Post-translational modifications of Hsp90 and translating the chaperone code

Mechanism of Long-Range Chromosome Motion Triggered by Gene Activation

(2020) Anqi Wang et al.   DEVELOPMENTAL CELL

A methylated lysine is a switch point for conformational communication in the chaperone Hsp90

(2020) Alexandra Rehn et al.   Nature Communications

Exploring Mechanisms of Communication Switching in the Hsp90-Cdc37 Regulatory Complexes with Client Kinases through Allosteric Coupling of Phosphorylation Sites: Perturbation-Based Modeling and Hierarchical Community Analysis of Residue Interaction Networks

(2020) Gabrielle Stetz et al.   Journal of Chemical Theory and Computation

Post-translational Regulation of FNIP1 Creates a Rheostat for the Molecular Chaperone Hsp90

(2019) Rebecca A. Sager et al.   Cell Reports

The conserved NxNNWHW motif in Aha-type co-chaperones modulates the kinetics of Hsp90 ATPase stimulation

(2019) Rebecca Mercier et al.   Nature Communications

Structure, Function, and Regulation of the Hsp90 Machinery

(2019) Maximilian M. Biebl et al.   Cold Spring Harbor Perspectives in Biology

The sensitivity to Hsp90 inhibitors of both normal and oncogenically transformed cells is determined by the equilibrium between cellular quiescence and activity

(2019) Pablo C. Echeverria et al.   PLoS One

Phosphorylation of HSP90 by protein kinase A is essential for the nuclear translocation of androgen receptor

(2019) Manisha Dagar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hsp90 middle domain phosphorylation initiates a complex conformational program to recruit the ATPase-stimulating cochaperone Aha1

(2019) Wanping Xu et al.   Nature Communications

A Bacterial Effector Mimics a Host HSP90 Client to Undermine Immunity

(2019) Victor A. Lopez et al.   CELL

Mutation of the co-chaperone Tsc1 in bladder cancer diminishes Hsp90 acetylation and reduces drug sensitivity and selectivity

(2019) Mark R. Woodford et al.   Oncotarget

SIRT2 reduces actin polymerization and cell migration through deacetylation and degradation of HSP90

(2018) Jung Sun Min et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Methods to validate Hsp90 inhibitor specificity, to identify off-target effects, and to rethink approaches for further clinical development

(2018) Len Neckers et al.   CELL STRESS & CHAPERONES

UbiSite approach for comprehensive mapping of lysine and N-terminal ubiquitination sites

(2018) Vyacheslav Akimov et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The novel histone de acetylase 6 inhibitor, MPT0G211, ameliorates tau phosphorylation and cognitive deficits in an Alzheimer’s disease model

(2018) Sheng-Jun Fan et al.   Cell Death & Disease

Phosphorylation induced cochaperone unfolding promotes kinase recruitment and client class-specific Hsp90 phosphorylation

(2018) Ashleigh B. Bachman et al.   Nature Communications

UbiSite approach for comprehensive mapping of lysine and N-terminal ubiquitination sites

(2018) Vyacheslav Akimov et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Dissecting Structure-Encoded Determinants of Allosteric Cross-Talk between Post-Translational Modification Sites in the Hsp90 Chaperones

(2018) Gabrielle Stetz et al.   Scientific Reports

A PQM-1-Mediated Response Triggers Transcellular Chaperone Signaling and Regulates Organismal Proteostasis

(2018) Daniel O’Brien et al.   Cell Reports

A Novel Method for Site-Specific Chemical Sumoylation: Sumoylation of Hsp90 Modulates Co-Chaperone Binding In Vitro

(2018) Annemarie Wolmarans et al.   BIOLOGICAL CHEMISTRY

Nuclear F-actin and myosins drive relocalization of heterochromatic breaks

(2018) Christopher P. Caridi et al.   NATURE

Nuclear ARP2/3 drives DNA break clustering for homology-directed repair

(2018) Benjamin R. Schrank et al.   NATURE

Hsp90α regulates ATM and NBN functions in sensing and repair of DNA double-strand breaks

(2017) Rosa Pennisi et al.   FEBS Journal

Isoform-Specific Phosphorylation in Human Hsp90β Affects Interaction with Clients and the Cochaperone Cdc37

