEN tumor-suppressor functions through maintaining heterochromatin structure
- (2015) Lili Gong et al. CELL CYCLE
- Age-related macular degeneration: genome-wide association studies to translation
- (2015) James R. M. Black et al. GENETICS IN MEDICINE
- Genome-Derived Cytosolic DNA Mediates Type I Interferon-Dependent Rejection of B Cell Lymphoma Cells
- (2015) Yu J. Shen et al. Cell Reports
- The cGAS-cGAMP-STING Pathway of Cytosolic DNA Sensing and Signaling
- (2014) Xin Cai et al. MOLECULAR CELL
- Geographic Atrophy
- (2014) Frank G. Holz et al. OPHTHALMOLOGY
- Oxidative Damage of DNA Confers Resistance to Cytosolic Nuclease TREX1 Degradation and Potentiates STING-Dependent Immune Sensing
- (2013) Nadine Gehrke et al. IMMUNITY
- BET Protein Function Is Required for Inflammation: Brd2 Genetic Disruption and BET Inhibitor JQ1 Impair Mouse Macrophage Inflammatory Responses
- (2013) A. C. Belkina et al. JOURNAL OF IMMUNOLOGY
- Mechanisms of Age-Related Macular Degeneration
- (2012) Jayakrishna Ambati et al. NEURON
- Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA
- (2012) J. Wu et al. SCIENCE
- Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway
- (2012) L. Sun et al. SCIENCE
- Systems-level analysis of age-related macular degeneration reveals global biomarkers and phenotype-specific functional networks
- (2012) Aaron M Newman et al. Genome Medicine
- Fragments of Genomic DNA Released by Injured Cells Activate Innate Immunity and Suppress Endocrine Function in the Thyroid
- (2011) Akira Kawashima et al. ENDOCRINOLOGY
- Suppression of inflammation by a synthetic histone mimic
- (2010) Edwige Nicodeme et al. NATURE
- The Sequence Alignment/Map format and SAMtools
- (2009) H. Li et al. BIOINFORMATICS
- STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling
- (2008) Hiroki Ishikawa et al. NATURE
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