标题
Arginase: An emerging and promising therapeutic target for cancer treatment
作者
关键词
Arginase, Cancer, Mechanism, L-arginine, Inhibitors, Therapeutic target
出版物
BIOMEDICINE & PHARMACOTHERAPY
Volume 149, Issue -, Pages 112840
出版商
Elsevier BV
发表日期
2022-03-19
DOI
10.1016/j.biopha.2022.112840
参考文献
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- Nod1 promotes colorectal carcinogenesis by regulating the immunosuppressive functions of tumor-infiltrating myeloid cells
- (2021) Charles Maisonneuve et al. Cell Reports
- Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
- (2021) Hyuna Sung et al. CA-A CANCER JOURNAL FOR CLINICIANS
- A Novel Oral Arginase 1/2 Inhibitor Enhances the Antitumor Effect of PD-1 Inhibition in Murine Experimental Gliomas by Altering the Immunosuppressive Environment
- (2021) Paulina Pilanc et al. Frontiers in Oncology
- The prognostic and therapeutic implications of distinct patterns of argininosuccinate synthase 1 (ASS1) and arginase-2 (ARG2) expression by cancer cells and tumor stroma in non-small-cell lung cancer
- (2021) Alexandra Giatromanolaki et al. Cancer & Metabolism
- ECM1 is an essential factor for the determination of M1 macrophage polarization in IBD in response to LPS stimulation
- (2020) Yaguang Zhang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Melanoma-associated fibroblasts impair CD8+ T cell function and modify expression of immune checkpoint regulators via increased arginase activity
- (2020) Barbara Érsek et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Arginase‐II promotes melanoma migration and adhesion through enhancing hydrogen peroxide production and STAT3 signaling
- (2020) Yi Yu et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Discovery and Pharmacokinetics of Sulfamides and Guanidines as Potent Human Arginase 1 Inhibitors
- (2020) Roman Blaszczyk et al. ACS Medicinal Chemistry Letters
- Circulating and tumor-infiltrating arginase 1-expressing cells in gastric adenocarcinoma patients were mainly immature and monocytic Myeloid-derived suppressor cells
- (2020) WeiHong Ren et al. Scientific Reports
- Myeloid Cell-Derived Arginase in Cancer Immune Response
- (2020) Tomasz M. Grzywa et al. Frontiers in Immunology
- Arginase-1+ Exosomes from Reprogrammed Macrophages Promote Glioblastoma Progression
- (2020) Juliana H. Azambuja et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- ERK signalling: a master regulator of cell behaviour, life and fate
- (2020) Hugo Lavoie et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Boronic acid-based arginase inhibitors in cancer immunotherapy
- (2020) Bartlomiej Borek et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Chlorogenic acid induces apoptosis, inhibits metastasis and improves antitumor immunity in breast cancer via the NF‑κB signaling pathway
- (2020) Anqi Zeng et al. ONCOLOGY REPORTS
- Mapping Metabolic Events in the Cancer Cell Cycle Reveals Arginine Catabolism in the Committed SG2M Phase
- (2019) Irena Roci et al. Cell Reports
- Peripheral memory T cells specific for Arginase-1
- (2019) Evelina Martinenaite et al. Cellular & Molecular Immunology
- MAPK/ERK Signaling in Regulation of Renal Differentiation
- (2019) Kurtzeborn et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Small extracellular vesicles containing arginase-1 suppress T-cell responses and promote tumor growth in ovarian carcinoma
- (2019) Malgorzata Czystowska-Kuzmicz et al. Nature Communications
- 440OPhase I study of the arginase inhibitor INCB001158 (1158) alone and in combination with pembrolizumab (PEM) in patients (Pts) with advanced/metastatic (adv/met) solid tumours
