Complex HuR function in pancreatic cancer cells

Cytoplasmic HuR Status Predicts Disease-free Survival in Resected Pancreatic Cancer

(2018) Talar Tatarian et al.   ANNALS OF SURGERY

CRISPR Knockout of the HuR Gene Causes a Xenograft Lethal Phenotype

(2017) Shruti Lal et al.   MOLECULAR CANCER RESEARCH

Regulation of HuR structure and function by dihydrotanshinone-I

(2017) Preet Lal et al.   NUCLEIC ACIDS RESEARCH

ROS in Cancer: The Burning Question

(2017) Iok In Christine Chio et al.   TRENDS IN MOLECULAR MEDICINE

Delivery of Therapeutics Targeting the mRNA-Binding Protein HuR Using 3DNA Nanocarriers Suppresses Ovarian Tumor Growth

(2016) Yu-Hung Huang et al.   CANCER RESEARCH

Genetic Diversity of Pancreatic Ductal Adenocarcinoma and Opportunities for Precision Medicine

(2016) Erik S. Knudsen et al.   GASTROENTEROLOGY

HuR Contributes to TRAIL Resistance by Restricting Death Receptor 4 Expression in Pancreatic Cancer Cells

(2016) C. Romeo et al.   MOLECULAR CANCER RESEARCH

Genomic analyses identify molecular subtypes of pancreatic cancer

(2016) Peter Bailey et al.   NATURE

Impact of HuR inhibition by the small molecule MS-444 on colorectal cancer cell tumorigenesis

(2016) Fernando F. Blanco et al.   Oncotarget

Inhibiting cytoplasmic accumulation of HuR synergizes genotoxic agents in urothelial carcinoma of the bladder

(2016) Jiawei Guo et al.   Oncotarget

Hallmarks of cancer and AU-rich elements

(2016) Khalid S. A. Khabar   Wiley Interdisciplinary Reviews-RNA

Posttranslational control of HuR function

(2016) Ioannis Grammatikakis et al.   Wiley Interdisciplinary Reviews-RNA

Identification and Validation of Novel Small Molecule Disruptors of HuR-mRNA Interaction

(2015) Xiaoqing Wu et al.   ACS Chemical Biology

Targeting the Multifaceted HuR Protein, Benefits and Caveats

(2015) Chiara Zucal et al.   CURRENT DRUG TARGETS

The mRNA-binding protein HuR promotes hypoxia-induced chemoresistance through posttranscriptional regulation of the proto-oncogene PIM1 in pancreatic cancer cells

(2015) F F Blanco et al.   ONCOGENE

Targeting the mRNA-binding protein HuR impairs malignant characteristics of pancreatic ductal adenocarcinoma cells

(2015) Masaya Jimbo et al.   Oncotarget

Discovery of a drug targeting microenvironmental support for lymphoma cells by screening using patient-derived xenograft cells

(2015) Keiki Sugimoto et al.   Scientific Reports

Dihydrotanshinone-I interferes with the RNA-binding activity of HuR affecting its post-transcriptional function

(2015) Vito Giuseppe D’Agostino et al.   Scientific Reports

dCK expression correlates with 5-fluorouracil efficacy and HuR cytoplasmic expression in pancreatic cancer

(2014) Florencia McAllister et al.   CANCER BIOLOGY & THERAPY

HuR Posttranscriptionally Regulates WEE1: Implications for the DNA Damage Response in Pancreatic Cancer Cells

(2014) S. Lal et al.   CANCER RESEARCH

Clinical significance of HuR expression in human malignancy

(2014) Ioly Kotta-Loizou et al.   MEDICAL ONCOLOGY

Repurposing the FDA-Approved Pinworm Drug Pyrvinium as a Novel Chemotherapeutic Agent for Intestinal Polyposis

(2014) Bin Li et al.   PLoS One

Ligand-Independent and Tissue-Selective Androgen Receptor Inhibition by Pyrvinium

(2013) Minyoung Lim et al.   ACS Chemical Biology

Multiple Functions of the RNA-Binding Protein HuR in Cancer Progression, Treatment Responses and Prognosis

(2013) Jun Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Increased Survival in Pancreatic Cancer with nab-Paclitaxel plus Gemcitabine

(2013) Daniel D. Von Hoff et al.   NEW ENGLAND JOURNAL OF MEDICINE

Tyrosine phosphorylation of HuR by JAK3 triggers dissociation and degradation of HuR target mRNAs

(2013) J.-H. Yoon et al.   NUCLEIC ACIDS RESEARCH

A Novel High Throughput Biochemical Assay to Evaluate the HuR Protein-RNA Complex Formation