(2017) Minh T.N. Nguyen et al.   JOURNAL OF MOLECULAR BIOLOGY

The Plasticity of the Hsp90 Co-chaperone System

(2017) Priyanka Sahasrabudhe et al.   MOLECULAR CELL

The HSP90 chaperone machinery

(2017) Florian H. Schopf et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cracking the Chaperone Code: Cellular Roles for Hsp70 Phosphorylation

(2017) Nitika et al.   TRENDS IN BIOCHEMICAL SCIENCES

The Hsp90 Chaperone Network Modulates Candida Virulence Traits

(2017) Teresa R. O’Meara et al.   TRENDS IN MICROBIOLOGY

An Hsp90 co-chaperone protein in yeast is functionally replaced by site-specific posttranslational modification in humans

(2017) Abbey D. Zuehlke et al.   Nature Communications

Differential Regulation of G1 CDK Complexes by the Hsp90-Cdc37 Chaperone System

(2017) Stephen T. Hallett et al.   Cell Reports

Cdc7-Dbf4-mediated phosphorylation of HSP90-S164 stabilizes HSP90-HCLK2-MRN complex to enhance ATR/ATM signaling that overcomes replication stress in cancer

(2017) An Ning Cheng et al.   Scientific Reports

HSP90 promotes Burkitt lymphoma cell survival by maintaining tonic B-cell receptor signaling

(2016) Roland Walter et al.   BLOOD

Histone Deacetylase 6–Controlled Hsp90 Acetylation Significantly Alters Mineralocorticoid Receptor Subcellular Dynamics But Not its Transcriptional Activity

(2016) Rubén Jiménez-Canino et al.   ENDOCRINOLOGY

Regulation of cell-non-autonomous proteostasis in metazoans

(2016) D. O'Brien et al.   Essays in Biochemistry

Extensive Citrullination Promotes Immunogenicity of HSP90 through Protein Unfolding and Exposure of Cryptic Epitopes

(2016) Timothy S. Travers et al.   JOURNAL OF IMMUNOLOGY

Quantitative Profiling of the Activity of Protein Lysine Methyltransferase SMYD2 Using SILAC-Based Proteomics

(2016) Jonathan B. Olsen et al.   MOLECULAR & CELLULAR PROTEOMICS

Molecular Mechanism of Protein Kinase Recognition and Sorting by the Hsp90 Kinome-Specific Cochaperone Cdc37

(2016) Dimitra Keramisanou et al.   MOLECULAR CELL

Extensive functional redundancy in the regulation ofCandida albicansdrug resistance and morphogenesis by lysine deacetylases Hos2, Hda1, Rpd3 and Rpd31

(2016) Xinliu Li et al.   MOLECULAR MICROBIOLOGY

The epichaperome is an integrated chaperome network that facilitates tumour survival

(2016) Anna Rodina et al.   NATURE

Importance of cycle timing for the function of the molecular chaperone Hsp90

(2016) Bettina K Zierer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Atomic structure of Hsp90-Cdc37-Cdk4 reveals that Hsp90 traps and stabilizes an unfolded kinase

(2016) K. A. Verba et al.   SCIENCE

Targeting WEE1 Kinase in Cancer

(2016) Christopher J. Matheson et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Importance of cycle timing for the function of the molecular chaperone Hsp90

(2016) Bettina K Zierer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

ATM is the primary kinase responsible for phosphorylation of Hsp90α after ionizing radiation

(2016) Ameer L. Elaimy et al.   Oncotarget

Mps1 Mediated Phosphorylation of Hsp90 Confers Renal Cell Carcinoma Sensitivity and Selectivity to Hsp90 Inhibitors

(2016) Mark R. Woodford et al.   Cell Reports

Methylglyoxal, a glycolysis side-product, induces Hsp90 glycation and YAP-mediated tumor growth and metastasis

(2016) Marie-Julie Nokin et al.   eLife

Requirement of HDAC6 for activation of Notch1 by TGF-β1

(2016) Brian Deskin et al.   Scientific Reports

Enhancement of Stress Resilience Through Histone Deacetylase 6–Mediated Regulation of Glucocorticoid Receptor Chaperone Dynamics

(2015) Jeanine Jochems et al.   BIOLOGICAL PSYCHIATRY

Regulation and function of the human HSP90AA1 gene

(2015) Abbey D. Zuehlke et al.   GENE

Casein Kinase 2 (CK2)-mediated Phosphorylation of Hsp90β as a Novel Mechanism of Rifampin-inducedMDR1Expression

(2015) So Won Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nitration of Hsp90 on Tyrosine 33 Regulates Mitochondrial Metabolism

