Heat shock proteins in cell signaling and cancer

The functions and regulation of heat shock proteins; key orchestrators of proteostasis and the heat shock response

(2021) Benjamin J. Lang et al.   ARCHIVES OF TOXICOLOGY

Mol* Viewer: modern web app for 3D visualization and analysis of large biomolecular structures

(2021) David Sehnal et al.   NUCLEIC ACIDS RESEARCH

At the Crossroads of Apoptosis and Autophagy: Multiple Roles of the Co-Chaperone BAG3 in Stress and Therapy Resistance of Cancer

(2020) Donat Kögel et al.   Cells

Post-translational modifications of Hsp70 family proteins: Expanding the chaperone code

(2020) Nitika et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Post-translational modifications of Hsp90 and translating the chaperone code

(2020) Sarah J. Backe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chemogenomic screening identifies the Hsp70 co-chaperone DNAJA1 as a hub for anticancer drug resistance

(2020) Nitika et al.   Scientific Reports

The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation

(2020) Kaushik Bhattacharya et al.   Nature Communications

The Hsp70 chaperone network

(2019) Rina Rosenzweig et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Methods to validate Hsp90 inhibitor specificity, to identify off-target effects, and to rethink approaches for further clinical development

(2018) Len Neckers et al.   CELL STRESS & CHAPERONES

Hsp90 Breaks the Deadlock of the Hsp70 Chaperone System

(2018) Tania Morán Luengo et al.   MOLECULAR CELL

Intra-molecular pathways of allosteric control in Hsp70s

(2018) Matthias P. Mayer   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

HSP90 inhibitors disrupt a transient HSP90-HSF1 interaction and identify a noncanonical model of HSP90-mediated HSF1 regulation

(2018) Toshiki Kijima et al.   Scientific Reports

Hsp90 Heterocomplexes Regulate Steroid Hormone Receptors: From Stress Response to Psychiatric Disease

(2018) Jeremy Baker et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Dynamic Phosphorylation of the C Terminus of Hsp70 Regulates the Mitochondrial Import of SOD2 and Redox Balance

(2018) Sara Zemanovic et al.   Cell Reports

The Role of the Multifunctional BAG3 Protein in Cellular Protein Quality Control and in Disease

(2017) Elisabeth Stürner et al.   Frontiers in Molecular Neuroscience

The epichaperome is an integrated chaperome network that facilitates tumour survival

(2016) Anna Rodina et al.   NATURE

Heat Shock Proteins Promote Cancer: It's a Protection Racket

(2016) Stuart K. Calderwood et al.   TRENDS IN BIOCHEMICAL SCIENCES

Mps1 Mediated Phosphorylation of Hsp90 Confers Renal Cell Carcinoma Sensitivity and Selectivity to Hsp90 Inhibitors

(2016) Mark R. Woodford et al.   Cell Reports

Validation of the Hsp70-Bag3 Protein-Protein Interaction as a Potential Therapeutic Target in Cancer

(2015) X. Li et al.   MOLECULAR CANCER THERAPEUTICS

Targeting the hsp70 gene delays mammary tumor initiation and inhibits tumor cell metastasis

(2015) J Gong et al.   ONCOGENE

A Bipartite Interaction between Hsp70 and CHIP Regulates Ubiquitination of Chaperoned Client Proteins

(2015) Huaqun Zhang et al.   STRUCTURE

Hsp70 Forms Antiparallel Dimers Stabilized by Post-translational Modifications to Position Clients for Transfer to Hsp90

(2015) Nina Morgner et al.   Cell Reports

c-Abl Mediated Tyrosine Phosphorylation of Aha1 Activates Its Co-chaperone Function in Cancer Cells

(2015) Diana M. Dunn et al.   Cell Reports

BAG3 induces the sequestration of proteasomal clients into cytoplasmic puncta

(2014) Melania Minoia et al.   Autophagy

Hsp70–Bag3 Interactions Regulate Cancer-Related Signaling Networks

(2014) Teresa A. Colvin et al.   CANCER RESEARCH

Retraction Notice: Regulatory Chaperone Complexes in Neurodegenerative Diseases: A Perspective on Therapeutic Intervention

(2014)   Current Alzheimer Research

Hsp70 in cancer: back to the future

(2014) M Y Sherman et al.   ONCOGENE

HSF1 regulation of β-catenin in mammary cancer cells through control of HuR/elavL1 expression