- (2019) A Naing et al. ANNALS OF ONCOLOGY
- Arginase-1-based vaccination against the tumor microenvironment: the identification of an optimal T-cell epitope
- (2019) Evelina Martinenaite et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- A novel mouse model demonstrates that oncogenic melanocyte stem cells engender melanoma resembling human disease
- (2019) Qi Sun et al. Nature Communications
- Extracellular Vesicles Shedding Promotes Melanoma Growth in Response to Chemotherapy
- (2019) Luciana Nogueira de Sousa Andrade et al. Scientific Reports
- The potential therapeutic effect of NG-hydroxy-nor-L-arginine in 7,12-dimethylbenz(a)anthracene-induced breast cancer in rats
- (2019) Nikolay Avtandilyan et al. EXPERIMENTAL AND MOLECULAR PATHOLOGY
- Mutations in the signal transducer and activator of transcription family of genes in cancer
- (2018) Nahid Shahmarvand et al. CANCER SCIENCE
- Research of novel anticancer agents targeting arginase inhibition
- (2018) Thanh-Nhat Pham et al. DRUG DISCOVERY TODAY
- Arginase-II negatively regulates renal aquaporin-2 and water reabsorption
- (2018) Ji Huang et al. FASEB JOURNAL
- Oligostilbenoids in Vitis vinifera L. Pinot Noir grape cane extract: Isolation, characterization, in vitro antioxidant capacity and anti-proliferative effect on cancer cells
- (2018) Vania Sáez et al. FOOD CHEMISTRY
- Increased number of arginase 1-positive cells in the stroma of carcinomas compared to precursor lesions and nonneoplastic tissues
- (2018) Tae Jung Jang et al. PATHOLOGY RESEARCH AND PRACTICE
- CD45+CD33lowCD11bdim myeloid-derived suppressor cells suppress CD8+ T cell activity via the IL-6/IL-8-arginase I axis in human gastric cancer
- (2018) Fang-yuan Mao et al. Cell Death & Disease
- Arginase-II activates mTORC1 through myosin-1b in vascular cell senescence and apoptosis
- (2018) Yi Yu et al. Cell Death & Disease
- Chitosan/poly (lactic acid)-coated piceatannol nanoparticles exert an in vitro apoptosis activity on liver, lung and breast cancer cell lines
- (2018) Jeevitha Dhanapal et al. Artificial Cells Nanomedicine and Biotechnology
- The Oncogenic Role of ARG1 in Progression and Metastasis of Hepatocellular Carcinoma
- (2018) Jia You et al. Biomed Research International
- Macrophage-derived IL-1β and TNF-α regulate arginine metabolism in neuroblastoma
- (2018) Livingstone Fultang et al. CANCER RESEARCH
- Cancer pharmacoprevention: Targeting polyamine metabolism to manage risk factors for colon cancer
- (2018) Eugene W. Gerner et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The potential effects of chlorogenic acid, the main phenolic components in coffee, on health: a comprehensive review of the literature
- (2017) Narges Tajik et al. EUROPEAN JOURNAL OF NUTRITION
- Chlorogenic acid inhibits hepatocellular carcinoma in vitro and in vivo
- (2017) Yuan Yan et al. JOURNAL OF NUTRITIONAL BIOCHEMISTRY
- Critical role for arginase 2 in obesity-associated pancreatic cancer
- (2017) Tamara Zaytouni et al. Nature Communications
- Frequent adaptive immune responses against arginase-1
- (2017) Evelina Martinenaite et al. OncoImmunology
- Inhibition of arginase by CB-1158 blocks myeloid cell-mediated immune suppression in the tumor microenvironment
- (2017) Susanne M. Steggerda et al. Journal for ImmunoTherapy of Cancer
- Serum-resistant CpG-STAT3 decoy for targeting survival and immune checkpoint signaling in acute myeloid leukemia
- (2016) Q. Zhang et al. BLOOD
- L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity
- (2016) Roger Geiger et al. CELL