(2015) Maria C. Franco et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure-based rational design of peptide hydroxamic acid inhibitors to target tumor necrosis factor-αconverting enzyme as potential therapeutics for hepatitis

(2015) Dan Wu et al.   JOURNAL OF DRUG TARGETING

Maximizing the Therapeutic Potential of HSP90 Inhibitors

(2015) L. M. Butler et al.   MOLECULAR CANCER RESEARCH

Stability of the Human Hsp90-p50Cdc37 Chaperone Complex against Nucleotides and Hsp90 Inhibitors, and the Influence of Phosphorylation by Casein Kinase 2

(2015) Sanne Olesen et al.   MOLECULES

Large-scale determination of absolute phosphorylation stoichiometries in human cells by motif-targeting quantitative proteomics

(2015) Chia-Feng Tsai et al.   Nature Communications

Targeting HSF1 disrupts HSP90 chaperone function in chronic lymphocytic leukemia

(2015) Siddhartha Ganguly et al.   Oncotarget

The Effects of Hsp90α1 Mutations on Myosin Thick Filament Organization

(2015) Qiuxia He et al.   PLoS One

Casein kinase 2 phosphorylation of Hsp90 threonine 22 modulates chaperone function and drug sensitivity

(2015) Mehdi Mollapour et al.   Oncotarget

Posttranslational modification and conformational state of Heat Shock Protein 90 differentially affect binding of chemically diverse small molecule inhibitors

(2015) Kristin Beebe et al.   Oncotarget

Identification of a ternary protein-complex as a therapeutic target for K-Ras-dependent colon cancer

(2015) Xiaomei Qi et al.   Oncotarget

Identification of a Key Lysine Residue in Heat Shock Protein 90 Required for Azole and Echinocandin Resistance in Aspergillus fumigatus

(2014) Frédéric Lamoth et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

SMYD2-dependent HSP90 methylation promotes cancer cell proliferation by regulating the chaperone complex formation

(2014) Ryuji Hamamoto et al.   CANCER LETTERS

Hyperglycaemic conditions perturb mouse oocyte in vitro developmental competence via beta-O-linked glycosylation of Heat shock protein 90

(2014) L.A. Frank et al.   HUMAN REPRODUCTION

Sumoylated HSP90 is a dominantly inherited plasma cell dyscrasias risk factor

(2014) Klaus-Dieter Preuss et al.   JOURNAL OF CLINICAL INVESTIGATION

Asymmetric Hsp90 N Domain SUMOylation Recruits Aha1 and ATP-Competitive Inhibitors

(2014) Mehdi Mollapour et al.   MOLECULAR CELL

PhosphoSitePlus, 2014: mutations, PTMs and recalibrations

(2014) Peter V. Hornbeck et al.   NUCLEIC ACIDS RESEARCH

The charged linker of the molecular chaperone Hsp90 modulates domain contacts and biological function

(2014) Markus Jahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ultradeep Human Phosphoproteome Reveals a Distinct Regulatory Nature of Tyr and Ser/Thr-Based Signaling

(2014) Kirti Sharma et al.   Cell Reports

LPS induces pp60c-src-mediated tyrosine phosphorylation of Hsp90 in lung vascular endothelial cells and mouse lung

(2013) Nektarios Barabutis et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Identification of Citrullinated Hsp90 Isoforms as Novel Autoantigens in Rheumatoid Arthritis-Associated Interstitial Lung Disease

(2013) Lisa Harlow et al.   ARTHRITIS AND RHEUMATISM

The regulatory mechanism of a client kinase controlling its own release from Hsp90 chaperone machinery through phosphorylation

(2013) Xin-an Lu et al.   BIOCHEMICAL JOURNAL

Regulation of molecular chaperones through post-translational modifications: Decrypting the chaperone code

(2013) Philippe Cloutier et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Sulphoxythiocarbamates modify cysteine residues in HSP90 causing degradation of client proteins and inhibition of cancer cell proliferation

(2013) Y Zhang et al.   BRITISH JOURNAL OF CANCER

Hsp90, an unlikely ally in the war on cancer

(2013) Jared J. Barrott et al.   FEBS Journal

Contributions of co-chaperones and post-translational modifications towards Hsp90 drug sensitivity

(2013) Annerleim Walton-Diaz et al.   Future Medicinal Chemistry

TAp73 Protein Stability Is Controlled by Histone Deacetylase 1 via Regulation of Hsp90 Chaperone Function