(2014) S-D Chou et al.   ONCOGENE

The Molecular Chaperone Hsp70 Activates Protein Phosphatase 5 (PP5) by Binding the Tetratricopeptide Repeat (TPR) Domain

(2013) Jamie N. Connarn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Effects of Threonine Phosphorylation on the Stability and Dynamics of the Central Molecular Switch Region of 18.5-kDa Myelin Basic Protein

(2013) Kenrick A. Vassall et al.   PLoS One

Heat shock proteins and heat shock factor 1 in carcinogenesis and tumor development: an update

(2012) Daniel R. Ciocca et al.   ARCHIVES OF TOXICOLOGY

Quantitative Analysis of Hsp90-Client Interactions Reveals Principles of Substrate Recognition

(2012) Mikko Taipale et al.   CELL

CDK-Dependent Hsp70 Phosphorylation Controls G1 Cyclin Abundance and Cell-Cycle Progression

(2012) Andrew W. Truman et al.   CELL

Hsp90 Molecular Chaperone Inhibitors: Are We There Yet?

(2012) L. Neckers et al.   CLINICAL CANCER RESEARCH

The anti-inflammatory mechanisms of Hsp70

(2012) Thiago J. Borges et al.   Frontiers in Immunology

Oncogenes induce senescence with incomplete growth arrest and suppress the DNA damage response in immortalized cells

(2011) Michael Y. Sherman et al.   AGING CELL

Human DNAJ in cancer and stem cells

(2011) Jason N. Sterrenberg et al.   CANCER LETTERS

BAG3 mediates chaperone-based aggresome-targeting and selective autophagy of misfolded proteins

(2011) Martin Gamerdinger et al.   EMBO REPORTS

Heat shock protein Hsp72 plays an essential role in Her2-induced mammary tumorigenesis

(2011) L Meng et al.   ONCOGENE

Role of molecular chaperones and TPR-domain proteins in the cytoplasmic transport of steroid receptors and their passage through the nuclear pore

(2011) Mario D. Galigniana et al.   Nucleus

Cooperativity within proximal phosphorylation sites is revealed from large-scale proteomics data

(2010) Regev Schweiger et al.   Biology Direct

Hsp90 phosphorylation, Wee1 and the cell cycle

(2010) Mehdi Mollapour et al.   CELL CYCLE

Versatile TPR domains accommodate different modes of target protein recognition and function

(2010) Rudi Kenneth Allan et al.   CELL STRESS & CHAPERONES

Regulatory mechanisms involved in the control of ubiquitin homeostasis

(2010) Y. Kimura et al.   JOURNAL OF BIOCHEMISTRY

The Tumor Suppressor hTid1 Inhibits STAT5b Activity via Functional Interaction

(2010) Isabelle Dhennin-Duthille et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IKK  protein is a target of BAG3 regulatory activity in human tumor growth

(2010) M. Ammirante et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphorylation-induced structural changes in smooth muscle myosin regulatory light chain

(2010) D. Kast et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Solution conformation of wild-type E. coli Hsp70 (DnaK) chaperone complexed with ADP and substrate

(2009) E. B. Bertelsen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The dual-specificity phosphatase hYVH1 interacts with Hsp70 and prevents heat-shock-induced cell death

(2008) Priya R. Sharda et al.   BIOCHEMICAL JOURNAL

Guidelines for the nomenclature of the human heat shock proteins

(2008) Harm H. Kampinga et al.   CELL STRESS & CHAPERONES

The BAG proteins: a ubiquitous family of chaperone regulators

(2008) M. Kabbage et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Heat Shock Protein Hsp72 Controls Oncogene-Induced Senescence Pathways in Cancer Cells

(2008) V. L. Gabai et al.   MOLECULAR AND CELLULAR BIOLOGY

Minireview: The Intersection of Steroid Receptors with Molecular Chaperones: Observations and Questions

(2008) David F. Smith et al.   MOLECULAR ENDOCRINOLOGY

Charge environments around phosphorylation sites in proteins

(2008) James Kitchen et al.   BMC STRUCTURAL BIOLOGY

The Role of heat shock protein 27 in extravillous trophoblast differentiation

(2007) S. Tartakover Matalon et al.   JOURNAL OF CELLULAR BIOCHEMISTRY