- Pharmacokinetics and Pharmacodynamics of Promising Arginase Inhibitors
- (2016) Khaled S. Abdelkawy et al. EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS
- Long non-coding RNA NEAT1 promotes malignant progression of thyroid carcinoma by regulating miRNA-214
- (2016) Jian-Hua Li et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- A Comprehensive Review on the Chemotherapeutic Potential of Piceatannol for Cancer Treatment, with Mechanistic Insights
- (2016) Mohamed Ali Seyed et al. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
- Arginase Inhibitors: A Rational Approach Over One Century
- (2016) Marc Pudlo et al. MEDICINAL RESEARCH REVIEWS
- Arginase 1 is an innate lymphoid-cell-intrinsic metabolic checkpoint controlling type 2 inflammation
- (2016) Laurel A Monticelli et al. NATURE IMMUNOLOGY
- The Nature of Myeloid-Derived Suppressor Cells in the Tumor Microenvironment
- (2016) Vinit Kumar et al. TRENDS IN IMMUNOLOGY
- Human cytomegalovirus may promote tumour progression by upregulating arginase-2
- (2016) Helena Costa et al. Oncotarget
- Modulation of L-Arginine-Arginase Metabolic Pathway Enzymes: Immunocytochemistry and mRNA Expression in Peripheral Blood and Tissue Levels in Head and Neck Squamous Cell Carcinomas in North East India
- (2015) Shilpee Srivastava et al. Asian Pacific Journal of Cancer Prevention
- Piceatannol Enhances the Antitumor Efficacy of Gemcitabine in Human A549 Non-Small Cell Lung Cancer Cells
- (2015) Bin Xu et al. ONCOLOGY RESEARCH
- Arginase: an old enzyme with new tricks
- (2015) Ruth B. Caldwell et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Immunosuppressive parameters in serum of ovarian cancer patients change during the disease course
- (2015) An Coosemans et al. OncoImmunology
- Resveratrol prevents hypoxia-induced arginase II expression and proliferation of human pulmonary artery smooth muscle cells via Akt-dependent signaling
- (2014) Bernadette Chen et al. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
- ARG2 impairs endothelial autophagy through regulation of MTOR and PRKAA/AMPK signaling in advanced atherosclerosis
- (2014) Yuyan Xiong et al. Autophagy
- Polyamines metabolism and breast cancer: state of the art and perspectives
- (2014) Manuela Cervelli et al. BREAST CANCER RESEARCH AND TREATMENT
- Mapping the immunosuppressive environment in uterine tumors: implications for immunotherapy
- (2014) Anke Vanderstraeten et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- p38 mitogen-activated protein kinase is involved in arginase-II-mediated eNOS-Uncoupling in Obesity
- (2014) Yi Yu et al. Cardiovascular Diabetology
- OxLDL Triggers Retrograde Translocation of Arginase2 in Aortic Endothelial Cells via ROCK and Mitochondrial Processing Peptidase
- (2014) Deepesh Pandey et al. CIRCULATION RESEARCH
- Significance of arginase determination in body fluids of patients with hepatocellular carcinoma and liver cirrhosis before and after surgical treatment
- (2014) Alicja Chrzanowska et al. CLINICAL BIOCHEMISTRY
- New insights into cancer immunoediting and its three component phases—elimination, equilibrium and escape
- (2014) Deepak Mittal et al. CURRENT OPINION IN IMMUNOLOGY
- Immunosuppression in cervical cancer with special reference to arginase activity
- (2014) Astrid M. Bedoya et al. GYNECOLOGIC ONCOLOGY
- Picking the Point of Inhibition: A Comparative Review of PI3K/AKT/mTOR Pathway Inhibitors
- (2014) R. Dienstmann et al. MOLECULAR CANCER THERAPEUTICS
- Altered arginine metabolism in Alzheimer's disease brains
- (2014) Ping Liu et al. NEUROBIOLOGY OF AGING
