Article
Medicine, Research & Experimental
Xiuhua Su, Tao Sun, Meng Li, Yuan Xia, Mingying Li, Dongmei Wang, Fei Lu, Jingjing Ye, Chunyan Ji
Summary: This study investigated the mechanism of Treg alterations in diffuse large B-cell lymphoma (DLBCL) and found that Lkb1 plays a critical role in Treg-mediated immune escape in DLBCL. The findings suggest that Lkb1 could be a potential target for immunotherapy in DLBCL.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Satu Salmi, Kaisla Halinen, Anton Lin, Sanna Suikkanen, Otto Jokelainen, Eija Rahunen, Hanna Siiskonen, Sanna Pasonen-Seppanen
Summary: In melanoma, CD8+ and GrB+ lymphocytes were found to be more abundant in pT4 melanomas and lymph node metastases compared to primaries. A low GrB/CD8 ratio was associated with better recurrence-free survival in primary melanomas, suggesting that GrB+ lymphocytes may represent activated immunosuppressive lymphocytes.
Review
Chemistry, Medicinal
Cheng Zuo, Yong-sheng Xu, Peng-fei He, Wen-jun Zhang
Summary: This paper discusses the mechanism and immunomodulatory function of P2X7 receptor involved in the progression of colorectal cancer (CRC), as well as the effect of antagonizing the activity of P2X7 receptor on CRC progression. The P2X7 receptor may serve as a new pharmacological molecular target for the treatment of CRC.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Oncology
Stine Emilie Weis-Banke, Thomas Landkildehus Lisle, Maria Perez-Penco, Aimilia Schina, Mie Linder Hubbe, Majken Siersbaek, Morten Orebo Holmstrom, Mia Aaboe Jorgensen, Inge Marie Svane, Ozcan Met, Niels Odum, Daniel Hargbol Madsen, Marco Donia, Lars Grontved, Mads Hald Andersen
Summary: This study identified the presence of ARG2-specific CD8(+) T cells in both healthy donors and patients with cancer. These T cells are capable of recognizing and responding to cancer cells and activated Tregs with high ARG2 expression. Furthermore, vaccination with ARG2-derived epitopes in a mouse tumor model resulted in tumor growth suppression and antitumorigenic immunomodulation.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Review
Oncology
Klaus Pantel, Catherine Alix-Panabieres
Summary: The research on circulating tumor cells (CTCs) has provided valuable insights into the mechanisms of cancer metastasis, the response to therapies, and the identification of new therapeutic targets. The presence and characteristics of CTCs have potential clinical applications in guiding decision-making in cancer management.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
Kevin Kos, Karin E. de Visser
Summary: The microenvironment of breast cancer is influenced by interactions between immune cells, particularly T-regs, which play a crucial role in tumor progression and prognosis. Understanding their biology and impact on breast cancer may lead to more effective immunotherapy strategies.
ANNUAL REVIEW OF CANCER BIOLOGY, VOL 5, 2021
(2021)
Review
Immunology
Yiran Qiu, Shouyu Ke, Jieqiong Chen, Zhizhen Qin, Wenle Zhang, Yaqin Yuan, Dehua Meng, Gang Zhao, Kejin Wu, Bin Li, Dan Li
Summary: This review summarizes the latest findings on the dynamic connections and reciprocal regulations of non-lymphoid Treg cell subsets in the immune escape of tumour cells in solid tumors, providing new insights for the development of next-generation engineered T cell-based immune treatments for solid tumors.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Agnete S. T. Engelsen, Maria L. Lotsberg, Raefa Abou Khouzam, Jean-Paul Thiery, James B. Lorens, Salem Chouaib, Stephane Terry
Summary: The development and implementation of Immune Checkpoint Inhibitors (ICI) have significantly improved the survival of metastatic cancer patients, but low response rates and limited understanding of mechanisms regulating anti-tumor immunity remain major concerns. AXL, a receptor tyrosine kinase, has been identified as a potential molecular target to overcome therapy resistance and improve ICI efficacy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Marit J. van Elsas, Camilla Labrie, Anders Etzerodt, Pornpimol Charoentong, Jordi J. C. van Stigt Thans, Thorbald Van Hall, Sjoerd H. van der Burg
Summary: A small population of CD163(hi) tissue-resident macrophages is identified to be responsible for primary and secondary resistance against T-cell-based immunotherapies. While these CD163(hi) M2 macrophages are resistant to Csf1r-targeted therapies, in-depth characterization and identification of the underlying mechanisms driving immunotherapy resistance allows the specific targeting of this subset of macrophages, thereby creating new opportunities for therapeutic intervention with the aim to overcome immunotherapy resistance.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Review