(2013) Vito G. D’Agostino et al.   PLoS One

The Antihelmintic Drug Pyrvinium Pamoate Targets Aggressive Breast Cancer

(2013) Wei Xu et al.   PLoS One

HuR is a post-transcriptional regulator of core metabolic enzymes in pancreatic cancer

(2013) Richard A Burkhart et al.   RNA Biology

HuR’s post-transcriptional regulation of death receptor 5 in pancreatic cancer cells

(2012) Danielle M. Pineda et al.   CANCER BIOLOGY & THERAPY

Regulation of the mRNA-Binding Protein HuR by Posttranslational Modification: Spotlight on Phosphorylation

(2012) Wolfgang Eberhardt et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

HuR thermal stability is dependent on domain binding and upon phosphorylation

(2012) Rafael Manfred Scheiba et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Hypoxia Predicts Aggressive Growth and Spontaneous Metastasis Formation from Orthotopically Grown Primary Xenografts of Human Pancreatic Cancer

(2011) Q. Chang et al.   CANCER RESEARCH

High-constitutive HuR phosphorylation at Ser 318 by PKCδ propagates tumor relevant functions in colon carcinoma cells

(2011) Anke Doller et al.   CARCINOGENESIS

Global dissociation of HuR-mRNA complexes promotes cell survival after ionizing radiation

(2011) Kiyoshi Masuda et al.   EMBO JOURNAL

The mRNA Stability Factor HuR Inhibits MicroRNA-16 Targeting of COX-2

(2011) L. E. Young et al.   MOLECULAR CANCER RESEARCH

Subtypes of pancreatic ductal adenocarcinoma and their differing responses to therapy

(2011) Eric A Collisson et al.   NATURE MEDICINE

Chk2-dependent HuR phosphorylation regulates occludin mRNA translation and epithelial barrier function

(2011) Ting-Xi Yu et al.   NUCLEIC ACIDS RESEARCH

H 2 O 2 Regulation of Vascular Function Through sGC mRNA Stabilization by HuR

(2010) Abel Martín-Garrido et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

miR-519 suppresses tumor growth by reducing HuR levels

(2010) Kotb Abdelmohsen et al.   CELL CYCLE

Tandem Phosphorylation of Serines 221 and 318 by Protein Kinase C  Coordinates mRNA Binding and Nucleocytoplasmic Shuttling of HuR

(2010) A. Doller et al.   MOLECULAR AND CELLULAR BIOLOGY

pp32 (ANP32A) Expression Inhibits Pancreatic Cancer Cell Growth and Induces Gemcitabine Resistance by Disrupting HuR Binding to mRNAs

(2010) Timothy K. Williams et al.   PLoS One

HuR's role in gemcitabine efficacy: an exception or opportunity?

(2010) Jonathan R. Brody et al.   Wiley Interdisciplinary Reviews-RNA

Posttranscriptional regulation of cancer traits by HuR

(2010) Kotb Abdelmohsen et al.   Wiley Interdisciplinary Reviews-RNA

The Role of HuR in Gemcitabine Efficacy in Pancreatic Cancer: HuR Up-regulates the Expression of the Gemcitabine Metabolizing Enzyme Deoxycytidine Kinase

(2009) C. L. Costantino et al.   CANCER RESEARCH

Phosphorylation of the HuR ligand APRIL by casein kinase 2 regulates CD83 expression

(2009) Jan Chemnitz et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Chemical inhibitors destabilize HuR binding to the AU-rich element of TNF-α mRNA

(2009) Min-Ju Chae et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

The mRNA Binding Proteins HuR and Tristetraprolin Regulate Cyclooxygenase 2 Expression During Colon Carcinogenesis

(2009) Lisa E. Young et al.   GASTROENTEROLOGY

Polyamines Regulate c-Myc Translation through Chk2-dependent HuR Phosphorylation

(2009) Lan Liu et al.   MOLECULAR BIOLOGY OF THE CELL

Polyamines modulate the subcellular localization of RNA-binding protein HuR through AMP-activated protein kinase-regulated phosphorylation and acetylation of importin α1

(2008) Tongtong Zou et al.   BIOCHEMICAL JOURNAL

Diverse molecular functions of Hu proteins

(2008) M. N. Hinman et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Nuclear HuR accumulation through phosphorylation by Cdk1

(2008) H. H. Kim et al.   GENES & DEVELOPMENT

miR-519 reduces cell proliferation by lowering RNA-binding protein HuR levels

(2008) K. Abdelmohsen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses

(2008) S. Jones et al.   SCIENCE