- Arginase and C-reactive protein as potential serum-based biomarker of head and neck squamous cell carcinoma patients of north east India
- (2014) Biswadeep Choudhury et al. TUMOR BIOLOGY
- Expression Quantitative Trait Loci and Receptor Pharmacology Implicate Arg1 and the GABA-A Receptor as Therapeutic Targets in Neuroblastoma
- (2014) Christopher S. Hackett et al. Cell Reports
- 2-Substituted-2-amino-6-boronohexanoic acids as arginase inhibitors
- (2013) Adam Golebiowski et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Acute myeloid leukemia creates an arginase-dependent immunosuppressive microenvironment
- (2013) F. Mussai et al. BLOOD
- Piceatannol suppresses the metastatic potential of MCF10A human breast epithelial cells harboring mutated H-ras by inhibiting MMP-2 expression
- (2013) NURY SONG et al. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
- Piceatannol Enhances Cisplatin Sensitivity in Ovarian Cancer via Modulation of p53, X-linked Inhibitor of Apoptosis Protein (XIAP), and Mitochondrial Fission
- (2013) Lee Farrand et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- STAT3 regulates arginase-I in myeloid-derived suppressor cells from cancer patients
- (2013) David Vasquez-Dunddel et al. JOURNAL OF CLINICAL INVESTIGATION
- Arginase-1 mRNA expression correlates with myeloid-derived suppressor cell levels in peripheral blood of NSCLC patients
- (2013) Marlies E. Heuvers et al. LUNG CANCER
- Arginase II Expressed in Cancer-Associated Fibroblasts Indicates Tissue Hypoxia and Predicts Poor Outcome in Patients with Pancreatic Cancer
- (2013) Yoshinori Ino et al. PLoS One
- Cytotoxicity of Tumor Antigen Specific Human T Cells Is Unimpaired by Arginine Depletion
- (2013) Markus Munder et al. PLoS One
- Proteomic Identification of Mitochondrial Targets of Arginase in Human Breast Cancer
- (2013) Rajan Singh et al. PLoS One
- Nitric oxide and cancer: a review
- (2013) Sheetal Korde Choudhari et al. World Journal of Surgical Oncology
- Comparative pharmacokinetics of Nω-hydroxy-nor-L-arginine, an arginase inhibitor, after single-dose intravenous, intraperitoneal and intratracheal administration to brown Norway rats
- (2013) Zuzana Havlinova et al. XENOBIOTICA
- Role of STAT3 in Cancer Metastasis and Translational Advances
- (2013) Mohammad Zahid Kamran et al. Biomed Research International
- Arginase‐II Induces Vascular Smooth Muscle Cell Senescence and Apoptosis Through p66Shc and p53 Independently of Its l ‐Arginine Ureahydrolase Activity: Implications for Atherosclerotic Plaque Vulnerability
- (2013) Yuyan Xiong et al. Journal of the American Heart Association
- Dendritic Cells in the Cancer Microenvironment
- (2013) Yang Ma et al. Journal of Cancer
- Polyamine-Blocking Therapy Reverses Immunosuppression in the Tumor Microenvironment
- (2013) C. S. Hayes et al. Cancer Immunology Research
- Positive crosstalk between arginase-II and S6K1 in vascular endothelial inflammation and aging
- (2012) Gautham Yepuri et al. AGING CELL
- Tissue microarray-based study of patients with lymph node-positive breast cancer shows tyrosine phosphorylation of signal transducer and activator of transcription 3 (tyrosine705-STAT3) is a marker of good prognosis
- (2012) Amir Sonnenblick et al. Clinical & Translational Oncology
- Targeting the MAPK–RAS–RAF signaling pathway in cancer therapy
- (2012) Libero Santarpia et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- Polymeric black tea polyphenols modulate the localization and activity of 12-O-tetradecanoylphorbol-13-acetate-mediated kinases in mouse skin: Mechanisms of their anti-tumor-promoting action