(2013) Jin Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of Missing Proteins in the neXtProt Database and Unregistered Phosphopeptides in the PhosphoSitePlus Database As Part of the Chromosome-Centric Human Proteome Project

(2013) Takashi Shiromizu et al.   JOURNAL OF PROTEOME RESEARCH

Quantitative phosphoproteomic profiling of human non-small cell lung cancer tumors

(2013) Devin K. Schweppe et al.   Journal of Proteomics

Integrated proteomic analysis of post-translational modifications by serial enrichment

(2013) Philipp Mertins et al.   NATURE METHODS

Histone deacetylase inhibitors increase glucocerebrosidase activity in Gaucher disease by modulation of molecular chaperones

(2013) C. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nitration of Hsp90 induces cell death

(2013) M. C. Franco et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The chaperone Hsp90: changing partners for demanding clients

(2013) Alina Röhl et al.   TRENDS IN BIOCHEMICAL SCIENCES

Lysine Succinylation Is a Frequently Occurring Modification in Prokaryotes and Eukaryotes and Extensively Overlaps with Acetylation

(2013) Brian T. Weinert et al.   Cell Reports

A Newly Uncovered Group of Distantly Related Lysine Methyltransferases Preferentially Interact with Molecular Chaperones to Regulate Their Activity

(2013) Philippe Cloutier et al.   PLoS Genetics

Modulation of the Cochaperone AHA1 Regulates Heat-Shock Protein 90 and Endothelial NO Synthase Activation by Vascular Endothelial Growth Factor

(2012) Fanny Desjardins et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Lysine methyltransferase Smyd2 regulates Hsp90-mediated protection of the sarcomeric titin springs and cardiac function

(2012) Tobias Voelkel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mechanistic aspects of the Hsp90 phosphoregulation

(2012) Joanna Soroka et al.   CELL CYCLE

Combined inhibition of Wee1 and Hsp90 activates intrinsic apoptosis in cancer cells

(2012) Aki Iwai et al.   CELL CYCLE

Hsp90 Molecular Chaperone Inhibitors: Are We There Yet?

(2012) L. Neckers et al.   CLINICAL CANCER RESEARCH

Smyd2 controls cytoplasmic lysine methylation of Hsp90 and myofilament organization

(2012) L. T. Donlin et al.   GENES & DEVELOPMENT

Heat Shock Protein 90α (Hsp90α) Is Phosphorylated in Response to DNA Damage and Accumulates in Repair Foci

(2012) Maria Quanz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hectd1 regulates intracellular localization and secretion of Hsp90 to control cellular behavior of the cranial mesenchyme

(2012) Anjali A. Sarkar et al.   JOURNAL OF CELL BIOLOGY

HDAC6 Regulates Glucocorticoid Receptor Signaling in Serotonin Pathways with Critical Impact on Stress Resilience

(2012) J. Espallergues et al.   JOURNAL OF NEUROSCIENCE

Toward a Comprehensive Characterization of a Human Cancer Cell Phosphoproteome

(2012) Houjiang Zhou et al.   JOURNAL OF PROTEOME RESEARCH

Mapping ofO-GlcNAc Sites of 20 S Proteasome Subunits and Hsp90 by a Novel Biotin-Cystamine Tag

(2012) Thorsten Overath et al.   MOLECULAR & CELLULAR PROTEOMICS

Phosphosignature Predicts Dasatinib Response in Non-small Cell Lung Cancer

(2012) Martin Klammer et al.   MOLECULAR & CELLULAR PROTEOMICS

Refined Preparation and Use of Anti-diglycine Remnant (K-ε-GG) Antibody Enables Routine Quantification of 10,000s of Ubiquitination Sites in Single Proteomics Experiments

(2012) Namrata D. Udeshi et al.   MOLECULAR & CELLULAR PROTEOMICS

Conformational Switching of the Molecular Chaperone Hsp90 via Regulated Phosphorylation

(2012) Joanna Soroka et al.   MOLECULAR CELL

Proteomic Investigations Reveal a Role for RNA Processing Factor THRAP3 in the DNA Damage Response

(2012) Petra Beli et al.   MOLECULAR CELL

Dynamic Tyrosine Phosphorylation Modulates Cycling of the HSP90-P50CDC37-AHA1 Chaperone Machine

