HSP90 inhibitors disrupt a transient HSP90-HSF1 interaction and identify a noncanonical model of HSP90-mediated HSF1 regulation

Mammalian Heat Shock Response and Mechanisms Underlying Its Genome-wide Transcriptional Regulation

(2016) Dig B. Mahat et al.   MOLECULAR CELL

Structure of human heat-shock transcription factor 1 in complex with DNA

(2016) Tobias Neudegger et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of human heat-shock transcription factor 1 in complex with DNA

(2016) Tobias Neudegger et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Molecular mechanism of thermosensory function of human heat shock transcription factor Hsf1

(2016) Nikolai Hentze et al.   eLife

Dynamic control of Hsf1 during heat shock by a chaperone switch and phosphorylation

(2016) Xu Zheng et al.   eLife

MEK Guards Proteome Stability and Inhibits Tumor-Suppressive Amyloidogenesis via HSF1

(2015) Zijian Tang et al.   CELL

Phase I study of the heat shock protein 90 (Hsp90) inhibitor onalespib (AT13387) administered on a daily for 2 consecutive days per week dosing schedule in patients with advanced solid tumors

(2015) Khanh Do et al.   INVESTIGATIONAL NEW DRUGS

Phase I/II Study of HSP90 Inhibitor AUY922 and Erlotinib forEGFR-Mutant Lung Cancer With Acquired Resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors

(2015) Melissa L. Johnson et al.   JOURNAL OF CLINICAL ONCOLOGY

Higher heat shock factor 1 expression in tumor stroma predicts poor prognosis in esophageal squamous cell carcinoma patients

(2015) Yuehua Liao et al.   Journal of Translational Medicine

Uncoupling Stress-Inducible Phosphorylation of Heat Shock Factor 1 from Its Activation

(2015) Marek A. Budzyński et al.   MOLECULAR AND CELLULAR BIOLOGY

Hsp90 interaction with clients

(2015) G. Elif Karagöz et al.   TRENDS IN BIOCHEMICAL SCIENCES

Client Proteins and Small Molecule Inhibitors Display Distinct Binding Preferences for Constitutive and Stress-Induced HSP90 Isoforms and Their Conformationally Restricted Mutants

(2015) Thomas L. Prince et al.   PLoS One

Posttranslational modification and conformational state of Heat Shock Protein 90 differentially affect binding of chemically diverse small molecule inhibitors

(2015) Kristin Beebe et al.   Oncotarget

First-in-Human Phase I Dose Escalation Study of a Second-Generation Non-Ansamycin HSP90 Inhibitor, AT13387, in Patients with Advanced Solid Tumors

(2014) G. I. Shapiro et al.   CLINICAL CANCER RESEARCH

HSF1 at a glance

(2014) A. Vihervaara et al.   JOURNAL OF CELL SCIENCE

A Direct Regulatory Interaction between Chaperonin TRiC and Stress-Responsive Transcription Factor HSF1

(2014) Daniel W. Neef et al.   Cell Reports

Hsp90, an unlikely ally in the war on cancer

(2013) Jared J. Barrott et al.   FEBS Journal

Quantitative Analysis of Hsp90-Client Interactions Reveals Principles of Substrate Recognition

(2012) Mikko Taipale et al.   CELL

HSF1 Drives a Transcriptional Program Distinct from Heat Shock to Support Highly Malignant Human Cancers

(2012) Marc L. Mendillo et al.   CELL

Hsp90 Molecular Chaperone Inhibitors: Are We There Yet?

(2012) L. Neckers et al.   CLINICAL CANCER RESEARCH

Tumor-Intrinsic and Tumor-Extrinsic Factors Impacting Hsp90- Targeted Therapy

(2012) S.V. Alarcon et al.   CURRENT MOLECULAR MEDICINE

Synthesis and Evaluation of Novologues as C-Terminal Hsp90 Inhibitors with Cytoprotective Activity against Sensory Neuron Glucotoxicity

(2012) Bhaskar Reddy Kusuma et al.   JOURNAL OF MEDICINAL CHEMISTRY

Post-Translational Modification of Human Heat Shock Factors and Their Functions: A Recent Update by Proteomic Approach

(2012) Yan-Ming Xu et al.   JOURNAL OF PROTEOME RESEARCH

Regulation of HSF1 Function in the Heat Stress Response: Implications in Aging and Disease

(2011) Julius Anckar et al.   Annual Review of Biochemistry

High levels of nuclear heat-shock factor 1 (HSF1) are associated with poor prognosis in breast cancer

(2011) S. Santagata et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Stress of Protein Misfolding: From Single Cells to Multicellular Organisms

(2011) T. Gidalevitz et al.   Cold Spring Harbor Perspectives in Biology

Modulation of Hsf1 activity by novobiocin and geldanamycin

(2009) Renaud Conde et al.   Biochemistry and Cell Biology

Novobiocin and Additional Inhibitors of the Hsp90 C-Terminal Nucleotide- binding Pocket

(2008) Alison Donnelly et al.   CURRENT MEDICINAL CHEMISTRY

Species-Dependent Ensembles of Conserved Conformational States Define the Hsp90 Chaperone ATPase Cycle

(2008) Daniel R. Southworth et al.   MOLECULAR CELL