The functions and regulation of heat shock proteins; key orchestrators of proteostasis and the heat shock response

Synonymous but not Silent: The Codon Usage Code for Gene Expression and Protein Folding

(2021) Yi Liu et al.   Annual Review of Biochemistry

Circadian rhythms in the absence of the clock gene Bmal1

(2020) Sandipan Ray et al.   SCIENCE

The epichaperome is a mediator of toxic hippocampal stress and leads to protein connectivity-based dysfunction

(2020) Maria Carmen Inda et al.   Nature Communications

Chaperone-Facilitated Aggregation of Thermo-Sensitive Proteins Shields Them from Degradation during Heat Stress

(2020) Margarita Cabrera et al.   Cell Reports

Immunological Outcomes Mediated Upon Binding of Heat Shock Proteins to Scavenger Receptors SCARF1 and LOX-1, and Endocytosis by Mononuclear Phagocytes

(2020) Ayesha Murshid et al.   Frontiers in Immunology

Behind closed gates – chaperones and charged residues determine protein fate

(2020) Margreet B Koopman et al.   EMBO JOURNAL

Autonomous aggregation suppression by acidic residues explains why chaperones favour basic residues

(2020) Bert Houben et al.   EMBO JOURNAL

Host expression system modulates recombinant Hsp70 activity through post‐translational modifications

(2020) Mauricio M. Rigo et al.   FEBS Journal

Kinetics of the conformational cycle of Hsp70 reveals the importance of the dynamic and heterogeneous nature of Hsp70 for its function

(2020) Si Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Molecular Chaperone CCT/TRiC: An Essential Component of Proteostasis and a Potential Modulator of Protein Aggregation

(2020) Julie Grantham   Frontiers in Genetics

RPAP3 C-Terminal Domain: A Conserved Domain for the Assembly of R2TP Co-Chaperone Complexes

(2020) Carlos F. Rodríguez et al.   Cells

HSF1: Primary Factor in Molecular Chaperone Expression and a Major Contributor to Cancer Morbidity

(2020) Thomas L. Prince et al.   Cells

Feedback regulation of heat shock factor 1 (Hsf1) activity by Hsp70‐mediated trimer unzipping and dissociation from DNA

(2020) Szymon W Kmiecik et al.   EMBO JOURNAL

Transient intracellular acidification regulates the core transcriptional heat shock response

(2020) Catherine G Triandafillou et al.   eLife

Hsp90 Co-chaperones Form Plastic Genetic Networks Adapted to Client Maturation

(2020) Maximilian M. Biebl et al.   Cell Reports

Multifaceted C-terminus of HSP70-interacting protein regulates tumorigenesis via protein quality control

(2019) Jinho Seo et al.   ARCHIVES OF PHARMACAL RESEARCH

Regulation of stress signaling pathways by protein lipoxidation

(2019) Tommi Patinen et al.   Redox Biology

Local unfolding of the HSP27 monomer regulates chaperone activity

(2019) T. Reid Alderson et al.   Nature Communications

Structure, Function, and Regulation of the Hsp90 Machinery

(2019) Maximilian M. Biebl et al.   Cold Spring Harbor Perspectives in Biology

Small heat shock proteins: multifaceted proteins with important implications for life

(2019) Serena Carra et al.   CELL STRESS & CHAPERONES

The Chaperonin TRiC/CCT Associates with Prefoldin through a Conserved Electrostatic Interface Essential for Cellular Proteostasis

(2019) Daniel Gestaut et al.   CELL

Structural mechanism for regulation of the AAA-ATPases RUVBL1-RUVBL2 in the R2TP co-chaperone revealed by cryo-EM

(2019) Hugo Muñoz-Hernández et al.   Science Advances

Deletion of heat shock protein 60 in adult mouse cardiomyocytes perturbs mitochondrial protein homeostasis and causes heart failure

(2019) Feifei Fan et al.   CELL DEATH AND DIFFERENTIATION

Structural and functional analysis of the role of the chaperonin CCT in mTOR complex assembly

(2019) Jorge Cuéllar et al.   Nature Communications

MZF1 and SCAND1 Reciprocally Regulate CDC37 Gene Expression in Prostate Cancer

(2019) Takanori Eguchi et al.   Cancers

Heat Shock Proteins Are Essential Components in Transformation and Tumor Progression: Cancer Cell Intrinsic Pathways and Beyond