Immunology
Celine Blaye, Thomas Boyer, Florent Peyraud, Charlotte Domblides, Nicolas Larmonier
Summary: Breast cancers are often associated with an immunosuppressive microenvironment, and myeloid cells play a major role in this tumor-promoting environment. Besides their immunosuppressive properties, breast cancer-induced myeloid cells also have a broad range of non-immunological tumor-promoting functions. However, there are difficulties and challenges in distinguishing specific subsets of these cells, hindering their selective targeting and use as potential biomarkers.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Ran Gao, Guo-Ping Shi, Jing Wang
Summary: Regulatory T cells (Tregs) are CD4(+) T cells that can suppress abnormal or excessive immune responses. Targeting Tregs selectively may alleviate their immunosuppressive activities and has shown promising results in preclinical and early-phase clinical trials. Combination therapy has been identified as a better choice than single immunotherapy, radiotherapy, or chemotherapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Maud Plaschka, Valentin Benboubker, Maxime Grimont, Justine Berthet, Laurie Tonon, Jonathan Lopez, Myrtille Le-Bouar, Brigitte Balme, Garance Tondeur, Arnaud de la Fouchardiere, Lionel Larue, Alain Puisieux, Yenkel Grinberg-Bleyer, Nathalie Bendriss-Vermare, Bertrand Dubois, Christophe Caux, Stephane Dalle, Julie Caramel
Summary: This study reveals that ZEB1 expression in melanoma cells is associated with decreased CD8(+) T cell infiltration, leading to tumor immune evasion and resistance to immune checkpoint blockade. ZEB1 directly represses the secretion of T cell-attracting chemokines, such as CXCL10, and targeting ZEB1 may enhance the efficacy of immunotherapy in melanoma.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Review
Pharmacology & Pharmacy
Qin Xie, Jian Ding, Yi Chen
Summary: CD8(+) T lymphocytes play a crucial role in host antitumor immunity, but tumor-driven microenvironments can inhibit their activation and cytotoxicity. Stromal cells exert immunosuppressive effects in the tumor microenvironment.
ACTA PHARMACEUTICA SINICA B
(2021)
Article
Medicine, Research & Experimental
Magdalena Hinterbrandner, Viviana Rubino, Carina Stoll, Stefan Forster, Noah Schnuriger, Ramin Radpour, Gabriela M. Baerlocher, Adrian F. Ochsenbein, Carsten Riether
Summary: The study showed that leukemia stem cells (LSCs) in chronic myeloid leukemia (CML) can be killed by CD8(+) cytotoxic T cells (CTLs) in vitro, but Tregs in CML bone marrow protect LSCs from CTL-mediated elimination in vivo. TNFRSF4 was identified as a potential target to reduce the function of Tregs and enhance antileukemic immunity in CML.
Review
Oncology
Robin Reschke, Daniel J. Olson
Summary: The lack of T cells in tumors is one of the main reasons for the failure of immunotherapy. Strengthening innate immune mechanisms can improve the efficacy of tumor immunotherapy, such as delivering innate immune factors into the tumor microenvironment. These mechanisms include immune sensing in the tumor and efficient antigen presentation, as well as important cells and molecules that promote T cell inflamed tumor formation and immune therapy response.
Review
Oncology
Yuri L. Bunimovich, Anton A. Keskinov, Galina V. Shurin, Michael R. Shurin
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2017)
Editorial Material
Medicine, Research & Experimental
Michael R. Shurin
JOURNAL OF CLINICAL INVESTIGATION
(2018)
Article
Oncology
Galina V. Shurin, Oleg Kruglov, Fei Ding, Yan Lin, Xingxing Hao, Anton A. Keskinov, Zhaoyang You, Anna E. Lokshin, William A. LaFramboise, Louis D. Falo, Michael R. Shurin, Yuri L. Bunimovich
Article
Biochemistry & Molecular Biology
Gulnur K. Zakiryanova, Elena Kustova, Nataliya T. Urazalieva, Emile T. Baimuchametov, Narymzhan N. Nakisbekov, Michael R. Shurin
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Review
Immunology
Michael R. Shurin, Galina V. Shurin, Samuel B. Zlotnikov, Yuri L. Bunimovich
JOURNAL OF IMMUNOLOGY
(2020)
Article
Oncology
Deena M. Maurer, Juraj Adamik, Patricia M. Santos, Jian Shi, Michael R. Shurin, John M. Kirkwood, Walter J. Storkus, Lisa H. Butterfield
CANCER IMMUNOLOGY RESEARCH
(2020)
Review
Cell Biology
Michael R. Shurin, James H. Baraldi, Galina V. Shurin
Summary: Surgery can promote cancer metastasis through mechanisms such as the release of neuroendocrine hormones, immunosuppression, neovascularization, and tissue remodeling. The role of neuroimmune regulation in surgery-associated metastasis is not well understood, highlighting the need for further research in this area.