(2012) Wanping Xu et al.   MOLECULAR CELL

Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass

(2012) Lou K. Povlsen et al.   NATURE CELL BIOLOGY

C-terminal phosphorylation of Hsp70 and Hsp90 regulates alternate binding to co-chaperones CHIP and HOP to determine cellular protein folding/degradation balances

(2012) P Muller et al.   ONCOGENE

Heat shock protein 90  (HSP90 ), a substrate and chaperone of DNA-PK necessary for the apoptotic response

(2012) S. Solier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Charged linker sequence modulates eukaryotic heat shock protein 90 (Hsp90) chaperone activity

(2012) S. Tsutsumi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lysine Deacetylases Hda1 and Rpd3 Regulate Hsp90 Function thereby Governing Fungal Drug Resistance

(2012) Nicole Robbins et al.   Cell Reports

Pnck induces ligand-independent EGFR degradation by probable perturbation of the Hsp90 chaperone complex

(2011) Tushar B. Deb et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Thr90phosphorylation of Hsp90α by protein kinase A regulates its chaperone machinery

(2011) Xiaofeng Wang et al.   BIOCHEMICAL JOURNAL

Evolution and function of diverse Hsp90 homologs and cochaperone proteins

(2011) Jill L. Johnson   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Inhibition of heat shock protein 90 (HSP90) as a therapeutic strategy for the treatment of myeloma and other cancers

(2011) Paul G. Richardson et al.   BRITISH JOURNAL OF HAEMATOLOGY

Transthiocarbamoylation of Proteins by Thiolated Isothiocyanates

(2011) Takahiro Shibata et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Proteome-wide, Quantitative Survey of In Vivo Ubiquitylation Sites Reveals Widespread Regulatory Roles

(2011) Sebastian A. Wagner et al.   MOLECULAR & CELLULAR PROTEOMICS

Threonine 22 Phosphorylation Attenuates Hsp90 Interaction with Cochaperones and Affects Its Chaperone Activity

(2011) Mehdi Mollapour et al.   MOLECULAR CELL

Quantitative Phosphoproteomics Identifies Substrates and Functional Modules of Aurora and Polo-Like Kinase Activities in Mitotic Cells

(2011) A. N. Kettenbach et al.   Science Signaling

Proteomic analyses of the SMYD family interactomes identify HSP90 as a novel target for SMYD2

(2011) Mohamed Abu-Farha et al.   Journal of Molecular Cell Biology

Tanespimycin monotherapy in relapsed multiple myeloma: results of a phase 1 dose-escalation study

(2010) Paul G. Richardson et al.   BRITISH JOURNAL OF HAEMATOLOGY

A Tissue-Specific Atlas of Mouse Protein Phosphorylation and Expression

(2010) Edward L. Huttlin et al.   CELL

Hsp90 phosphorylation, Wee1 and the cell cycle

(2010) Mehdi Mollapour et al.   CELL CYCLE

Role for NAD(P)H:quinone Oxidoreductase 1 and Manganese-Dependent Superoxide Dismutase in 17-(Allylamino)-17-demethoxygeldanamycin-Induced Heat Shock Protein 90 Inhibition in Pancreatic Cancer Cells

(2010) D. Siegel et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Brain Phosphoproteome Obtained by a FASP-Based Method Reveals Plasma Membrane Protein Topology

(2010) Jacek R. Wiśniewski et al.   JOURNAL OF PROTEOME RESEARCH

Mass Spectrometric Analysis of Lysine Ubiquitylation Reveals Promiscuity at Site Level

(2010) Jannie M. R. Danielsen et al.   MOLECULAR & CELLULAR PROTEOMICS

Asymmetric Activation of the Hsp90 Dimer by Its Cochaperone Aha1

(2010) Marco Retzlaff et al.   MOLECULAR CELL

Swe1Wee1-Dependent Tyrosine Phosphorylation of Hsp90 Regulates Distinct Facets of Chaperone Function

(2010) Mehdi Mollapour et al.   MOLECULAR CELL

A chemical and phosphoproteomic characterization of dasatinib action in lung cancer

(2010) Jiannong Li et al.   Nature Chemical Biology

Mixed Hsp90–cochaperone complexes are important for the progression of the reaction cycle

(2010) Jing Li et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cotreatment with panobinostat and JAK2 inhibitor TG101209 attenuates JAK2V617F levels and signaling and exerts synergistic cytotoxic effects against human myeloproliferative neoplastic cells