(2019) Lang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Nascent Polypeptide Domain Topology and Elongation Rate Direct the Cotranslational Hierarchy of Hsp70 and TRiC/CCT

(2019) Kevin C. Stein et al.   MOLECULAR CELL

Kinetic trapping in protein folding

(2019) Angela E Varela et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Cytoplasmic protein misfolding titrates Hsp70 to activate nuclear Hsf1

(2019) Anna E Masser et al.   eLife

Impact of Carcinogenic Chromium on the Cellular Response to Proteotoxic Stress

(2019) Leonardo M. R. Ferreira et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

An unexpected second binding site for polypeptide substrates is essential for Hsp70 chaperone activity

(2019) Hongtao Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein–Protein Interactions in the Molecular Chaperone Network

(2018) Rebecca Freilich et al.   ACCOUNTS OF CHEMICAL RESEARCH

Hsp90 inhibitors as senolytic drugs to extend healthy aging

(2018) Heike Fuhrmann-Stroissnigg et al.   CELL CYCLE

Alteration of Tumor Metabolism by CD4+ T Cells Leads to TNF-α-Dependent Intensification of Oxidative Stress and Tumor Cell Death

(2018) Tsadik Habtetsion et al.   Cell Metabolism

The small heat shock protein Hsp27 binds α-synuclein fibrils, preventing elongation and cytotoxicity

(2018) Dezerae Cox et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cellular Handling of Protein Aggregates by Disaggregation Machines

(2018) Axel Mogk et al.   MOLECULAR CELL

Hsp90 Breaks the Deadlock of the Hsp70 Chaperone System

(2018) Tania Morán Luengo et al.   MOLECULAR CELL

The coming of age of chaperone-mediated autophagy

(2018) Susmita Kaushik et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Organoids with cancer stem cell-like properties secrete exosomes and HSP90 in a 3D nanoenvironment

(2018) Takanori Eguchi et al.   PLoS One

HSP90 inhibitors disrupt a transient HSP90-HSF1 interaction and identify a noncanonical model of HSP90-mediated HSF1 regulation

(2018) Toshiki Kijima et al.   Scientific Reports

Hsf1 Phosphorylation Generates Cell-to-Cell Variation in Hsp90 Levels and Promotes Phenotypic Plasticity

(2018) Xu Zheng et al.   Cell Reports

A PQM-1-Mediated Response Triggers Transcellular Chaperone Signaling and Regulates Organismal Proteostasis

(2018) Daniel O’Brien et al.   Cell Reports

Hsf1 and Hsp70 constitute a two-component feedback loop that regulates the yeast heat shock response

(2018) Joanna Krakowiak et al.   eLife

Quantification of Hsp90 availability reveals differential coupling to the heat shock response

(2018) Brian D. Alford et al.   JOURNAL OF CELL BIOLOGY

The chaperonin TRiC/CCT is essential for the action of bacterial glycosylating protein toxins like Clostridium difficile toxins A and B

(2018) Marcus Steinemann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

March1-dependent modulation of donor MHC II on CD103+ dendritic cells mitigates alloimmunity

(2018) Thiago J. Borges et al.   Nature Communications

Dual targeting of HSP70 does not induce the heat shock response and synergistically reduces cell viability in muscle invasive bladder cancer

(2018) Thomas Prince et al.   Oncotarget

DAF-21/Hsp90 is required for C. elegans longevity by ensuring DAF-16/FOXO isoform A function

(2018) Milán Somogyvári et al.   Scientific Reports

Chaperome heterogeneity and its implications for cancer study and treatment

(2018) Tai Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human stress-inducible Hsp70 has a high propensity to form ATP-dependent antiparallel dimers that are differentially regulated by co-chaperone binding

(2018) Filip Trcka et al.   MOLECULAR & CELLULAR PROTEOMICS

Allosteric landscapes of eukaryotic cytoplasmic Hsp70s are shaped by evolutionary tuning of key interfaces

(2018) Wenli Meng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HSP90-incorporating chaperome networks as biosensor for disease-related pathways in patient-specific midbrain dopamine neurons

(2018) Sarah Kishinevsky et al.   Nature Communications

The Hsp70–Hsp90 Chaperone Cascade in Protein Folding

(2018) Tania Morán Luengo et al.   TRENDS IN CELL BIOLOGY

BAG3 Is a Modular, Scaffolding Protein that physically Links Heat Shock Protein 70 (Hsp70) to the Small Heat Shock Proteins

(2017) Jennifer N. Rauch et al.   JOURNAL OF MOLECULAR BIOLOGY

Is the hydrophobic core a universal structural element in proteins?

