Age-related macular degeneration: genome-wide association studies to translation

The Membrane Attack Complex in Aging Human Choriocapillaris

(2014) Robert F. Mullins et al.   AMERICAN JOURNAL OF PATHOLOGY

Personalized ophthalmology

(2014) L.F. Porter et al.   CLINICAL GENETICS

Genetic variants in the complement system predisposing to age-related macular degeneration: A review

(2014) Elizabeth C. Schramm et al.   MOLECULAR IMMUNOLOGY

Defining the role of common variation in the genomic and biological architecture of adult human height

(2014) Andrew R Wood et al.   NATURE GENETICS

23andMe and the FDA

(2014) George J. Annas et al.   NEW ENGLAND JOURNAL OF MEDICINE

Nature and nurture- genes and environment- predict onset and progression of macular degeneration

(2014) Lucia Sobrin et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Tissue-Specific Host Recognition by Complement Factor H Is Mediated by Differential Activities of Its Glycosaminoglycan-Binding Regions

(2013) S. J. Clark et al.   JOURNAL OF IMMUNOLOGY

Seven new loci associated with age-related macular degeneration

(2013) Lars G Fritsche et al.   NATURE GENETICS

Inclusion of Genotype with Fundus Phenotype Improves Accuracy of Predicting Choroidal Neovascularization and Geographic Atrophy

(2013) Lorah T. Perlee et al.   OPHTHALMOLOGY

Systemic Complement Inhibition with Eculizumab for Geographic Atrophy in Age-Related Macular Degeneration

(2013) Zohar Yehoshua et al.   OPHTHALMOLOGY

Five Years of GWAS Discovery

(2012) Peter M. Visscher et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The estimated prevalence and incidence of late stage age related macular degeneration in the UK

(2012) Christopher G Owen et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

Complement factor H genetic variant and age-related macular degeneration: effect size, modifiers and relationship to disease subtype

(2012) Reecha Sofat et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Age-related macular degeneration

(2012) Laurence S Lim et al.   LANCET

Effect of communicating DNA based risk assessments for Crohn's disease on smoking cessation: randomised controlled trial

(2012) G. J. Hollands et al.   BMJ-British Medical Journal

Common variants near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration

(2011) Yi Yu et al.   HUMAN MOLECULAR GENETICS

A rare penetrant mutation in CFH confers high risk of age-related macular degeneration

(2011) Soumya Raychaudhuri et al.   NATURE GENETICS

Genome-wide association study identifies two susceptibility loci for exudative age-related macular degeneration in the Japanese population

(2011) Satoshi Arakawa et al.   NATURE GENETICS

Myositis Ossificans

(2011) Deborah A. Martin et al.   NEW ENGLAND JOURNAL OF MEDICINE

Age-related macular degeneration: current treatment and future options

(2011) Tanya Moutray et al.   Therapeutic Advances in Chronic Disease

GCTA: A Tool for Genome-wide Complex Trait Analysis

(2010) Jian Yang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Genome-Wide Association Studies: Results from the First Few Years and Potential Implications for Clinical Medicine

(2010) Joel N. Hirschhorn et al.   Annual Review of Medicine

Complement factor H and age-related macular degeneration: the role of glycosaminoglycan recognition in disease pathology

(2010) Simon J. Clark et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Impaired Binding of the Age-related Macular Degeneration-associated Complement Factor H 402H Allotype to Bruch's Membrane in Human Retina

(2010) Simon J. Clark et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration

(2010) W. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Common vs. rare allele hypotheses for complex diseases

(2009) Nicholas J Schork et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Finding the missing heritability of complex diseases

(2009) Teri A. Manolio et al.   NATURE

Variation near complement factor I is associated with risk of advanced AMD

(2008) Jesen A Fagerness et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

The developing mosaic of autoimmune disease risk

(2008) Lisa M Maier et al.   NATURE GENETICS