(2009) Y. Wang et al.   BLOOD

Spatially and kinetically resolved changes in the conformational dynamics of the Hsp90 chaperone machine

(2009) Christian Graf et al.   EMBO JOURNAL

Hsp90 is regulated by a switch point in the C-terminal domain

(2009) Marco Retzlaff et al.   EMBO REPORTS

A Truncated Form of p23 Down-regulates Telomerase Activity via Disruption of Hsp90 Function

(2009) Sang Hyeok Woo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Charged Linker Region Is an Important Regulator of Hsp90 Function

(2009) Otmar Hainzl et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of Residues on Hsp70 and Hsp90 Ubiquitinated by the Cochaperone CHIP

(2009) Lenka Kundrat et al.   JOURNAL OF MOLECULAR BIOLOGY

Functional Proteomics Identifies Targets of Phosphorylation by B-Raf Signaling in Melanoma

(2009) William M. Old et al.   MOLECULAR CELL

HDAC6 Regulates Androgen Receptor Hypersensitivity and Nuclear Localization via Modulating Hsp90 Acetylation in Castration-Resistant Prostate Cancer

(2009) Junkui Ai et al.   MOLECULAR ENDOCRINOLOGY

The large conformational changes of Hsp90 are only weakly coupled to ATP hydrolysis

(2009) Moritz Mickler et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Dissection of the ATP-induced conformational cycle of the molecular chaperone Hsp90

(2009) Martin Hessling et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Sulforaphane destabilizes the androgen receptor in prostate cancer cells by inactivating histone deacetylase 6

(2009) A. Gibbs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The regulatory mechanism of Hsp90α secretion and its function in tumor malignancy

(2009) Xiaofeng Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions

(2009) C. Choudhary et al.   SCIENCE

Quantitative Phosphoproteomic Analysis of T Cell Receptor Signaling Reveals System-Wide Modulation of Protein-Protein Interactions

(2009) V. Mayya et al.   Science Signaling

The complex dance of the molecular chaperone Hsp90

(2009) Len Neckers et al.   TRENDS IN BIOCHEMICAL SCIENCES

Class II histone deacetylases play pivotal roles in heat shock protein 90-mediated proteasomal degradation of vascular endothelial growth factor receptors

(2008) Jung-Hyun Park et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

HDAC6 inhibition enhances 17-AAG-mediated abrogation of hsp90 chaperone function in human leukemia cells

(2008) R. Rao et al.   BLOOD

Molecular and biologic characterization and drug sensitivity of pan-histone deacetylase inhibitor-resistant acute myeloid leukemia cells

(2008) W. Fiskus et al.   BLOOD

Role of Acetylation and Extracellular Location of Heat Shock Protein 90  in Tumor Cell Invasion

(2008) Y. Yang et al.   CANCER RESEARCH

Tubocapsenolide A, a Novel Withanolide, Inhibits Proliferation and Induces Apoptosis in MDA-MB-231 Cells by Thiol Oxidation of Heat Shock Proteins

(2008) Wen-Ying Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional Role of HSP90 Complexes with Endothelial Nitric-oxide Synthase (eNOS) and Calpain on Nitric Oxide Generation in Endothelial Cells

(2008) Monica Averna et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intra- and Intermonomer Interactions Are Required to Synergistically Facilitate ATP Hydrolysis in Hsp90

(2008) Christian N. Cunningham et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of Apoptosome Formation by Suppression of Hsp90  Phosphorylation in Tyrosine Kinase-Induced Leukemias

(2008) M. Kurokawa et al.   MOLECULAR AND CELLULAR BIOLOGY

Mice Lacking Histone Deacetylase 6 Have Hyperacetylated Tubulin but Are Viable and Develop Normally

(2008) Y. Zhang et al.   MOLECULAR AND CELLULAR BIOLOGY

Hsp90-Dependent Activation of Protein Kinases Is Regulated by Chaperone-Targeted Dephosphorylation of Cdc37

(2008) Cara K. Vaughan et al.   MOLECULAR CELL

Cross-talk between GlcNAcylation and phosphorylation: Site-specific phosphorylation dynamics in response to globally elevated O-GlcNAc

(2008) Z. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A quantitative atlas of mitotic phosphorylation

(2008) N. Dephoure et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Large-Scale Identification and Evolution Indexing of Tyrosine Phosphorylation Sites from Murine Brain

(2007) Bryan A. Ballif et al.   JOURNAL OF PROTEOME RESEARCH