(2017) Barbara Kalinowska et al.   JOURNAL OF MOLECULAR MODELING

The HSP90 chaperone machinery

(2017) Florian H. Schopf et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The diverse roles of Hsp90 and where to find them

(2017) Patricija Van Oosten-Hawle et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Heat shock proteins and cancer: intracellular chaperones or extracellular signalling ligands?

(2017) Stuart K. Calderwood   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Biology of Hsp47 (Serpin H1), a collagen-specific molecular chaperone

(2017) Shinya Ito et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Cracking the Chaperone Code: Cellular Roles for Hsp70 Phosphorylation

(2017) Nitika et al.   TRENDS IN BIOCHEMICAL SCIENCES

The diverse roles of Hsp90 and where to find them

(2017) Patricija Van Oosten-Hawle et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Features of the Chaperone Cellular Network Revealed through Systematic Interaction Mapping

(2017) Kamran Rizzolo et al.   Cell Reports

UBQLN2 Mediates Autophagy-Independent Protein Aggregate Clearance by the Proteasome

(2016) Roland Hjerpe et al.   CELL

The Helicobacter pylori cytotoxin CagA is essential for suppressing host heat shock protein expression

(2016) Ben J. Lang et al.   CELL STRESS & CHAPERONES

Model systems of protein-misfolding diseases reveal chaperone modifiers of proteotoxicity

(2016) Marc Brehme et al.   Disease Models & Mechanisms

Regulation of cell-non-autonomous proteostasis in metazoans

(2016) D. O'Brien et al.   Essays in Biochemistry

Non-canonical Interactions between Heat Shock Cognate Protein 70 (Hsc70) and Bcl2-associated Anthanogene (BAG) Co-Chaperones Are Important for Client Release

(2016) Jennifer N. Rauch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The epichaperome is an integrated chaperome network that facilitates tumour survival

(2016) Anna Rodina et al.   NATURE

Molecular basis of HSF regulation

(2016) Akira Nakai   NATURE STRUCTURAL & MOLECULAR BIOLOGY

In vivo aspects of protein folding and quality control

(2016) D. Balchin et al.   SCIENCE

Atomic structure of Hsp90-Cdc37-Cdk4 reveals that Hsp90 traps and stabilizes an unfolded kinase

(2016) K. A. Verba et al.   SCIENCE

Heat Shock Proteins Promote Cancer: It's a Protection Racket

(2016) Stuart K. Calderwood et al.   TRENDS IN BIOCHEMICAL SCIENCES

Small heat shock proteins sequester misfolding proteins in near-native conformation for cellular protection and efficient refolding

(2016) Sophia Ungelenk et al.   Nature Communications

Molecular basis of HSF regulation

(2016) Akira Nakai   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Dynamic control of Hsf1 during heat shock by a chaperone switch and phosphorylation

(2016) Xu Zheng et al.   eLife

TRIM28 as a novel transcriptional elongation factor

(2015) Heeyoun Bunch et al.   BMC MOLECULAR BIOLOGY

Quantitative proteomics of heat-treated human cells show an across-the-board mild depletion of housekeeping proteins to massively accumulate few HSPs

(2015) Andrija Finka et al.   CELL STRESS & CHAPERONES

Combined HSP90 and kinase inhibitor therapy: Insights from The Cancer Genome Atlas

(2015) Harvey Schwartz et al.   CELL STRESS & CHAPERONES

A Functional DnaK Dimer Is Essential for the Efficient Interaction with Hsp40 Heat Shock Protein

(2015) Evans Boateng Sarbeng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein Quality Control under Oxidative Stress Conditions