Article
Medical Laboratory Technology
Nathan Cook, Lingqing Xu, Shaymaa Hegazy, Bradley J. Wheeler, Adam R. Anderson, Nancy Critelli, Mary Yost, Anita K. McElroy, Michael R. Shurin, Sarah E. Wheeler
Summary: The study aimed to detect antibodies to different SARS-CoV-2 antigens, analyzing the performance of the BioRad SARS-CoV-2 IgG multiplex assay in terms of diagnostic accuracy, differentiation of vaccination and natural disease, and retrospective exposure determination. Results showed that the assay is comparable to existing methods, achieving 100% sensitivity when all markers are included, with practical implications for research and infection prevention strategies.
CLINICAL BIOCHEMISTRY
(2021)
Article
Microbiology
Sarah E. Wheeler, Galina Shurin, Mary Yost, Adam Anderson, Lisa Pinto, Alan Wells, Michael R. Shurin
Summary: Understanding the development and duration of virus-specific antibodies after COVID-19 vaccination is important for controlling the pandemic. Postvaccination antibody testing can help in monitoring individuals after vaccination and selecting those who may require additional doses or not need vaccination.
MICROBIOLOGY SPECTRUM
(2021)
Article
Microbiology
Lingqing Xu, Joshua Doyle, Dominique J. Barbeau, Valerie Le Sage, Alan Wells, W. Paul Duprex, Michael R. Shurin, Sarah E. Wheeler, Anita K. McElroy
Summary: This study found a 4.5-fold increase in SARS-CoV-2 seroprevalence from Fall 2020 to February 2021 in Allegheny County, Pennsylvania, due to increased incidence of both natural disease and vaccination. The neutralization titer was significantly correlated with RBD titer but not with N titer. In the February cohort, higher median income and white race were associated with serological findings consistent with vaccination.
Review
Oncology
James H. Baraldi, German Martyn, Galina Shurin, Michael R. Shurin
Summary: This comprehensive review summarizes the literature on tumor innervation, addressing the evidence, historical developments, and important mechanisms related to tumor development. It concludes that solid tumors are innervated and that nerves, neurons, and glia play a functional role in tumor development.
Review
Oncology
Nuray Erin, Galina V. Shurin, James H. Baraldi, Michael R. Shurin
Summary: Sensory nerve fibers and the vagus nerve play crucial roles in tumor growth and spread. Current findings are contradictory, likely due to the stage and aggressiveness of the tumor model. Sensory neurons and Schwann cells are important players in tumor development, growth, and progression.
Article
Oncology
Shuhui Cao, Yue Wang, Yan Zhou, Yao Zhang, Xuxinyi Ling, Lincheng Zhang, Jingwen Li, Yu Yang, Weimin Wang, Michael R. Shurin, Hua Zhong
Summary: This study demonstrates the role of tumor-associated Schwann cells in the progression of small-cell lung cancer by constructing a mRNA-miRNA-lncRNA network. The findings improve our understanding of the interaction between tumor cells and Schwann cells, and provide insights into cancer progression.
Article
Cell Biology
Galina Shurin, Kavita Vats, Oleg Kruglov, Yuri L. Bunimovich, Michael R. Shurin
Summary: Nerve-cancer crosstalk is controlled by Schwann cells, which can be stimulated by tumor cells to produce prostaglandin E. This inhibits the proliferation of activated T cells and leads to T cell exhaustion. Understanding this pathway is important for the development of cancer therapies.
Editorial Material
Immunology
Michael R. Shurin
IMMUNOTARGETS AND THERAPY
(2018)