- (2012) Gaurav Kumar et al. FREE RADICAL BIOLOGY AND MEDICINE
- Interferon-Gamma-Induced Nitric Oxide Inhibits the Proliferation of Murine Renal Cell Carcinoma Cells
- (2012) David J. Tate Jr. et al. International Journal of Biological Sciences
- Arginase Activity in Patients with Breast Cancer: An Analysis of Plasma, Tumors, and Its Relationship with the Presence of the Estrogen Receptor
- (2012) Gabriel Perez et al. ONKOLOGIE
- Arginase II Promotes Macrophage Inflammatory Responses Through Mitochondrial Reactive Oxygen Species, Contributing to Insulin Resistance and Atherogenesis
- (2012) Xiu‐Fen Ming et al. Journal of the American Heart Association
- Expression patterns of the immunomodulatory enzyme arginase 1 in blood, lymph nodes and tumor tissue of early-stage breast cancer patients
- (2012) Jana de Boniface et al. OncoImmunology
- Arginine and polyamines in Helicobacter pylori-induced immune dysregulation and gastric carcinogenesis
- (2011) Rupesh Chaturvedi et al. AMINO ACIDS
- Global cancer statistics
- (2011) Ahmedin Jemal et al. CA-A CANCER JOURNAL FOR CLINICIANS
- Neutrophil Degranulation and Immunosuppression in Patients with GBM: Restoration of Cellular Immune Function by Targeting Arginase I
- (2011) T. R. Sippel et al. CLINICAL CANCER RESEARCH
- Selective apoptotic effects of piceatannol and myricetin in human cancer cells
- (2011) Paloma Morales et al. JOURNAL OF APPLIED TOXICOLOGY
- The mechanisms by which polyamines accelerate tumor spread
- (2011) Kuniyasu Soda JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Cancer Immunoediting: Integrating Immunity's Roles in Cancer Suppression and Promotion
- (2011) R. D. Schreiber et al. SCIENCE
- Inhibition of human arginase I by substrate and product analogues
- (2010) Luigi Di Costanzo et al. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
- Cardiovascular effects of arginase inhibition in spontaneously hypertensive rats with fully developed hypertension
- (2010) Teddy Bagnost et al. CARDIOVASCULAR RESEARCH
- Arginase 2 and nitric oxide synthase: Pathways associated with the pathogenesis of thyroid tumors
- (2010) Maria Sharmila A. Sousa et al. FREE RADICAL BIOLOGY AND MEDICINE
- Arginase I–Producing Myeloid-Derived Suppressor Cells in Renal Cell Carcinoma Are a Subpopulation of Activated Granulocytes
- (2009) Paulo C. Rodriguez et al. CANCER RESEARCH
- IL-8 induces exocytosis of arginase 1 by neutrophil polymorphonuclears in nonsmall cell lung cancer
- (2009) Rita Rotondo et al. INTERNATIONAL JOURNAL OF CANCER
- Myeloid-Derived Suppressor Cells: Linking Inflammation and Cancer
- (2009) S. Ostrand-Rosenberg et al. JOURNAL OF IMMUNOLOGY
- Apoptosis-Inducing High.NO Concentrations Are Not Sustained Either in Nascent or in Developed Cancers
- (2008) Adam Heller ChemMedChem
- l-Arginine as a factor increasing arginase significance in diagnosis of primary and metastatic colorectal cancer
- (2008) Wojciech Graboń et al. CLINICAL BIOCHEMISTRY
- Concepts of neural nitric oxide-mediated transmission
- (2008) John Garthwaite EUROPEAN JOURNAL OF NEUROSCIENCE
- Arginase 2 is expressed by human lung cancer, but it neither induces immune suppression, nor affects disease progression
- (2008) Rita Rotondo et al. INTERNATIONAL JOURNAL OF CANCER
- Effect of arginase II on L-arginine depletion and cell growth in murine cell lines of renal cell carcinoma
- (2008) David J Tate et al. Journal of Hematology & Oncology
- Murine ovarian cancer vascular leukocytes require arginase-1 activity for T cell suppression
- (2008) S. Peter Bak et al. MOLECULAR IMMUNOLOGY
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