(2015) Jan-Ulrik Dahl et al.   JOURNAL OF MOLECULAR BIOLOGY

How Hsp70 Molecular Machines Interact with Their Substrates to Mediate Diverse Physiological Functions

(2015) Eugenia M. Clerico et al.   JOURNAL OF MOLECULAR BIOLOGY

A First Line of Stress Defense: Small Heat Shock Proteins and Their Function in Protein Homeostasis

(2015) Martin Haslbeck et al.   JOURNAL OF MOLECULAR BIOLOGY

Intercellular chaperone transmission via exosomes contributes to maintenance of protein homeostasis at the organismal level

(2015) Toshihide Takeuchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathways of allosteric regulation in Hsp70 chaperones

(2015) Roman Kityk et al.   Nature Communications

Transcriptional elongation requires DNA break-induced signalling

(2015) Heeyoun Bunch et al.   Nature Communications

Functional Diversification and Specialization of Cytosolic 70-kDa Heat Shock Proteins

(2015) Chelsea McCallister et al.   Scientific Reports

Hsp70 Forms Antiparallel Dimers Stabilized by Post-translational Modifications to Position Clients for Transfer to Hsp90

(2015) Nina Morgner et al.   Cell Reports

Client Proteins and Small Molecule Inhibitors Display Distinct Binding Preferences for Constitutive and Stress-Induced HSP90 Isoforms and Their Conformationally Restricted Mutants

(2015) Thomas L. Prince et al.   PLoS One

Casein kinase 2 phosphorylation of Hsp90 threonine 22 modulates chaperone function and drug sensitivity

(2015) Mehdi Mollapour et al.   Oncotarget

Endoplasmic Reticulum Stress and Oxidative Stress in Cell Fate Decision and Human Disease

(2014) Stewart Siyan Cao et al.   ANTIOXIDANTS & REDOX SIGNALING

Hsp70–Bag3 Interactions Regulate Cancer-Related Signaling Networks

(2014) Teresa A. Colvin et al.   CANCER RESEARCH

Glucocorticoid Receptor Function Regulated by Coordinated Action of the Hsp90 and Hsp70 Chaperone Cycles

(2014) Elaine Kirschke et al.   CELL

DrosophilaSpag Is the Homolog of RNA Polymerase II-associated Protein 3 (RPAP3) and Recruits the Heat Shock Proteins 70 and 90 (Hsp70 and Hsp90) during the Assembly of Cellular Machineries

(2014) Nour El Houda Benbahouche et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The ensemble nature of allostery

(2014) Hesam N. Motlagh et al.   NATURE

TRIM28 regulates RNA polymerase II promoter-proximal pausing and pause release

(2014) Heeyoun Bunch et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The nature of protein folding pathways

(2014) S. Walter Englander et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural characterization of the substrate transfer mechanism in Hsp70/Hsp90 folding machinery mediated by Hop

(2014) Sara Alvira et al.   Nature Communications

A Chaperome Subnetwork Safeguards Proteostasis in Aging and Neurodegenerative Disease

(2014) Marc Brehme et al.   Cell Reports

A Direct Regulatory Interaction between Chaperonin TRiC and Stress-Responsive Transcription Factor HSF1

(2014) Daniel W. Neef et al.   Cell Reports

HspB1, HspB5 and HspB4 in Human Cancers: Potent Oncogenic Role of Some of Their Client Proteins

(2014) André-Patrick Arrigo et al.   Cancers

Regulation of molecular chaperones through post-translational modifications: Decrypting the chaperone code

(2013) Philippe Cloutier et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Activation of the antioxidant response in methionine deprived human cells results in an HSF1-independent increase in HSPA1A mRNA levels

(2013) Sanne M.M. Hensen et al.   BIOCHIMIE

The Cotranslational Function of Ribosome-Associated Hsp70 in Eukaryotic Protein Homeostasis

(2013) Felix Willmund et al.   CELL

Alcohol stress, membranes, and chaperones

(2013) Melinda E. Tóth et al.   CELL STRESS & CHAPERONES

Proteomic data from human cell cultures refine mechanisms of chaperone-mediated protein homeostasis

