Review
Oncology
Agnese Montanino, Anna Manzo, Guido Carillio, Giuliano Palumbo, Giovanna Esposito, Vincenzo Sforza, Raffaele Costanzo, Claudia Sandomenico, Gerardo Botti, Maria C. Piccirillo, Priscilla Cascetta, Giacomo Pascarella, Carmine La Manna, Nicola Normanno, Alessandro Morabito
Summary: Inhibition of angiogenesis has shown efficacy in treating SCLC, with anlotinib being the only drug that has demonstrated improvement in both overall survival (OS) and progression-free survival (PFS) in Chinese patients. Future challenges include evaluating angiogenesis inhibitors in combination with immune-checkpoint inhibitors and chemotherapy in SCLC patients, as well as identifying predictive biomarkers of response to these agents.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Xinlong Xie, Qiying Wu, Yuhong Liu, Chunyang Chen, Zeguo Chen, Chao Xie, Mingzhe Song, Zhenlin Jiang, Xiaoke Qi, Sixi Liu, Zhenjie Tang, Zhongshi Wu
Summary: This study evaluated the effect of VEGF on neointimal hyperplasia and local inflammatory responses in decellularized small-diameter vascular grafts. The results showed that local administration of VEGF attenuated neointimal hyperplasia by inducing macrophage M2 polarization and modulating the inflammatory response.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Medicine, Research & Experimental
Xun-Huang Duan, Rui Chen, Dao-Sheng Li, Ai-Hua Luo, Lin-Lang Guo
Summary: The RNA-binding protein, HuR, has been found to play an oncogenic role in various cancers, including small cell lung cancer (SCLC). This study investigated the role of HuR in SCLC chemoresistance and its potential molecular mechanism involving Fibroblast growth factor receptor-like 1 (FGFRL1). The results showed that HuR expression levels were increased in drug-resistant SCLC cell lines and knocking down HuR enhanced drug sensitivity, apoptosis, and cell cycle arrest. Furthermore, HuR was found to regulate FGFRL1 expression levels, suggesting its involvement in SCLC chemoresistance.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)
Review
Cell Biology
Yelda Pakize Kina, Ali Khadim, Werner Seeger, Elie El Agha
Summary: Multiple factors converge to coordinate organogenesis, particularly in the context of lung development where airway branching is considered a rate-limiting step. The reciprocal interaction between the vascular network and airway tree plays a critical role in their patterning, branching, and alignment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Medicine, Research & Experimental
Mehdi Badaoui, Cyril Sobolewski, Alexandre Luscher, Marc Bacchetta, Thilo Kohler, Christian van Delden, Michelangelo Foti, Marc Chanson
Summary: Cystic fibrosis (CF) is a chronic respiratory disease caused by bacterial infections, with Pseudomonas aeruginosa (Pa) being the main pathogen. The overexpression of Vav3, a guanine nucleotide exchange factor, is induced by the upregulation of mRNA-stabilizing protein HuR in CF patients. The accumulation of HuR in the cytoplasm of CF airway epithelial cells stabilizes Vav3 mRNA, leading to the formation of fibronectin-made bacterial docking platforms and Pa adhesion. Targeting HuR could be a promising strategy to prevent Pa infection in CF.
Article
Multidisciplinary Sciences
Chin-Kuo Lin, Tzu-Hsiung Huang, Cheng-Ta Yang, Chung-Sheng Shi
Summary: The study found that lung-recruited monocytes post-VILI are predominantly Ly6C(+low), and pulmonary VEGF decreases initially but increases significantly on days 7 and 14 after injury. There is a strong positive correlation between VEGF expression and alveolar epithelial cell proliferation, and the restoration of pulmonary VEGF by monocytes may play a crucial role in post-VILI lung repair.
Article
Environmental Sciences
Su Min Ji, Jae-Sun Choi, Ji Young Lee, Sungyeon Kim, Woom-Yee Bae, Ye Won Jang, Ja-Eun Kim, Seung Hyeun Lee, Seungyoon Nam, Joo-Won Jeong
Summary: Fine particulate matter (PM2.5) is associated with worldwide public health problems, including epigenetic and microenvironmental changes in lung cancer. This study found that relatively lower concentrations of PM2.5 increased angiogenic activities in endothelial cells and non-small cell lung carcinoma cells, and induced the expression of hypoxia-inducible factor-1a (HIF-1a) to promote the growth and angiogenesis of lung cancer in a mouse tumor model. Lung cancer patients in countries with high PM2.5 levels had high expression of angiogenic factors such as vascular endothelial growth factor (VEGF), which led to a lower survival rate. These findings provide new insights into the mechanisms of HIF-1a-mediated angiogenesis in lung cancer patients exposed to mild PM2.5.
