Quantification of Metabotropic Glutamate Receptor 5 Availability With Both [11C]ABP688 and [18F]FPEB Positron Emission Tomography in the Sapap3 Knockout Mouse Model for Obsessive-Compulsive–like Behavior

Harmonizing the Neurobiology and Treatment of Obsessive-Compulsive Disorder

(2021) Wayne K. Goodman et al.   AMERICAN JOURNAL OF PSYCHIATRY

Study of influence of the glutamatergic concentration of [18F]FPEB binding to metabotropic glutamate receptor subtype 5 with N-acetylcysteine challenge in rats and SRM/PET study in human healthy volunteers

(2021) Anne-Claire Dupont et al.   Translational Psychiatry

Progression of obsessive compulsive disorder-like grooming in Sapap3 knockout mice: A longitudinal [11C]ABP688 PET study

(2020) Dorien Glorie et al.   NEUROPHARMACOLOGY

Astrocytic Glutamate Transporter 1 (GLT1) Deficiency Reduces Anxiety- and Depression-Like Behaviors in Mice

(2020) Yun-Fang Jia et al.   Frontiers in Behavioral Neuroscience

A Review of Molecular Imaging of Glutamate Receptors

(2020) Jong-Hoon Kim et al.   MOLECULES

Targeting presynaptic H3 heteroreceptor in nucleus accumbens to improve anxiety and obsessive-compulsive-like behaviors

(2020) Xiao-Yang Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Behavioral and synaptic alterations relevant to obsessive-compulsive disorder in mice with increased EAAT3 expression

(2019) Claudia Delgado-Acevedo et al.   NEUROPSYCHOPHARMACOLOGY

Measuring the effects of ketamine on mGluR5 using [18F]FPEB and PET

(2019) Sophie E Holmes et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Metabotropic Glutamatergic Receptor 5 and Stress Disorders: Knowledge Gained From Receptor Imaging Studies

(2018) Irina Esterlis et al.   BIOLOGICAL PSYCHIATRY

Test-retest variability of [11 C]ABP688 estimates of metabotropic glutamate receptor subtype 5 availability in humans

(2018) Kelly Smart et al.   SYNAPSE

Noninvasive Relative Quantification of [11C]ABP688 PET Imaging in Mice Versus an Input Function Measured Over an Arteriovenous Shunt

(2018) Jeroen Verhaeghe et al.   Frontiers in Neurology

Revealing the complex genetic architecture of obsessive–compulsive disorder using meta-analysis

(2017) Paul D Arnold et al.   MOLECULAR PSYCHIATRY

Ketamine-induced reduction in mGluR5 availability is associated with an antidepressant response: an [11C]ABP688 and PET imaging study in depression

(2017) I Esterlis et al.   MOLECULAR PSYCHIATRY

Increased Metabotropic Glutamate Receptor 5 Signaling Underlies Obsessive-Compulsive Disorder-like Behavioral and Striatal Circuit Abnormalities in Mice

(2016) Kristen K. Ade et al.   BIOLOGICAL PSYCHIATRY

Metabotropic glutamate receptor 5 – a promising target in drug development and neuroimaging

(2016) Rajapillai L. I. Pillai et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

In vivo variation in same-day estimates of metabotropic glutamate receptor subtype 5 binding using [11C]ABP688 and [18F]FPEB

(2016) Christine DeLorenzo et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Kinetic modeling and long-term test-retest reproducibility of the mGluR5 PET tracer18F-FPEB in human brain

(2016) Gil Leurquin-Sterk et al.   SYNAPSE

In Vivo Ketamine-Induced Changes in [ 11 C]ABP688 Binding to Metabotropic Glutamate Receptor Subtype 5

(2015) Christine DeLorenzo et al.   BIOLOGICAL PSYCHIATRY

Test–retest reproducibility of the metabotropic glutamate receptor 5 ligand [18F]FPEB with bolus plus constant infusion in humans

(2015) Eunkyung Park et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Preclinical Evaluation and Quantification of 18F-FPEB as a Radioligand for PET Imaging of the Metabotropic Glutamate Receptor 5

(2015) B. de Laat et al.   JOURNAL OF NUCLEAR MEDICINE

Astroglial Glutamate Transporter Deficiency Increases Synaptic Excitability and Leads to Pathological Repetitive Behaviors in Mice

(2015) Tomomi Aida et al.   NEUROPSYCHOPHARMACOLOGY

Synaptic basis of social dysfunction: a focus on postsynaptic proteins linking group-I mGluRs with AMPARs and NMDARs

(2014) Eoin C. O'Connor et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Metabotropic glutamate receptor 5 binding in patients with obsessive-compulsive disorder

(2014) Funda Akkus et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Relationship between In Vivo Receptor Occupancy and Efficacy of Metabotropic Glutamate Receptor Subtype 5 Allosteric Modulators with Different In Vitro Binding Profiles

(2014) Jerri M Rook et al.   NEUROPSYCHOPHARMACOLOGY

18F-FPEB, a PET Radiopharmaceutical for Quantifying Metabotropic Glutamate 5 Receptors: A First-in-Human Study of Radiochemical Safety, Biokinetics, and Radiation Dosimetry

(2013) D. F. Wong et al.   JOURNAL OF NUCLEAR MEDICINE

N-Acetylcysteine- and MK-801-Induced Changes in Glutamate Levels Do Not Affect In Vivo Binding of Metabotropic Glutamate 5 Receptor Radioligand 11C-ABP688 in Rat Brain

(2013) T. Wyckhuys et al.   JOURNAL OF NUCLEAR MEDICINE

Constitutive internalization and recycling of metabotropic glutamate receptor 5 (mGluR5)

(2012) Rishi Raj Trivedi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Test-retest stability of cerebral mGluR5 quantification using [11C]ABP688 and positron emission tomography in rats

(2012) David Elmenhorst et al.   SYNAPSE

In vivo positron emission tomography imaging with [11C]ABP688: binding variability and specificity for the metabotropic glutamate receptor subtype 5 in baboons

(2011) Christine DeLorenzo et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Glutamate abnormalities in obsessive compulsive disorder: Neurobiology, pathophysiology, and treatment

(2011) Christopher Pittenger et al.   PHARMACOLOGY & THERAPEUTICS

The role of glutamate signaling in the pathogenesis and treatment of obsessive–compulsive disorder

(2011) Ke Wu et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Metabotropic Glutamate Receptors: Physiology, Pharmacology, and Disease

(2010) Colleen M. Niswender et al.   Annual Review of Pharmacology and Toxicology

Deep Brain Stimulation of the Nucleus Accumbens for Treatment-Refractory Obsessive-Compulsive Disorder

(2010) Damiaan Denys et al.   ARCHIVES OF GENERAL PSYCHIATRY

In vivo and in vitro Validation of Reference Tissue Models for the mGluR5 Ligand [11C]ABP688

(2010) David Elmenhorst et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Waxholm Space: An image-based reference for coordinating mouse brain research

(2010) G. Allan Johnson et al.   NEUROIMAGE

Evaluation of a bolus/infusion protocol for 11C-ABP688, a PET tracer for mGluR5

(2010) Cyrill Burger et al.   NUCLEAR MEDICINE AND BIOLOGY

Obsessive-compulsive disorder

(2009) Jonathan S Abramowitz et al.   LANCET

The epidemiology of obsessive-compulsive disorder in the National Comorbidity Survey Replication

(2008) A M Ruscio et al.   MOLECULAR PSYCHIATRY