(2013) Andrija Finka et al.   CELL STRESS & CHAPERONES

Redox regulation of protein kinases

(2013) Aoife Corcoran et al.   FEBS Journal

Fever, hyperthermia and the heat shock response

(2013) Ishwar S. Singh et al.   INTERNATIONAL JOURNAL OF HYPERTHERMIA

Binding of Human Nucleotide Exchange Factors to Heat Shock Protein 70 (Hsp70) Generates Functionally Distinct Complexesin Vitro

(2013) Jennifer N. Rauch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Accelerated neurodegeneration through chaperone-mediated oligomerization of tau

(2013) Laura J. Blair et al.   JOURNAL OF CLINICAL INVESTIGATION

Transcellular chaperone signaling: an organismal strategy for integrated cell stress responses

(2013) P. van Oosten-Hawle et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Extracellular Heat Shock Protein 90 Signals through Subdomain II and the NPVY Motif of LRP-1 Receptor to Akt1 and Akt2: a Circuit Essential for Promoting Skin Cell Migration In Vitro and Wound Healing In Vivo

(2013) F. Tsen et al.   MOLECULAR AND CELLULAR BIOLOGY

Structure and function of Hip, an attenuator of the Hsp70 chaperone cycle

(2013) Zhuo Li et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A pseudogene long-noncoding-RNA network regulates PTEN transcription and translation in human cells

(2013) Per Johnsson et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Folding the proteome

(2013) Esther Braselmann et al.   TRENDS IN BIOCHEMICAL SCIENCES

Identification of a Tissue-Selective Heat Shock Response Regulatory Network

(2013) Eric Guisbert et al.   PLoS Genetics

Quantitative Analysis of Hsp90-Client Interactions Reveals Principles of Substrate Recognition

(2012) Mikko Taipale et al.   CELL

HspB1 Dynamic Phospho-Oligomeric Structure Dependent Interactome as Cancer Therapeutic Target

(2012) A.-P. Arrigo et al.   CURRENT MOLECULAR MEDICINE

The Stability of the Small Nucleolar Ribonucleoprotein (snoRNP) Assembly Protein Pih1 inSaccharomyces cerevisiaeIs Modulated by Its C Terminus

(2012) Alexandr Paci et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Toll-like Receptor Agonists and Febrile Range Hyperthermia Synergize to Induce Heat Shock Protein 70 Expression and Extracellular Release

(2012) Aditi Gupta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure and Dynamics of the ATP-Bound Open Conformation of Hsp70 Chaperones

(2012) Roman Kityk et al.   MOLECULAR CELL

Promoter-proximal pausing of RNA polymerase II: emerging roles in metazoans

(2012) Karen Adelman et al.   NATURE REVIEWS GENETICS

C-terminal phosphorylation of Hsp70 and Hsp90 regulates alternate binding to co-chaperones CHIP and HOP to determine cellular protein folding/degradation balances

(2012) P Muller et al.   ONCOGENE

mTOR Is Essential for the Proteotoxic Stress Response, HSF1 Activation and Heat Shock Protein Synthesis

(2012) Shiuh-Dih Chou et al.   PLoS One

The conserved arginine 380 of Hsp90 is not a catalytic residue, but stabilizes the closed conformation required for ATP hydrolysis

(2012) Christian N. Cunningham et al.   PROTEIN SCIENCE

Targeting Heat Shock Proteins 70/90 and Proteasome for Cancer Therapy

(2011) R. E. Wang   CURRENT MEDICINAL CHEMISTRY

Ubiquitin–proteasome pathway and cellular responses to oxidative stress

(2011) Fu Shang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Autophagy, protein aggregation and hyperthermia: A mini-review

(2011) Yue Zhang et al.   INTERNATIONAL JOURNAL OF HYPERTHERMIA

Coordinated Post-transcriptional Regulation of Hsp70.3 Gene Expression by MicroRNA and Alternative Polyadenylation

(2011) Michael Tranter et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Threonine 22 Phosphorylation Attenuates Hsp90 Interaction with Cochaperones and Affects Its Chaperone Activity

(2011) Mehdi Mollapour et al.   MOLECULAR CELL

Mechanics of Hsp70 chaperones enables differential interaction with client proteins

(2011) Rainer Schlecht et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Protein Kinase A Regulates Molecular Chaperone Transcription and Protein Aggregation