ENVIRONMENTAL POLLUTION
(2023)
Article
Oncology
Tomoyuki Naito, Yuji Minegishi, Hideaki Shiraishi, Tatsuhiko Hoshino, Junichi Maeda, Toshiya Yokota, Shingo Ikeda, Miyanaga Akihiko, Masahiro Seike
Summary: The study explores the impact of background cardiovascular risk factors on VEGF inhibitor-related adverse vascular events (AVEs) in NSCLC patients. It found that male gender, smoking history, hypertension, dyslipidemia, diabetes, and cardiovascular disease were associated with increased risk of VEGF-related AVEs. Hypertension and chronic kidney disease were associated with discontinuation due to VEGF-related AVEs. The study recommends caution in using VEGF inhibitors for patients with ≥3 cardiovascular risk factors.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Letter
Medicine, General & Internal
Benjamin Sommer Thinggaard, Frederik Pedersen, Jakob Grauslund, Lonny Stokholm
Summary: This cohort study examines the use and forecast of intravitreal injections of vascular endothelial growth factor inhibitor in Denmark from 2007 through 2022.
Article
Oncology
Yali Wang, Weimin Zhang, Wenzhong Liu, Lijie Huang, Yan Wang, Dan Li, Guangchao Wang, Zitong Zhao, Xinming Chi, Yu Xue, Yongmei Song, Xuefeng Liu, Qimin Zhan
Summary: This study revealed a novel lncRNA-guided mechanism of lymph node metastasis in ESCC, in which VESTAR played a key role in lymphatic metastasis. This may provide a potential target for the treatment of ESCC lymphatic metastasis.
Article
Oncology
Kenji Nakahama, Hiroyasu Kaneda, Masahiko Osawa, Mitsuru Fukui, Motohiro Izumi, Naoki Yoshimoto, Akira Sugimoto, Hiroaki Nagamine, Koichi Ogawa, Yoshiya Matsumoto, Kenji Sawa, Yoko Tani, Shigeki Mitsuoka, Tetsuya Watanabe, Kazuhisa Asai, Tomoya Kawaguchi
Summary: This study found that the expression of vascular endothelial growth factor receptor 2 in immune cells can affect the therapeutic efficacy of immune-checkpoint inhibitors in patients with advanced non-small cell lung cancer, while the expression in tumor cells does not significantly impact the treatment outcome.
Article
Biochemistry & Molecular Biology
Yueshuang Ke, Xueping Lv, Xingyue Fu, Jing Zhang, Ameer Ali Bohio, Xianlu Zeng, Wenjing Hao, Ruoxi Wang, Istvan Boldogh, Xueqing Ba
Summary: PARylation is an important post-translational modification that increases the formation of HuR oligomer/multimer, which in turn promotes the disassociation of miRISC and stabilizes pro-inflammatory gene mRNAs.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Genevieve A. Secker, Natasha L. Harvey
Summary: The importance of lymphatic vessels in human diseases, the initiation of lymphatic vascular development during embryogenesis, and the role of VEGF/VEGFR signaling in driving the construction of lymphatic vessels were discussed in this review.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Carlos Escudero, Jesenia Acurio, Eduardo Lopez, Andres Rodriguez, Antonia Benavente, Evelyn Lara, Steven J. Korzeniewski
Summary: Circulating VEGF levels were found to be elevated 24-48 hours after acute ischemic stroke and were associated with prognosis of moderate to severe disability at 6 months. Combining VEGF with interleukin 6 and C-reactive protein significantly improved predictive performance compared to using VEGF alone.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yanjin Sun, Siyuan Zhan, Sen Zhao, Tao Zhong, Linjie Wang, Jiazhong Guo, Dinghui Dai, Dandan Li, Jiaxue Cao, Li Li, Hongping Zhang
Summary: HuR is highly expressed in goat skeletal muscle and plays a crucial role in promoting muscle differentiation by increasing the stability of Myomaker mRNA. Overexpression of HuR accelerates muscle cell differentiation and formation of myotubes, while knockdown of HuR has the opposite effects. HuR binds to Myomaker, increasing its mRNA stability and positively regulating its expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)