(2011) Yue Zhang et al.   PLoS One

Physical limits of cells and proteomes

(2011) K. A. Dill et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Meta-analysis of heat- and chemically upregulated chaperone genes in plant and human cells

(2010) Andrija Finka et al.   CELL STRESS & CHAPERONES

Chaperone-Assisted Selective Autophagy Is Essential for Muscle Maintenance

(2010) Verena Arndt et al.   CURRENT BIOLOGY

CHIP participates in protein triage decisions by preferentially ubiquitinating Hsp70-bound substrates

(2010) Marta Stankiewicz et al.   FEBS Journal

Heat Shock Protein 90 Mediates Efficient Antigen Cross Presentation through the Scavenger Receptor Expressed by Endothelial Cells-I

(2010) A. Murshid et al.   JOURNAL OF IMMUNOLOGY

Heat shock proteins in toxicology: How close and how far?

(2010) Subash C. Gupta et al.   LIFE SCIENCES

Biological and Structural Basis for Aha1 Regulation of Hsp90 ATPase Activity in Maintaining Proteostasis in the Human Disease Cystic Fibrosis

(2010) Atanas V. Koulov et al.   MOLECULAR BIOLOGY OF THE CELL

The Heat Shock Response: Life on the Verge of Death

(2010) Klaus Richter et al.   MOLECULAR CELL

Asymmetric Activation of the Hsp90 Dimer by Its Cochaperone Aha1

(2010) Marco Retzlaff et al.   MOLECULAR CELL

The kinetic parameters and energy cost of the Hsp70 chaperone as a polypeptide unfoldase

(2010) Sandeep K Sharma et al.   Nature Chemical Biology

Hyperthermia in the febrile range induces HSP72 expression proportional to exposure temperature but not to HSF-1 DNA-binding activity in human lung epithelial A549 cells

(2009) Mohan E. Tulapurkar et al.   CELL STRESS & CHAPERONES

The Shock of Aging: Molecular Chaperones and the Heat Shock Response in Longevity and Aging – A Mini-Review

(2009) Stuart K. Calderwood et al.   GERONTOLOGY

Hyperthermia classic commentary: ‘Arrhenius relationships from the molecule and cell to the clinic’ by William Dewey,Int. J. Hyperthermia, 10:457–483, 1994

(2009) William C. Dewey et al.   INTERNATIONAL JOURNAL OF HYPERTHERMIA

Selective Accumulation of Aggregation-Prone Proteasome Substrates in Response to Proteotoxic Stress

(2009) F. A. Salomons et al.   MOLECULAR AND CELLULAR BIOLOGY

The hsp90-FKBP52 Complex Links the Mineralocorticoid Receptor to Motor Proteins and Persists Bound to the Receptor in Early Nuclear Events

(2009) M. D. Galigniana et al.   MOLECULAR AND CELLULAR BIOLOGY

Dissection of the ATP-induced conformational cycle of the molecular chaperone Hsp90

(2009) Martin Hessling et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Solution conformation of wild-type E. coli Hsp70 (DnaK) chaperone complexed with ADP and substrate

(2009) E. B. Bertelsen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stress-Inducible Regulation of Heat Shock Factor 1 by the Deacetylase SIRT1

(2009) S. D. Westerheide et al.   SCIENCE

Sending Signals Dynamically

(2009) R. G. Smock et al.   SCIENCE

Accurate Prediction of DnaK-Peptide Binding via Homology Modelling and Experimental Data

(2009) Joost Van Durme et al.   PLoS Computational Biology

hsp70 genes in the human genome: Conservation and differentiation patterns predict a wide array of overlapping and specialized functions

(2008) Luciano Brocchieri et al.   BMC EVOLUTIONARY BIOLOGY

Guidelines for the nomenclature of the human heat shock proteins

(2008) Harm H. Kampinga et al.   CELL STRESS & CHAPERONES

Transduced human PEP-1-heat shock protein 27 efficiently protects against brain ischemic insult

(2008) Jae J. An et al.   FEBS Journal

Defining the TRiC/CCT interactome links chaperonin function to stabilization of newly made proteins with complex topologies

(2008) Alice Y Yam et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Adapting Proteostasis for Disease Intervention

(2008) William E. Balch et al.   SCIENCE